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<meta name="HW.identifier" content="/ajnr/20/10/1956.atom" />
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<meta name="DC.Title" content="Memory Dysfunction in Multiple Sclerosis Corresponds to Juxtacortical Lesion Load on Fast Fluid-Attenuated Inversion-Recovery MR Images" />
<meta name="DC.Date" content="1999-11-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: MR imaging is a sensitive diagnostic tool and paraclinical marker of disease activity and prognosis in multiple sclerosis (MS), yet the role of MR imaging of MS is controversial. The aim of this study was to describe the relationship between cognitive function and MS lesion size and position, as shown on comparative images from conventional spin-echo (CSE) and fast fluid-attenuated inversion-recovery (fast FLAIR) MR studies.

METHODS: CSE and fast FLAIR sequences consisted of 40 noncontiguous, 3-mm-thick axial sections matched for geometric position in 18 patients with relapsing-remitting MS. Lesions were scored for size, anatomic position, and their comparative appearance on CSE and fast FLAIR images. The neuropsychological assessment tested general psychological performance, memory, and frontal lobe executive function.

RESULTS: Fast FLAIR images showed significantly more small (146 versus six) and medium-sized (18 versus four) juxtacortical lesions than did CSE sequences. Small juxtacortical lesions displayed only on fast FLAIR images had a distinctive appearance, suggestive of small areas of perivascular inflammation. The number of these lesions corresponded to reduced performance on the fifth and delayed trials of the Rey Auditory Verbal Learning memory function test.

CONCLUSION: Fast FLAIR images show small lesions at the juxtacortical boundary that are not seen on CSE studies. The presence of such lesions correlates with impaired retention of information in memory tasks, which is characteristic of cognitive problems in patients with MS." />
<meta name="DC.Contributor" content="David Michael Moriarty" />
<meta name="DC.Contributor" content="Alison Jane Blackshaw" />
<meta name="DC.Contributor" content="Paul Robert Talbot" />
<meta name="DC.Contributor" content="Helen Louise Griffiths" />
<meta name="DC.Contributor" content="Julie Sarah Snowden" />
<meta name="DC.Contributor" content="Valerie Fern Hillier" />
<meta name="DC.Contributor" content="Stephen Capener" />
<meta name="DC.Contributor" content="Roger David Laitt" />
<meta name="DC.Contributor" content="Alan Jackson" />
<meta name="article:published_time" content="1999-11-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="Memory Dysfunction in Multiple Sclerosis Corresponds to Juxtacortical Lesion Load on Fast Fluid-Attenuated Inversion-Recovery MR Images" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; MR imaging is a sensitive diagnostic tool and paraclinical marker of disease activity and prognosis in multiple sclerosis (MS), yet the role of MR imaging of MS is controversial. The aim of this study was to describe the relationship between cognitive function and MS lesion size and position, as shown on comparative images from conventional spin-echo (CSE) and fast fluid-attenuated inversion-recovery (fast FLAIR) MR studies.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; CSE and fast FLAIR sequences consisted of 40 noncontiguous, 3-mm-thick axial sections matched for geometric position in 18 patients with relapsing-remitting MS. Lesions were scored for size, anatomic position, and their comparative appearance on CSE and fast FLAIR images. The neuropsychological assessment tested general psychological performance, memory, and frontal lobe executive function.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; Fast FLAIR images showed significantly more small (146 versus six) and medium-sized (18 versus four) juxtacortical lesions than did CSE sequences. Small juxtacortical lesions displayed only on fast FLAIR images had a distinctive appearance, suggestive of small areas of perivascular inflammation. The number of these lesions corresponded to reduced performance on the fifth and delayed trials of the Rey Auditory Verbal Learning memory function test.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Fast FLAIR images show small lesions at the juxtacortical boundary that are not seen on CSE studies. The presence of such lesions correlates with impaired retention of information in memory tasks, which is characteristic of cognitive problems in patients with MS.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="1999/11/01" />
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<meta name="citation_issn" content="0195-6108" />
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<meta name="citation_author" content="David Michael Moriarty" />
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<meta name="twitter:title" content="Memory Dysfunction in Multiple Sclerosis Corresponds to Juxtacortical Lesion Load on Fast Fluid-Attenuated Inversion-Recovery MR Images" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: MR imaging is a sensitive diagnostic tool and paraclinical marker of disease activity and prognosis in multiple sclerosis (MS), yet the role of MR imaging of MS is controversial. The aim of this study was to describe the relationship between cognitive function and MS lesion size and position, as shown on comparative images from conventional spin-echo (CSE) and fast fluid-attenuated inversion-recovery (fast FLAIR) MR studies.

METHODS: CSE and fast FLAIR sequences consisted of 40 noncontiguous, 3-mm-thick axial sections matched for geometric position in 18 patients with relapsing-remitting MS. Lesions were scored for size, anatomic position, and their comparative appearance on CSE and fast FLAIR images. The neuropsychological assessment tested general psychological performance, memory, and frontal lobe executive function.

RESULTS: Fast FLAIR images showed significantly more small (146 versus six) and medium-sized (18 versus four) juxtacortical lesions than did CSE sequences. Small juxtacortical lesions displayed only on fast FLAIR images had a distinctive appearance, suggestive of small areas of perivascular inflammation. The number of these lesions corresponded to reduced performance on the fifth and delayed trials of the Rey Auditory Verbal Learning memory function test.

CONCLUSION: Fast FLAIR images show small lesions at the juxtacortical boundary that are not seen on CSE studies. The presence of such lesions correlates with impaired retention of information in memory tasks, which is characteristic of cognitive problems in patients with MS." />
<meta name="og-title" property="og:title" content="Memory Dysfunction in Multiple Sclerosis Corresponds to Juxtacortical Lesion Load on Fast Fluid-Attenuated Inversion-Recovery MR Images" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: MR imaging is a sensitive diagnostic tool and paraclinical marker of disease activity and prognosis in multiple sclerosis (MS), yet the role of MR imaging of MS is controversial. The aim of this study was to describe the relationship between cognitive function and MS lesion size and position, as shown on comparative images from conventional spin-echo (CSE) and fast fluid-attenuated inversion-recovery (fast FLAIR) MR studies.

METHODS: CSE and fast FLAIR sequences consisted of 40 noncontiguous, 3-mm-thick axial sections matched for geometric position in 18 patients with relapsing-remitting MS. Lesions were scored for size, anatomic position, and their comparative appearance on CSE and fast FLAIR images. The neuropsychological assessment tested general psychological performance, memory, and frontal lobe executive function.

RESULTS: Fast FLAIR images showed significantly more small (146 versus six) and medium-sized (18 versus four) juxtacortical lesions than did CSE sequences. Small juxtacortical lesions displayed only on fast FLAIR images had a distinctive appearance, suggestive of small areas of perivascular inflammation. The number of these lesions corresponded to reduced performance on the fifth and delayed trials of the Rey Auditory Verbal Learning memory function test.

CONCLUSION: Fast FLAIR images show small lesions at the juxtacortical boundary that are not seen on CSE studies. The presence of such lesions correlates with impaired retention of information in memory tasks, which is characteristic of cognitive problems in patients with MS." />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node2503--5" data-node-nid="2503" id="top-node-2503--61746339501" data-pisa="ajnr;20/10/1956" data-pisa-master="ajnr;20/10/1956" data-apath="/ajnr/20/10/1956.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Brain</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Memory Dysfunction in Multiple Sclerosis Corresponds to Juxtacortical Lesion Load on Fast Fluid-Attenuated Inversion-Recovery MR Images</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">David Michael Moriarty</span>, <span class="highwire-citation-author" data-delta="1">Alison Jane Blackshaw</span>, <span class="highwire-citation-author" data-delta="2">Paul Robert Talbot</span>, <span class="highwire-citation-author" data-delta="3">Helen Louise Griffiths</span>, <span class="highwire-citation-author" data-delta="4">Julie Sarah Snowden</span>, <span class="highwire-citation-author" data-delta="5">Valerie Fern Hillier</span>, <span class="highwire-citation-author" data-delta="6">Stephen Capener</span>, <span class="highwire-citation-author" data-delta="7">Roger David Laitt</span> and <span class="highwire-citation-author" data-delta="8">Alan Jackson</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 1999,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1956-1962; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-2503--61746339501" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">David Michael Moriarty </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=David%2BMichael%2BMoriarty%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Moriarty%20DM&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ADavid%2BMichael%2BMoriarty%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 20</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 10 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Nov 1999 </div></div>
      
      
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      <div class="highwire-cite-title">Memory Dysfunction in Multiple Sclerosis Corresponds to Juxtacortical Lesion Load on Fast Fluid-Attenuated Inversion-Recovery MR Images</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">David Michael</span> <span class="nlm-surname">Moriarty</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Alison Jane</span> <span class="nlm-surname">Blackshaw</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Paul Robert</span> <span class="nlm-surname">Talbot</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Helen Louise</span> <span class="nlm-surname">Griffiths</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Julie Sarah</span> <span class="nlm-surname">Snowden</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Valerie Fern</span> <span class="nlm-surname">Hillier</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Stephen</span> <span class="nlm-surname">Capener</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Roger David</span> <span class="nlm-surname">Laitt</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Alan</span> <span class="nlm-surname">Jackson</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1956-1962; </span></div>
  
  
  
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      <div class="highwire-cite-title">Memory Dysfunction in Multiple Sclerosis Corresponds to Juxtacortical Lesion Load on Fast Fluid-Attenuated Inversion-Recovery MR Images</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">David Michael</span> <span class="nlm-surname">Moriarty</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Alison Jane</span> <span class="nlm-surname">Blackshaw</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Paul Robert</span> <span class="nlm-surname">Talbot</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Helen Louise</span> <span class="nlm-surname">Griffiths</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Julie Sarah</span> <span class="nlm-surname">Snowden</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Valerie Fern</span> <span class="nlm-surname">Hillier</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Stephen</span> <span class="nlm-surname">Capener</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Roger David</span> <span class="nlm-surname">Laitt</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Alan</span> <span class="nlm-surname">Jackson</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1956-1962; </span></div>
  
  
  
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