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<meta name="DC.Title" content="Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?" />
<meta name="DC.Date" content="2006-04-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="INTRODUCTION: Noninvasive measurements of cerebral blood volume (CBV) and contrast transfer coefficient (Ktrans) have potential benefits in the diagnosis and therapeutic management of adult glioma. This study examines the relationship between CBV, Ktrans, and overall survival.

METHODS AND MATERIALS: Twenty-seven adult patients with glioma underwent T1-weighted dynamic contrast-enhanced MR imaging, and parametric maps of CBV and Ktrans were calculated. The relationship of histologic grade, CBV, Ktrans, age, sex, surgical resection, and use of adjuvant therapy to survival were analyzed by using the logrank method and Cox regression analysis. The Kaplan-Meier method for displaying survival curves was used. The relationship of factors such as comorbidity, elevated intracranial pressure, size of nonenhancing tumor, and peritumoral edema were not considered.

RESULTS: Both CBV ( P &lt; .01) and Ktrans ( P &lt; .01) show a significant relationship to histologic grade. CBV ( P = .004), Ktrans ( P = .008), and histologic grade ( P &lt; .001) all demonstrate a significant association with patient survival when analyzed individually. Cox regression analysis identified only histologic grade ( P &lt; .01) and Ktrans ( P &lt; .05) as independent significant prognostic indicators. Examination of survival data from high-grade (III and IV) tumors demonstrated a linear relationship between Ktrans and patient survival ( P &lt; .01).

CONCLUSION: This study suggests a direct relationship between Ktrans and length of survival in high-grade gliomas, which could be of clinical importance. CBV relates directly to histologic grade but provides no independent prognostic information over and above that provided by grade. Further large prospective studies should be planned to test whether this observation holds true." />
<meta name="DC.Contributor" content="S.J. Mills" />
<meta name="DC.Contributor" content="T.A. Patankar" />
<meta name="DC.Contributor" content="H.A. Haroon" />
<meta name="DC.Contributor" content="D. Balériaux" />
<meta name="DC.Contributor" content="R. Swindell" />
<meta name="DC.Contributor" content="A. Jackson" />
<meta name="article:published_time" content="2006-04-01" />
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<meta name="citation_title" content="Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;INTRODUCTION:&lt;/b&gt; Noninvasive measurements of cerebral blood volume (CBV) and contrast transfer coefficient (K&lt;sup&gt;trans&lt;/sup&gt;) have potential benefits in the diagnosis and therapeutic management of adult glioma. This study examines the relationship between CBV, K&lt;sup&gt;trans&lt;/sup&gt;, and overall survival.&lt;/p&gt;&lt;p&gt;&lt;b&gt;METHODS AND MATERIALS:&lt;/b&gt; Twenty-seven adult patients with glioma underwent T1-weighted dynamic contrast-enhanced MR imaging, and parametric maps of CBV and K&lt;sup&gt;trans&lt;/sup&gt; were calculated. The relationship of histologic grade, CBV, K&lt;sup&gt;trans&lt;/sup&gt;, age, sex, surgical resection, and use of adjuvant therapy to survival were analyzed by using the logrank method and Cox regression analysis. The Kaplan-Meier method for displaying survival curves was used. The relationship of factors such as comorbidity, elevated intracranial pressure, size of nonenhancing tumor, and peritumoral edema were not considered.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Both CBV (&lt;i&gt;P&lt;/i&gt; &amp;lt; .01) and K&lt;sup&gt;trans&lt;/sup&gt; (&lt;i&gt;P&lt;/i&gt; &amp;lt; .01) show a significant relationship to histologic grade. CBV (&lt;i&gt;P&lt;/i&gt; = .004), K&lt;sup&gt;trans&lt;/sup&gt; (&lt;i&gt;P&lt;/i&gt; = .008), and histologic grade (&lt;i&gt;P&lt;/i&gt; &amp;lt; .001) all demonstrate a significant association with patient survival when analyzed individually. Cox regression analysis identified only histologic grade (&lt;i&gt;P&lt;/i&gt; &amp;lt; .01) and K&lt;sup&gt;trans&lt;/sup&gt; (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05) as independent significant prognostic indicators. Examination of survival data from high-grade (III and IV) tumors demonstrated a linear relationship between K&lt;sup&gt;trans&lt;/sup&gt; and patient survival (&lt;i&gt;P&lt;/i&gt; &amp;lt; .01).&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION:&lt;/b&gt; This study suggests a direct relationship between K&lt;sup&gt;trans&lt;/sup&gt; and length of survival in high-grade gliomas, which could be of clinical importance. CBV relates directly to histologic grade but provides no independent prognostic information over and above that provided by grade. Further large prospective studies should be planned to test whether this observation holds true.&lt;/p&gt;" />
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<meta name="twitter:title" content="Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?" />
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<meta name="twitter:description" content="INTRODUCTION: Noninvasive measurements of cerebral blood volume (CBV) and contrast transfer coefficient (Ktrans) have potential benefits in the diagnosis and therapeutic management of adult glioma. This study examines the relationship between CBV, Ktrans, and overall survival.

METHODS AND MATERIALS: Twenty-seven adult patients with glioma underwent T1-weighted dynamic contrast-enhanced MR imaging, and parametric maps of CBV and Ktrans were calculated. The relationship of histologic grade, CBV, Ktrans, age, sex, surgical resection, and use of adjuvant therapy to survival were analyzed by using the logrank method and Cox regression analysis. The Kaplan-Meier method for displaying survival curves was used. The relationship of factors such as comorbidity, elevated intracranial pressure, size of nonenhancing tumor, and peritumoral edema were not considered.

RESULTS: Both CBV ( P &lt; .01) and Ktrans ( P &lt; .01) show a significant relationship to histologic grade. CBV ( P = .004), Ktrans ( P = .008), and histologic grade ( P &lt; .001) all demonstrate a significant association with patient survival when analyzed individually. Cox regression analysis identified only histologic grade ( P &lt; .01) and Ktrans ( P &lt; .05) as independent significant prognostic indicators. Examination of survival data from high-grade (III and IV) tumors demonstrated a linear relationship between Ktrans and patient survival ( P &lt; .01).

CONCLUSION: This study suggests a direct relationship between Ktrans and length of survival in high-grade gliomas, which could be of clinical importance. CBV relates directly to histologic grade but provides no independent prognostic information over and above that provided by grade. Further large prospective studies should be planned to test whether this observation holds true." />
<meta name="og-title" property="og:title" content="Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/27/4/853" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="INTRODUCTION: Noninvasive measurements of cerebral blood volume (CBV) and contrast transfer coefficient (Ktrans) have potential benefits in the diagnosis and therapeutic management of adult glioma. This study examines the relationship between CBV, Ktrans, and overall survival.

METHODS AND MATERIALS: Twenty-seven adult patients with glioma underwent T1-weighted dynamic contrast-enhanced MR imaging, and parametric maps of CBV and Ktrans were calculated. The relationship of histologic grade, CBV, Ktrans, age, sex, surgical resection, and use of adjuvant therapy to survival were analyzed by using the logrank method and Cox regression analysis. The Kaplan-Meier method for displaying survival curves was used. The relationship of factors such as comorbidity, elevated intracranial pressure, size of nonenhancing tumor, and peritumoral edema were not considered.

RESULTS: Both CBV ( P &lt; .01) and Ktrans ( P &lt; .01) show a significant relationship to histologic grade. CBV ( P = .004), Ktrans ( P = .008), and histologic grade ( P &lt; .001) all demonstrate a significant association with patient survival when analyzed individually. Cox regression analysis identified only histologic grade ( P &lt; .01) and Ktrans ( P &lt; .05) as independent significant prognostic indicators. Examination of survival data from high-grade (III and IV) tumors demonstrated a linear relationship between Ktrans and patient survival ( P &lt; .01).

CONCLUSION: This study suggests a direct relationship between Ktrans and length of survival in high-grade gliomas, which could be of clinical importance. CBV relates directly to histologic grade but provides no independent prognostic information over and above that provided by grade. Further large prospective studies should be planned to test whether this observation holds true." />
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      <h1 class="highwire-cite-title" id="page-title">Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S.J. Mills</span>, <span class="highwire-citation-author" data-delta="1">T.A. Patankar</span>, <span class="highwire-citation-author" data-delta="2">H.A. Haroon</span>, <span class="highwire-citation-author" data-delta="3">D. Balériaux</span>, <span class="highwire-citation-author" data-delta="4">R. Swindell</span> and <span class="highwire-citation-author" data-delta="5">A. Jackson</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2006,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">27 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">853-858; </span></div>
  
  
  
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      <div class="highwire-cite-title">Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">S.J.</span> <span class="nlm-surname">Mills</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">T.A.</span> <span class="nlm-surname">Patankar</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">H.A.</span> <span class="nlm-surname">Haroon</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Balériaux</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Swindell</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Jackson</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2006, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">27 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">853-858; </span></div>
  
  
  
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      <div class="highwire-cite-title">Do Cerebral Blood Volume and Contrast Transfer Coefficient Predict Prognosis in Human Glioma?</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">S.J.</span> <span class="nlm-surname">Mills</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">T.A.</span> <span class="nlm-surname">Patankar</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">H.A.</span> <span class="nlm-surname">Haroon</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">D.</span> <span class="nlm-surname">Balériaux</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Swindell</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Jackson</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2006, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">27 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">853-858; </span></div>
  
  
  
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