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<meta name="DC.Title" content="MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis" />
<meta name="DC.Date" content="1999-11-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a demyelinating disease most often associated with progressive physical impairment; however, its effects are noted to extend beyond physical disability. Our purpose was to determine the relationship between T2 lesion volume and neurocognitive and physical disability in relapsing-remitting multiple sclerosis.

METHODS: We studied a cohort of 19 patients with relapsing-remitting MS. Of this group, there were 15 women and four men from varying socioeconomic backgrounds. This volunteer sample was selected from a larger group of 53 patients with MS in our longitudinal MS study because they had been untreated with any beta-interferon medications, had been followed for at least 12 months, and had a clinical status of relapsing-remitting MS.

RESULTS: Of 12 neurocognitive parameters tested, two correlated significantly with lesion loads. The correlation of the Symbol-Digit Modalities test, which analyzes information-processing speed, was significant ( P = .0204). The correlation of the fifth trial of the Rey Auditory Verbal Learning test, which tests verbal long-term memory, was also significant ( P = .0348). None of the other 10 neurocognitive examinations, however, showed a significant correlation with total lesion volume (Paced Auditory Serial Addition test-1.6, P = .7381; Paced Auditory Serial Addition test-2.0, P = .4180; Controlled Oral Word Association test, P = .8906; Category Fluency test, P = .4423; Bells test, P = .9097; Rey Auditory Verbal Learning test-delay, P = .9843, Rey Auditory Verbal Learning test-recognition, P = .7467; Word Span test, P = .4939; Road Map test, P = 0.4939). The lesion load also did not correlate with the physical disability scales as rated according to the Expanded Disability Status Scale ( P = .68) or Ambulation Index ( P = .95).

CONCLUSION: Our results indicate that T2 lesion volume does not seem to be a robust surrogate marker of neuropsychological impairment in patients with MS. We think that global measurements of parameters that are more specific to the disease process may offer more precise correlation with cognitive dysfunction and other disability parameters." />
<meta name="DC.Contributor" content="Jennifer C. Fulton" />
<meta name="DC.Contributor" content="Robert I. Grossman" />
<meta name="DC.Contributor" content="Jayaram Udupa" />
<meta name="DC.Contributor" content="Lois J. Mannon" />
<meta name="DC.Contributor" content="Murray Grossman" />
<meta name="DC.Contributor" content="Luogang Wei" />
<meta name="DC.Contributor" content="Marcia Polansky" />
<meta name="DC.Contributor" content="Dennis L. Kolson" />
<meta name="article:published_time" content="1999-11-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Multiple sclerosis (MS) is a demyelinating disease most often associated with progressive physical impairment; however, its effects are noted to extend beyond physical disability. Our purpose was to determine the relationship between T2 lesion volume and neurocognitive and physical disability in relapsing-remitting multiple sclerosis.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; We studied a cohort of 19 patients with relapsing-remitting MS. Of this group, there were 15 women and four men from varying socioeconomic backgrounds. This volunteer sample was selected from a larger group of 53 patients with MS in our longitudinal MS study because they had been untreated with any beta-interferon medications, had been followed for at least 12 months, and had a clinical status of relapsing-remitting MS.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; Of 12 neurocognitive parameters tested, two correlated significantly with lesion loads. The correlation of the Symbol-Digit Modalities test, which analyzes information-processing speed, was significant (&lt;i&gt;P&lt;/i&gt; = .0204). The correlation of the fifth trial of the Rey Auditory Verbal Learning test, which tests verbal long-term memory, was also significant (&lt;i&gt;P&lt;/i&gt; = .0348). None of the other 10 neurocognitive examinations, however, showed a significant correlation with total lesion volume (Paced Auditory Serial Addition test-1.6, &lt;i&gt;P&lt;/i&gt; = .7381; Paced Auditory Serial Addition test-2.0, &lt;i&gt;P&lt;/i&gt; = .4180; Controlled Oral Word Association test, &lt;i&gt;P&lt;/i&gt; = .8906; Category Fluency test, &lt;i&gt;P&lt;/i&gt; = .4423; Bells test, &lt;i&gt;P&lt;/i&gt; = .9097; Rey Auditory Verbal Learning test-delay, &lt;i&gt;P&lt;/i&gt; = .9843, Rey Auditory Verbal Learning test-recognition, &lt;i&gt;P&lt;/i&gt; = .7467; Word Span test, &lt;i&gt;P&lt;/i&gt; = .4939; Road Map test, &lt;i&gt;P&lt;/i&gt; = 0.4939). The lesion load also did not correlate with the physical disability scales as rated according to the Expanded Disability Status Scale (&lt;i&gt;P&lt;/i&gt; = .68) or Ambulation Index (&lt;i&gt;P&lt;/i&gt; = .95).&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Our results indicate that T2 lesion volume does not seem to be a robust surrogate marker of neuropsychological impairment in patients with MS. We think that global measurements of parameters that are more specific to the disease process may offer more precise correlation with cognitive dysfunction and other disability parameters.&lt;/p&gt;" />
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<meta name="citation_publication_date" content="1999/11/01" />
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<meta name="citation_author" content="Luogang Wei" />
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<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Cognitive dysfunction in multiple sclerosis.: I. Frequency, patterns, and prediction;citation_pages=685-691;citation_volume=41;citation_year=1991;citation_issue=5;citation_issn=0028-3878;citation_pmid=2027484;citation_doi=10.1212/WNL.41.5.685" />
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<meta name="twitter:title" content="MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a demyelinating disease most often associated with progressive physical impairment; however, its effects are noted to extend beyond physical disability. Our purpose was to determine the relationship between T2 lesion volume and neurocognitive and physical disability in relapsing-remitting multiple sclerosis.

METHODS: We studied a cohort of 19 patients with relapsing-remitting MS. Of this group, there were 15 women and four men from varying socioeconomic backgrounds. This volunteer sample was selected from a larger group of 53 patients with MS in our longitudinal MS study because they had been untreated with any beta-interferon medications, had been followed for at least 12 months, and had a clinical status of relapsing-remitting MS.

RESULTS: Of 12 neurocognitive parameters tested, two correlated significantly with lesion loads. The correlation of the Symbol-Digit Modalities test, which analyzes information-processing speed, was significant ( P = .0204). The correlation of the fifth trial of the Rey Auditory Verbal Learning test, which tests verbal long-term memory, was also significant ( P = .0348). None of the other 10 neurocognitive examinations, however, showed a significant correlation with total lesion volume (Paced Auditory Serial Addition test-1.6, P = .7381; Paced Auditory Serial Addition test-2.0, P = .4180; Controlled Oral Word Association test, P = .8906; Category Fluency test, P = .4423; Bells test, P = .9097; Rey Auditory Verbal Learning test-delay, P = .9843, Rey Auditory Verbal Learning test-recognition, P = .7467; Word Span test, P = .4939; Road Map test, P = 0.4939). The lesion load also did not correlate with the physical disability scales as rated according to the Expanded Disability Status Scale ( P = .68) or Ambulation Index ( P = .95).

CONCLUSION: Our results indicate that T2 lesion volume does not seem to be a robust surrogate marker of neuropsychological impairment in patients with MS. We think that global measurements of parameters that are more specific to the disease process may offer more precise correlation with cognitive dysfunction and other disability parameters." />
<meta name="og-title" property="og:title" content="MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/20/10/1951" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Multiple sclerosis (MS) is a demyelinating disease most often associated with progressive physical impairment; however, its effects are noted to extend beyond physical disability. Our purpose was to determine the relationship between T2 lesion volume and neurocognitive and physical disability in relapsing-remitting multiple sclerosis.

METHODS: We studied a cohort of 19 patients with relapsing-remitting MS. Of this group, there were 15 women and four men from varying socioeconomic backgrounds. This volunteer sample was selected from a larger group of 53 patients with MS in our longitudinal MS study because they had been untreated with any beta-interferon medications, had been followed for at least 12 months, and had a clinical status of relapsing-remitting MS.

RESULTS: Of 12 neurocognitive parameters tested, two correlated significantly with lesion loads. The correlation of the Symbol-Digit Modalities test, which analyzes information-processing speed, was significant ( P = .0204). The correlation of the fifth trial of the Rey Auditory Verbal Learning test, which tests verbal long-term memory, was also significant ( P = .0348). None of the other 10 neurocognitive examinations, however, showed a significant correlation with total lesion volume (Paced Auditory Serial Addition test-1.6, P = .7381; Paced Auditory Serial Addition test-2.0, P = .4180; Controlled Oral Word Association test, P = .8906; Category Fluency test, P = .4423; Bells test, P = .9097; Rey Auditory Verbal Learning test-delay, P = .9843, Rey Auditory Verbal Learning test-recognition, P = .7467; Word Span test, P = .4939; Road Map test, P = 0.4939). The lesion load also did not correlate with the physical disability scales as rated according to the Expanded Disability Status Scale ( P = .68) or Ambulation Index ( P = .95).

CONCLUSION: Our results indicate that T2 lesion volume does not seem to be a robust surrogate marker of neuropsychological impairment in patients with MS. We think that global measurements of parameters that are more specific to the disease process may offer more precise correlation with cognitive dysfunction and other disability parameters." />
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      <h1 class="highwire-cite-title" id="page-title">MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Jennifer C. Fulton</span>, <span class="highwire-citation-author" data-delta="1">Robert I. Grossman</span>, <span class="highwire-citation-author" data-delta="2">Jayaram Udupa</span>, <span class="highwire-citation-author" data-delta="3">Lois J. Mannon</span>, <span class="highwire-citation-author" data-delta="4">Murray Grossman</span>, <span class="highwire-citation-author" data-delta="5">Luogang Wei</span>, <span class="highwire-citation-author" data-delta="6">Marcia Polansky</span> and <span class="highwire-citation-author" data-delta="7">Dennis L. Kolson</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 1999,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1951-1955; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-2502--62100490542" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Jennifer C. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 20</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 10 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Nov 1999 </div></div>
      
      
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      <div class="highwire-article-citation highwire-citation-type-highwire-article cite-tool-node2502" data-node-nid="2502" id="citation-node-2502--22055216315" data-pisa="ajnr;20/10/1951" data-pisa-master="ajnr;20/10/1951" data-apath="/ajnr/20/10/1951.atom"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-standard clearfix">
  
  
  
  
      <div class="highwire-cite-title">MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Jennifer C.</span> <span class="nlm-surname">Fulton</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Robert I.</span> <span class="nlm-surname">Grossman</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Jayaram</span> <span class="nlm-surname">Udupa</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Lois J.</span> <span class="nlm-surname">Mannon</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Murray</span> <span class="nlm-surname">Grossman</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Luogang</span> <span class="nlm-surname">Wei</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Marcia</span> <span class="nlm-surname">Polansky</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Dennis L.</span> <span class="nlm-surname">Kolson</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1951-1955; </span></div>
  
  
  
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      <div class="highwire-cite-title">MR Lesion Load and Cognitive Function in Patients with Relapsing-Remitting Multiple Sclerosis</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Jennifer C.</span> <span class="nlm-surname">Fulton</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Robert I.</span> <span class="nlm-surname">Grossman</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Jayaram</span> <span class="nlm-surname">Udupa</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Lois J.</span> <span class="nlm-surname">Mannon</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Murray</span> <span class="nlm-surname">Grossman</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Luogang</span> <span class="nlm-surname">Wei</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Marcia</span> <span class="nlm-surname">Polansky</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Dennis L.</span> <span class="nlm-surname">Kolson</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1951-1955; </span></div>
  
  
  
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