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<meta name="DC.Title" content="Posttherapeutic Intraaxial Brain Tumor: The Value of Perfusion-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue" />
<meta name="DC.Date" content="2000-05-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Differentiation of tumor recurrence from treatment-related changes may be difficult with conventional MR imaging when newly enhancing lesions appear. Our aim was to determine the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating recurrent neoplasm from nonneoplastic contrast-enhancing tissue.

METHODS : Twenty patients in whom new enhancing lesions developed within irradiated regions were examined prospectively with perfusion-sensitive contrast-enhanced MR imaging. Twelve of them also underwent thallous chloride Tl 201 single-photon emission tomography (201Tl-SPECT). Normalized relative cerebral blood volume (rCBV) ratios and thallium indexes were evaluated to determine whether the new enhancing lesions were recurrent or not. Five instances of tumor recurrence and one of radiation necrosis were verified histologically; in the others, tumor recurrence was distinguished by lesions that progressively increased in size on serial MR examinations over at least 5 months, and nonneoplastic contrast-enhancing tissue was distinguished by lesions that disappeared or decreased in size on serial MR studies over at least 9 months.

RESULTS: When normalized rCBV ratios were higher than 2.6 or lower than 0.6, enhancing lesions were either recurrent (n = 5) or nonneoplastic contrast-enhancing tissue (n = 3), respectively. All nonneoplastic contrast-enhancing tissue had a low thallium index, whereas three of four recurrent lesions had a high index.

CONCLUSION: An enhancing lesion with a normalized rCBV ratio higher than 2.6 or lower than 0.6 may suggest tumor recurrence or nonneoplastic contrast-enhancing tissue, respectively. In these cases, further examination with 201Tl-SPECT may not be necessary. However, when the normalized rCBV ratio is between 0.6 and 2.6, 201Tl-SPECT may be useful in making the differentiation." />
<meta name="DC.Contributor" content="Takeshi Sugahara" />
<meta name="DC.Contributor" content="Yukunori Korogi" />
<meta name="DC.Contributor" content="Seiji Tomiguchi" />
<meta name="DC.Contributor" content="Yoshinori Shigematsu" />
<meta name="DC.Contributor" content="Ichiro Ikushima" />
<meta name="DC.Contributor" content="Tomohiro Kira" />
<meta name="DC.Contributor" content="Luxia Liang" />
<meta name="DC.Contributor" content="Yukitaka Ushio" />
<meta name="DC.Contributor" content="Mutsumasa Takahashi" />
<meta name="article:published_time" content="2000-05-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Posttherapeutic Intraaxial Brain Tumor: The Value of Perfusion-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Differentiation of tumor recurrence from treatment-related changes may be difficult with conventional MR imaging when newly enhancing lesions appear. Our aim was to determine the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating recurrent neoplasm from nonneoplastic contrast-enhancing tissue.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS&lt;/i&gt;: Twenty patients in whom new enhancing lesions developed within irradiated regions were examined prospectively with perfusion-sensitive contrast-enhanced MR imaging. Twelve of them also underwent thallous chloride Tl 201 single-photon emission tomography (&lt;sup&gt;201&lt;/sup&gt;Tl-SPECT). Normalized relative cerebral blood volume (rCBV) ratios and thallium indexes were evaluated to determine whether the new enhancing lesions were recurrent or not. Five instances of tumor recurrence and one of radiation necrosis were verified histologically; in the others, tumor recurrence was distinguished by lesions that progressively increased in size on serial MR examinations over at least 5 months, and nonneoplastic contrast-enhancing tissue was distinguished by lesions that disappeared or decreased in size on serial MR studies over at least 9 months.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; When normalized rCBV ratios were higher than 2.6 or lower than 0.6, enhancing lesions were either recurrent (n = 5) or nonneoplastic contrast-enhancing tissue (n = 3), respectively. All nonneoplastic contrast-enhancing tissue had a low thallium index, whereas three of four recurrent lesions had a high index.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; An enhancing lesion with a normalized rCBV ratio higher than 2.6 or lower than 0.6 may suggest tumor recurrence or nonneoplastic contrast-enhancing tissue, respectively. In these cases, further examination with &lt;sup&gt;201&lt;/sup&gt;Tl-SPECT may not be necessary. However, when the normalized rCBV ratio is between 0.6 and 2.6, &lt;sup&gt;201&lt;/sup&gt;Tl-SPECT may be useful in making the differentiation.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Differentiating recurrent tumor from radiation necrosis: time for re- evaluation of positron emission tomography?;citation_pages=407-413;citation_volume=19;citation_year=1998;citation_issue=3;citation_issn=0195-6108;citation_pmid=9541290" />
<meta name="citation_reference" content="citation_pages=538;citation_volume=14;citation_year=1992" />
<meta name="citation_reference" content="citation_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_title=Dynamic imaging with lanthanide chelates in normal brain: contrast due to magnetic susceptibility effects.;citation_pages=164-174;citation_volume=6;citation_year=1988;citation_issue=2;citation_pmid=3367774;citation_doi=10.1002/mrm.1910060205" />
<meta name="citation_reference" content="citation_title=J Magn Reson;citation_pages=41;citation_volume=78;citation_year=1988" />
<meta name="citation_reference" content="citation_title=Radiology;citation_journal_abbrev=Radiology;citation_title=Cerebral blood flow determination by rapid-sequence computed tomography: theoretical analysis;citation_pages=679-686;citation_volume=137;citation_year=1980;citation_issue=3;citation_issn=0033-8419;citation_pmid=7003648" />
<meta name="citation_reference" content="citation_title=American Journal of Roentgenology;citation_journal_abbrev=Am. J. Roentgenol.;citation_title=Correlation of MR imaging-determined cerebral blood volume maps with histologic and angiographic determination of vascularity of gliomas;citation_pages=1479-1486;citation_volume=171;citation_year=1998;citation_issue=6;citation_issn=0361-803X;citation_pmid=9843274;citation_doi=10.2214/ajr.171.6.9843274" />
<meta name="citation_reference" content="citation_title=Acta neurochirurgica;citation_journal_abbrev=Acta Neurochir (Wien);citation_title=Late vascular effects of whole brain X-irradiation in the mouse.;citation_pages=87-102;citation_volume=64;citation_year=1982;citation_issue=1-2;citation_pmid=7124475;citation_doi=10.1007/BF01405622" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Radiation injury of the brain.;citation_pages=45-62;citation_volume=12;citation_year=1991;citation_issue=1;citation_issn=0195-6108;citation_pmid=7502957" />
<meta name="citation_reference" content="citation_title=International journal of radiation oncology, biology, physics;citation_journal_abbrev=Int J Radiat Oncol Biol Phys;citation_title=Magnetic resonance imaging of cranial radiation lesions.;citation_pages=1093-1098;citation_volume=13;citation_year=1987;citation_issue=7;citation_pmid=3597151" />
<meta name="citation_reference" content="citation_title=Radiology;citation_journal_abbrev=Radiology;citation_title=Experimental radiation injury: combined MR imaging and spectroscopy;citation_pages=305-309;citation_volume=169;citation_year=1988;citation_issue=2;citation_issn=0033-8419;citation_pmid=3174977" />
<meta name="citation_reference" content="citation_title=Acta radiologica.  Oncology;citation_journal_abbrev=Acta Radiol Oncol;citation_title=Permeability of the blood-brain barrier in the rat after local proton irradiation.;citation_pages=267-271;citation_volume=21;citation_year=1982;citation_issue=4;citation_pmid=6293269;citation_doi=10.3109/02841868209134015" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Experimental MR study of cerebral radiation injury: quantitative T2 changes over time and histopathologic correlation;citation_pages=79-85;citation_volume=16;citation_year=1995;citation_issue=1;citation_issn=0195-6108;citation_pmid=7900606" />
<meta name="citation_reference" content="citation_title=International journal of hyperthermia :  the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group;citation_journal_abbrev=Int J Hyperthermia;citation_title=Tumour microcirculation as a target for hyperthermia.;citation_pages=111-137;citation_volume=2;citation_year=1986;citation_issue=2;citation_pmid=3540146" />
<meta name="citation_reference" content="citation_title=IEEE transactions on bio-medical engineering;citation_journal_abbrev=IEEE Trans Biomed Eng;citation_title=Implication of blood flow in hyperthermic treatment of tumors.;citation_pages=9-16;citation_volume=31;citation_year=1984;citation_issue=1;citation_pmid=6724614" />
<meta name="citation_reference" content="citation_title=Seminars in roentgenology;citation_journal_abbrev=Semin Roentgenol;citation_title=Vascular patterns in cerebral neoplasms and their differential diagnosis.;citation_pages=59-69;citation_volume=6;citation_year=1971;citation_issue=1;citation_pmid=4347113" />
<meta name="citation_reference" content="citation_title=American Journal of Roentgenology;citation_journal_abbrev=Am. J. Roentgenol.;citation_title=VASCULAR STRUCTURE OF GLIOBLASTOMAS;citation_pages=795-805;citation_volume=105;citation_year=1969;citation_issue=4;citation_issn=0361-803X" />
<meta name="citation_reference" content="citation_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_title=Radiation necrosis or glioma recurrence: is computer-assisted stereotactic biopsy useful?;citation_pages=436-444;citation_volume=82;citation_year=1995;citation_issue=3;citation_pmid=7861222" />
<meta name="citation_reference" content="citation_title=American Journal of Roentgenology;citation_journal_abbrev=Am. J. Roentgenol.;citation_title=Cerebral necrosis after radiotherapy and/or intraarterial chemotherapy for brain tumors: PET and neuropathologic studies;citation_pages=189-197;citation_volume=150;citation_year=1988;citation_issue=1;citation_issn=0361-803X;citation_pmid=3257119" />
<meta name="citation_reference" content="citation_title=Journal of neuropathology and experimental neurology;citation_journal_abbrev=J Neuropathol Exp Neurol;citation_title=Delayed radiation effects in the brains of monkeys exposed to x- and gamma-rays.;citation_pages=50-79;citation_volume=27;citation_year=1968;citation_issue=1;citation_pmid=4968535" />
<meta name="citation_reference" content="citation_title=Radiology;citation_journal_abbrev=Radiology;citation_title=Radiation-induced telangiectasia in the brain simulates cryptic vascular malformations at MR imaging;citation_pages=629-636;citation_volume=193;citation_year=1994;citation_issue=3;citation_issn=0033-8419;citation_pmid=7972799" />
<meta name="citation_reference" content="citation_title=Acta pathologica japonica;citation_journal_abbrev=Acta Pathol Jpn;citation_title=Radiation encephalopathy--an autopsy case and some comments on the pathogenesis of delayed radionecrosis of central nervous system.;citation_pages=867-883;citation_volume=23;citation_year=1973;citation_issue=4;citation_pmid=4801713" />
<meta name="citation_reference" content="citation_title=Brain research;citation_journal_abbrev=Brain Res;citation_title=Thallium-201 uptake relates to membrane potential and potassium permeability in human glioma cells.;citation_pages=30-36;citation_volume=500;citation_year=1989;citation_issue=1-2;citation_pmid=2605498;citation_doi=10.1016/0006-8993(89)90296-5" />
<meta name="citation_reference" content="citation_title=American Journal of Roentgenology;citation_journal_abbrev=Am. J. Roentgenol.;citation_title=Diagnosis of recurrent brain tumor: value of 201Tl SPECT vs 18F- fluorodeoxyglucose PET;citation_pages=1459-1465;citation_volume=163;citation_year=1994;citation_issue=6;citation_issn=0361-803X;citation_pmid=7992747" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Single-photon emission CT in the evaluation of recurrent brain tumor in patients treated with gamma knife radiosurgery or conventional radiation therapy;citation_pages=1681-1686;citation_volume=17;citation_year=1996;citation_issue=9;citation_issn=0195-6108;citation_pmid=8896622" />
<meta name="citation_reference" content="citation_title=Nuclear medicine communications;citation_journal_abbrev=Nucl Med Commun;citation_title=201Tl single photon emission tomography in the evaluation of residual and recurrent astrocytoma.;citation_pages=140-143;citation_volume=15;citation_year=1994;citation_issue=3;citation_pmid=8190401" />
<meta name="citation_reference" content="citation_pages=415;citation_volume=10;citation_year=1996" />
<meta name="citation_reference" content="citation_title=The Canadian journal of neurological sciences. Le journal canadien des sciences neurologiques;citation_journal_abbrev=Can J Neurol Sci;citation_title=Magnetic resonance spectroscopy guided brain tumor resection: differentiation between recurrent glioma and radiation change in two diagnostically difficult cases.;citation_pages=13-22;citation_volume=25;citation_year=1998;citation_issue=1;citation_pmid=9532276" />
<meta name="twitter:title" content="Posttherapeutic Intraaxial Brain Tumor: The Value of Perfusion-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Differentiation of tumor recurrence from treatment-related changes may be difficult with conventional MR imaging when newly enhancing lesions appear. Our aim was to determine the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating recurrent neoplasm from nonneoplastic contrast-enhancing tissue.

METHODS : Twenty patients in whom new enhancing lesions developed within irradiated regions were examined prospectively with perfusion-sensitive contrast-enhanced MR imaging. Twelve of them also underwent thallous chloride Tl 201 single-photon emission tomography (201Tl-SPECT). Normalized relative cerebral blood volume (rCBV) ratios and thallium indexes were evaluated to determine whether the new enhancing lesions were recurrent or not. Five instances of tumor recurrence and one of radiation necrosis were verified histologically; in the others, tumor recurrence was distinguished by lesions that progressively increased in size on serial MR examinations over at least 5 months, and nonneoplastic contrast-enhancing tissue was distinguished by lesions that disappeared or decreased in size on serial MR studies over at least 9 months.

RESULTS: When normalized rCBV ratios were higher than 2.6 or lower than 0.6, enhancing lesions were either recurrent (n = 5) or nonneoplastic contrast-enhancing tissue (n = 3), respectively. All nonneoplastic contrast-enhancing tissue had a low thallium index, whereas three of four recurrent lesions had a high index.

CONCLUSION: An enhancing lesion with a normalized rCBV ratio higher than 2.6 or lower than 0.6 may suggest tumor recurrence or nonneoplastic contrast-enhancing tissue, respectively. In these cases, further examination with 201Tl-SPECT may not be necessary. However, when the normalized rCBV ratio is between 0.6 and 2.6, 201Tl-SPECT may be useful in making the differentiation." />
<meta name="og-title" property="og:title" content="Posttherapeutic Intraaxial Brain Tumor: The Value of Perfusion-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/21/5/901" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Differentiation of tumor recurrence from treatment-related changes may be difficult with conventional MR imaging when newly enhancing lesions appear. Our aim was to determine the value of perfusion-sensitive contrast-enhanced MR imaging for differentiating recurrent neoplasm from nonneoplastic contrast-enhancing tissue.

METHODS : Twenty patients in whom new enhancing lesions developed within irradiated regions were examined prospectively with perfusion-sensitive contrast-enhanced MR imaging. Twelve of them also underwent thallous chloride Tl 201 single-photon emission tomography (201Tl-SPECT). Normalized relative cerebral blood volume (rCBV) ratios and thallium indexes were evaluated to determine whether the new enhancing lesions were recurrent or not. Five instances of tumor recurrence and one of radiation necrosis were verified histologically; in the others, tumor recurrence was distinguished by lesions that progressively increased in size on serial MR examinations over at least 5 months, and nonneoplastic contrast-enhancing tissue was distinguished by lesions that disappeared or decreased in size on serial MR studies over at least 9 months.

RESULTS: When normalized rCBV ratios were higher than 2.6 or lower than 0.6, enhancing lesions were either recurrent (n = 5) or nonneoplastic contrast-enhancing tissue (n = 3), respectively. All nonneoplastic contrast-enhancing tissue had a low thallium index, whereas three of four recurrent lesions had a high index.

CONCLUSION: An enhancing lesion with a normalized rCBV ratio higher than 2.6 or lower than 0.6 may suggest tumor recurrence or nonneoplastic contrast-enhancing tissue, respectively. In these cases, further examination with 201Tl-SPECT may not be necessary. However, when the normalized rCBV ratio is between 0.6 and 2.6, 201Tl-SPECT may be useful in making the differentiation." />
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    <title>Posttherapeutic Intraaxial Brain Tumor: The Value of Perfusion-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue | American Journal of Neuroradiology</title>  
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">BRAIN</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Posttherapeutic Intraaxial Brain Tumor: The Value of Perfusion-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Takeshi Sugahara</span>, <span class="highwire-citation-author" data-delta="1">Yukunori Korogi</span>, <span class="highwire-citation-author" data-delta="2">Seiji Tomiguchi</span>, <span class="highwire-citation-author" data-delta="3">Yoshinori Shigematsu</span>, <span class="highwire-citation-author" data-delta="4">Ichiro Ikushima</span>, <span class="highwire-citation-author" data-delta="5">Tomohiro Kira</span>, <span class="highwire-citation-author" data-delta="6">Luxia Liang</span>, <span class="highwire-citation-author" data-delta="7">Yukitaka Ushio</span> and <span class="highwire-citation-author" data-delta="8">Mutsumasa Takahashi</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2000,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">21 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">901-909; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-11588--61663701073" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Takeshi Sugahara </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Takeshi%2BSugahara%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sugahara%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ATakeshi%2BSugahara%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Yukunori 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 21</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 5 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 May 2000 </div></div>
      
      
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      <div class="highwire-cite-title">Posttherapeutic Intraaxial Brain Tumor: The Value of Perfusion-sensitive Contrast-enhanced MR Imaging for Differentiating Tumor Recurrence from Nonneoplastic Contrast-enhancing Tissue</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Takeshi</span> <span class="nlm-surname">Sugahara</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Yukunori</span> <span class="nlm-surname">Korogi</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Seiji</span> <span class="nlm-surname">Tomiguchi</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Yoshinori</span> <span class="nlm-surname">Shigematsu</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Ichiro</span> <span class="nlm-surname">Ikushima</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Tomohiro</span> <span class="nlm-surname">Kira</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Luxia</span> <span class="nlm-surname">Liang</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Yukitaka</span> <span class="nlm-surname">Ushio</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Mutsumasa</span> <span class="nlm-surname">Takahashi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2000, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">21 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">901-909; </span></div>
  
  
  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2000, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">21 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">901-909; </span></div>
  
  
  
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