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<meta name="DC.Title" content="Relationship between MR Imaging and Histopathologic Findings of the Brain in Extremely Sick Preterm Infants" />
<meta name="DC.Date" content="1999-07-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: MR imaging can now be used safely in extremely preterm infants. The aim of this study was to compare the MR imaging appearance of the immature brain with neuropathologic findings at postmortem examination.

METHODS: Seven extremely sick preterm infants, born at a median of 24 weeks' gestation, were studied using T1- and T2-weighted MR sequences. Infants died at a median of 3 days after initial MR imaging, and postmortem examinations were carried out.

RESULTS: The cortex and germinal matrix were seen as areas of low signal intensity on T2-weighted images, which corresponded to their highly cellular histologic appearance. The periventricular and subcortical layers of white matter had a high signal intensity, corresponding to high fiber and relatively low cellular density; the intermediate layer of low signal intensity corresponded to a dense band of migrating cells. Regions of acute hemorrhage were seen as low signal intensity and regions of infarction as high signal intensity on T2-weighted images. One infant with mild periventricular leukomalacia had some low signal intensity on T1-weighted images, but no focal changes on T2-weighted images. Regions of neuronal mineralization, seen in association with infarction and capillary proliferation, within the basal ganglia and thalami were characterized by very low signal intensity on T2-weighted images and by very high signal intensity on T1-weighted images. There were no imaging abnormalities detected in regions with more subtle histologic abnormalities, such as increased glial or apoptotic cells.

CONCLUSION: MR imaging can be used to observe normal developing brain anatomy in extremely premature infants; it can detect areas of hemorrhage and infarction within the developing brain, but conventional MR imaging may not detect more subtle histologic abnormalities." />
<meta name="DC.Contributor" content="Ursula Felderhoff-Mueser" />
<meta name="DC.Contributor" content="Mary A. Rutherford" />
<meta name="DC.Contributor" content="Waney V. Squier" />
<meta name="DC.Contributor" content="Philip Cox" />
<meta name="DC.Contributor" content="Elia F. Maalouf" />
<meta name="DC.Contributor" content="Serena J. Counsell" />
<meta name="DC.Contributor" content="Graeme M. Bydder" />
<meta name="DC.Contributor" content="A. David Edwards" />
<meta name="article:published_time" content="1999-07-01" />
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<meta name="citation_title" content="Relationship between MR Imaging and Histopathologic Findings of the Brain in Extremely Sick Preterm Infants" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; MR imaging can now be used safely in extremely preterm infants. The aim of this study was to compare the MR imaging appearance of the immature brain with neuropathologic findings at postmortem examination.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Seven extremely sick preterm infants, born at a median of 24 weeks9 gestation, were studied using T1- and T2-weighted MR sequences. Infants died at a median of 3 days after initial MR imaging, and postmortem examinations were carried out.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; The cortex and germinal matrix were seen as areas of low signal intensity on T2-weighted images, which corresponded to their highly cellular histologic appearance. The periventricular and subcortical layers of white matter had a high signal intensity, corresponding to high fiber and relatively low cellular density; the intermediate layer of low signal intensity corresponded to a dense band of migrating cells. Regions of acute hemorrhage were seen as low signal intensity and regions of infarction as high signal intensity on T2-weighted images. One infant with mild periventricular leukomalacia had some low signal intensity on T1-weighted images, but no focal changes on T2-weighted images. Regions of neuronal mineralization, seen in association with infarction and capillary proliferation, within the basal ganglia and thalami were characterized by very low signal intensity on T2-weighted images and by very high signal intensity on T1-weighted images. There were no imaging abnormalities detected in regions with more subtle histologic abnormalities, such as increased glial or apoptotic cells.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; MR imaging can be used to observe normal developing brain anatomy in extremely premature infants; it can detect areas of hemorrhage and infarction within the developing brain, but conventional MR imaging may not detect more subtle histologic abnormalities.&lt;/p&gt;" />
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<meta name="twitter:title" content="Relationship between MR Imaging and Histopathologic Findings of the Brain in Extremely Sick Preterm Infants" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: MR imaging can now be used safely in extremely preterm infants. The aim of this study was to compare the MR imaging appearance of the immature brain with neuropathologic findings at postmortem examination.

METHODS: Seven extremely sick preterm infants, born at a median of 24 weeks' gestation, were studied using T1- and T2-weighted MR sequences. Infants died at a median of 3 days after initial MR imaging, and postmortem examinations were carried out.

RESULTS: The cortex and germinal matrix were seen as areas of low signal intensity on T2-weighted images, which corresponded to their highly cellular histologic appearance. The periventricular and subcortical layers of white matter had a high signal intensity, corresponding to high fiber and relatively low cellular density; the intermediate layer of low signal intensity corresponded to a dense band of migrating cells. Regions of acute hemorrhage were seen as low signal intensity and regions of infarction as high signal intensity on T2-weighted images. One infant with mild periventricular leukomalacia had some low signal intensity on T1-weighted images, but no focal changes on T2-weighted images. Regions of neuronal mineralization, seen in association with infarction and capillary proliferation, within the basal ganglia and thalami were characterized by very low signal intensity on T2-weighted images and by very high signal intensity on T1-weighted images. There were no imaging abnormalities detected in regions with more subtle histologic abnormalities, such as increased glial or apoptotic cells.

CONCLUSION: MR imaging can be used to observe normal developing brain anatomy in extremely premature infants; it can detect areas of hemorrhage and infarction within the developing brain, but conventional MR imaging may not detect more subtle histologic abnormalities." />
<meta name="og-title" property="og:title" content="Relationship between MR Imaging and Histopathologic Findings of the Brain in Extremely Sick Preterm Infants" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/20/7/1349" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: MR imaging can now be used safely in extremely preterm infants. The aim of this study was to compare the MR imaging appearance of the immature brain with neuropathologic findings at postmortem examination.

METHODS: Seven extremely sick preterm infants, born at a median of 24 weeks' gestation, were studied using T1- and T2-weighted MR sequences. Infants died at a median of 3 days after initial MR imaging, and postmortem examinations were carried out.

RESULTS: The cortex and germinal matrix were seen as areas of low signal intensity on T2-weighted images, which corresponded to their highly cellular histologic appearance. The periventricular and subcortical layers of white matter had a high signal intensity, corresponding to high fiber and relatively low cellular density; the intermediate layer of low signal intensity corresponded to a dense band of migrating cells. Regions of acute hemorrhage were seen as low signal intensity and regions of infarction as high signal intensity on T2-weighted images. One infant with mild periventricular leukomalacia had some low signal intensity on T1-weighted images, but no focal changes on T2-weighted images. Regions of neuronal mineralization, seen in association with infarction and capillary proliferation, within the basal ganglia and thalami were characterized by very low signal intensity on T2-weighted images and by very high signal intensity on T1-weighted images. There were no imaging abnormalities detected in regions with more subtle histologic abnormalities, such as increased glial or apoptotic cells.

CONCLUSION: MR imaging can be used to observe normal developing brain anatomy in extremely premature infants; it can detect areas of hemorrhage and infarction within the developing brain, but conventional MR imaging may not detect more subtle histologic abnormalities." />
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Ursula Felderhoff-Mueser</span>, <span class="highwire-citation-author" data-delta="1">Mary A. Rutherford</span>, <span class="highwire-citation-author" data-delta="2">Waney V. Squier</span>, <span class="highwire-citation-author" data-delta="3">Philip Cox</span>, <span class="highwire-citation-author" data-delta="4">Elia F. Maalouf</span>, <span class="highwire-citation-author" data-delta="5">Serena J. Counsell</span>, <span class="highwire-citation-author" data-delta="6">Graeme M. Bydder</span> and <span class="highwire-citation-author" data-delta="7">A. David Edwards</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">July 1999,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1349-1357; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-2191--61921342012" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Ursula Felderhoff-Mueser </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Ursula%2BFelderhoff-Mueser%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Felderhoff-Mueser%20U&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AUrsula%2BFelderhoff-Mueser%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Mary A. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 20</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 7 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jul 1999 </div></div>
      
      
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      <div class="highwire-cite-title">Relationship between MR Imaging and Histopathologic Findings of the Brain in Extremely Sick Preterm Infants</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Ursula</span> <span class="nlm-surname">Felderhoff-Mueser</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Mary A.</span> <span class="nlm-surname">Rutherford</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Waney V.</span> <span class="nlm-surname">Squier</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Philip</span> <span class="nlm-surname">Cox</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Elia F.</span> <span class="nlm-surname">Maalouf</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Serena J.</span> <span class="nlm-surname">Counsell</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Graeme M.</span> <span class="nlm-surname">Bydder</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">A. David</span> <span class="nlm-surname">Edwards</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jul 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1349-1357; </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Ursula</span> <span class="nlm-surname">Felderhoff-Mueser</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Mary A.</span> <span class="nlm-surname">Rutherford</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Waney V.</span> <span class="nlm-surname">Squier</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Philip</span> <span class="nlm-surname">Cox</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Elia F.</span> <span class="nlm-surname">Maalouf</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Serena J.</span> <span class="nlm-surname">Counsell</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Graeme M.</span> <span class="nlm-surname">Bydder</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">A. David</span> <span class="nlm-surname">Edwards</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jul 1999, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">20 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1349-1357; </span></div>
  
  
  
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