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<meta name="DC.Title" content="Quantitative MR Imaging R2 Relaxometry in Elderly Participants Reporting Memory Loss" />
<meta name="DC.Date" content="2006-02-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: In Alzheimer disease (AD), elevated brain iron concentrations in gray matter suggest a disruption in iron homeostasis, while demyelination processes in white matter increase the water content. Our aim was to assess whether the transverse proton relaxation rate, or R2, an MR imaging parameter affected by changes in brain iron concentration and water content, was different in elderly participants with mild to severe levels of cognitive impairment compared with healthy controls.

METHODS: Twelve elderly participants reporting memory problems and 11 healthy volunteers underwent single-spin-echo MR imaging in a 1.5T scanner, with subsequent neuropsychological testing. R2 data were collected from 14 brain regions in cortical and subcortical gray and white matter. Those with memory complaints were separated into 2 further subgroups: MC1 (no objective cognitive impairment) and MC2 (mild to severe objective cognitive impairment).

RESULTS: Mean brain R2 values from the 11 controls correlated strongly ( r = 0.94, P &lt; .0001) with reference brain iron concentrations for healthy adults. R2 values in the MC1 and MC2 subgroups were significantly higher in the right temporal cortex and significantly lower in the left internal capsule, compared with healthy controls. R2 values in the MC2 subgroup were significantly lower in the left temporal and frontal white matter, compared with healthy controls.

CONCLUSIONS: R2 differences between both subgroups and the healthy controls suggest iron has increased in the temporal cortex, and myelin has been lost from several white matter regions in those with memory complaints, consistent with incipient AD pathogenesis and biochemical data." />
<meta name="DC.Contributor" content="M.J. House" />
<meta name="DC.Contributor" content="T.G. St. Pierre" />
<meta name="DC.Contributor" content="J.K. Foster" />
<meta name="DC.Contributor" content="R.N. Martins" />
<meta name="DC.Contributor" content="R. Clarnette" />
<meta name="article:published_time" content="2006-02-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Quantitative MR Imaging R2 Relaxometry in Elderly Participants Reporting Memory Loss" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; In Alzheimer disease (AD), elevated brain iron concentrations in gray matter suggest a disruption in iron homeostasis, while demyelination processes in white matter increase the water content. Our aim was to assess whether the transverse proton relaxation rate, or R&lt;sub&gt;2&lt;/sub&gt;, an MR imaging parameter affected by changes in brain iron concentration and water content, was different in elderly participants with mild to severe levels of cognitive impairment compared with healthy controls.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS:&lt;/b&gt; Twelve elderly participants reporting memory problems and 11 healthy volunteers underwent single-spin-echo MR imaging in a 1.5T scanner, with subsequent neuropsychological testing. R&lt;sub&gt;2&lt;/sub&gt; data were collected from 14 brain regions in cortical and subcortical gray and white matter. Those with memory complaints were separated into 2 further subgroups: MC1 (no objective cognitive impairment) and MC2 (mild to severe objective cognitive impairment).&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Mean brain R&lt;sub&gt;2&lt;/sub&gt; values from the 11 controls correlated strongly (&lt;i&gt;r&lt;/i&gt; = 0.94, &lt;i&gt;P&lt;/i&gt; &amp;lt; .0001) with reference brain iron concentrations for healthy adults. R&lt;sub&gt;2&lt;/sub&gt; values in the MC1 and MC2 subgroups were significantly higher in the right temporal cortex and significantly lower in the left internal capsule, compared with healthy controls. R&lt;sub&gt;2&lt;/sub&gt; values in the MC2 subgroup were significantly lower in the left temporal and frontal white matter, compared with healthy controls.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS:&lt;/b&gt; R&lt;sub&gt;2&lt;/sub&gt; differences between both subgroups and the healthy controls suggest iron has increased in the temporal cortex, and myelin has been lost from several white matter regions in those with memory complaints, consistent with incipient AD pathogenesis and biochemical data.&lt;/p&gt;" />
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<meta name="twitter:title" content="Quantitative MR Imaging R2 Relaxometry in Elderly Participants Reporting Memory Loss" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: In Alzheimer disease (AD), elevated brain iron concentrations in gray matter suggest a disruption in iron homeostasis, while demyelination processes in white matter increase the water content. Our aim was to assess whether the transverse proton relaxation rate, or R2, an MR imaging parameter affected by changes in brain iron concentration and water content, was different in elderly participants with mild to severe levels of cognitive impairment compared with healthy controls.

METHODS: Twelve elderly participants reporting memory problems and 11 healthy volunteers underwent single-spin-echo MR imaging in a 1.5T scanner, with subsequent neuropsychological testing. R2 data were collected from 14 brain regions in cortical and subcortical gray and white matter. Those with memory complaints were separated into 2 further subgroups: MC1 (no objective cognitive impairment) and MC2 (mild to severe objective cognitive impairment).

RESULTS: Mean brain R2 values from the 11 controls correlated strongly ( r = 0.94, P &lt; .0001) with reference brain iron concentrations for healthy adults. R2 values in the MC1 and MC2 subgroups were significantly higher in the right temporal cortex and significantly lower in the left internal capsule, compared with healthy controls. R2 values in the MC2 subgroup were significantly lower in the left temporal and frontal white matter, compared with healthy controls.

CONCLUSIONS: R2 differences between both subgroups and the healthy controls suggest iron has increased in the temporal cortex, and myelin has been lost from several white matter regions in those with memory complaints, consistent with incipient AD pathogenesis and biochemical data." />
<meta name="og-title" property="og:title" content="Quantitative MR Imaging R2 Relaxometry in Elderly Participants Reporting Memory Loss" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/27/2/430" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: In Alzheimer disease (AD), elevated brain iron concentrations in gray matter suggest a disruption in iron homeostasis, while demyelination processes in white matter increase the water content. Our aim was to assess whether the transverse proton relaxation rate, or R2, an MR imaging parameter affected by changes in brain iron concentration and water content, was different in elderly participants with mild to severe levels of cognitive impairment compared with healthy controls.

METHODS: Twelve elderly participants reporting memory problems and 11 healthy volunteers underwent single-spin-echo MR imaging in a 1.5T scanner, with subsequent neuropsychological testing. R2 data were collected from 14 brain regions in cortical and subcortical gray and white matter. Those with memory complaints were separated into 2 further subgroups: MC1 (no objective cognitive impairment) and MC2 (mild to severe objective cognitive impairment).

RESULTS: Mean brain R2 values from the 11 controls correlated strongly ( r = 0.94, P &lt; .0001) with reference brain iron concentrations for healthy adults. R2 values in the MC1 and MC2 subgroups were significantly higher in the right temporal cortex and significantly lower in the left internal capsule, compared with healthy controls. R2 values in the MC2 subgroup were significantly lower in the left temporal and frontal white matter, compared with healthy controls.

CONCLUSIONS: R2 differences between both subgroups and the healthy controls suggest iron has increased in the temporal cortex, and myelin has been lost from several white matter regions in those with memory complaints, consistent with incipient AD pathogenesis and biochemical data." />
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      <h1 class="highwire-cite-title" id="page-title">Quantitative MR Imaging R<sub>2</sub> Relaxometry in Elderly Participants Reporting Memory Loss</h1>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 2006,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">27 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">430-439; </span></div>
  
  
  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 27</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 2 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">February, 2006 </div></div>
      
      
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      <div class="highwire-cite-title">Quantitative MR Imaging R<sub>2</sub> Relaxometry in Elderly Participants Reporting Memory Loss</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.J.</span> <span class="nlm-surname">House</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">T.G.</span> <span class="nlm-surname">St. Pierre</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.K.</span> <span class="nlm-surname">Foster</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">R.N.</span> <span class="nlm-surname">Martins</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Clarnette</span></span></span></div>
  
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