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<meta name="DC.Title" content="Contrast-Enhanced MR Angiography of the Carotid and Vertebrobasilar Circulations" />
<meta name="DC.Date" content="2005-09-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Contrast-enhanced MR angiography (CE MRA) is a proven diagnostic tool in evaluation of the carotid arteries; however, few studies have addressed its accuracy in the vertebrobasilar system. The purpose of this study was to assess the sensitivity and specificity of CE MRA compared with digital subtraction angiography (DSA) for detection of vertebrobasilar disease.

METHODS: Forty patients with suspected atherosclerotic disease of the carotid and vertebrobasilar circulations underwent CE MRA on a 1.5T MR imaging scanner by use of a coronal 3D gradient-echo pulse sequence after intravenous injection of gadolinium diethylene triamine penta-acetic acid. All patients had correlative DSA within a 1-month period. CE MRA images were randomized and then independently assessed by 2 observers who were blinded to the DSA results. DSA examinations were analyzed in a similar manner. Each observer was asked to report the presence or absence of clinically significant stenosis (&gt;50%), occlusion, fistula, aneurysm, and dissection. The MRA findings were then correlated with DSA.

RESULTS: The sensitivity and specificity of MRA for detection of disease in the entire carotid and vertebrobasilar systems were 90% and 97%, respectively; for the carotid system alone, the sensitivity and specificity were 94% and 97%, respectively; and for the vertebrobasilar system they were 88% and 98% respectively. The overall interobserver reliability was 98% (κ = 0.92).

CONCLUSION: CE MRA is accurate at detecting disease not only in the carotid vessels, but also in the vertebrobasilar circulation, and has the potential to provide a comprehensive and noninvasive evaluation of the head and neck arteries in a single study." />
<meta name="DC.Contributor" content="Carina W. Yang" />
<meta name="DC.Contributor" content="James C. Carr" />
<meta name="DC.Contributor" content="Stephen F. Futterer" />
<meta name="DC.Contributor" content="Mark D. Morasch" />
<meta name="DC.Contributor" content="Benson P. Yang" />
<meta name="DC.Contributor" content="Stephanie M. Shors" />
<meta name="DC.Contributor" content="J. Paul Finn" />
<meta name="article:published_time" content="2005-09-01" />
<meta name="article:section" content="HEAD AND NECK" />
<meta name="citation_title" content="Contrast-Enhanced MR Angiography of the Carotid and Vertebrobasilar Circulations" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;BACKGROUND AND PURPOSE:&lt;/i&gt; Contrast-enhanced MR angiography (CE MRA) is a proven diagnostic tool in evaluation of the carotid arteries; however, few studies have addressed its accuracy in the vertebrobasilar system. The purpose of this study was to assess the sensitivity and specificity of CE MRA compared with digital subtraction angiography (DSA) for detection of vertebrobasilar disease.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Forty patients with suspected atherosclerotic disease of the carotid and vertebrobasilar circulations underwent CE MRA on a 1.5T MR imaging scanner by use of a coronal 3D gradient-echo pulse sequence after intravenous injection of gadolinium diethylene triamine penta-acetic acid. All patients had correlative DSA within a 1-month period. CE MRA images were randomized and then independently assessed by 2 observers who were blinded to the DSA results. DSA examinations were analyzed in a similar manner. Each observer was asked to report the presence or absence of clinically significant stenosis (&amp;gt;50%), occlusion, fistula, aneurysm, and dissection. The MRA findings were then correlated with DSA.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; The sensitivity and specificity of MRA for detection of disease in the entire carotid and vertebrobasilar systems were 90% and 97%, respectively; for the carotid system alone, the sensitivity and specificity were 94% and 97%, respectively; and for the vertebrobasilar system they were 88% and 98% respectively. The overall interobserver reliability was 98% (κ = 0.92).&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; CE MRA is accurate at detecting disease not only in the carotid vessels, but also in the vertebrobasilar circulation, and has the potential to provide a comprehensive and noninvasive evaluation of the head and neck arteries in a single study.&lt;/p&gt;" />
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<meta name="citation_author" content="Carina W. Yang" />
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<meta name="twitter:title" content="Contrast-Enhanced MR Angiography of the Carotid and Vertebrobasilar Circulations" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Contrast-enhanced MR angiography (CE MRA) is a proven diagnostic tool in evaluation of the carotid arteries; however, few studies have addressed its accuracy in the vertebrobasilar system. The purpose of this study was to assess the sensitivity and specificity of CE MRA compared with digital subtraction angiography (DSA) for detection of vertebrobasilar disease.

METHODS: Forty patients with suspected atherosclerotic disease of the carotid and vertebrobasilar circulations underwent CE MRA on a 1.5T MR imaging scanner by use of a coronal 3D gradient-echo pulse sequence after intravenous injection of gadolinium diethylene triamine penta-acetic acid. All patients had correlative DSA within a 1-month period. CE MRA images were randomized and then independently assessed by 2 observers who were blinded to the DSA results. DSA examinations were analyzed in a similar manner. Each observer was asked to report the presence or absence of clinically significant stenosis (&gt;50%), occlusion, fistula, aneurysm, and dissection. The MRA findings were then correlated with DSA.

RESULTS: The sensitivity and specificity of MRA for detection of disease in the entire carotid and vertebrobasilar systems were 90% and 97%, respectively; for the carotid system alone, the sensitivity and specificity were 94% and 97%, respectively; and for the vertebrobasilar system they were 88% and 98% respectively. The overall interobserver reliability was 98% (κ = 0.92).

CONCLUSION: CE MRA is accurate at detecting disease not only in the carotid vessels, but also in the vertebrobasilar circulation, and has the potential to provide a comprehensive and noninvasive evaluation of the head and neck arteries in a single study." />
<meta name="og-title" property="og:title" content="Contrast-Enhanced MR Angiography of the Carotid and Vertebrobasilar Circulations" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/26/8/2095" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Contrast-enhanced MR angiography (CE MRA) is a proven diagnostic tool in evaluation of the carotid arteries; however, few studies have addressed its accuracy in the vertebrobasilar system. The purpose of this study was to assess the sensitivity and specificity of CE MRA compared with digital subtraction angiography (DSA) for detection of vertebrobasilar disease.

METHODS: Forty patients with suspected atherosclerotic disease of the carotid and vertebrobasilar circulations underwent CE MRA on a 1.5T MR imaging scanner by use of a coronal 3D gradient-echo pulse sequence after intravenous injection of gadolinium diethylene triamine penta-acetic acid. All patients had correlative DSA within a 1-month period. CE MRA images were randomized and then independently assessed by 2 observers who were blinded to the DSA results. DSA examinations were analyzed in a similar manner. Each observer was asked to report the presence or absence of clinically significant stenosis (&gt;50%), occlusion, fistula, aneurysm, and dissection. The MRA findings were then correlated with DSA.

RESULTS: The sensitivity and specificity of MRA for detection of disease in the entire carotid and vertebrobasilar systems were 90% and 97%, respectively; for the carotid system alone, the sensitivity and specificity were 94% and 97%, respectively; and for the vertebrobasilar system they were 88% and 98% respectively. The overall interobserver reliability was 98% (κ = 0.92).

CONCLUSION: CE MRA is accurate at detecting disease not only in the carotid vessels, but also in the vertebrobasilar circulation, and has the potential to provide a comprehensive and noninvasive evaluation of the head and neck arteries in a single study." />
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      <h1 class="highwire-cite-title" id="page-title">Contrast-Enhanced MR Angiography of the Carotid and Vertebrobasilar Circulations</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Carina W. Yang</span>, <span class="highwire-citation-author" data-delta="1">James C. Carr</span>, <span class="highwire-citation-author" data-delta="2">Stephen F. Futterer</span>, <span class="highwire-citation-author" data-delta="3">Mark D. Morasch</span>, <span class="highwire-citation-author" data-delta="4">Benson P. Yang</span>, <span class="highwire-citation-author" data-delta="5">Stephanie M. Shors</span> and <span class="highwire-citation-author" data-delta="6">J. Paul Finn</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2005,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2095-2101; </span></div>
  
  
  
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