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<meta name="DC.Title" content="Proton MR Spectroscopy in Patients with Complex Partial Seizures: Single-Voxel Spectroscopy versus Chemical-Shift Imaging" />
<meta name="DC.Date" content="1999-04-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Proton MR spectroscopy has recently been applied to the evaluation of seizures, but few comparisons have been made between different clinical spectroscopic techniques. Our goal was to determine whether there is a significant difference between hippocampal NAA/(Cho+Cr) ratios obtained by single-voxel spectroscopy (SVS) and by chemical-shift imaging (CSI).

METHODS: Twelve healthy adults and eight patients with complex partial seizures were studied on a 1.5-T MR scanner using a proton SVS method. Another 12 healthy adults and 10 patients with complex partial seizures were recruited for a proton CSI study, which was performed on a different 1.5-T MR system. The NAA/(Cho+Cr) ratio was calculated from the integral peak areas by curve fitting. The two-tailed t -test was used for statistical analysis.

RESULTS: The mean value ± standard deviation of the hippocampal NAA/(Cho+Cr) ratio in healthy control subjects was 0.63 ± 0.07 by SVS, with 0.62 ± 0.15 for the anterior hippocampus and 0.65 ± 0.11 for the posterior hippocampus by CSI. There was no significant difference between the control group data obtained by SVS and those by CSI, nor was there a regional difference in the CSI NAA/(Cho+Cr) ratio in the hippocampus. Relative to the control group, the patients with seizures had a significant decrease in the NAA/(Cho+Cr) ratio in the abnormal hippocampus: −28% by SVS, and −24% in the anterior hippocampus and −18% in the posterior hippocampus by CSI. Proton SVS and CSI detected hippocampal abnormalities, unilateral or bilateral, in all patients of each group.

CONCLUSION: Under similar measurement conditions, proton SVS and CSI provide similar NAA/(Cho+Cr) ratios among healthy control subjects, and they possess comparable ability for detecting hippocampal abnormalities in patients with complex partial seizures." />
<meta name="DC.Contributor" content="Yuan-Yu Hsu" />
<meta name="DC.Contributor" content="Chen Chang" />
<meta name="DC.Contributor" content="Chen-Nen Chang" />
<meta name="DC.Contributor" content="Nai-Shin Chu" />
<meta name="DC.Contributor" content="Kun-Eng Lim" />
<meta name="DC.Contributor" content="Jee-Ching Hsu" />
<meta name="article:published_time" content="1999-04-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Proton MR Spectroscopy in Patients with Complex Partial Seizures: Single-Voxel Spectroscopy versus Chemical-Shift Imaging" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Proton MR spectroscopy has recently been applied to the evaluation of seizures, but few comparisons have been made between different clinical spectroscopic techniques. Our goal was to determine whether there is a significant difference between hippocampal NAA/(Cho+Cr) ratios obtained by single-voxel spectroscopy (SVS) and by chemical-shift imaging (CSI).&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Twelve healthy adults and eight patients with complex partial seizures were studied on a 1.5-T MR scanner using a proton SVS method. Another 12 healthy adults and 10 patients with complex partial seizures were recruited for a proton CSI study, which was performed on a different 1.5-T MR system. The NAA/(Cho+Cr) ratio was calculated from the integral peak areas by curve fitting. The two-tailed &lt;i&gt;t&lt;/i&gt;-test was used for statistical analysis.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; The mean value ± standard deviation of the hippocampal NAA/(Cho+Cr) ratio in healthy control subjects was 0.63 ± 0.07 by SVS, with 0.62 ± 0.15 for the anterior hippocampus and 0.65 ± 0.11 for the posterior hippocampus by CSI. There was no significant difference between the control group data obtained by SVS and those by CSI, nor was there a regional difference in the CSI NAA/(Cho+Cr) ratio in the hippocampus. Relative to the control group, the patients with seizures had a significant decrease in the NAA/(Cho+Cr) ratio in the abnormal hippocampus: −28% by SVS, and −24% in the anterior hippocampus and −18% in the posterior hippocampus by CSI. Proton SVS and CSI detected hippocampal abnormalities, unilateral or bilateral, in all patients of each group.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Under similar measurement conditions, proton SVS and CSI provide similar NAA/(Cho+Cr) ratios among healthy control subjects, and they possess comparable ability for detecting hippocampal abnormalities in patients with complex partial seizures.&lt;/p&gt;" />
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<meta name="citation_publication_date" content="1999/04/01" />
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<meta name="citation_author" content="Yuan-Yu Hsu" />
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<meta name="citation_reference" content="citation_title=American Journal of Roentgenology;citation_journal_abbrev=Am. J. Roentgenol.;citation_title=Clinical MR spectroscopy: fundamentals, current applications, and future potential;citation_pages=1337-1347;citation_volume=164;citation_year=1995;citation_issue=6;citation_issn=0361-803X;citation_pmid=7754871" />
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<meta name="citation_reference" content="citation_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_title=Localized high-resolution proton NMR spectroscopy using stimulated echoes: initial applications to human brain in vivo.;citation_pages=79-93;citation_volume=9;citation_year=1989;citation_issue=1;citation_pmid=2540396;citation_doi=10.1002/mrm.1910090110" />
<meta name="citation_reference" content="citation_title=J Magn Reson;citation_pages=147;citation_volume=51;citation_year=1983" />
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<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Magnetic resonance spectroscopy in temporal lobe epilepsy;citation_pages=1411-1411;citation_volume=44;citation_year=1994;citation_issue=8;citation_issn=0028-3878;citation_pmid=8058140" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Single-voxel proton MR spectroscopy and positron emission tomography for lateralization of refractory temporal lobe epilepsy;citation_pages=1-8;citation_volume=19;citation_year=1998;citation_issue=1;citation_issn=0195-6108;citation_pmid=9432150" />
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<meta name="twitter:title" content="Proton MR Spectroscopy in Patients with Complex Partial Seizures: Single-Voxel Spectroscopy versus Chemical-Shift Imaging" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Proton MR spectroscopy has recently been applied to the evaluation of seizures, but few comparisons have been made between different clinical spectroscopic techniques. Our goal was to determine whether there is a significant difference between hippocampal NAA/(Cho+Cr) ratios obtained by single-voxel spectroscopy (SVS) and by chemical-shift imaging (CSI).

METHODS: Twelve healthy adults and eight patients with complex partial seizures were studied on a 1.5-T MR scanner using a proton SVS method. Another 12 healthy adults and 10 patients with complex partial seizures were recruited for a proton CSI study, which was performed on a different 1.5-T MR system. The NAA/(Cho+Cr) ratio was calculated from the integral peak areas by curve fitting. The two-tailed t -test was used for statistical analysis.

RESULTS: The mean value ± standard deviation of the hippocampal NAA/(Cho+Cr) ratio in healthy control subjects was 0.63 ± 0.07 by SVS, with 0.62 ± 0.15 for the anterior hippocampus and 0.65 ± 0.11 for the posterior hippocampus by CSI. There was no significant difference between the control group data obtained by SVS and those by CSI, nor was there a regional difference in the CSI NAA/(Cho+Cr) ratio in the hippocampus. Relative to the control group, the patients with seizures had a significant decrease in the NAA/(Cho+Cr) ratio in the abnormal hippocampus: −28% by SVS, and −24% in the anterior hippocampus and −18% in the posterior hippocampus by CSI. Proton SVS and CSI detected hippocampal abnormalities, unilateral or bilateral, in all patients of each group.

CONCLUSION: Under similar measurement conditions, proton SVS and CSI provide similar NAA/(Cho+Cr) ratios among healthy control subjects, and they possess comparable ability for detecting hippocampal abnormalities in patients with complex partial seizures." />
<meta name="og-title" property="og:title" content="Proton MR Spectroscopy in Patients with Complex Partial Seizures: Single-Voxel Spectroscopy versus Chemical-Shift Imaging" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/20/4/643" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Proton MR spectroscopy has recently been applied to the evaluation of seizures, but few comparisons have been made between different clinical spectroscopic techniques. Our goal was to determine whether there is a significant difference between hippocampal NAA/(Cho+Cr) ratios obtained by single-voxel spectroscopy (SVS) and by chemical-shift imaging (CSI).

METHODS: Twelve healthy adults and eight patients with complex partial seizures were studied on a 1.5-T MR scanner using a proton SVS method. Another 12 healthy adults and 10 patients with complex partial seizures were recruited for a proton CSI study, which was performed on a different 1.5-T MR system. The NAA/(Cho+Cr) ratio was calculated from the integral peak areas by curve fitting. The two-tailed t -test was used for statistical analysis.

RESULTS: The mean value ± standard deviation of the hippocampal NAA/(Cho+Cr) ratio in healthy control subjects was 0.63 ± 0.07 by SVS, with 0.62 ± 0.15 for the anterior hippocampus and 0.65 ± 0.11 for the posterior hippocampus by CSI. There was no significant difference between the control group data obtained by SVS and those by CSI, nor was there a regional difference in the CSI NAA/(Cho+Cr) ratio in the hippocampus. Relative to the control group, the patients with seizures had a significant decrease in the NAA/(Cho+Cr) ratio in the abnormal hippocampus: −28% by SVS, and −24% in the anterior hippocampus and −18% in the posterior hippocampus by CSI. Proton SVS and CSI detected hippocampal abnormalities, unilateral or bilateral, in all patients of each group.

CONCLUSION: Under similar measurement conditions, proton SVS and CSI provide similar NAA/(Cho+Cr) ratios among healthy control subjects, and they possess comparable ability for detecting hippocampal abnormalities in patients with complex partial seizures." />
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 20</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 4 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Apr 1999 </div></div>
      
      
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      <div class="highwire-cite-title">Proton MR Spectroscopy in Patients with Complex Partial Seizures: Single-Voxel Spectroscopy versus Chemical-Shift Imaging</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Yuan-Yu</span> <span class="nlm-surname">Hsu</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Chen</span> <span class="nlm-surname">Chang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Chen-Nen</span> <span class="nlm-surname">Chang</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Nai-Shin</span> <span class="nlm-surname">Chu</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Kun-Eng</span> <span class="nlm-surname">Lim</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Jee-Ching</span> <span class="nlm-surname">Hsu</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">643-651; </span></div>
  
  
  
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      <div class="highwire-cite-title">Proton MR Spectroscopy in Patients with Complex Partial Seizures: Single-Voxel Spectroscopy versus Chemical-Shift Imaging</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Yuan-Yu</span> <span class="nlm-surname">Hsu</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Chen</span> <span class="nlm-surname">Chang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Chen-Nen</span> <span class="nlm-surname">Chang</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Nai-Shin</span> <span class="nlm-surname">Chu</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Kun-Eng</span> <span class="nlm-surname">Lim</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Jee-Ching</span> <span class="nlm-surname">Hsu</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">643-651; </span></div>
  
  
  
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