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<meta name="DC.Title" content="Early Assessment of Brain Maturation by MR Imaging Segmentation in Neonates and Premature Infants" />
<meta name="DC.Date" content="2006-05-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="PURPOSE: We evaluated the impact of premature extrauterine life on brain maturation.

PATIENTS AND METHODS: Twelve neonates underwent MR imaging at 40 (39.64 ± 0.98) weeks (full term). Fifteen premature infants underwent 2 MR imaging examinations, after birth (preterm at birth) and at 40 weeks (41.03 ± 1.33) (preterm at term). A 3D MR imaging technique was used to measure brain volumes compared with intracranial volume: total brain volume, cortical gray matter, myelinated white matter, unmyelinated white matter, basal ganglia (BG), and CSF.

RESULTS: The average absolute volume of intracranial volume (269.8 mL ± 36.5), total brain volume (246.5 ± 32.3), cortical gray matter (85.53 mL ± 22.23), unmyelinated white matter (142.4 mL ±14.98), and myelinated white matter (6.099 mL ±1.82) for preterm at birth was significantly lower compared with that for the preterm at term: the average global volume of intracranial volume (431.7 ± 69.98), total brain volume (391 ± 66,1), cortical gray matter (179 mL ± 41.54), unmyelinated white matter (185.3 mL ± 30.8), and myelinated white matter (10.66 mL ± 3.05). It was also lower compared with that of full-term infants: intracranial volume (427.4 mL ± 53.84), total brain volume (394 ± 49.22), cortical gray matter (181.4 ± 29.27), unmyelinated white matter (183.4 ± 27.37), and myelinated white matter (10.72 ± 4.63). The relative volume of cortical gray matter (30.62 ± 5.13) and of unmyelinated white matter (53.15 ± 4.8) for preterm at birth was significantly different compared with the relative volume of cortical gray matter (41.05 ± 5.44) and of unmyelinated white matter (43.22 ± 5.11) for the preterm at term. Premature infants had similar brain tissue volumes at 40 weeks to full-term infants.

CONCLUSION: MR segmentation techniques demonstrate that cortical neonatal maturation in moderately premature infants at term and term-born infants was similar." />
<meta name="DC.Contributor" content="A. Zacharia" />
<meta name="DC.Contributor" content="S. Zimine" />
<meta name="DC.Contributor" content="K.O. Lovblad" />
<meta name="DC.Contributor" content="S. Warfield" />
<meta name="DC.Contributor" content="H. Thoeny" />
<meta name="DC.Contributor" content="C. Ozdoba" />
<meta name="DC.Contributor" content="E. Bossi" />
<meta name="DC.Contributor" content="R. Kreis" />
<meta name="DC.Contributor" content="C. Boesch" />
<meta name="DC.Contributor" content="G. Schroth" />
<meta name="DC.Contributor" content="P.S. Hüppi" />
<meta name="article:published_time" content="2006-05-01" />
<meta name="article:section" content="PEDIATRICS" />
<meta name="citation_title" content="Early Assessment of Brain Maturation by MR Imaging Segmentation in Neonates and Premature Infants" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;PURPOSE:&lt;/b&gt; We evaluated the impact of premature extrauterine life on brain maturation.&lt;/p&gt;&lt;p&gt;&lt;b&gt;PATIENTS AND METHODS:&lt;/b&gt; Twelve neonates underwent MR imaging at 40 (39.64 ± 0.98) weeks (full term). Fifteen premature infants underwent 2 MR imaging examinations, after birth (preterm at birth) and at 40 weeks (41.03 ± 1.33) (preterm at term). A 3D MR imaging technique was used to measure brain volumes compared with intracranial volume: total brain volume, cortical gray matter, myelinated white matter, unmyelinated white matter, basal ganglia (BG), and CSF.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; The average absolute volume of intracranial volume (269.8 mL ± 36.5), total brain volume (246.5 ± 32.3), cortical gray matter (85.53 mL ± 22.23), unmyelinated white matter (142.4 mL ±14.98), and myelinated white matter (6.099 mL ±1.82) for preterm at birth was significantly lower compared with that for the preterm at term: the average global volume of intracranial volume (431.7 ± 69.98), total brain volume (391 ± 66,1), cortical gray matter (179 mL ± 41.54), unmyelinated white matter (185.3 mL ± 30.8), and myelinated white matter (10.66 mL ± 3.05). It was also lower compared with that of full-term infants: intracranial volume (427.4 mL ± 53.84), total brain volume (394 ± 49.22), cortical gray matter (181.4 ± 29.27), unmyelinated white matter (183.4 ± 27.37), and myelinated white matter (10.72 ± 4.63). The relative volume of cortical gray matter (30.62 ± 5.13) and of unmyelinated white matter (53.15 ± 4.8) for preterm at birth was significantly different compared with the relative volume of cortical gray matter (41.05 ± 5.44) and of unmyelinated white matter (43.22 ± 5.11) for the preterm at term. Premature infants had similar brain tissue volumes at 40 weeks to full-term infants.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION:&lt;/b&gt; MR segmentation techniques demonstrate that cortical neonatal maturation in moderately premature infants at term and term-born infants was similar.&lt;/p&gt;" />
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<meta name="twitter:title" content="Early Assessment of Brain Maturation by MR Imaging Segmentation in Neonates and Premature Infants" />
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<meta name="twitter:description" content="PURPOSE: We evaluated the impact of premature extrauterine life on brain maturation.

PATIENTS AND METHODS: Twelve neonates underwent MR imaging at 40 (39.64 ± 0.98) weeks (full term). Fifteen premature infants underwent 2 MR imaging examinations, after birth (preterm at birth) and at 40 weeks (41.03 ± 1.33) (preterm at term). A 3D MR imaging technique was used to measure brain volumes compared with intracranial volume: total brain volume, cortical gray matter, myelinated white matter, unmyelinated white matter, basal ganglia (BG), and CSF.

RESULTS: The average absolute volume of intracranial volume (269.8 mL ± 36.5), total brain volume (246.5 ± 32.3), cortical gray matter (85.53 mL ± 22.23), unmyelinated white matter (142.4 mL ±14.98), and myelinated white matter (6.099 mL ±1.82) for preterm at birth was significantly lower compared with that for the preterm at term: the average global volume of intracranial volume (431.7 ± 69.98), total brain volume (391 ± 66,1), cortical gray matter (179 mL ± 41.54), unmyelinated white matter (185.3 mL ± 30.8), and myelinated white matter (10.66 mL ± 3.05). It was also lower compared with that of full-term infants: intracranial volume (427.4 mL ± 53.84), total brain volume (394 ± 49.22), cortical gray matter (181.4 ± 29.27), unmyelinated white matter (183.4 ± 27.37), and myelinated white matter (10.72 ± 4.63). The relative volume of cortical gray matter (30.62 ± 5.13) and of unmyelinated white matter (53.15 ± 4.8) for preterm at birth was significantly different compared with the relative volume of cortical gray matter (41.05 ± 5.44) and of unmyelinated white matter (43.22 ± 5.11) for the preterm at term. Premature infants had similar brain tissue volumes at 40 weeks to full-term infants.

CONCLUSION: MR segmentation techniques demonstrate that cortical neonatal maturation in moderately premature infants at term and term-born infants was similar." />
<meta name="og-title" property="og:title" content="Early Assessment of Brain Maturation by MR Imaging Segmentation in Neonates and Premature Infants" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/27/5/972" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="PURPOSE: We evaluated the impact of premature extrauterine life on brain maturation.

PATIENTS AND METHODS: Twelve neonates underwent MR imaging at 40 (39.64 ± 0.98) weeks (full term). Fifteen premature infants underwent 2 MR imaging examinations, after birth (preterm at birth) and at 40 weeks (41.03 ± 1.33) (preterm at term). A 3D MR imaging technique was used to measure brain volumes compared with intracranial volume: total brain volume, cortical gray matter, myelinated white matter, unmyelinated white matter, basal ganglia (BG), and CSF.

RESULTS: The average absolute volume of intracranial volume (269.8 mL ± 36.5), total brain volume (246.5 ± 32.3), cortical gray matter (85.53 mL ± 22.23), unmyelinated white matter (142.4 mL ±14.98), and myelinated white matter (6.099 mL ±1.82) for preterm at birth was significantly lower compared with that for the preterm at term: the average global volume of intracranial volume (431.7 ± 69.98), total brain volume (391 ± 66,1), cortical gray matter (179 mL ± 41.54), unmyelinated white matter (185.3 mL ± 30.8), and myelinated white matter (10.66 mL ± 3.05). It was also lower compared with that of full-term infants: intracranial volume (427.4 mL ± 53.84), total brain volume (394 ± 49.22), cortical gray matter (181.4 ± 29.27), unmyelinated white matter (183.4 ± 27.37), and myelinated white matter (10.72 ± 4.63). The relative volume of cortical gray matter (30.62 ± 5.13) and of unmyelinated white matter (53.15 ± 4.8) for preterm at birth was significantly different compared with the relative volume of cortical gray matter (41.05 ± 5.44) and of unmyelinated white matter (43.22 ± 5.11) for the preterm at term. Premature infants had similar brain tissue volumes at 40 weeks to full-term infants.

CONCLUSION: MR segmentation techniques demonstrate that cortical neonatal maturation in moderately premature infants at term and term-born infants was similar." />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node7113--5" data-node-nid="7113" id="top-node-7113--61651781748" data-pisa="ajnr;27/5/972" data-pisa-master="ajnr;27/5/972" data-apath="/ajnr/27/5/972.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">PEDIATRICS</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Early Assessment of Brain Maturation by MR Imaging Segmentation in Neonates and Premature Infants</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">A. Zacharia</span>, <span class="highwire-citation-author" data-delta="1">S. Zimine</span>, <span class="highwire-citation-author" data-delta="2">K.O. Lovblad</span>, <span class="highwire-citation-author" data-delta="3">S. Warfield</span>, <span class="highwire-citation-author" data-delta="4">H. Thoeny</span>, <span class="highwire-citation-author" data-delta="5">C. Ozdoba</span>, <span class="highwire-citation-author" data-delta="6">E. Bossi</span>, <span class="highwire-citation-author" data-delta="7">R. Kreis</span>, <span class="highwire-citation-author" data-delta="8">C. Boesch</span>, <span class="highwire-citation-author" data-delta="9">G. Schroth</span> and <span class="highwire-citation-author" data-delta="10">P.S. Hüppi</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2006,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">27 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">972-977; </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-7113--61651781748" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">A. Zacharia </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BZacharia%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zacharia%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BZacharia%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">S. 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    <div class="highwire-markup"><div xmlns="http://www.w3.org/1999/xhtml" data-highwire-cite-ref-tooltip-instance="highwire_reflinks_tooltip" class="content-block-markup" xmlns:xhtml="http://www.w3.org/1999/xhtml"><div class="article abstract-view"><span class="highwire-journal-article-marker-start"></span><div class="section abstract" id="abstract-1"><h2>Abstract</h2><p id="p-1"><strong>PURPOSE:</strong> We evaluated the impact of premature extrauterine life on brain maturation.</p><p id="p-2"><strong>PATIENTS AND METHODS:</strong> Twelve neonates underwent MR imaging at 40 (39.64 ± 0.98) weeks (full term). Fifteen premature infants underwent 2 MR imaging examinations, after birth (preterm at birth) and at 40 weeks (41.03 ± 1.33) (preterm at term). A 3D MR imaging technique was used to measure brain volumes compared with intracranial volume: total brain volume, cortical gray matter, myelinated white matter, unmyelinated white matter, basal ganglia (BG), and CSF.</p><p id="p-3"><strong>RESULTS:</strong> The average absolute volume of intracranial volume (269.8 mL ± 36.5), total brain volume (246.5 ± 32.3), cortical gray matter (85.53 mL ± 22.23), unmyelinated white matter (142.4 mL ±14.98), and myelinated white matter (6.099 mL ±1.82) for preterm at birth was significantly lower compared with that for the preterm at term: the average global volume of intracranial volume (431.7 ± 69.98), total brain volume (391 ± 66,1), cortical gray matter (179 mL ± 41.54), unmyelinated white matter (185.3 mL ± 30.8), and myelinated white matter (10.66 mL ± 3.05). It was also lower compared with that of full-term infants: intracranial volume (427.4 mL ± 53.84), total brain volume (394 ± 49.22), cortical gray matter (181.4 ± 29.27), unmyelinated white matter (183.4 ± 27.37), and myelinated white matter (10.72 ± 4.63). The relative volume of cortical gray matter (30.62 ± 5.13) and of unmyelinated white matter (53.15 ± 4.8) for preterm at birth was significantly different compared with the relative volume of cortical gray matter (41.05 ± 5.44) and of unmyelinated white matter (43.22 ± 5.11) for the preterm at term. Premature infants had similar brain tissue volumes at 40 weeks to full-term infants.</p><p id="p-4"><strong>CONCLUSION:</strong> MR segmentation techniques demonstrate that cortical neonatal maturation in moderately premature infants at term and term-born infants was similar.</p></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/27/5/972.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 27</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 5 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">May 2006 </div></div>
      
      
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      <div class="highwire-cite-title">Early Assessment of Brain Maturation by MR Imaging Segmentation in Neonates and Premature Infants</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2006, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">27 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">972-977; </span></div>
  
  
  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2006, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">27 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">972-977; </span></div>
  
  
  
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