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<meta name="DC.Title" content="Dynamic Helical CT of T1 and T2 Glottic Carcinomas: Predictive Value for Local Control with Radiation Therapy" />
<meta name="DC.Date" content="2000-08-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Tumor volume and cartilage invasion have been suggested as prognostic factors of glottic carcinomas following definitive radiation therapy. Radiologic examinations provide additional information regarding the deep extension of tumor. We determined whether dynamic helical CT can predict local control of early (T1 and T2 stage) glottic carcinomas treated with definitive radiation therapy.

METHODS: Sixty-eight patients with early glottic carcinoma evaluated on pretreatment dynamic helical CT were treated with definitive radiation therapy. Tumor detectability, maximum dimension, tumor volume, and involvement of anatomic subsites (anterior commissure, ventricle, subglottic region, and thyroid and arytenoid cartilages) were determined by consensus by three radiologists without previous knowledge of the clinical information. The CT findings were correlated with local control.

RESULTS: The two-year local control rate was 76%; 91% for T1 and 60% for T2 lesions. Univariate analysis revealed clinical T stage, tumor detectability, maximum dimension, tumor volume, anterior commissure involvement, ventricle involvement, and thyroid cartilage involvement as significant prognostic factors. Thyroid cartilage involvement was an independent predictor by multivariate analysis. The lesions separate from the thyroid cartilage had a 95% probability of local control, whereas the lesions adjacent to the cartilage had only a 42% control rate.

CONCLUSION: Dynamic helical CT provides prognostic information for the results of definitive radiation therapy. Patients with a tumor adjacent to the thyroid cartilage had an increased risk of local failure." />
<meta name="DC.Contributor" content="Ryuji Murakami" />
<meta name="DC.Contributor" content="Mitsuhiro Furusawa" />
<meta name="DC.Contributor" content="Yuji Baba" />
<meta name="DC.Contributor" content="Ryuichi Nishimura" />
<meta name="DC.Contributor" content="Fumihiro Katsura" />
<meta name="DC.Contributor" content="Masao Eura" />
<meta name="DC.Contributor" content="Keisuke Masuyama" />
<meta name="DC.Contributor" content="Mutsumasa Takahashi" />
<meta name="article:published_time" content="2000-08-01" />
<meta name="article:section" content="HEAD AND NECK" />
<meta name="citation_title" content="Dynamic Helical CT of T1 and T2 Glottic Carcinomas: Predictive Value for Local Control with Radiation Therapy" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Tumor volume and cartilage invasion have been suggested as prognostic factors of glottic carcinomas following definitive radiation therapy. Radiologic examinations provide additional information regarding the deep extension of tumor. We determined whether dynamic helical CT can predict local control of early (T1 and T2 stage) glottic carcinomas treated with definitive radiation therapy.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Sixty-eight patients with early glottic carcinoma evaluated on pretreatment dynamic helical CT were treated with definitive radiation therapy. Tumor detectability, maximum dimension, tumor volume, and involvement of anatomic subsites (anterior commissure, ventricle, subglottic region, and thyroid and arytenoid cartilages) were determined by consensus by three radiologists without previous knowledge of the clinical information. The CT findings were correlated with local control.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; The two-year local control rate was 76%; 91% for T1 and 60% for T2 lesions. Univariate analysis revealed clinical T stage, tumor detectability, maximum dimension, tumor volume, anterior commissure involvement, ventricle involvement, and thyroid cartilage involvement as significant prognostic factors. Thyroid cartilage involvement was an independent predictor by multivariate analysis. The lesions separate from the thyroid cartilage had a 95% probability of local control, whereas the lesions adjacent to the cartilage had only a 42% control rate.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Dynamic helical CT provides prognostic information for the results of definitive radiation therapy. Patients with a tumor adjacent to the thyroid cartilage had an increased risk of local failure.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2000/08/01" />
<meta name="citation_mjid" content="ajnr;21/7/1320" />
<meta name="citation_id" content="21/7/1320" />
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<meta name="citation_issn" content="0195-6108" />
<meta name="citation_issn" content="1936-959X" />
<meta name="citation_pmid" content="10954287" />
<meta name="citation_volume" content="21" />
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<meta name="citation_article_type" content="Research Article" />
<meta name="citation_section" content="HEAD AND NECK" />
<meta name="citation_firstpage" content="1320" />
<meta name="citation_lastpage" content="1326" />
<meta name="citation_author" content="Ryuji Murakami" />
<meta name="citation_author_institution" content="From the Departments of Radiology (R.M., M.F., Y.B., R.N., M.T.) and Otorhinolaryngology (F.K., M.E., K.M.), Kumamoto University School of Medicine, Kumamoto, Japan." />
<meta name="citation_author" content="Mitsuhiro Furusawa" />
<meta name="citation_author_institution" content="From the Departments of Radiology (R.M., M.F., Y.B., R.N., M.T.) and Otorhinolaryngology (F.K., M.E., K.M.), Kumamoto University School of Medicine, Kumamoto, Japan." />
<meta name="citation_author" content="Yuji Baba" />
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<meta name="citation_author" content="Ryuichi Nishimura" />
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<meta name="citation_author" content="Fumihiro Katsura" />
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<meta name="citation_author" content="Masao Eura" />
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<meta name="citation_author" content="Keisuke Masuyama" />
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<meta name="citation_author" content="Mutsumasa Takahashi" />
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<meta name="twitter:title" content="Dynamic Helical CT of T1 and T2 Glottic Carcinomas: Predictive Value for Local Control with Radiation Therapy" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Tumor volume and cartilage invasion have been suggested as prognostic factors of glottic carcinomas following definitive radiation therapy. Radiologic examinations provide additional information regarding the deep extension of tumor. We determined whether dynamic helical CT can predict local control of early (T1 and T2 stage) glottic carcinomas treated with definitive radiation therapy.

METHODS: Sixty-eight patients with early glottic carcinoma evaluated on pretreatment dynamic helical CT were treated with definitive radiation therapy. Tumor detectability, maximum dimension, tumor volume, and involvement of anatomic subsites (anterior commissure, ventricle, subglottic region, and thyroid and arytenoid cartilages) were determined by consensus by three radiologists without previous knowledge of the clinical information. The CT findings were correlated with local control.

RESULTS: The two-year local control rate was 76%; 91% for T1 and 60% for T2 lesions. Univariate analysis revealed clinical T stage, tumor detectability, maximum dimension, tumor volume, anterior commissure involvement, ventricle involvement, and thyroid cartilage involvement as significant prognostic factors. Thyroid cartilage involvement was an independent predictor by multivariate analysis. The lesions separate from the thyroid cartilage had a 95% probability of local control, whereas the lesions adjacent to the cartilage had only a 42% control rate.

CONCLUSION: Dynamic helical CT provides prognostic information for the results of definitive radiation therapy. Patients with a tumor adjacent to the thyroid cartilage had an increased risk of local failure." />
<meta name="og-title" property="og:title" content="Dynamic Helical CT of T1 and T2 Glottic Carcinomas: Predictive Value for Local Control with Radiation Therapy" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Tumor volume and cartilage invasion have been suggested as prognostic factors of glottic carcinomas following definitive radiation therapy. Radiologic examinations provide additional information regarding the deep extension of tumor. We determined whether dynamic helical CT can predict local control of early (T1 and T2 stage) glottic carcinomas treated with definitive radiation therapy.

METHODS: Sixty-eight patients with early glottic carcinoma evaluated on pretreatment dynamic helical CT were treated with definitive radiation therapy. Tumor detectability, maximum dimension, tumor volume, and involvement of anatomic subsites (anterior commissure, ventricle, subglottic region, and thyroid and arytenoid cartilages) were determined by consensus by three radiologists without previous knowledge of the clinical information. The CT findings were correlated with local control.

RESULTS: The two-year local control rate was 76%; 91% for T1 and 60% for T2 lesions. Univariate analysis revealed clinical T stage, tumor detectability, maximum dimension, tumor volume, anterior commissure involvement, ventricle involvement, and thyroid cartilage involvement as significant prognostic factors. Thyroid cartilage involvement was an independent predictor by multivariate analysis. The lesions separate from the thyroid cartilage had a 95% probability of local control, whereas the lesions adjacent to the cartilage had only a 42% control rate.

CONCLUSION: Dynamic helical CT provides prognostic information for the results of definitive radiation therapy. Patients with a tumor adjacent to the thyroid cartilage had an increased risk of local failure." />
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<div id="hw-article-author-popups-top-node-2257--6160468784" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Ryuji Murakami </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (R.M., M.F., Y.B., R.N., M.T.) and Otorhinolaryngology (F.K., M.E., K.M.), Kumamoto University School of Medicine, Kumamoto, Japan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Ryuji%2BMurakami%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Murakami%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ARyuji%2BMurakami%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Mitsuhiro Furusawa </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (R.M., M.F., Y.B., R.N., M.T.) and Otorhinolaryngology (F.K., M.E., K.M.), Kumamoto University School of Medicine, Kumamoto, Japan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Mitsuhiro%2BFurusawa%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Furusawa%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AMitsuhiro%2BFurusawa%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">Yuji Baba </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (R.M., M.F., Y.B., R.N., M.T.) and Otorhinolaryngology (F.K., M.E., K.M.), Kumamoto University School of Medicine, Kumamoto, Japan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Yuji%2BBaba%2B" 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class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Ryuichi%2BNishimura%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Nishimura%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ARyuichi%2BNishimura%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">Fumihiro Katsura </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Radiology (R.M., M.F., Y.B., R.N., M.T.) and Otorhinolaryngology (F.K., M.E., K.M.), Kumamoto University School of Medicine, Kumamoto, Japan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Fumihiro%2BKatsura%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Katsura%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AFumihiro%2BKatsura%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">Masao Eura </div><div 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 21</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 7 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Aug 2000 </div></div>
      
      
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      <div class="highwire-cite-title">Dynamic Helical CT of T1 and T2 Glottic Carcinomas: Predictive Value for Local Control with Radiation Therapy</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Ryuji</span> <span class="nlm-surname">Murakami</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Mitsuhiro</span> <span class="nlm-surname">Furusawa</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Yuji</span> <span class="nlm-surname">Baba</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Ryuichi</span> <span class="nlm-surname">Nishimura</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Fumihiro</span> <span class="nlm-surname">Katsura</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Masao</span> <span class="nlm-surname">Eura</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Keisuke</span> <span class="nlm-surname">Masuyama</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Mutsumasa</span> <span class="nlm-surname">Takahashi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2000, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">21 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1320-1326; </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Ryuji</span> <span class="nlm-surname">Murakami</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Mitsuhiro</span> <span class="nlm-surname">Furusawa</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Yuji</span> <span class="nlm-surname">Baba</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Ryuichi</span> <span class="nlm-surname">Nishimura</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Fumihiro</span> <span class="nlm-surname">Katsura</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Masao</span> <span class="nlm-surname">Eura</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Keisuke</span> <span class="nlm-surname">Masuyama</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Mutsumasa</span> <span class="nlm-surname">Takahashi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2000, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">21 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1320-1326; </span></div>
  
  
  
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