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<meta name="DC.Description" content="Summary: Few reports of temporary disruption of the blood-brain barrier (BBB) following neurointerventional procedures, presumably caused by nonionic radiographic contrast medium (CM), exist in the literature. We described such a case in a 72-year-old man presenting with acute subarachnoid hemorrhage, who underwent coil embolization of a ruptured anterior communicating artery complex aneurysm. At the time of his follow-up CT examination, a large amount of iodine was found in the cerebrospinal fluid (CSF). Because of this experience, the iodine concentration in the CSF of five other patients who also underwent an intracranial endovascular procedure was measured. It was concluded that this increased iodine might have been caused by temporary leakage or breakdown of the BBB. Even if the total amount of CM may not be excessive, the disproportionately high concentration injected into a single vascular territory may pose a unique set of variables increasing the risk of BBB disruption." />
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<meta name="DC.Contributor" content="Toshi Abe" />
<meta name="DC.Contributor" content="Masaru Hirohata" />
<meta name="DC.Contributor" content="Norimitsu Tanaka" />
<meta name="DC.Contributor" content="Kazuyuki Kojima" />
<meta name="DC.Contributor" content="Hiroshi Nishimura" />
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<meta name="twitter:title" content="Blood Brain–Barrier Disruption of Nonionic Iodinated Contrast Medium Following Coil Embolization of a Ruptured Intracerebral Aneurysm" />
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<meta name="twitter:description" content="Summary: Few reports of temporary disruption of the blood-brain barrier (BBB) following neurointerventional procedures, presumably caused by nonionic radiographic contrast medium (CM), exist in the literature. We described such a case in a 72-year-old man presenting with acute subarachnoid hemorrhage, who underwent coil embolization of a ruptured anterior communicating artery complex aneurysm. At the time of his follow-up CT examination, a large amount of iodine was found in the cerebrospinal fluid (CSF). Because of this experience, the iodine concentration in the CSF of five other patients who also underwent an intracranial endovascular procedure was measured. It was concluded that this increased iodine might have been caused by temporary leakage or breakdown of the BBB. Even if the total amount of CM may not be excessive, the disproportionately high concentration injected into a single vascular territory may pose a unique set of variables increasing the risk of BBB disruption." />
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<meta name="og-description" property="og:description" content="Summary: Few reports of temporary disruption of the blood-brain barrier (BBB) following neurointerventional procedures, presumably caused by nonionic radiographic contrast medium (CM), exist in the literature. We described such a case in a 72-year-old man presenting with acute subarachnoid hemorrhage, who underwent coil embolization of a ruptured anterior communicating artery complex aneurysm. At the time of his follow-up CT examination, a large amount of iodine was found in the cerebrospinal fluid (CSF). Because of this experience, the iodine concentration in the CSF of five other patients who also underwent an intracranial endovascular procedure was measured. It was concluded that this increased iodine might have been caused by temporary leakage or breakdown of the BBB. Even if the total amount of CM may not be excessive, the disproportionately high concentration injected into a single vascular territory may pose a unique set of variables increasing the risk of BBB disruption." />
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      <h1 class="highwire-cite-title" id="page-title">Blood Brain–Barrier Disruption of Nonionic Iodinated Contrast Medium Following Coil Embolization of a Ruptured Intracerebral Aneurysm</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Yusuke Uchiyama</span>, <span class="highwire-citation-author" data-delta="1">Toshi Abe</span>, <span class="highwire-citation-author" data-delta="2">Masaru Hirohata</span>, <span class="highwire-citation-author" data-delta="3">Norimitsu Tanaka</span>, <span class="highwire-citation-author" data-delta="4">Kazuyuki Kojima</span>, <span class="highwire-citation-author" data-delta="5">Hiroshi Nishimura</span>, <span class="highwire-citation-author" data-delta="6">Alexander M. Norbash</span> and <span class="highwire-citation-author" data-delta="7">Naofumi Hayabuchi</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2004,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">25 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1783-1786; </span></div>
  
  
  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 25</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 10 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Nov 2004 </div></div>
      
      
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      <div class="highwire-cite-title">Blood Brain–Barrier Disruption of Nonionic Iodinated Contrast Medium Following Coil Embolization of a Ruptured Intracerebral Aneurysm</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2004, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">25 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1783-1786; </span></div>
  
  
  
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      <div class="highwire-cite-title">Blood Brain–Barrier Disruption of Nonionic Iodinated Contrast Medium Following Coil Embolization of a Ruptured Intracerebral Aneurysm</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Yusuke</span> <span class="nlm-surname">Uchiyama</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Toshi</span> <span class="nlm-surname">Abe</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Masaru</span> <span class="nlm-surname">Hirohata</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Norimitsu</span> <span class="nlm-surname">Tanaka</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Kazuyuki</span> <span class="nlm-surname">Kojima</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Hiroshi</span> <span class="nlm-surname">Nishimura</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Alexander M.</span> <span class="nlm-surname">Norbash</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Naofumi</span> <span class="nlm-surname">Hayabuchi</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2004, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">25 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1783-1786; </span></div>
  
  
  
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