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<meta name="DC.Title" content="Apparent Diffusion Coefficient Mapping of the Hippocampus and the Amygdala in Pharmaco-Resistant Temporal Lobe Epilepsy" />
<meta name="DC.Date" content="2006-03-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: The purpose of this study is to determine whether interictal apparent diffusion coefficients (ADC) provide a robust means for detecting amygdalo-hippocampal abnormalities in adult patients with localization-related chronic temporal lobe epilepsy (TLE) undergoing presurgical evaluation.

METHODS: Fifty-five patients and 20 age-matched controls were studied with hippocampal and amygdala ADC maps (HADC and AMYADC), volumes (HCVOL, AMYVOL), T2 relaxometry (HCT2, AMYT2), and hippocampal N -acetylaspartate to choline and creatine/phosphocreatine ratios (HCSI). Mean values and 99% confidence ellipses were computed for the groups. Individual ADC mapping was compared with electroencephalography (EEG) data and further correlated with the quantitative MR measures and with the age at onset and duration of TLE. Moreover, we evaluated the association and the predictive value of HADC and AMYADC with respect to the surgical outcome in a subgroup of patients ( n = 21) operated on the side of maximal EEG lateralization and with MR imaging criteria for hippocampal sclerosis, 71% of which became seizure-free.

RESULTS: In controls, there was no relation between ADC values and age, sex, or right-left asymmetries. In TLE groups with right ( n = 29) or left epileptogenic foci ( n = 26), group comparisons showed that ADC mapping detected changes ipsilateral to the focus in the hippocampus ( P &lt;.01) and the amygdala ( P &lt;.05), accordingly with the volumes, T2 maps, and HCSI. Significant Pearson correlations (2-tailed) were obtained between ADC maps and the volume of the hippocampus ( r = −0.64) and of the amygdala ( r = −0.55; both P &lt;.01), T2 ( r = 0.70, r = 0.29; both P &lt;.01), but not with HCSI. Individual ADC analysis showed ipsilateral pathology in 82% of cases (hippocampus) and 35% (amygdala) and included a moderate association between ipsilateral HADC and AMYADC ( r = 0.54; P &lt;.01). Bilateral abnormalities were found in 7% (hippocampus) and 5% (amygdala) of cases. Except for HCSI and the amygdala data, there were significant correlations between the asymmetry indices and the duration of epilepsy (HADC: r = 0.42; HCT2: r = 0.50; HCVOL: r = 0.35; all P &lt;.01). Age at onset was associated only with ipsilateral HADC ( r = 0.35; P &lt;.01) and HCVOL and HCT2 (both P &lt;.05). The association with postsurgical successes was characteristic of HADC (Fisher exact test, 2-tailed: P =.031; Spearman correlation: r s = −0.75; P =.0002), but not AMYADC. The predictive value regarding a favorable outcome was 0.87 (odds ratio 26; 95% confidence interval 2.33–38.86). As determined by regression models, both larger ipsilateral HADCs and asymmetry indices predicted surgical success.

CONCLUSION: Interictal ADC mapping lateralizes efficiently the lesion side in accordance with the EEG data and might be used to study the differential regional aspects of mesio-temporal sclerosis. HADC—not AMYADC—maps discriminate favorably postoperative outcome and can be added to the multidisciplinary evaluation workout of pharmacoresistant TLE patients." />
<meta name="DC.Contributor" content="P.M. Gonçalves Pereira" />
<meta name="DC.Contributor" content="E. Oliveira" />
<meta name="DC.Contributor" content="P. Rosado" />
<meta name="article:published_time" content="2006-03-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Apparent Diffusion Coefficient Mapping of the Hippocampus and the Amygdala in Pharmaco-Resistant Temporal Lobe Epilepsy" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; The purpose of this study is to determine whether interictal apparent diffusion coefficients (ADC) provide a robust means for detecting amygdalo-hippocampal abnormalities in adult patients with localization-related chronic temporal lobe epilepsy (TLE) undergoing presurgical evaluation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS:&lt;/b&gt; Fifty-five patients and 20 age-matched controls were studied with hippocampal and amygdala ADC maps (HADC and AMYADC), volumes (HCVOL, AMYVOL), T2 relaxometry (HCT2, AMYT2), and hippocampal &lt;i&gt;N&lt;/i&gt;-acetylaspartate to choline and creatine/phosphocreatine ratios (HCSI). Mean values and 99% confidence ellipses were computed for the groups. Individual ADC mapping was compared with electroencephalography (EEG) data and further correlated with the quantitative MR measures and with the age at onset and duration of TLE. Moreover, we evaluated the association and the predictive value of HADC and AMYADC with respect to the surgical outcome in a subgroup of patients (&lt;i&gt;n&lt;/i&gt; = 21) operated on the side of maximal EEG lateralization and with MR imaging criteria for hippocampal sclerosis, 71% of which became seizure-free.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; In controls, there was no relation between ADC values and age, sex, or right-left asymmetries. In TLE groups with right (&lt;i&gt;n&lt;/i&gt; = 29) or left epileptogenic foci (&lt;i&gt;n&lt;/i&gt; = 26), group comparisons showed that ADC mapping detected changes ipsilateral to the focus in the hippocampus (&lt;i&gt;P&lt;/i&gt; &amp;lt;.01) and the amygdala (&lt;i&gt;P&lt;/i&gt; &amp;lt;.05), accordingly with the volumes, T2 maps, and HCSI. Significant Pearson correlations (2-tailed) were obtained between ADC maps and the volume of the hippocampus (&lt;i&gt;r&lt;/i&gt; = −0.64) and of the amygdala (&lt;i&gt;r&lt;/i&gt; = −0.55; both &lt;i&gt;P&lt;/i&gt; &amp;lt;.01), T2 (&lt;i&gt;r&lt;/i&gt; = 0.70, &lt;i&gt;r&lt;/i&gt; = 0.29; both &lt;i&gt;P&lt;/i&gt; &amp;lt;.01), but not with HCSI. Individual ADC analysis showed ipsilateral pathology in 82% of cases (hippocampus) and 35% (amygdala) and included a moderate association between ipsilateral HADC and AMYADC (&lt;i&gt;r&lt;/i&gt; = 0.54; &lt;i&gt;P&lt;/i&gt; &amp;lt;.01). Bilateral abnormalities were found in 7% (hippocampus) and 5% (amygdala) of cases. Except for HCSI and the amygdala data, there were significant correlations between the asymmetry indices and the duration of epilepsy (HADC: &lt;i&gt;r&lt;/i&gt; = 0.42; HCT2: &lt;i&gt;r&lt;/i&gt; = 0.50; HCVOL: &lt;i&gt;r&lt;/i&gt; = 0.35; all &lt;i&gt;P&lt;/i&gt; &amp;lt;.01). Age at onset was associated only with ipsilateral HADC (&lt;i&gt;r&lt;/i&gt; = 0.35; &lt;i&gt;P&lt;/i&gt; &amp;lt;.01) and HCVOL and HCT2 (both &lt;i&gt;P&lt;/i&gt; &amp;lt;.05). The association with postsurgical successes was characteristic of HADC (Fisher exact test, 2-tailed: &lt;i&gt;P&lt;/i&gt; =.031; Spearman correlation: &lt;i&gt;r&lt;/i&gt;&lt;sub&gt;s&lt;/sub&gt; = −0.75; &lt;i&gt;P&lt;/i&gt; =.0002), but not AMYADC. The predictive value regarding a favorable outcome was 0.87 (odds ratio 26; 95% confidence interval 2.33–38.86). As determined by regression models, both larger ipsilateral HADCs and asymmetry indices predicted surgical success.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION:&lt;/b&gt; Interictal ADC mapping lateralizes efficiently the lesion side in accordance with the EEG data and might be used to study the differential regional aspects of mesio-temporal sclerosis. HADC—not AMYADC—maps discriminate favorably postoperative outcome and can be added to the multidisciplinary evaluation workout of pharmacoresistant TLE patients.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_author" content="P.M. Gonçalves Pereira" />
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<meta name="citation_reference" content="citation_title=Surgical treatment of the epilepsies.;citation_pages=49;citation_year=1993" />
<meta name="citation_reference" content="citation_title=Epilepsy surgery.;citation_pages=95;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Surgical treatment of the epilepsies.;citation_pages=511;citation_year=1987" />
<meta name="citation_reference" content="citation_title=Mayo Clinic Proceedings;citation_journal_abbrev=Mayo Clin Proc.;citation_title=Intractable partial epilepsy: evaluation and treatment.;citation_pages=1578-1586;citation_volume=65;citation_year=1990;citation_issue=12;citation_issn=0025-6196;citation_pmid=2123956" />
<meta name="citation_reference" content="citation_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_title=A Randomized, Controlled Trial of Surgery for Temporal-Lobe Epilepsy;citation_pages=311-318;citation_volume=345;citation_year=2001;citation_issue=5;citation_issn=0028-4793;citation_pmid=11484687;citation_doi=10.1056/NEJM200108023450501" />
<meta name="citation_reference" content="citation_title=Archives of Neurology;citation_journal_abbrev=Arch Neurol;citation_title=Etiology and Pathogenesis of Temporal Lobe Epilepsy;citation_pages=233-248;citation_volume=10;citation_year=1964;citation_issue=3;citation_issn=0003-9942;citation_pmid=14106980;citation_doi=10.1001/archneur.1964.00460150003001" />
<meta name="citation_reference" content="citation_title=Brain;citation_journal_abbrev=Brain;citation_title=EPILEPSY AND THE TEMPORAL LOBES: A CLINICAL, ELECTROENCEPHALOGRAPHIC AND NEUROPATHOLOGICAL STUDY OF THE BRAIN IN EPILEPSY, WITH PARTICULAR REFERENCE TO THE TEMPORAL LOBES;citation_pages=499-530;citation_volume=89;citation_year=1966;citation_issue=3;citation_issn=0006-8950;citation_pmid=5922048;citation_doi=10.1093/brain/89.3.499" />
<meta name="citation_reference" content="citation_title=The neuropathology of temporal lobe epilepsy.;citation_year=1988" />
<meta name="citation_reference" content="citation_title=Epilepsia;citation_journal_abbrev=Epilepsia;citation_title=ILAE Commission Report. Mesial temporal lobe epilepsy with hippocampal sclerosis.;citation_pages=695-714;citation_volume=45;citation_year=2004;citation_issue=6;citation_pmid=15144438;citation_doi=10.1111/j.0013-9580.2004.09004.x" />
<meta name="citation_reference" content="citation_title=Journal of neuropathology and experimental neurology;citation_journal_abbrev=J Neuropathol Exp Neurol;citation_title=Subregional pathology of the amygdala complex and entorhinal region in surgical specimens from patients with pharmacoresistant temporal lobe epilepsy.;citation_pages=907-920;citation_volume=59;citation_year=2000;citation_issue=10;citation_pmid=11079781" />
<meta name="citation_reference" content="citation_title=Epilepsia;citation_journal_abbrev=Epilepsia;citation_title=Neuroimaging in temporal lobe epilepsy: test sensitivity and relationships to pathology and postoperative outcome.;citation_pages=624-634;citation_volume=33;citation_year=1992;citation_issue=4;citation_pmid=1628575;citation_doi=10.1111/j.1528-1157.1992.tb02338.x" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=MR in temporal lobe epilepsy: analysis with pathologic confirmation;citation_pages=19-27;citation_volume=19;citation_year=1998;citation_issue=1;citation_issn=0195-6108;citation_pmid=9432153" />
<meta name="citation_reference" content="citation_title=Journal of Neurology, Neurosurgery &amp; Psychiatry;citation_journal_abbrev=J. Neurol. Neurosurg. Psychiatry;citation_title=Amygdalar sclerosis: preoperative indicators and outcome after temporal lobectomy.;citation_pages=1099-1105;citation_volume=57;citation_year=1994;citation_issue=9;citation_issn=0022-3050;citation_pmid=8089678;citation_doi=10.1136/jnnp.57.9.1099" />
<meta name="citation_reference" content="citation_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_title=Amygdaloid sclerosis in temporal lobe epilepsy.;citation_pages=622-631;citation_volume=33;citation_year=1993;citation_issue=6;citation_pmid=8498843;citation_doi=10.1002/ana.410330611" />
<meta name="citation_reference" content="citation_title=Brain;citation_journal_abbrev=Brain;citation_title=Relationship between atrophy of the amygdala and ictal fear in temporal lobe epilepsy;citation_pages=739-746;citation_volume=117;citation_year=1994;citation_issue=4;citation_issn=0006-8950;citation_pmid=7922461;citation_doi=10.1093/brain/117.4.739" />
<meta name="citation_reference" content="citation_title=Epilepsy surgery.;citation_pages=979;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Brain;citation_journal_abbrev=Brain;citation_title=HIPPOCAMPAL VOLUMETRIC AND MORPHOMETRIC STUDIES IN FRONTAL AND TEMPORAL LOBE EPILEPSY;citation_pages=1001-1015;citation_volume=115;citation_year=1992;citation_issue=4;citation_issn=0006-8950;citation_pmid=1393499;citation_doi=10.1093/brain/115.4.1001" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Detection of hippocampal pathology in intractable partial epilepsy: Increased sensitivity with quantitative magnetic resonance T2 relaxometry;citation_pages=1793-1793;citation_volume=43;citation_year=1993;citation_issue=9;citation_issn=0028-3878;citation_pmid=8414034" />
<meta name="citation_reference" content="citation_title=Magnetic resonance imaging clinics of North America;citation_journal_abbrev=Magn Reson Imaging Clin N Am;citation_title=MR spectroscopy in the evaluation of epilepsy.;citation_pages=21-29;citation_volume=6;citation_year=1998;citation_issue=1;citation_pmid=9449738" />
<meta name="citation_reference" content="citation_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_title=Magnetic resonance image-based hippocampal volumetry: correlation with outcome after temporal lobectomy.;citation_pages=138-146;citation_volume=31;citation_year=1992;citation_issue=2;citation_pmid=1575452;citation_doi=10.1002/ana.410310204" />
<meta name="citation_reference" content="citation_title=Epilepsia;citation_journal_abbrev=Epilepsia;citation_title=Depth electrode studies in temporal lobe epilepsy: relation to quantitative magnetic resonance imaging and operative outcome.;citation_pages=230-235;citation_volume=36;citation_year=1995;citation_issue=3;citation_pmid=7614905" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Multimodality MRI in mesial temporal sclerosis: Relative sensitivity and specificity;citation_pages=774-778;citation_volume=49;citation_year=1997;citation_issue=3;citation_issn=0028-3878;citation_pmid=9305339" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Predictive value of 1H MRSI for outcome in temporal lobectomy;citation_pages=694-694;citation_volume=53;citation_year=1999;citation_issue=4;citation_issn=0028-3878;citation_pmid=10489028" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Predicting surgical outcome in temporal lobe epilepsy patients using MRI and MRSI;citation_pages=1505-1512;citation_volume=58;citation_year=2002;citation_issue=10;citation_issn=0028-3878;citation_pmid=12034787" />
<meta name="citation_reference" content="citation_title=Quantitative MRI of the brain: measuring changes caused by disease.;citation_pages=203;citation_year=2003" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Diffusion mapping applied to mesial temporal lobe epilepsy: Preliminary observations;citation_pages=173-173;citation_volume=53;citation_year=1999;citation_issue=1;citation_issn=0028-3878;citation_pmid=10408555;citation_doi=10.1159/000006592" />
<meta name="citation_reference" content="citation_title=Magnetic resonance imaging;citation_journal_abbrev=Magn Reson Imaging;citation_title=Water diffusion in the human hippocampus in epilepsy.;citation_pages=29-36;citation_volume=17;citation_year=1999;citation_issue=1;citation_pmid=9888396;citation_doi=10.1016/S0730-725X(98)00153-2" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Comparative diagnostic utility of 1H MRS and DWI in evaluation of temporal lobe epilepsy;citation_pages=1745-1753;citation_volume=58;citation_year=2002;citation_issue=12;citation_issn=0028-3878;citation_pmid=12084871" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Apparent Diffusion Coefficient Value of the Hippocampus in Patients with Hippocampal Sclerosis and in Healthy Volunteers;citation_pages=809-812;citation_volume=23;citation_year=2002;citation_issue=5;citation_issn=0195-6108;citation_pmid=12006282" />
<meta name="citation_reference" content="citation_title=Epilepsia;citation_journal_abbrev=Epilepsia;citation_title=Brain diffusion after single seizures.;citation_pages=54-63;citation_volume=44;citation_year=2003;citation_issue=1;citation_pmid=12581230" />
<meta name="citation_reference" content="citation_title=European journal of neurology :  the official journal of the European Federation of Neurological Societies;citation_journal_abbrev=Eur J Neurol;citation_title=Measures of hippocampal volumes, diffusion and 1H MRS metabolic abnormalities in temporal lobe epilepsy provide partially complementary information.;citation_pages=195-205;citation_volume=11;citation_year=2004;citation_issue=3;citation_pmid=15009165;citation_doi=10.1046/j.1351-5101.2003.00737.x" />
<meta name="citation_reference" content="citation_title=Journal of psychiatric research;citation_journal_abbrev=J Psychiatr Res;citation_title=&amp;quot;Mini-mental state&amp;quot;. A practical method for grading the cognitive state of patients for the clinician.;citation_pages=189-198;citation_volume=12;citation_year=1975;citation_issue=3;citation_pmid=1202204;citation_doi=10.1016/0022-3956(75)90026-6" />
<meta name="citation_reference" content="citation_title=Epilepsia;citation_journal_abbrev=Epilepsia;citation_title=Proposal for revised classification of epilepsies and epileptic syndromes. Commission on Classification and Terminology of the International League Against Epilepsy.;citation_pages=389-399;citation_volume=30;citation_year=1989;citation_issue=4;citation_pmid=2502382;citation_doi=10.1111/j.1528-1157.1989.tb05316.x" />
<meta name="citation_reference" content="citation_title=MAGMA Magn Reson Mat Phys Biol Med;citation_pages=19;citation_volume=18;citation_year=2005" />
<meta name="citation_reference" content="citation_title=Atlas of regional anatomy of the brain using MRI—with functional correlations.;citation_pages=161;citation_year=2000" />
<meta name="citation_reference" content="citation_title=Proceedings of the 19th Annual Meeting of the European Society for Magnetic Resonance in Medicine and Biology (ESMRMB).;citation_pages=80;citation_year=2002" />
<meta name="citation_reference" content="citation_title=MAGMA Magn Reson Mat Phys Biol Med;citation_pages=S119;citation_volume=16;citation_year=2003" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Anatomic basis of amygdaloid and hippocampal volume measurement by magnetic resonance imaging;citation_pages=1743-1743;citation_volume=42;citation_year=1992;citation_issue=9;citation_issn=0028-3878;citation_pmid=1513464" />
<meta name="citation_reference" content="citation_title=Brain research.  Brain research reviews;citation_journal_abbrev=Brain Res Brain Res Rev;citation_title=The human amygdala: a systematic review and meta-analysis of volumetric magnetic resonance imaging.;citation_pages=84-105;citation_volume=39;citation_year=2002;citation_issue=1;citation_pmid=12086710;citation_doi=10.1016/S0165-0173(02)00160-1" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=MRI volumetric measurement of amygdala and hippocampus in temporal lobe epilepsy;citation_pages=719-719;citation_volume=43;citation_year=1993;citation_issue=4;citation_issn=0028-3878;citation_pmid=8469329" />
<meta name="citation_reference" content="citation_title=Journal of Anatomy;citation_journal_abbrev=Journal of Anatomy;citation_title=The development of the human hippocampal fissure.;citation_pages=655-676;citation_volume=101;citation_year=1967;citation_issue=Pt 4;citation_pmid=6059818" />
<meta name="citation_reference" content="citation_title=Radiology;citation_journal_abbrev=Radiology;citation_title=Hippocampal sulcus remnant: potential cause of change in signal intensity in the hippocampus;citation_pages=743-746;citation_volume=188;citation_year=1993;citation_issue=3;citation_issn=0033-8419;citation_pmid=8351342" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Volumetric MRI analysis of the amygdala and the hippocampus in subjects with age-associated memory impairment: Correlation to visual and verbal memory;citation_pages=1660-1660;citation_volume=44;citation_year=1994;citation_issue=9;citation_issn=0028-3878;citation_pmid=7936293" />
<meta name="citation_reference" content="citation_title=Journal of Microscopy (Oxford);citation_journal_abbrev=Journal of Microscopy (Oxford);citation_title=The efficiency of systematic sampling in stereology and its prediction.;citation_pages=229-263;citation_volume=147;citation_year=1987;citation_issue=Pt 3;citation_pmid=3430576;citation_doi=10.1111/j.1365-2818.1987.tb02837.x" />
<meta name="citation_reference" content="citation_title=British Journal of Radiology;citation_journal_abbrev=Br. J. Radiol.;citation_title=The benefit of stereology for quantitative radiology;citation_pages=679-697;citation_volume=73;citation_year=2000;citation_issue=871;citation_issn=0007-1285;citation_pmid=11089458" />
<meta name="citation_reference" content="citation_title=Epilepsy research;citation_journal_abbrev=Epilepsy Res;citation_title=MRI volumetry and T2 relaxometry of the amygdala in newly diagnosed and chronic temporal lobe epilepsy.;citation_pages=39-50;citation_volume=28;citation_year=1997;citation_issue=1;citation_pmid=9255598;citation_doi=10.1016/S0920-1211(97)00029-6" />
<meta name="citation_reference" content="citation_title=Proceedings of the 6th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM).;citation_pages=1390;citation_year=1998" />
<meta name="citation_reference" content="citation_title=Epileptic seizures: pathophysiology and clinical semiology.;citation_pages=796;citation_year=2000" />
<meta name="citation_reference" content="citation_title=Prog Brain Res;citation_pages=297;citation_year=2002" />
<meta name="citation_reference" content="citation_title=Radiology;citation_journal_abbrev=Radiology;citation_title=Temporal lobe epilepsy: bilateral hippocampal metabolite changes revealed at proton MR spectroscopic imaging;citation_pages=809-817;citation_volume=202;citation_year=1997;citation_issue=3;citation_issn=0033-8419;citation_pmid=9051038" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Entorhinal cortex in temporal lobe epilepsy: A quantitative MRI study;citation_pages=1870-1870;citation_volume=52;citation_year=1999;citation_issue=9;citation_issn=0028-3878;citation_pmid=10371536" />
<meta name="citation_reference" content="citation_title=Electroencephalogr Clin Neurophysiol;citation_pages=370;citation_volume=10;citation_year=1958;citation_doi=10.1016/0013-4694(58)90053-1" />
<meta name="citation_reference" content="citation_title=Archives of Neurology;citation_journal_abbrev=Arch Neurol;citation_title=Is Ictal Recording Mandatory in Temporal Lobe Epilepsy?: Not When the Interictal Electroencephalogram and Hippocampal Atrophy Coincide;citation_pages=497-500;citation_volume=57;citation_year=2000;citation_issue=4;citation_issn=0003-9942;citation_pmid=10768623;citation_doi=10.1001/archneur.57.4.497" />
<meta name="citation_reference" content="citation_title=Brain;citation_journal_abbrev=Brain;citation_title=Right hemisphere restitution of language and memory functions in right hemisphere language-dominant patients with left temporal lobe epilepsy;citation_pages=729-737;citation_volume=117;citation_year=1994;citation_issue=4;citation_issn=0006-8950;citation_pmid=7922460;citation_doi=10.1093/brain/117.4.729" />
<meta name="citation_reference" content="citation_title=Adv Tech Stand Neurosurg;citation_pages=93;citation_year=1985" />
<meta name="citation_reference" content="citation_title=Surgical treatment of the epilepsies.;citation_pages=609;citation_year=1993" />
<meta name="citation_reference" content="citation_title=Lancet;citation_journal_abbrev=Lancet;citation_title=Statistical methods for assessing agreement between two methods of clinical measurement.;citation_pages=307-310;citation_volume=1;citation_year=1986;citation_issue=8476;citation_pmid=2868172;citation_doi=10.1016/S0140-6736(86)90837-8" />
<meta name="citation_reference" content="citation_title=Giorn Inst Ital Att;citation_pages=83;citation_volume=4;citation_year=1933" />
<meta name="citation_reference" content="citation_title=J Am Stat Assoc;citation_pages=399;citation_volume=62;citation_year=1967;citation_doi=10.2307/2283970" />
<meta name="citation_reference" content="citation_title=Biometrika;citation_journal_abbrev=Biometrika;citation_title=RELATIONS BETWEEN TWO SETS OF VARIATES;citation_pages=321-377;citation_volume=28;citation_year=1936;citation_issue=3-4;citation_issn=0006-3444;citation_doi=10.1093/biomet/28.3-4.321" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Diffusion-Weighted MR Imaging in Normal Human Brains in Various Age Groups;citation_pages=194-199;citation_volume=23;citation_year=2002;citation_issue=2;citation_issn=0195-6108;citation_pmid=11847041" />
<meta name="citation_reference" content="citation_title=Neuroradiology;citation_journal_abbrev=Neuroradiology;citation_title=An alternative explanation of the origin of the signal in diffusion-weighted MRI.;citation_pages=96-98;citation_volume=42;citation_year=2000;citation_issue=2;citation_pmid=10663482;citation_doi=10.1007/s002340050022" />
<meta name="citation_reference" content="citation_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_title=Magnetic resonance imaging-based volume studies in temporal lobe epilepsy: pathological correlations.;citation_pages=31-36;citation_volume=30;citation_year=1991;citation_issue=1;citation_pmid=1929226;citation_doi=10.1002/ana.410300107" />
<meta name="citation_reference" content="citation_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_title=Quantitative magnetic resonance imaging in temporal lobe epilepsy: relationship to neuropathology and neuropsychological function.;citation_pages=629-637;citation_volume=31;citation_year=1992;citation_issue=6;citation_pmid=1514774;citation_doi=10.1002/ana.410310610" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Hippocampal pathology in refractory temporal lobe epilepsy: T2-weighted signal change reflects dentate gliosis;citation_pages=265-271;citation_volume=58;citation_year=2002;citation_issue=2;citation_issn=0028-3878;citation_pmid=11805255" />
<meta name="citation_reference" content="citation_title=Archives of Neurology;citation_journal_abbrev=Arch Neurol;citation_title=Magnetic Resonance Spectroscopic Imaging in Temporal Lobe Epilepsy: Neuronal Dysfunction or Cell Loss?;citation_pages=2048-2053;citation_volume=58;citation_year=2001;citation_issue=12;citation_issn=0003-9942;citation_pmid=11735779;citation_doi=10.1001/archneur.58.12.2048" />
<meta name="citation_reference" content="citation_title=Epilepsy research;citation_journal_abbrev=Epilepsy Res;citation_title=Introduction to temporal lobe epilepsy.;citation_pages=141-150;citation_volume=26;citation_year=1996;citation_issue=1;citation_pmid=8985696;citation_doi=10.1016/S0920-1211(96)00043-5" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Recurrent seizures may cause hippocambal damage in temporal lobe epilepsy;citation_pages=1377-1382;citation_volume=50;citation_year=1998;citation_issue=5;citation_issn=0028-3878;citation_pmid=9595990" />
<meta name="citation_reference" content="citation_title=Epilepsy research;citation_journal_abbrev=Epilepsy Res;citation_title=Hippocampal and amygdaloid damage in partial epilepsy: a cross-sectional MRI study of 241 patients.;citation_pages=69-82;citation_volume=46;citation_year=2001;citation_issue=1;citation_pmid=11395291;citation_doi=10.1016/S0920-1211(01)00258-3" />
<meta name="citation_reference" content="citation_title=Epilepsia;citation_journal_abbrev=Epilepsia;citation_title=Neuronal cell death in a rat model for mesial temporal lobe epilepsy is induced by the initial status epilepticus and not by later repeated spontaneous seizures.;citation_pages=647-658;citation_volume=44;citation_year=2003;citation_issue=5;citation_pmid=12752463;citation_doi=10.1046/j.1528-1157.2003.53902.x" />
<meta name="citation_reference" content="citation_title=Annals of neurology;citation_journal_abbrev=Ann Neurol;citation_title=Prognostic value of proton magnetic resonance spectroscopic imaging for surgical outcome in patients with intractable temporal lobe epilepsy and bilateral hippocampal atrophy.;citation_pages=195-200;citation_volume=47;citation_year=2000;citation_issue=2;citation_pmid=10665490;citation_doi=10.1002/1531-8249(200002)47:2&lt;195::AID-ANA9&gt;3.0.CO;2-2" />
<meta name="citation_reference" content="citation_title=Proceedings of the 12th Scientific Meeting and Exhibition of the International Society of Magnetic Resonance in Medicine (ISMRM).;citation_pages=1298;citation_year=2004" />
<meta name="citation_reference" content="citation_title=Epilepsy &amp; behavior :  E&amp;B;citation_journal_abbrev=Epilepsy Behav;citation_title=Apparent diffusion coefficient measurements in the hippocampus and amygdala of patients with temporal lobe seizures and in healthy volunteers.;citation_pages=250-256;citation_volume=6;citation_year=2005;citation_issue=2;citation_pmid=15710312;citation_doi=10.1016/j.yebeh.2004.12.008" />
<meta name="citation_reference" content="citation_title=Epilepsia;citation_journal_abbrev=Epilepsia;citation_title=Limbic system abnormalities associated with Ammon's horn sclerosis do not alter seizure outcome after amygdalohippocampectomy.;citation_pages=549-555;citation_volume=46;citation_year=2005;citation_issue=4;citation_pmid=15816949" />
<meta name="twitter:title" content="Apparent Diffusion Coefficient Mapping of the Hippocampus and the Amygdala in Pharmaco-Resistant Temporal Lobe Epilepsy" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/27/3.cover.gif" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: The purpose of this study is to determine whether interictal apparent diffusion coefficients (ADC) provide a robust means for detecting amygdalo-hippocampal abnormalities in adult patients with localization-related chronic temporal lobe epilepsy (TLE) undergoing presurgical evaluation.

METHODS: Fifty-five patients and 20 age-matched controls were studied with hippocampal and amygdala ADC maps (HADC and AMYADC), volumes (HCVOL, AMYVOL), T2 relaxometry (HCT2, AMYT2), and hippocampal N -acetylaspartate to choline and creatine/phosphocreatine ratios (HCSI). Mean values and 99% confidence ellipses were computed for the groups. Individual ADC mapping was compared with electroencephalography (EEG) data and further correlated with the quantitative MR measures and with the age at onset and duration of TLE. Moreover, we evaluated the association and the predictive value of HADC and AMYADC with respect to the surgical outcome in a subgroup of patients ( n = 21) operated on the side of maximal EEG lateralization and with MR imaging criteria for hippocampal sclerosis, 71% of which became seizure-free.

RESULTS: In controls, there was no relation between ADC values and age, sex, or right-left asymmetries. In TLE groups with right ( n = 29) or left epileptogenic foci ( n = 26), group comparisons showed that ADC mapping detected changes ipsilateral to the focus in the hippocampus ( P &lt;.01) and the amygdala ( P &lt;.05), accordingly with the volumes, T2 maps, and HCSI. Significant Pearson correlations (2-tailed) were obtained between ADC maps and the volume of the hippocampus ( r = −0.64) and of the amygdala ( r = −0.55; both P &lt;.01), T2 ( r = 0.70, r = 0.29; both P &lt;.01), but not with HCSI. Individual ADC analysis showed ipsilateral pathology in 82% of cases (hippocampus) and 35% (amygdala) and included a moderate association between ipsilateral HADC and AMYADC ( r = 0.54; P &lt;.01). Bilateral abnormalities were found in 7% (hippocampus) and 5% (amygdala) of cases. Except for HCSI and the amygdala data, there were significant correlations between the asymmetry indices and the duration of epilepsy (HADC: r = 0.42; HCT2: r = 0.50; HCVOL: r = 0.35; all P &lt;.01). Age at onset was associated only with ipsilateral HADC ( r = 0.35; P &lt;.01) and HCVOL and HCT2 (both P &lt;.05). The association with postsurgical successes was characteristic of HADC (Fisher exact test, 2-tailed: P =.031; Spearman correlation: r s = −0.75; P =.0002), but not AMYADC. The predictive value regarding a favorable outcome was 0.87 (odds ratio 26; 95% confidence interval 2.33–38.86). As determined by regression models, both larger ipsilateral HADCs and asymmetry indices predicted surgical success.

CONCLUSION: Interictal ADC mapping lateralizes efficiently the lesion side in accordance with the EEG data and might be used to study the differential regional aspects of mesio-temporal sclerosis. HADC—not AMYADC—maps discriminate favorably postoperative outcome and can be added to the multidisciplinary evaluation workout of pharmacoresistant TLE patients." />
<meta name="og-title" property="og:title" content="Apparent Diffusion Coefficient Mapping of the Hippocampus and the Amygdala in Pharmaco-Resistant Temporal Lobe Epilepsy" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/27/3/671" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: The purpose of this study is to determine whether interictal apparent diffusion coefficients (ADC) provide a robust means for detecting amygdalo-hippocampal abnormalities in adult patients with localization-related chronic temporal lobe epilepsy (TLE) undergoing presurgical evaluation.

METHODS: Fifty-five patients and 20 age-matched controls were studied with hippocampal and amygdala ADC maps (HADC and AMYADC), volumes (HCVOL, AMYVOL), T2 relaxometry (HCT2, AMYT2), and hippocampal N -acetylaspartate to choline and creatine/phosphocreatine ratios (HCSI). Mean values and 99% confidence ellipses were computed for the groups. Individual ADC mapping was compared with electroencephalography (EEG) data and further correlated with the quantitative MR measures and with the age at onset and duration of TLE. Moreover, we evaluated the association and the predictive value of HADC and AMYADC with respect to the surgical outcome in a subgroup of patients ( n = 21) operated on the side of maximal EEG lateralization and with MR imaging criteria for hippocampal sclerosis, 71% of which became seizure-free.

RESULTS: In controls, there was no relation between ADC values and age, sex, or right-left asymmetries. In TLE groups with right ( n = 29) or left epileptogenic foci ( n = 26), group comparisons showed that ADC mapping detected changes ipsilateral to the focus in the hippocampus ( P &lt;.01) and the amygdala ( P &lt;.05), accordingly with the volumes, T2 maps, and HCSI. Significant Pearson correlations (2-tailed) were obtained between ADC maps and the volume of the hippocampus ( r = −0.64) and of the amygdala ( r = −0.55; both P &lt;.01), T2 ( r = 0.70, r = 0.29; both P &lt;.01), but not with HCSI. Individual ADC analysis showed ipsilateral pathology in 82% of cases (hippocampus) and 35% (amygdala) and included a moderate association between ipsilateral HADC and AMYADC ( r = 0.54; P &lt;.01). Bilateral abnormalities were found in 7% (hippocampus) and 5% (amygdala) of cases. Except for HCSI and the amygdala data, there were significant correlations between the asymmetry indices and the duration of epilepsy (HADC: r = 0.42; HCT2: r = 0.50; HCVOL: r = 0.35; all P &lt;.01). Age at onset was associated only with ipsilateral HADC ( r = 0.35; P &lt;.01) and HCVOL and HCT2 (both P &lt;.05). The association with postsurgical successes was characteristic of HADC (Fisher exact test, 2-tailed: P =.031; Spearman correlation: r s = −0.75; P =.0002), but not AMYADC. The predictive value regarding a favorable outcome was 0.87 (odds ratio 26; 95% confidence interval 2.33–38.86). As determined by regression models, both larger ipsilateral HADCs and asymmetry indices predicted surgical success.

CONCLUSION: Interictal ADC mapping lateralizes efficiently the lesion side in accordance with the EEG data and might be used to study the differential regional aspects of mesio-temporal sclerosis. HADC—not AMYADC—maps discriminate favorably postoperative outcome and can be added to the multidisciplinary evaluation workout of pharmacoresistant TLE patients." />
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      <h1 class="highwire-cite-title" id="page-title">Apparent Diffusion Coefficient Mapping of the Hippocampus and the Amygdala in Pharmaco-Resistant Temporal Lobe Epilepsy</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">P.M. Gonçalves Pereira</span>, <span class="highwire-citation-author" data-delta="1">E. Oliveira</span> and <span class="highwire-citation-author" data-delta="2">P. Rosado</span></span></div>
  
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<div id="hw-article-author-popups-top-node-6899--62010131108" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">P.M. Gonçalves Pereira </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.M.%2BGon%C3%A7alves%2BPereira%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Pereira%20PG&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.M.%2BGon%25C3%25A7alves%2BPereira%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">E. Oliveira </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=E.%2BOliveira%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Oliveira%20E&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AE.%2BOliveira%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">P. Rosado </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.%2BRosado%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Rosado%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.%2BRosado%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 27</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 3 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">March, 2006 </div></div>
      
      
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