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<meta name="DC.Title" content="MR Imaging Assessment of Myelination in the Very Preterm Brain" />
<meta name="DC.Date" content="2002-05-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: MR imaging was performed in very preterm infants by using an MR imager in the neonatal intensive care unit. The aims of this study were to assess the development of myelination in the preterm brain based on MR imaging findings and to compare the ability of T1-weighted conventional spin-echo, inversion recovery fast spin-echo, and T2-weighted fast spin-echo MR imaging to show myelination in these infants.

METHODS: MR imaging was performed for 26 preterm infants with a median gestational age of 28 weeks who had normal neurodevelopmental outcomes at 2 years corrected age.

RESULTS: Myelin was evident in the gracile and cuneate nuclei and fasciculi, vestibular nuclei, cerebellar vermis, inferior and superior cerebellar peduncles, dentate nucleus, medial longitudinal fasciculus, medial geniculate bodies, subthalamic nuclei, inferior olivary nuclei, ventrolateral nuclei of the thalamus, decussation of the superior cerebellar peduncles, medial lemnisci, lateral lemnisci, and inferior colliculi at ≤28 weeks gestational age. From this gestational age, myelination was not visualized at any new site until 36 weeks gestational age, when myelin was visualized in the corona radiata, posterior limb of the internal capsule, corticospinal tracts of the precentral and postcentral gyri, and lateral geniculate bodies. T2-weighted fast spin-echo MR imaging showed myelin in gray matter nuclei at an earlier gestational age than did T1-weighted conventional spin-echo or inversion recovery fast spin-echo MR imaging. T1-weighted conventional spin-echo MR imaging showed myelin earlier in some white matter tracts in the preterm brain.

CONCLUSION: Myelination was evident in numerous gray and white matter structures in the very preterm brain. A knowledge of myelination milestones will allow delays to be detected at an early stage." />
<meta name="DC.Contributor" content="Serena J. Counsell" />
<meta name="DC.Contributor" content="Elia F. Maalouf" />
<meta name="DC.Contributor" content="Alison M. Fletcher" />
<meta name="DC.Contributor" content="Philip Duggan" />
<meta name="DC.Contributor" content="Malcolm Battin" />
<meta name="DC.Contributor" content="Helen J. Lewis" />
<meta name="DC.Contributor" content="Amy H. Herlihy" />
<meta name="DC.Contributor" content="A. David Edwards" />
<meta name="DC.Contributor" content="Graeme M. Bydder" />
<meta name="DC.Contributor" content="Mary A. Rutherford" />
<meta name="article:published_time" content="2002-05-01" />
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<meta name="citation_title" content="MR Imaging Assessment of Myelination in the Very Preterm Brain" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; MR imaging was performed in very preterm infants by using an MR imager in the neonatal intensive care unit. The aims of this study were to assess the development of myelination in the preterm brain based on MR imaging findings and to compare the ability of T1-weighted conventional spin-echo, inversion recovery fast spin-echo, and T2-weighted fast spin-echo MR imaging to show myelination in these infants.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; MR imaging was performed for 26 preterm infants with a median gestational age of 28 weeks who had normal neurodevelopmental outcomes at 2 years corrected age.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; Myelin was evident in the gracile and cuneate nuclei and fasciculi, vestibular nuclei, cerebellar vermis, inferior and superior cerebellar peduncles, dentate nucleus, medial longitudinal fasciculus, medial geniculate bodies, subthalamic nuclei, inferior olivary nuclei, ventrolateral nuclei of the thalamus, decussation of the superior cerebellar peduncles, medial lemnisci, lateral lemnisci, and inferior colliculi at ≤28 weeks gestational age. From this gestational age, myelination was not visualized at any new site until 36 weeks gestational age, when myelin was visualized in the corona radiata, posterior limb of the internal capsule, corticospinal tracts of the precentral and postcentral gyri, and lateral geniculate bodies. T2-weighted fast spin-echo MR imaging showed myelin in gray matter nuclei at an earlier gestational age than did T1-weighted conventional spin-echo or inversion recovery fast spin-echo MR imaging. T1-weighted conventional spin-echo MR imaging showed myelin earlier in some white matter tracts in the preterm brain.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Myelination was evident in numerous gray and white matter structures in the very preterm brain. A knowledge of myelination milestones will allow delays to be detected at an early stage.&lt;/p&gt;" />
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<meta name="twitter:title" content="MR Imaging Assessment of Myelination in the Very Preterm Brain" />
<meta name="twitter:card" content="summary_large_image" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: MR imaging was performed in very preterm infants by using an MR imager in the neonatal intensive care unit. The aims of this study were to assess the development of myelination in the preterm brain based on MR imaging findings and to compare the ability of T1-weighted conventional spin-echo, inversion recovery fast spin-echo, and T2-weighted fast spin-echo MR imaging to show myelination in these infants.

METHODS: MR imaging was performed for 26 preterm infants with a median gestational age of 28 weeks who had normal neurodevelopmental outcomes at 2 years corrected age.

RESULTS: Myelin was evident in the gracile and cuneate nuclei and fasciculi, vestibular nuclei, cerebellar vermis, inferior and superior cerebellar peduncles, dentate nucleus, medial longitudinal fasciculus, medial geniculate bodies, subthalamic nuclei, inferior olivary nuclei, ventrolateral nuclei of the thalamus, decussation of the superior cerebellar peduncles, medial lemnisci, lateral lemnisci, and inferior colliculi at ≤28 weeks gestational age. From this gestational age, myelination was not visualized at any new site until 36 weeks gestational age, when myelin was visualized in the corona radiata, posterior limb of the internal capsule, corticospinal tracts of the precentral and postcentral gyri, and lateral geniculate bodies. T2-weighted fast spin-echo MR imaging showed myelin in gray matter nuclei at an earlier gestational age than did T1-weighted conventional spin-echo or inversion recovery fast spin-echo MR imaging. T1-weighted conventional spin-echo MR imaging showed myelin earlier in some white matter tracts in the preterm brain.

CONCLUSION: Myelination was evident in numerous gray and white matter structures in the very preterm brain. A knowledge of myelination milestones will allow delays to be detected at an early stage." />
<meta name="og-title" property="og:title" content="MR Imaging Assessment of Myelination in the Very Preterm Brain" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/23/5/872" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: MR imaging was performed in very preterm infants by using an MR imager in the neonatal intensive care unit. The aims of this study were to assess the development of myelination in the preterm brain based on MR imaging findings and to compare the ability of T1-weighted conventional spin-echo, inversion recovery fast spin-echo, and T2-weighted fast spin-echo MR imaging to show myelination in these infants.

METHODS: MR imaging was performed for 26 preterm infants with a median gestational age of 28 weeks who had normal neurodevelopmental outcomes at 2 years corrected age.

RESULTS: Myelin was evident in the gracile and cuneate nuclei and fasciculi, vestibular nuclei, cerebellar vermis, inferior and superior cerebellar peduncles, dentate nucleus, medial longitudinal fasciculus, medial geniculate bodies, subthalamic nuclei, inferior olivary nuclei, ventrolateral nuclei of the thalamus, decussation of the superior cerebellar peduncles, medial lemnisci, lateral lemnisci, and inferior colliculi at ≤28 weeks gestational age. From this gestational age, myelination was not visualized at any new site until 36 weeks gestational age, when myelin was visualized in the corona radiata, posterior limb of the internal capsule, corticospinal tracts of the precentral and postcentral gyri, and lateral geniculate bodies. T2-weighted fast spin-echo MR imaging showed myelin in gray matter nuclei at an earlier gestational age than did T1-weighted conventional spin-echo or inversion recovery fast spin-echo MR imaging. T1-weighted conventional spin-echo MR imaging showed myelin earlier in some white matter tracts in the preterm brain.

CONCLUSION: Myelination was evident in numerous gray and white matter structures in the very preterm brain. A knowledge of myelination milestones will allow delays to be detected at an early stage." />
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<div id="hw-article-author-popups-top-node-10023--6530952062" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Serena J. Counsell </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Serena%2BJ.%2BCounsell%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Counsell%20SJ&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3ASerena%2BJ.%2BCounsell%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">Elia F. 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      <div class="highwire-cite-title">MR Imaging Assessment of Myelination in the Very Preterm Brain</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Serena J.</span> <span class="nlm-surname">Counsell</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Elia F.</span> <span class="nlm-surname">Maalouf</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Alison M.</span> <span class="nlm-surname">Fletcher</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Philip</span> <span class="nlm-surname">Duggan</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Malcolm</span> <span class="nlm-surname">Battin</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Helen J.</span> <span class="nlm-surname">Lewis</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Amy H.</span> <span class="nlm-surname">Herlihy</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">A. David</span> <span class="nlm-surname">Edwards</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Graeme M.</span> <span class="nlm-surname">Bydder</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Mary A.</span> <span class="nlm-surname">Rutherford</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2002, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">23 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">872-881; </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Serena J.</span> <span class="nlm-surname">Counsell</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Elia F.</span> <span class="nlm-surname">Maalouf</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Alison M.</span> <span class="nlm-surname">Fletcher</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Philip</span> <span class="nlm-surname">Duggan</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Malcolm</span> <span class="nlm-surname">Battin</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Helen J.</span> <span class="nlm-surname">Lewis</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Amy H.</span> <span class="nlm-surname">Herlihy</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">A. David</span> <span class="nlm-surname">Edwards</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Graeme M.</span> <span class="nlm-surname">Bydder</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">Mary A.</span> <span class="nlm-surname">Rutherford</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2002, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">23 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">872-881; </span></div>
  
  
  
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