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<meta name="DC.Title" content="Delayed Encephalopathy of Acute Carbon Monoxide Intoxication: Diffusivity of Cerebral White Matter Lesions" />
<meta name="DC.Date" content="2003-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Carbon monoxide intoxication has delayed effects on the cerebral white matter characterized by bilateral, confluent lesions that reflect diffuse demyelination. To increase our understanding of this process, we assessed the diffusion characteristics of these lesions.

METHODS: Five consecutive patients with delayed encephalopathy of CO intoxication were examined with diffusion MR imaging. Diffusion-weighted images (DWIs) were obtained 25–95 days after their exposure to CO and during a relapse of neuropsychiatric symptoms, which occurred after an initial recovery. Imaging was performed at 1.5 T by using a spin-echo echo-planar sequence with diffusion gradients of 0, 500, and 1000 s/mm2. DWIs and apparent diffusion coefficient (ADC) maps were visually evaluated, and mean ADCs were calculated from the periventricular white matter and the centrum semiovale, where confluent hyperintensity was seen on T2-weighted images. Findings were compared with those of normal-looking white matter.

RESULTS: In all five patients, both T2-weighted images and DWIs showed the white matter lesions as bilateral, diffuse, confluent areas of hyperintensity in the periventricular white matter and centrum semiovale. On ADC maps, these lesions were isointense, with focal areas of hypointensity (n = 4) or diffuse hypointensity (n = 1). Mean ADC values of the white matter lesions were significantly lower than those of normal-looking white matter, regardless of their isointensity or hypointensity on ADC maps ( P &lt; .05).

CONCLUSION: Bilateral, confluent, white matter lesions in patients with delayed encephalopathy of CO intoxication show decreased diffusivity." />
<meta name="DC.Contributor" content="Ji-hoon Kim" />
<meta name="DC.Contributor" content="Kee-Hyun Chang" />
<meta name="DC.Contributor" content="In Chan Song" />
<meta name="DC.Contributor" content="Keon Ha Kim" />
<meta name="DC.Contributor" content="Bae Ju Kwon" />
<meta name="DC.Contributor" content="Hyo-Cheol Kim" />
<meta name="DC.Contributor" content="Jae Hyoung Kim" />
<meta name="DC.Contributor" content="Moon Hee Han" />
<meta name="article:published_time" content="2003-09-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Delayed Encephalopathy of Acute Carbon Monoxide Intoxication: Diffusivity of Cerebral White Matter Lesions" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Carbon monoxide intoxication has delayed effects on the cerebral white matter characterized by bilateral, confluent lesions that reflect diffuse demyelination. To increase our understanding of this process, we assessed the diffusion characteristics of these lesions.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Five consecutive patients with delayed encephalopathy of CO intoxication were examined with diffusion MR imaging. Diffusion-weighted images (DWIs) were obtained 25–95 days after their exposure to CO and during a relapse of neuropsychiatric symptoms, which occurred after an initial recovery. Imaging was performed at 1.5 T by using a spin-echo echo-planar sequence with diffusion gradients of 0, 500, and 1000 s/mm&lt;sup&gt;2&lt;/sup&gt;. DWIs and apparent diffusion coefficient (ADC) maps were visually evaluated, and mean ADCs were calculated from the periventricular white matter and the centrum semiovale, where confluent hyperintensity was seen on T2-weighted images. Findings were compared with those of normal-looking white matter.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; In all five patients, both T2-weighted images and DWIs showed the white matter lesions as bilateral, diffuse, confluent areas of hyperintensity in the periventricular white matter and centrum semiovale. On ADC maps, these lesions were isointense, with focal areas of hypointensity (n = 4) or diffuse hypointensity (n = 1). Mean ADC values of the white matter lesions were significantly lower than those of normal-looking white matter, regardless of their isointensity or hypointensity on ADC maps (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05).&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Bilateral, confluent, white matter lesions in patients with delayed encephalopathy of CO intoxication show decreased diffusivity.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2003/09/01" />
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<meta name="citation_author" content="Ji-hoon Kim" />
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<meta name="citation_author" content="Bae Ju Kwon" />
<meta name="citation_author" content="Hyo-Cheol Kim" />
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<meta name="twitter:title" content="Delayed Encephalopathy of Acute Carbon Monoxide Intoxication: Diffusivity of Cerebral White Matter Lesions" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Carbon monoxide intoxication has delayed effects on the cerebral white matter characterized by bilateral, confluent lesions that reflect diffuse demyelination. To increase our understanding of this process, we assessed the diffusion characteristics of these lesions.

METHODS: Five consecutive patients with delayed encephalopathy of CO intoxication were examined with diffusion MR imaging. Diffusion-weighted images (DWIs) were obtained 25–95 days after their exposure to CO and during a relapse of neuropsychiatric symptoms, which occurred after an initial recovery. Imaging was performed at 1.5 T by using a spin-echo echo-planar sequence with diffusion gradients of 0, 500, and 1000 s/mm2. DWIs and apparent diffusion coefficient (ADC) maps were visually evaluated, and mean ADCs were calculated from the periventricular white matter and the centrum semiovale, where confluent hyperintensity was seen on T2-weighted images. Findings were compared with those of normal-looking white matter.

RESULTS: In all five patients, both T2-weighted images and DWIs showed the white matter lesions as bilateral, diffuse, confluent areas of hyperintensity in the periventricular white matter and centrum semiovale. On ADC maps, these lesions were isointense, with focal areas of hypointensity (n = 4) or diffuse hypointensity (n = 1). Mean ADC values of the white matter lesions were significantly lower than those of normal-looking white matter, regardless of their isointensity or hypointensity on ADC maps ( P &lt; .05).

CONCLUSION: Bilateral, confluent, white matter lesions in patients with delayed encephalopathy of CO intoxication show decreased diffusivity." />
<meta name="og-title" property="og:title" content="Delayed Encephalopathy of Acute Carbon Monoxide Intoxication: Diffusivity of Cerebral White Matter Lesions" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Carbon monoxide intoxication has delayed effects on the cerebral white matter characterized by bilateral, confluent lesions that reflect diffuse demyelination. To increase our understanding of this process, we assessed the diffusion characteristics of these lesions.

METHODS: Five consecutive patients with delayed encephalopathy of CO intoxication were examined with diffusion MR imaging. Diffusion-weighted images (DWIs) were obtained 25–95 days after their exposure to CO and during a relapse of neuropsychiatric symptoms, which occurred after an initial recovery. Imaging was performed at 1.5 T by using a spin-echo echo-planar sequence with diffusion gradients of 0, 500, and 1000 s/mm2. DWIs and apparent diffusion coefficient (ADC) maps were visually evaluated, and mean ADCs were calculated from the periventricular white matter and the centrum semiovale, where confluent hyperintensity was seen on T2-weighted images. Findings were compared with those of normal-looking white matter.

RESULTS: In all five patients, both T2-weighted images and DWIs showed the white matter lesions as bilateral, diffuse, confluent areas of hyperintensity in the periventricular white matter and centrum semiovale. On ADC maps, these lesions were isointense, with focal areas of hypointensity (n = 4) or diffuse hypointensity (n = 1). Mean ADC values of the white matter lesions were significantly lower than those of normal-looking white matter, regardless of their isointensity or hypointensity on ADC maps ( P &lt; .05).

CONCLUSION: Bilateral, confluent, white matter lesions in patients with delayed encephalopathy of CO intoxication show decreased diffusivity." />
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      <h1 class="highwire-cite-title" id="page-title">Delayed Encephalopathy of Acute Carbon Monoxide Intoxication: Diffusivity of Cerebral White Matter Lesions</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Ji-hoon Kim</span>, <span class="highwire-citation-author" data-delta="1">Kee-Hyun Chang</span>, <span class="highwire-citation-author" data-delta="2">In Chan Song</span>, <span class="highwire-citation-author" data-delta="3">Keon Ha Kim</span>, <span class="highwire-citation-author" data-delta="4">Bae Ju Kwon</span>, <span class="highwire-citation-author" data-delta="5">Hyo-Cheol Kim</span>, <span class="highwire-citation-author" data-delta="6">Jae Hyoung Kim</span> and <span class="highwire-citation-author" data-delta="7">Moon Hee Han</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2003,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">24 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1592-1597; </span></div>
  
  
  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 24</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 8 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Sep 2003 </div></div>
      
      
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      <div class="highwire-cite-title">Delayed Encephalopathy of Acute Carbon Monoxide Intoxication: Diffusivity of Cerebral White Matter Lesions</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Ji-hoon</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Kee-Hyun</span> <span class="nlm-surname">Chang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">In Chan</span> <span class="nlm-surname">Song</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Keon Ha</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Bae Ju</span> <span class="nlm-surname">Kwon</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Hyo-Cheol</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Jae Hyoung</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Moon Hee</span> <span class="nlm-surname">Han</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2003, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">24 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1592-1597; </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Ji-hoon</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Kee-Hyun</span> <span class="nlm-surname">Chang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">In Chan</span> <span class="nlm-surname">Song</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Keon Ha</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Bae Ju</span> <span class="nlm-surname">Kwon</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Hyo-Cheol</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Jae Hyoung</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Moon Hee</span> <span class="nlm-surname">Han</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2003, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">24 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1592-1597; </span></div>
  
  
  
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