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<meta name="DC.Title" content="Radiologic Morphology of Low-Grade Primary Central Nervous System Lymphoma in Immunocompetent Patients" />
<meta name="DC.Date" content="2005-11-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Primary central nervous system lymphomas (PCNSLs) are usually high-grade and are rarely low-grade non-Hodgkin lymphomas (NHLs). On MR imaging, PCNSLs typically present as contrast-enhancing lesions in contact with the subarachnoid space without evidence of necrosis. We evaluated the radiologic morphology and clinical characteristics of low-grade PCNSLs, hypothesizing that they may differ from high-grade PCNSLs.

METHODS: Records were reviewed from 332 patients screened for inclusion in 3 multicenter prospective trials. MR imaging scans were obtained from all patients and were centrally reviewed by 2 consultant neuroradiologists.

RESULTS: Ten patients (3%) with low-grade PCNSLs (7 men and 3 women; median age, 59 years; age range, 19–61 years) were identified. Four patients had one lesion, 2 patients 2 lesions, and 4 patients had multiple lesions. The following radiologic features infrequently seen in high-grade PCNSLs were found in a substantial proportion of patients: location in deep structures or spine ( n =6); lack of periventricular location ( n =5); hyperintensity on T2-weighted images ( n =10); moderate or absent contrast enhancement ( n =6); and heterogeneous contrast enhancement ( n =5). In 8 patients, &gt;2 of these features were present in at least one lesion, and, thus, the radiologic appearance was assessed atypical of high-grade PCNSLs. The atypical radiologic appearance in combination with atypical or mild symptoms resulted in a false or delayed diagnosis.

CONCLUSION: Low-grade PCNSLs may have a variable and atypical radiologic morphology compared with high-grade PCNSLs with the risk of false or delayed diagnosis." />
<meta name="DC.Contributor" content="Kristoph Jahnke" />
<meta name="DC.Contributor" content="Andreas Schilling" />
<meta name="DC.Contributor" content="Jens Heidenreich" />
<meta name="DC.Contributor" content="Harald Stein" />
<meta name="DC.Contributor" content="Mario Brock" />
<meta name="DC.Contributor" content="Eckhard Thiel" />
<meta name="DC.Contributor" content="Agnieszka Korfel" />
<meta name="article:published_time" content="2005-11-01" />
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<meta name="citation_title" content="Radiologic Morphology of Low-Grade Primary Central Nervous System Lymphoma in Immunocompetent Patients" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Primary central nervous system lymphomas (PCNSLs) are usually high-grade and are rarely low-grade non-Hodgkin lymphomas (NHLs). On MR imaging, PCNSLs typically present as contrast-enhancing lesions in contact with the subarachnoid space without evidence of necrosis. We evaluated the radiologic morphology and clinical characteristics of low-grade PCNSLs, hypothesizing that they may differ from high-grade PCNSLs.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Records were reviewed from 332 patients screened for inclusion in 3 multicenter prospective trials. MR imaging scans were obtained from all patients and were centrally reviewed by 2 consultant neuroradiologists.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; Ten patients (3%) with low-grade PCNSLs (7 men and 3 women; median age, 59 years; age range, 19–61 years) were identified. Four patients had one lesion, 2 patients 2 lesions, and 4 patients had multiple lesions. The following radiologic features infrequently seen in high-grade PCNSLs were found in a substantial proportion of patients: location in deep structures or spine (&lt;i&gt;n&lt;/i&gt;=6); lack of periventricular location (&lt;i&gt;n&lt;/i&gt;=5); hyperintensity on T2-weighted images (&lt;i&gt;n&lt;/i&gt;=10); moderate or absent contrast enhancement (&lt;i&gt;n&lt;/i&gt;=6); and heterogeneous contrast enhancement (&lt;i&gt;n&lt;/i&gt;=5). In 8 patients, &amp;gt;2 of these features were present in at least one lesion, and, thus, the radiologic appearance was assessed atypical of high-grade PCNSLs. The atypical radiologic appearance in combination with atypical or mild symptoms resulted in a false or delayed diagnosis.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; Low-grade PCNSLs may have a variable and atypical radiologic morphology compared with high-grade PCNSLs with the risk of false or delayed diagnosis.&lt;/p&gt;" />
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<meta name="twitter:title" content="Radiologic Morphology of Low-Grade Primary Central Nervous System Lymphoma in Immunocompetent Patients" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Primary central nervous system lymphomas (PCNSLs) are usually high-grade and are rarely low-grade non-Hodgkin lymphomas (NHLs). On MR imaging, PCNSLs typically present as contrast-enhancing lesions in contact with the subarachnoid space without evidence of necrosis. We evaluated the radiologic morphology and clinical characteristics of low-grade PCNSLs, hypothesizing that they may differ from high-grade PCNSLs.

METHODS: Records were reviewed from 332 patients screened for inclusion in 3 multicenter prospective trials. MR imaging scans were obtained from all patients and were centrally reviewed by 2 consultant neuroradiologists.

RESULTS: Ten patients (3%) with low-grade PCNSLs (7 men and 3 women; median age, 59 years; age range, 19–61 years) were identified. Four patients had one lesion, 2 patients 2 lesions, and 4 patients had multiple lesions. The following radiologic features infrequently seen in high-grade PCNSLs were found in a substantial proportion of patients: location in deep structures or spine ( n =6); lack of periventricular location ( n =5); hyperintensity on T2-weighted images ( n =10); moderate or absent contrast enhancement ( n =6); and heterogeneous contrast enhancement ( n =5). In 8 patients, &gt;2 of these features were present in at least one lesion, and, thus, the radiologic appearance was assessed atypical of high-grade PCNSLs. The atypical radiologic appearance in combination with atypical or mild symptoms resulted in a false or delayed diagnosis.

CONCLUSION: Low-grade PCNSLs may have a variable and atypical radiologic morphology compared with high-grade PCNSLs with the risk of false or delayed diagnosis." />
<meta name="og-title" property="og:title" content="Radiologic Morphology of Low-Grade Primary Central Nervous System Lymphoma in Immunocompetent Patients" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Primary central nervous system lymphomas (PCNSLs) are usually high-grade and are rarely low-grade non-Hodgkin lymphomas (NHLs). On MR imaging, PCNSLs typically present as contrast-enhancing lesions in contact with the subarachnoid space without evidence of necrosis. We evaluated the radiologic morphology and clinical characteristics of low-grade PCNSLs, hypothesizing that they may differ from high-grade PCNSLs.

METHODS: Records were reviewed from 332 patients screened for inclusion in 3 multicenter prospective trials. MR imaging scans were obtained from all patients and were centrally reviewed by 2 consultant neuroradiologists.

RESULTS: Ten patients (3%) with low-grade PCNSLs (7 men and 3 women; median age, 59 years; age range, 19–61 years) were identified. Four patients had one lesion, 2 patients 2 lesions, and 4 patients had multiple lesions. The following radiologic features infrequently seen in high-grade PCNSLs were found in a substantial proportion of patients: location in deep structures or spine ( n =6); lack of periventricular location ( n =5); hyperintensity on T2-weighted images ( n =10); moderate or absent contrast enhancement ( n =6); and heterogeneous contrast enhancement ( n =5). In 8 patients, &gt;2 of these features were present in at least one lesion, and, thus, the radiologic appearance was assessed atypical of high-grade PCNSLs. The atypical radiologic appearance in combination with atypical or mild symptoms resulted in a false or delayed diagnosis.

CONCLUSION: Low-grade PCNSLs may have a variable and atypical radiologic morphology compared with high-grade PCNSLs with the risk of false or delayed diagnosis." />
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2005,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2446-2454; </span></div>
  
  
  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 26</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 10 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Nov 2005 </div></div>
      
      
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      <div class="highwire-cite-title">Radiologic Morphology of Low-Grade Primary Central Nervous System Lymphoma in Immunocompetent Patients</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Kristoph</span> <span class="nlm-surname">Jahnke</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Andreas</span> <span class="nlm-surname">Schilling</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Jens</span> <span class="nlm-surname">Heidenreich</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Harald</span> <span class="nlm-surname">Stein</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Mario</span> <span class="nlm-surname">Brock</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Eckhard</span> <span class="nlm-surname">Thiel</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Agnieszka</span> <span class="nlm-surname">Korfel</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2446-2454; </span></div>
  
  
  
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      <div class="highwire-cite-title">Radiologic Morphology of Low-Grade Primary Central Nervous System Lymphoma in Immunocompetent Patients</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Kristoph</span> <span class="nlm-surname">Jahnke</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Andreas</span> <span class="nlm-surname">Schilling</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Jens</span> <span class="nlm-surname">Heidenreich</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Harald</span> <span class="nlm-surname">Stein</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Mario</span> <span class="nlm-surname">Brock</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Eckhard</span> <span class="nlm-surname">Thiel</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Agnieszka</span> <span class="nlm-surname">Korfel</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2446-2454; </span></div>
  
  
  
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