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<meta name="DC.Title" content="Multiple Sclerosis: Comparison of Trace Apparent Diffusion Coefficients with MR Enhancement Pattern of Lesions" />
<meta name="DC.Date" content="2000-05-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Diffusion-weighted MR imaging and the trace apparent diffusion coefficient (ADC) provide important structural information about tissues. The purpose of this study was to investigate the relationship between trace ADC values and the enhancement pattern of multiple sclerosis (MS) lesions.

METHODS: Ninety-six lesions, identified in 24 patients with MS, were characterized by their enhancement pattern on contrast-enhanced T1-weighted MR images. There were 57 nonenhancing lesions (NELs), 28 homogeneously enhancing lesions (HELs), and 11 ring-enhancing lesions (RELs). The trace ADC means for each type of lesion and for normal-appearing white matter (NAWM) were calculated and compared using Student's t -test.

RESULTS: The mean trace ADC values for HELs (mean, 7.7 × 10−10 m2s−1; SD, 1.4 × 10−10 m2s−1) were less than those for RELs (mean, 1.2 × 10−9 m2s−1; SD, 3.5 × 10−10 m2s−1) and NELs (mean, 1.3 × 10−9 m2s−1; SD, 2.6 × 10−10 m2s−1). There was a significant difference between the mean trace ADC values of HELs and RELs as well as between those for HELs and NELs. There was also a significant difference in the mean trace ADC values between all lesion types and NAWM (mean, 6.9 × 10−10 m2s−1; SD, 5.0 × 10−11 m2s−1).

CONCLUSION: We found a predictable relationship between mean trace ADC and the pattern of enhancement in MS lesions, corresponding to reported histopathologic differences in myelination between lesion types and magnetization transfer ratios." />
<meta name="DC.Contributor" content="Sudipta Roychowdhury" />
<meta name="DC.Contributor" content="Joseph A. Maldjian" />
<meta name="DC.Contributor" content="Robert I. Grossman" />
<meta name="article:published_time" content="2000-05-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Multiple Sclerosis: Comparison of Trace Apparent Diffusion Coefficients with MR Enhancement Pattern of Lesions" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Diffusion-weighted MR imaging and the trace apparent diffusion coefficient (ADC) provide important structural information about tissues. The purpose of this study was to investigate the relationship between trace ADC values and the enhancement pattern of multiple sclerosis (MS) lesions.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Ninety-six lesions, identified in 24 patients with MS, were characterized by their enhancement pattern on contrast-enhanced T1-weighted MR images. There were 57 nonenhancing lesions (NELs), 28 homogeneously enhancing lesions (HELs), and 11 ring-enhancing lesions (RELs). The trace ADC means for each type of lesion and for normal-appearing white matter (NAWM) were calculated and compared using Student9s &lt;i&gt;t&lt;/i&gt;-test.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; The mean trace ADC values for HELs (mean, 7.7 × 10&lt;sup&gt;−10&lt;/sup&gt; m&lt;sup&gt;2&lt;/sup&gt;s&lt;sup&gt;−1&lt;/sup&gt;; SD, 1.4 × 10&lt;sup&gt;−10&lt;/sup&gt; m&lt;sup&gt;2&lt;/sup&gt;s&lt;sup&gt;−1&lt;/sup&gt;) were less than those for RELs (mean, 1.2 × 10&lt;sup&gt;−9&lt;/sup&gt; m&lt;sup&gt;2&lt;/sup&gt;s&lt;sup&gt;−1&lt;/sup&gt;; SD, 3.5 × 10&lt;sup&gt;−10&lt;/sup&gt; m&lt;sup&gt;2&lt;/sup&gt;s&lt;sup&gt;−1&lt;/sup&gt;) and NELs (mean, 1.3 × 10&lt;sup&gt;−9&lt;/sup&gt; m&lt;sup&gt;2&lt;/sup&gt;s&lt;sup&gt;−1&lt;/sup&gt;; SD, 2.6 × 10&lt;sup&gt;−10&lt;/sup&gt; m&lt;sup&gt;2&lt;/sup&gt;s&lt;sup&gt;−1&lt;/sup&gt;). There was a significant difference between the mean trace ADC values of HELs and RELs as well as between those for HELs and NELs. There was also a significant difference in the mean trace ADC values between all lesion types and NAWM (mean, 6.9 × 10&lt;sup&gt;−10&lt;/sup&gt; m&lt;sup&gt;2&lt;/sup&gt;s&lt;sup&gt;−1&lt;/sup&gt;; SD, 5.0 × 10&lt;sup&gt;−11&lt;/sup&gt; m&lt;sup&gt;2&lt;/sup&gt;s&lt;sup&gt;−1&lt;/sup&gt;).&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; We found a predictable relationship between mean trace ADC and the pattern of enhancement in MS lesions, corresponding to reported histopathologic differences in myelination between lesion types and magnetization transfer ratios.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_title=Correlation between magnetic resonance imaging findings and lesion development in chronic, active multiple sclerosis.;citation_pages=661-669;citation_volume=34;citation_year=1993;citation_issue=5;citation_pmid=8239560;citation_doi=10.1002/ana.410340507" />
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<meta name="twitter:title" content="Multiple Sclerosis: Comparison of Trace Apparent Diffusion Coefficients with MR Enhancement Pattern of Lesions" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Diffusion-weighted MR imaging and the trace apparent diffusion coefficient (ADC) provide important structural information about tissues. The purpose of this study was to investigate the relationship between trace ADC values and the enhancement pattern of multiple sclerosis (MS) lesions.

METHODS: Ninety-six lesions, identified in 24 patients with MS, were characterized by their enhancement pattern on contrast-enhanced T1-weighted MR images. There were 57 nonenhancing lesions (NELs), 28 homogeneously enhancing lesions (HELs), and 11 ring-enhancing lesions (RELs). The trace ADC means for each type of lesion and for normal-appearing white matter (NAWM) were calculated and compared using Student's t -test.

RESULTS: The mean trace ADC values for HELs (mean, 7.7 × 10−10 m2s−1; SD, 1.4 × 10−10 m2s−1) were less than those for RELs (mean, 1.2 × 10−9 m2s−1; SD, 3.5 × 10−10 m2s−1) and NELs (mean, 1.3 × 10−9 m2s−1; SD, 2.6 × 10−10 m2s−1). There was a significant difference between the mean trace ADC values of HELs and RELs as well as between those for HELs and NELs. There was also a significant difference in the mean trace ADC values between all lesion types and NAWM (mean, 6.9 × 10−10 m2s−1; SD, 5.0 × 10−11 m2s−1).

CONCLUSION: We found a predictable relationship between mean trace ADC and the pattern of enhancement in MS lesions, corresponding to reported histopathologic differences in myelination between lesion types and magnetization transfer ratios." />
<meta name="og-title" property="og:title" content="Multiple Sclerosis: Comparison of Trace Apparent Diffusion Coefficients with MR Enhancement Pattern of Lesions" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Diffusion-weighted MR imaging and the trace apparent diffusion coefficient (ADC) provide important structural information about tissues. The purpose of this study was to investigate the relationship between trace ADC values and the enhancement pattern of multiple sclerosis (MS) lesions.

METHODS: Ninety-six lesions, identified in 24 patients with MS, were characterized by their enhancement pattern on contrast-enhanced T1-weighted MR images. There were 57 nonenhancing lesions (NELs), 28 homogeneously enhancing lesions (HELs), and 11 ring-enhancing lesions (RELs). The trace ADC means for each type of lesion and for normal-appearing white matter (NAWM) were calculated and compared using Student's t -test.

RESULTS: The mean trace ADC values for HELs (mean, 7.7 × 10−10 m2s−1; SD, 1.4 × 10−10 m2s−1) were less than those for RELs (mean, 1.2 × 10−9 m2s−1; SD, 3.5 × 10−10 m2s−1) and NELs (mean, 1.3 × 10−9 m2s−1; SD, 2.6 × 10−10 m2s−1). There was a significant difference between the mean trace ADC values of HELs and RELs as well as between those for HELs and NELs. There was also a significant difference in the mean trace ADC values between all lesion types and NAWM (mean, 6.9 × 10−10 m2s−1; SD, 5.0 × 10−11 m2s−1).

CONCLUSION: We found a predictable relationship between mean trace ADC and the pattern of enhancement in MS lesions, corresponding to reported histopathologic differences in myelination between lesion types and magnetization transfer ratios." />
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      <h1 class="highwire-cite-title" id="page-title">Multiple Sclerosis: Comparison of Trace Apparent Diffusion Coefficients with MR Enhancement Pattern of Lesions</h1>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2000,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">21 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">869-874; </span></div>
  
  
  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 21</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 5 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 May 2000 </div></div>
      
      
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      <div class="highwire-cite-title">Multiple Sclerosis: Comparison of Trace Apparent Diffusion Coefficients with MR Enhancement Pattern of Lesions</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Sudipta</span> <span class="nlm-surname">Roychowdhury</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Joseph A.</span> <span class="nlm-surname">Maldjian</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Robert I.</span> <span class="nlm-surname">Grossman</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2000, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">21 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">869-874; </span></div>
  
  
  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2000, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">21 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">869-874; </span></div>
  
  
  
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