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<meta name="DC.Title" content="Dynamic CT Measurement of Cerebral Blood Flow: A Validation Study" />
<meta name="DC.Date" content="1999-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Our objective was to develop a method to correct for the effect of partial volume averaging (PVA) in the CT measurement of contrast enhancement in small arteries, and to validate a dynamic contrast-enhanced CT method for the measurement of regional cerebral blood flow (rCBF).

METHODS: Contrast-enhanced CT scans of tubes of known inner diameters were obtained to estimate the size-dependent scaling factors (PVSF) due to PVA. The background-subtracted image profiles of the contrast-filled tubes were fitted to gaussian curves, and the standard deviations (SDs) of these curves were correlated with the PVSF of each tube. In the second part of this investigation, 13 studies were performed in six New Zealand white rabbits under normal conditions. Dynamic CT measurements of rCBF, regional cerebral blood volume (rCBV), and regional mean transit time (rMTT) were calculated in the left and right parietal lobes and the basal ganglia. The CT rCBF values were compared with those obtained by the microsphere method, which is the standard of reference.

RESULTS: We found strong correlations for the SDs of the gaussian curves to the known inner diameters of the tubes and to their size-related PVSF. These correlations demonstrated that the error from PVA in the measurement of arterial enhancement can be corrected without knowledge of the actual size of the artery. The animal studies revealed a mean (±SD) rCBF of 73.3 ± 31.5 mL/100 g per minute, a mean rCBV of 1.93 ± 0.74 mL/100 g, and a mean rMTT of 1.81 ± 1.02 seconds. A strong correlation was found between rCBF values derived by the CT and the microsphere methods.

CONCLUSION: We have validated a new dynamic CT method for measuring rCBF. The accuracy of this technique suggests that it can be used as an alternative diagnostic tool to assess the cerebral hemodynamics in experimental and clinical situations." />
<meta name="DC.Contributor" content="Aleksa Cenic" />
<meta name="DC.Contributor" content="Darius G. Nabavi" />
<meta name="DC.Contributor" content="Rosemary A. Craen" />
<meta name="DC.Contributor" content="Adrian W. Gelb" />
<meta name="DC.Contributor" content="Ting-Yim Lee" />
<meta name="article:published_time" content="1999-01-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Dynamic CT Measurement of Cerebral Blood Flow: A Validation Study" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Our objective was to develop a method to correct for the effect of partial volume averaging (PVA) in the CT measurement of contrast enhancement in small arteries, and to validate a dynamic contrast-enhanced CT method for the measurement of regional cerebral blood flow (rCBF).&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Contrast-enhanced CT scans of tubes of known inner diameters were obtained to estimate the size-dependent scaling factors (PVSF) due to PVA. The background-subtracted image profiles of the contrast-filled tubes were fitted to gaussian curves, and the standard deviations (SDs) of these curves were correlated with the PVSF of each tube. In the second part of this investigation, 13 studies were performed in six New Zealand white rabbits under normal conditions. Dynamic CT measurements of rCBF, regional cerebral blood volume (rCBV), and regional mean transit time (rMTT) were calculated in the left and right parietal lobes and the basal ganglia. The CT rCBF values were compared with those obtained by the microsphere method, which is the standard of reference.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; We found strong correlations for the SDs of the gaussian curves to the known inner diameters of the tubes and to their size-related PVSF. These correlations demonstrated that the error from PVA in the measurement of arterial enhancement can be corrected without knowledge of the actual size of the artery. The animal studies revealed a mean (±SD) rCBF of 73.3 ± 31.5 mL/100 g per minute, a mean rCBV of 1.93 ± 0.74 mL/100 g, and a mean rMTT of 1.81 ± 1.02 seconds. A strong correlation was found between rCBF values derived by the CT and the microsphere methods.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; We have validated a new dynamic CT method for measuring rCBF. The accuracy of this technique suggests that it can be used as an alternative diagnostic tool to assess the cerebral hemodynamics in experimental and clinical situations.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="1999/01/01" />
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<meta name="citation_author" content="Aleksa Cenic" />
<meta name="citation_author_institution" content="From the Imaging Research Laboratories, John P. Robarts Research Institute (A.C., D.G.N., T-Y.L.); the Medical Biophysics Department, The University of Western Ontario (A.C., T-Y.L.); the Lawson Research Institute, St Joseph's Health Centre, (A.C., T-Y.L.); and the Department of Anaesthesia, University Campus, London Health Sciences Centre (R.A.C., A.W.G.), London, Ontario, Canada." />
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<meta name="citation_author_institution" content="From the Imaging Research Laboratories, John P. Robarts Research Institute (A.C., D.G.N., T-Y.L.); the Medical Biophysics Department, The University of Western Ontario (A.C., T-Y.L.); the Lawson Research Institute, St Joseph's Health Centre, (A.C., T-Y.L.); and the Department of Anaesthesia, University Campus, London Health Sciences Centre (R.A.C., A.W.G.), London, Ontario, Canada." />
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<meta name="citation_author_institution" content="From the Imaging Research Laboratories, John P. Robarts Research Institute (A.C., D.G.N., T-Y.L.); the Medical Biophysics Department, The University of Western Ontario (A.C., T-Y.L.); the Lawson Research Institute, St Joseph's Health Centre, (A.C., T-Y.L.); and the Department of Anaesthesia, University Campus, London Health Sciences Centre (R.A.C., A.W.G.), London, Ontario, Canada." />
<meta name="citation_author" content="Adrian W. Gelb" />
<meta name="citation_author_institution" content="From the Imaging Research Laboratories, John P. Robarts Research Institute (A.C., D.G.N., T-Y.L.); the Medical Biophysics Department, The University of Western Ontario (A.C., T-Y.L.); the Lawson Research Institute, St Joseph's Health Centre, (A.C., T-Y.L.); and the Department of Anaesthesia, University Campus, London Health Sciences Centre (R.A.C., A.W.G.), London, Ontario, Canada." />
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<meta name="twitter:title" content="Dynamic CT Measurement of Cerebral Blood Flow: A Validation Study" />
<meta name="twitter:card" content="summary" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Our objective was to develop a method to correct for the effect of partial volume averaging (PVA) in the CT measurement of contrast enhancement in small arteries, and to validate a dynamic contrast-enhanced CT method for the measurement of regional cerebral blood flow (rCBF).

METHODS: Contrast-enhanced CT scans of tubes of known inner diameters were obtained to estimate the size-dependent scaling factors (PVSF) due to PVA. The background-subtracted image profiles of the contrast-filled tubes were fitted to gaussian curves, and the standard deviations (SDs) of these curves were correlated with the PVSF of each tube. In the second part of this investigation, 13 studies were performed in six New Zealand white rabbits under normal conditions. Dynamic CT measurements of rCBF, regional cerebral blood volume (rCBV), and regional mean transit time (rMTT) were calculated in the left and right parietal lobes and the basal ganglia. The CT rCBF values were compared with those obtained by the microsphere method, which is the standard of reference.

RESULTS: We found strong correlations for the SDs of the gaussian curves to the known inner diameters of the tubes and to their size-related PVSF. These correlations demonstrated that the error from PVA in the measurement of arterial enhancement can be corrected without knowledge of the actual size of the artery. The animal studies revealed a mean (±SD) rCBF of 73.3 ± 31.5 mL/100 g per minute, a mean rCBV of 1.93 ± 0.74 mL/100 g, and a mean rMTT of 1.81 ± 1.02 seconds. A strong correlation was found between rCBF values derived by the CT and the microsphere methods.

CONCLUSION: We have validated a new dynamic CT method for measuring rCBF. The accuracy of this technique suggests that it can be used as an alternative diagnostic tool to assess the cerebral hemodynamics in experimental and clinical situations." />
<meta name="og-title" property="og:title" content="Dynamic CT Measurement of Cerebral Blood Flow: A Validation Study" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/20/1/63" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Our objective was to develop a method to correct for the effect of partial volume averaging (PVA) in the CT measurement of contrast enhancement in small arteries, and to validate a dynamic contrast-enhanced CT method for the measurement of regional cerebral blood flow (rCBF).

METHODS: Contrast-enhanced CT scans of tubes of known inner diameters were obtained to estimate the size-dependent scaling factors (PVSF) due to PVA. The background-subtracted image profiles of the contrast-filled tubes were fitted to gaussian curves, and the standard deviations (SDs) of these curves were correlated with the PVSF of each tube. In the second part of this investigation, 13 studies were performed in six New Zealand white rabbits under normal conditions. Dynamic CT measurements of rCBF, regional cerebral blood volume (rCBV), and regional mean transit time (rMTT) were calculated in the left and right parietal lobes and the basal ganglia. The CT rCBF values were compared with those obtained by the microsphere method, which is the standard of reference.

RESULTS: We found strong correlations for the SDs of the gaussian curves to the known inner diameters of the tubes and to their size-related PVSF. These correlations demonstrated that the error from PVA in the measurement of arterial enhancement can be corrected without knowledge of the actual size of the artery. The animal studies revealed a mean (±SD) rCBF of 73.3 ± 31.5 mL/100 g per minute, a mean rCBV of 1.93 ± 0.74 mL/100 g, and a mean rMTT of 1.81 ± 1.02 seconds. A strong correlation was found between rCBF values derived by the CT and the microsphere methods.

CONCLUSION: We have validated a new dynamic CT method for measuring rCBF. The accuracy of this technique suggests that it can be used as an alternative diagnostic tool to assess the cerebral hemodynamics in experimental and clinical situations." />
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<div id="hw-article-author-popups-top-node-2097--6807195515" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Aleksa Cenic </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging Research Laboratories, John P. Robarts Research Institute (A.C., D.G.N., T-Y.L.); the Medical Biophysics Department, The University of Western Ontario (A.C., T-Y.L.); the Lawson Research Institute, St Joseph's Health Centre, (A.C., T-Y.L.); and the Department of Anaesthesia, University Campus, London Health Sciences Centre (R.A.C., A.W.G.), London, Ontario, Canada.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Aleksa%2BCenic%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cenic%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AAleksa%2BCenic%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Darius G. Nabavi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging Research Laboratories, John P. Robarts Research Institute (A.C., D.G.N., T-Y.L.); the Medical Biophysics Department, The University of Western Ontario (A.C., T-Y.L.); the Lawson Research Institute, St Joseph's Health Centre, (A.C., T-Y.L.); and the Department of Anaesthesia, University Campus, London Health Sciences Centre (R.A.C., A.W.G.), London, Ontario, Canada.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Darius%2BG.%2BNabavi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Nabavi%20DG&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ADarius%2BG.%2BNabavi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">Rosemary A. Craen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging Research Laboratories, John P. Robarts Research Institute (A.C., D.G.N., T-Y.L.); the Medical Biophysics Department, The University of Western Ontario (A.C., T-Y.L.); the Lawson Research Institute, St Joseph's Health Centre, (A.C., T-Y.L.); and the Department of Anaesthesia, University Campus, London Health Sciences Centre (R.A.C., A.W.G.), London, Ontario, Canada.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Rosemary%2BA.%2BCraen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Craen%20RA&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ARosemary%2BA.%2BCraen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Adrian W. Gelb </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging Research Laboratories, John P. Robarts Research Institute (A.C., D.G.N., T-Y.L.); the Medical Biophysics Department, The University of Western Ontario (A.C., T-Y.L.); the Lawson Research Institute, St Joseph's Health Centre, (A.C., T-Y.L.); and the Department of Anaesthesia, University Campus, London Health Sciences Centre (R.A.C., A.W.G.), London, Ontario, Canada.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Adrian%2BW.%2BGelb%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gelb%20AW&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AAdrian%2BW.%2BGelb%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Ting-Yim Lee </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Imaging Research Laboratories, John P. Robarts Research Institute (A.C., D.G.N., T-Y.L.); the Medical Biophysics Department, The University of Western Ontario (A.C., T-Y.L.); the Lawson Research Institute, St Joseph's Health Centre, (A.C., T-Y.L.); and the Department of Anaesthesia, University Campus, London Health Sciences Centre (R.A.C., A.W.G.), London, Ontario, Canada.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Ting-Yim%2BLee%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lee%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ATing-Yim%2BLee%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 20</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 1 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jan 1999 </div></div>
      
      
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      <div class="highwire-cite-title">Dynamic CT Measurement of Cerebral Blood Flow: A Validation Study</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Aleksa</span> <span class="nlm-surname">Cenic</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Darius G.</span> <span class="nlm-surname">Nabavi</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Rosemary A.</span> <span class="nlm-surname">Craen</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Adrian W.</span> <span class="nlm-surname">Gelb</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Ting-Yim</span> <span class="nlm-surname">Lee</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">63-73; </span></div>
  
  
  
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      <div class="highwire-cite-title">Dynamic CT Measurement of Cerebral Blood Flow: A Validation Study</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Aleksa</span> <span class="nlm-surname">Cenic</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Darius G.</span> <span class="nlm-surname">Nabavi</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Rosemary A.</span> <span class="nlm-surname">Craen</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Adrian W.</span> <span class="nlm-surname">Gelb</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Ting-Yim</span> <span class="nlm-surname">Lee</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">63-73; </span></div>
  
  
  
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