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<meta name="DC.Title" content="Proton MR Spectroscopy in Wilson Disease: Analysis of 36 Cases" />
<meta name="DC.Date" content="2005-05-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Wilson disease (WD) is rare but one of the few metabolic disorders that can possibly benefit from effective available treatments. The literature regarding proton MR spectroscopy (MRS) in WD is scarce and controversial. The purpose of this study was to determine the brain metabolic changes due to WD by using MRS. To our knowledge, this is the first time that MRS was performed in such a large sample of patients with WD.

METHODS: Thirty-six patients with WD and 37 healthy volunteers were examined with MRS in the parieto-occipital cortex, frontal white matter, and basal ganglia (BG). Ratios of the following metabolites were calculated in relation to creatine (Cr): N -acetylaspartate (NAA), choline (Cho), myo-inositol (mI), and glutamine/glutamate (Glx). The mean peak line width was measured on each spectrum.

RESULTS: Compared with control subjects, patients with WD had significantly decreased NAA/Cr ratios in the three studied areas ( P &lt; .005) and an increased mI/Cr ratio in the BG ( P &lt; .001). Cho/Cr and Glx/Cr did not differ between the groups. The mean peak line in the BG was wider in patients than in control subjects.

CONCLUSION: WD is unequivocally associated with MRS changes that could possibly be assigned to neuronal loss (in the three studied areas), to gliosis, and to iron and/or copper deposition in the BG." />
<meta name="DC.Contributor" content="Leandro T. Lucato" />
<meta name="DC.Contributor" content="Maria Concepción G. Otaduy" />
<meta name="DC.Contributor" content="Egberto R. Barbosa" />
<meta name="DC.Contributor" content="Alexandre A. C. Machado" />
<meta name="DC.Contributor" content="Alexander McKinney" />
<meta name="DC.Contributor" content="Luiz A. Bacheschi" />
<meta name="DC.Contributor" content="Milberto Scaff" />
<meta name="DC.Contributor" content="Giovanni G. Cerri" />
<meta name="DC.Contributor" content="Claudia C. Leite" />
<meta name="article:published_time" content="2005-05-01" />
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<meta name="citation_title" content="Proton MR Spectroscopy in Wilson Disease: Analysis of 36 Cases" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Wilson disease (WD) is rare but one of the few metabolic disorders that can possibly benefit from effective available treatments. The literature regarding proton MR spectroscopy (MRS) in WD is scarce and controversial. The purpose of this study was to determine the brain metabolic changes due to WD by using MRS. To our knowledge, this is the first time that MRS was performed in such a large sample of patients with WD.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Thirty-six patients with WD and 37 healthy volunteers were examined with MRS in the parieto-occipital cortex, frontal white matter, and basal ganglia (BG). Ratios of the following metabolites were calculated in relation to creatine (Cr): &lt;i&gt;N&lt;/i&gt;-acetylaspartate (NAA), choline (Cho), myo-inositol (mI), and glutamine/glutamate (Glx). The mean peak line width was measured on each spectrum.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; Compared with control subjects, patients with WD had significantly decreased NAA/Cr ratios in the three studied areas (&lt;i&gt;P&lt;/i&gt; &amp;lt; .005) and an increased mI/Cr ratio in the BG (&lt;i&gt;P&lt;/i&gt; &amp;lt; .001). Cho/Cr and Glx/Cr did not differ between the groups. The mean peak line in the BG was wider in patients than in control subjects.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; WD is unequivocally associated with MRS changes that could possibly be assigned to neuronal loss (in the three studied areas), to gliosis, and to iron and/or copper deposition in the BG.&lt;/p&gt;" />
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<meta name="twitter:title" content="Proton MR Spectroscopy in Wilson Disease: Analysis of 36 Cases" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Wilson disease (WD) is rare but one of the few metabolic disorders that can possibly benefit from effective available treatments. The literature regarding proton MR spectroscopy (MRS) in WD is scarce and controversial. The purpose of this study was to determine the brain metabolic changes due to WD by using MRS. To our knowledge, this is the first time that MRS was performed in such a large sample of patients with WD.

METHODS: Thirty-six patients with WD and 37 healthy volunteers were examined with MRS in the parieto-occipital cortex, frontal white matter, and basal ganglia (BG). Ratios of the following metabolites were calculated in relation to creatine (Cr): N -acetylaspartate (NAA), choline (Cho), myo-inositol (mI), and glutamine/glutamate (Glx). The mean peak line width was measured on each spectrum.

RESULTS: Compared with control subjects, patients with WD had significantly decreased NAA/Cr ratios in the three studied areas ( P &lt; .005) and an increased mI/Cr ratio in the BG ( P &lt; .001). Cho/Cr and Glx/Cr did not differ between the groups. The mean peak line in the BG was wider in patients than in control subjects.

CONCLUSION: WD is unequivocally associated with MRS changes that could possibly be assigned to neuronal loss (in the three studied areas), to gliosis, and to iron and/or copper deposition in the BG." />
<meta name="og-title" property="og:title" content="Proton MR Spectroscopy in Wilson Disease: Analysis of 36 Cases" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Wilson disease (WD) is rare but one of the few metabolic disorders that can possibly benefit from effective available treatments. The literature regarding proton MR spectroscopy (MRS) in WD is scarce and controversial. The purpose of this study was to determine the brain metabolic changes due to WD by using MRS. To our knowledge, this is the first time that MRS was performed in such a large sample of patients with WD.

METHODS: Thirty-six patients with WD and 37 healthy volunteers were examined with MRS in the parieto-occipital cortex, frontal white matter, and basal ganglia (BG). Ratios of the following metabolites were calculated in relation to creatine (Cr): N -acetylaspartate (NAA), choline (Cho), myo-inositol (mI), and glutamine/glutamate (Glx). The mean peak line width was measured on each spectrum.

RESULTS: Compared with control subjects, patients with WD had significantly decreased NAA/Cr ratios in the three studied areas ( P &lt; .005) and an increased mI/Cr ratio in the BG ( P &lt; .001). Cho/Cr and Glx/Cr did not differ between the groups. The mean peak line in the BG was wider in patients than in control subjects.

CONCLUSION: WD is unequivocally associated with MRS changes that could possibly be assigned to neuronal loss (in the three studied areas), to gliosis, and to iron and/or copper deposition in the BG." />
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<div id="hw-article-author-popups-top-node-2851--61699330297" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">Leandro T. 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      <div class="highwire-cite-title">Proton MR Spectroscopy in Wilson Disease: Analysis of 36 Cases</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Leandro T.</span> <span class="nlm-surname">Lucato</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Maria Concepción G.</span> <span class="nlm-surname">Otaduy</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Egberto R.</span> <span class="nlm-surname">Barbosa</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Alexandre A. C.</span> <span class="nlm-surname">Machado</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Alexander</span> <span class="nlm-surname">McKinney</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Luiz A.</span> <span class="nlm-surname">Bacheschi</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Milberto</span> <span class="nlm-surname">Scaff</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Giovanni G.</span> <span class="nlm-surname">Cerri</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Claudia C.</span> <span class="nlm-surname">Leite</span></span></span></div>
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">Leandro T.</span> <span class="nlm-surname">Lucato</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Maria Concepción G.</span> <span class="nlm-surname">Otaduy</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Egberto R.</span> <span class="nlm-surname">Barbosa</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Alexandre A. C.</span> <span class="nlm-surname">Machado</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Alexander</span> <span class="nlm-surname">McKinney</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Luiz A.</span> <span class="nlm-surname">Bacheschi</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Milberto</span> <span class="nlm-surname">Scaff</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">Giovanni G.</span> <span class="nlm-surname">Cerri</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">Claudia C.</span> <span class="nlm-surname">Leite</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1066-1071; </span></div>
  
  
  
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