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<meta name="DC.Title" content="Assessment of Diagnostic Accuracy of Perfusion MR Imaging in Primary and Metastatic Solitary Malignant Brain Tumors" />
<meta name="DC.Date" content="2005-10-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="PURPOSE: The purpose of this study was to estimate the diagnostic accuracy of relative cerebral blood volume (rCBV) measurement in preoperative grading and differentiation of solitary intra-axial malignant brain tumors.

METHODS: Thirty-six low-grade glial tumors (LGGTs), 22 high-grade glial tumors (HGGTs), and 17 metastases (METs) were prospectively evaluated by MR imaging and standard dynamic susceptibility contrast-enhanced gradient echo, echoplanar imaging during first pass of a bolus injection of contrast material. Normalized rCBV values from tumoral (rCBVT) and peritumoral (rCBVP) areas were calculated by standard software and statistically tested independently.

RESULTS: The mean differences of rCBVT and rCBVP values between LGGT (2.30 ± 1.12 and 1.18 ± 0.24) and HGGT (5.42 ± 1.52 and 2.17 ± 0.82) ( P &lt; .001); HGGTs and METs (3.21 ± 0.98 and 0.97 ± 0.09) ( P &lt; .001); and LGGTs and METs ( P &lt; .05 and P &lt; .001, respectively) were significant. No clear cutoff value was present. A clear rCBVT cutoff value of 2.6 was detected for differentiation of low- (1.75 ± 0.38; LGA) versus high-grade (4.78 ± 0.99; HGA) astrocytomas when nonastrocytic glial tumors were excluded. The rCBVT values were linearly correlated with degree of malignancy ( r = 0.869; P &lt; .001). Cutoff rCBVP values of 1.1 and 1.2 were quite effective in differentiation of METs from LGGTs and HGGTs, respectively. The overall efficacy of rCBV was higher in grading than in differentiation.

CONCLUSION: The diagnostic accuracy of rCBV measurement is higher in grading of glial brain tumors than in differentiation of HGGTs from solitary intra-axial METs. The astrocytic and nonastrocytic glial tumors have to be evaluated separately for precise grading." />
<meta name="DC.Contributor" content="Nail Bulakbasi" />
<meta name="DC.Contributor" content="Murat Kocaoglu" />
<meta name="DC.Contributor" content="Anar Farzaliyev" />
<meta name="DC.Contributor" content="Cem Tayfun" />
<meta name="DC.Contributor" content="Taner Ucoz" />
<meta name="DC.Contributor" content="Ibrahim Somuncu" />
<meta name="article:published_time" content="2005-10-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Assessment of Diagnostic Accuracy of Perfusion MR Imaging in Primary and Metastatic Solitary Malignant Brain Tumors" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;i&gt;PURPOSE:&lt;/i&gt; The purpose of this study was to estimate the diagnostic accuracy of relative cerebral blood volume (rCBV) measurement in preoperative grading and differentiation of solitary intra-axial malignant brain tumors.&lt;/p&gt;&lt;p&gt;&lt;i&gt;METHODS:&lt;/i&gt; Thirty-six low-grade glial tumors (LGGTs), 22 high-grade glial tumors (HGGTs), and 17 metastases (METs) were prospectively evaluated by MR imaging and standard dynamic susceptibility contrast-enhanced gradient echo, echoplanar imaging during first pass of a bolus injection of contrast material. Normalized rCBV values from tumoral (rCBV&lt;sub&gt;T&lt;/sub&gt;) and peritumoral (rCBV&lt;sub&gt;P&lt;/sub&gt;) areas were calculated by standard software and statistically tested independently.&lt;/p&gt;&lt;p&gt;&lt;i&gt;RESULTS:&lt;/i&gt; The mean differences of rCBV&lt;sub&gt;T&lt;/sub&gt; and rCBV&lt;sub&gt;P&lt;/sub&gt; values between LGGT (2.30 ± 1.12 and 1.18 ± 0.24) and HGGT (5.42 ± 1.52 and 2.17 ± 0.82) (&lt;i&gt;P&lt;/i&gt; &amp;lt; .001); HGGTs and METs (3.21 ± 0.98 and 0.97 ± 0.09) (&lt;i&gt;P&lt;/i&gt; &amp;lt; .001); and LGGTs and METs (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05 and &lt;i&gt;P&lt;/i&gt; &amp;lt; .001, respectively) were significant. No clear cutoff value was present. A clear rCBV&lt;sub&gt;T&lt;/sub&gt; cutoff value of 2.6 was detected for differentiation of low- (1.75 ± 0.38; LGA) versus high-grade (4.78 ± 0.99; HGA) astrocytomas when nonastrocytic glial tumors were excluded. The rCBV&lt;sub&gt;T&lt;/sub&gt; values were linearly correlated with degree of malignancy (&lt;i&gt;r&lt;/i&gt; = 0.869; &lt;i&gt;P&lt;/i&gt; &amp;lt; .001). Cutoff rCBV&lt;sub&gt;P&lt;/sub&gt; values of 1.1 and 1.2 were quite effective in differentiation of METs from LGGTs and HGGTs, respectively. The overall efficacy of rCBV was higher in grading than in differentiation.&lt;/p&gt;&lt;p&gt;&lt;i&gt;CONCLUSION:&lt;/i&gt; The diagnostic accuracy of rCBV measurement is higher in grading of glial brain tumors than in differentiation of HGGTs from solitary intra-axial METs. The astrocytic and nonastrocytic glial tumors have to be evaluated separately for precise grading.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2005/10/01" />
<meta name="citation_mjid" content="ajnr;26/9/2187" />
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<meta name="citation_author" content="Nail Bulakbasi" />
<meta name="citation_author" content="Murat Kocaoglu" />
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<meta name="citation_author" content="Cem Tayfun" />
<meta name="citation_author" content="Taner Ucoz" />
<meta name="citation_author" content="Ibrahim Somuncu" />
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<meta name="twitter:title" content="Assessment of Diagnostic Accuracy of Perfusion MR Imaging in Primary and Metastatic Solitary Malignant Brain Tumors" />
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<meta name="twitter:description" content="PURPOSE: The purpose of this study was to estimate the diagnostic accuracy of relative cerebral blood volume (rCBV) measurement in preoperative grading and differentiation of solitary intra-axial malignant brain tumors.

METHODS: Thirty-six low-grade glial tumors (LGGTs), 22 high-grade glial tumors (HGGTs), and 17 metastases (METs) were prospectively evaluated by MR imaging and standard dynamic susceptibility contrast-enhanced gradient echo, echoplanar imaging during first pass of a bolus injection of contrast material. Normalized rCBV values from tumoral (rCBVT) and peritumoral (rCBVP) areas were calculated by standard software and statistically tested independently.

RESULTS: The mean differences of rCBVT and rCBVP values between LGGT (2.30 ± 1.12 and 1.18 ± 0.24) and HGGT (5.42 ± 1.52 and 2.17 ± 0.82) ( P &lt; .001); HGGTs and METs (3.21 ± 0.98 and 0.97 ± 0.09) ( P &lt; .001); and LGGTs and METs ( P &lt; .05 and P &lt; .001, respectively) were significant. No clear cutoff value was present. A clear rCBVT cutoff value of 2.6 was detected for differentiation of low- (1.75 ± 0.38; LGA) versus high-grade (4.78 ± 0.99; HGA) astrocytomas when nonastrocytic glial tumors were excluded. The rCBVT values were linearly correlated with degree of malignancy ( r = 0.869; P &lt; .001). Cutoff rCBVP values of 1.1 and 1.2 were quite effective in differentiation of METs from LGGTs and HGGTs, respectively. The overall efficacy of rCBV was higher in grading than in differentiation.

CONCLUSION: The diagnostic accuracy of rCBV measurement is higher in grading of glial brain tumors than in differentiation of HGGTs from solitary intra-axial METs. The astrocytic and nonastrocytic glial tumors have to be evaluated separately for precise grading." />
<meta name="og-title" property="og:title" content="Assessment of Diagnostic Accuracy of Perfusion MR Imaging in Primary and Metastatic Solitary Malignant Brain Tumors" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/26/9/2187" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="PURPOSE: The purpose of this study was to estimate the diagnostic accuracy of relative cerebral blood volume (rCBV) measurement in preoperative grading and differentiation of solitary intra-axial malignant brain tumors.

METHODS: Thirty-six low-grade glial tumors (LGGTs), 22 high-grade glial tumors (HGGTs), and 17 metastases (METs) were prospectively evaluated by MR imaging and standard dynamic susceptibility contrast-enhanced gradient echo, echoplanar imaging during first pass of a bolus injection of contrast material. Normalized rCBV values from tumoral (rCBVT) and peritumoral (rCBVP) areas were calculated by standard software and statistically tested independently.

RESULTS: The mean differences of rCBVT and rCBVP values between LGGT (2.30 ± 1.12 and 1.18 ± 0.24) and HGGT (5.42 ± 1.52 and 2.17 ± 0.82) ( P &lt; .001); HGGTs and METs (3.21 ± 0.98 and 0.97 ± 0.09) ( P &lt; .001); and LGGTs and METs ( P &lt; .05 and P &lt; .001, respectively) were significant. No clear cutoff value was present. A clear rCBVT cutoff value of 2.6 was detected for differentiation of low- (1.75 ± 0.38; LGA) versus high-grade (4.78 ± 0.99; HGA) astrocytomas when nonastrocytic glial tumors were excluded. The rCBVT values were linearly correlated with degree of malignancy ( r = 0.869; P &lt; .001). Cutoff rCBVP values of 1.1 and 1.2 were quite effective in differentiation of METs from LGGTs and HGGTs, respectively. The overall efficacy of rCBV was higher in grading than in differentiation.

CONCLUSION: The diagnostic accuracy of rCBV measurement is higher in grading of glial brain tumors than in differentiation of HGGTs from solitary intra-axial METs. The astrocytic and nonastrocytic glial tumors have to be evaluated separately for precise grading." />
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">BRAIN</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Assessment of Diagnostic Accuracy of Perfusion MR Imaging in Primary and Metastatic Solitary Malignant Brain Tumors</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">Nail Bulakbasi</span>, <span class="highwire-citation-author" data-delta="1">Murat Kocaoglu</span>, <span class="highwire-citation-author" data-delta="2">Anar Farzaliyev</span>, <span class="highwire-citation-author" data-delta="3">Cem Tayfun</span>, <span class="highwire-citation-author" data-delta="4">Taner Ucoz</span> and <span class="highwire-citation-author" data-delta="5">Ibrahim Somuncu</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">October 2005,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2187-2199; </span></div>
  
  
  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 26</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 9 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Oct 2005 </div></div>
      
      
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      <div class="highwire-cite-title">Assessment of Diagnostic Accuracy of Perfusion MR Imaging in Primary and Metastatic Solitary Malignant Brain Tumors</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2005, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">26 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">2187-2199; </span></div>
  
  
  
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