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<meta name="DC.Title" content="Selective Intraarterial Nimodipine Treatment in an Experimental Subarachnoid Hemorrhage Model" />
<meta name="DC.Date" content="2005-06-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKROUND AND PURPOSE: Cerebral vasospasm secondary to subarachnoid hemorrhage (SAH) has been a serious clinical problem. The aim of the present study is to evaluate the efficacy of selective intraarterial (IA) nimodipine treatment in a rabbit model of chronic cerebral vasospasm.

METHODS: Twenty-two adult New-Zealand rabbits of either sex, weighing 2500–3800 g were used for this study. Following a control angiography, all animals received 1 mL of fresh unheparinized autologuous arterial blood into the cisterna magna. Three days later, the presence of vasospasm was demonstrated angiographically by selective vertebral artery injection. The experimental design was as follows: separate groups of animals ( n =5, in each group) received nimodipine (0.05 mg/kg), papaverine (6 mg/kg), or vehicle intraarterially, after placement of a microcatheter into the vertebral artery. Another group ( n =5) received nimodipine (0.05 mg/kg) directly into the cisterna magna, and vehicle injection was made into cisterna magna in two other animals. Thirty minutes after treatment, angiographies were repeated and changes in arterial diameter were expressed as percentages of control.

RESULTS: IA nimodipine and IA papaverine were effective in relieving veretebral and basilary vasospasm ( P &lt; .05). IA nimodipine was more effective than IA papaverine ( P &lt; .05). IA nimodipine was not more effective than intrathecal (IT) nimodipine in relieving vertebral artery vasospasm, although it was more effective than IT nimodipine in basilar artery. Vehicle injections (IA or IT) failed to reverse the vasospasm induced by autologuous blood injection.

CONCLUSION: This study showed that selective IA nimodipine treatment may be considered as an alternative in the treatment of chronic vasospasm following SAH." />
<meta name="DC.Contributor" content="M. Murat Firat" />
<meta name="DC.Contributor" content="Veli Gelebek" />
<meta name="DC.Contributor" content="Hakan S. Orer" />
<meta name="DC.Contributor" content="Deniz Belen" />
<meta name="DC.Contributor" content="Ahmet K. Firat" />
<meta name="DC.Contributor" content="Ferhun Balkanci" />
<meta name="article:published_time" content="2005-06-01" />
<meta name="article:section" content="INTERVENTIONAL" />
<meta name="citation_title" content="Selective Intraarterial Nimodipine Treatment in an Experimental Subarachnoid Hemorrhage Model" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKROUND AND PURPOSE:&lt;/i&gt; Cerebral vasospasm secondary to subarachnoid hemorrhage (SAH) has been a serious clinical problem. The aim of the present study is to evaluate the efficacy of selective intraarterial (IA) nimodipine treatment in a rabbit model of chronic cerebral vasospasm.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Twenty-two adult New-Zealand rabbits of either sex, weighing 2500–3800 g were used for this study. Following a control angiography, all animals received 1 mL of fresh unheparinized autologuous arterial blood into the cisterna magna. Three days later, the presence of vasospasm was demonstrated angiographically by selective vertebral artery injection. The experimental design was as follows: separate groups of animals (&lt;i&gt;n&lt;/i&gt;=5, in each group) received nimodipine (0.05 mg/kg), papaverine (6 mg/kg), or vehicle intraarterially, after placement of a microcatheter into the vertebral artery. Another group (&lt;i&gt;n&lt;/i&gt;=5) received nimodipine (0.05 mg/kg) directly into the cisterna magna, and vehicle injection was made into cisterna magna in two other animals. Thirty minutes after treatment, angiographies were repeated and changes in arterial diameter were expressed as percentages of control.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; IA nimodipine and IA papaverine were effective in relieving veretebral and basilary vasospasm (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05). IA nimodipine was more effective than IA papaverine (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05). IA nimodipine was not more effective than intrathecal (IT) nimodipine in relieving vertebral artery vasospasm, although it was more effective than IT nimodipine in basilar artery. Vehicle injections (IA or IT) failed to reverse the vasospasm induced by autologuous blood injection.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; This study showed that selective IA nimodipine treatment may be considered as an alternative in the treatment of chronic vasospasm following SAH.&lt;/p&gt;" />
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<meta name="citation_publication_date" content="2005/06/01" />
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<meta name="twitter:title" content="Selective Intraarterial Nimodipine Treatment in an Experimental Subarachnoid Hemorrhage Model" />
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<meta name="twitter:description" content="BACKROUND AND PURPOSE: Cerebral vasospasm secondary to subarachnoid hemorrhage (SAH) has been a serious clinical problem. The aim of the present study is to evaluate the efficacy of selective intraarterial (IA) nimodipine treatment in a rabbit model of chronic cerebral vasospasm.

METHODS: Twenty-two adult New-Zealand rabbits of either sex, weighing 2500–3800 g were used for this study. Following a control angiography, all animals received 1 mL of fresh unheparinized autologuous arterial blood into the cisterna magna. Three days later, the presence of vasospasm was demonstrated angiographically by selective vertebral artery injection. The experimental design was as follows: separate groups of animals ( n =5, in each group) received nimodipine (0.05 mg/kg), papaverine (6 mg/kg), or vehicle intraarterially, after placement of a microcatheter into the vertebral artery. Another group ( n =5) received nimodipine (0.05 mg/kg) directly into the cisterna magna, and vehicle injection was made into cisterna magna in two other animals. Thirty minutes after treatment, angiographies were repeated and changes in arterial diameter were expressed as percentages of control.

RESULTS: IA nimodipine and IA papaverine were effective in relieving veretebral and basilary vasospasm ( P &lt; .05). IA nimodipine was more effective than IA papaverine ( P &lt; .05). IA nimodipine was not more effective than intrathecal (IT) nimodipine in relieving vertebral artery vasospasm, although it was more effective than IT nimodipine in basilar artery. Vehicle injections (IA or IT) failed to reverse the vasospasm induced by autologuous blood injection.

CONCLUSION: This study showed that selective IA nimodipine treatment may be considered as an alternative in the treatment of chronic vasospasm following SAH." />
<meta name="og-title" property="og:title" content="Selective Intraarterial Nimodipine Treatment in an Experimental Subarachnoid Hemorrhage Model" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKROUND AND PURPOSE: Cerebral vasospasm secondary to subarachnoid hemorrhage (SAH) has been a serious clinical problem. The aim of the present study is to evaluate the efficacy of selective intraarterial (IA) nimodipine treatment in a rabbit model of chronic cerebral vasospasm.

METHODS: Twenty-two adult New-Zealand rabbits of either sex, weighing 2500–3800 g were used for this study. Following a control angiography, all animals received 1 mL of fresh unheparinized autologuous arterial blood into the cisterna magna. Three days later, the presence of vasospasm was demonstrated angiographically by selective vertebral artery injection. The experimental design was as follows: separate groups of animals ( n =5, in each group) received nimodipine (0.05 mg/kg), papaverine (6 mg/kg), or vehicle intraarterially, after placement of a microcatheter into the vertebral artery. Another group ( n =5) received nimodipine (0.05 mg/kg) directly into the cisterna magna, and vehicle injection was made into cisterna magna in two other animals. Thirty minutes after treatment, angiographies were repeated and changes in arterial diameter were expressed as percentages of control.

RESULTS: IA nimodipine and IA papaverine were effective in relieving veretebral and basilary vasospasm ( P &lt; .05). IA nimodipine was more effective than IA papaverine ( P &lt; .05). IA nimodipine was not more effective than intrathecal (IT) nimodipine in relieving vertebral artery vasospasm, although it was more effective than IT nimodipine in basilar artery. Vehicle injections (IA or IT) failed to reverse the vasospasm induced by autologuous blood injection.

CONCLUSION: This study showed that selective IA nimodipine treatment may be considered as an alternative in the treatment of chronic vasospasm following SAH." />
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<div id="hw-article-author-popups-top-node-2909--6561191726" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">M. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 26</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 6 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jun 2005 </div></div>
      
      
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      <div class="highwire-cite-title">Selective Intraarterial Nimodipine Treatment in an Experimental Subarachnoid Hemorrhage Model</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M. Murat</span> <span class="nlm-surname">Firat</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Veli</span> <span class="nlm-surname">Gelebek</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Hakan S.</span> <span class="nlm-surname">Orer</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Deniz</span> <span class="nlm-surname">Belen</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Ahmet K.</span> <span class="nlm-surname">Firat</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Ferhun</span> <span class="nlm-surname">Balkanci</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1357-1362; </span></div>
  
  
  
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      <div class="highwire-cite-title">Selective Intraarterial Nimodipine Treatment in an Experimental Subarachnoid Hemorrhage Model</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M. Murat</span> <span class="nlm-surname">Firat</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">Veli</span> <span class="nlm-surname">Gelebek</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">Hakan S.</span> <span class="nlm-surname">Orer</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">Deniz</span> <span class="nlm-surname">Belen</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Ahmet K.</span> <span class="nlm-surname">Firat</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">Ferhun</span> <span class="nlm-surname">Balkanci</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1357-1362; </span></div>
  
  
  
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