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<meta name="DC.Title" content="Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy Z-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography" />
<meta name="DC.Date" content="2007-04-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: In Alzheimer disease (AD), a peculiar regional cerebral blood flow (rCBF) abnormality has been reported in the posterior cingulate gyri and precunei, even at a very early stage. We performed a multicenter brain perfusion single-photon emission tomography (SPECT) study to evaluate the discrimination ability of an easy Z -score imaging system (eZIS) with a common normal data base between patients with very early AD at the stage of mild cognitive impairment and age-matched healthy controls.

MATERIALS AND METHODS: For a multicenter study, SPECT images of 40 patients with AD and 40 healthy volunteers were acquired from 4 gamma camera systems in 4 different institutions. Systematic differences of SPECT images between gamma cameras were corrected by using conversion maps calculated from the SPECT images of the same brain phantom. Receiver operating characteristic (ROC) analysis was performed to discriminate patients and controls by using a Z -score in the volume of interest (VOI), which had been defined as a region related to AD in subjects other than those in a multicenter study.

RESULTS: Bilateral posterior cingulate gyri, precunei, and parietal cortices were defined as a VOI showing rCBF reduction in very early AD. A new indicator of rCBF abnormality in the VOI provided 86% accuracy for distinction of AD and healthy controls in the multicenter study. The area under the ROC curve was 0.934.

CONCLUSION: Because an eZIS can use a common normal data base by converting site-specific SPECT data to the core data, the eZIS was useful for automated diagnosis of very early AD in routine studies in multiple institutions." />
<meta name="DC.Contributor" content="H. Matsuda" />
<meta name="DC.Contributor" content="S. Mizumura" />
<meta name="DC.Contributor" content="T. Nagao" />
<meta name="DC.Contributor" content="T. Ota" />
<meta name="DC.Contributor" content="T. Iizuka" />
<meta name="DC.Contributor" content="K. Nemoto" />
<meta name="DC.Contributor" content="N. Takemura" />
<meta name="DC.Contributor" content="H. Arai" />
<meta name="DC.Contributor" content="A. Homma" />
<meta name="article:published_time" content="2007-04-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy Z-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; In Alzheimer disease (AD), a peculiar regional cerebral blood flow (rCBF) abnormality has been reported in the posterior cingulate gyri and precunei, even at a very early stage. We performed a multicenter brain perfusion single-photon emission tomography (SPECT) study to evaluate the discrimination ability of an easy &lt;i&gt;Z&lt;/i&gt;-score imaging system (eZIS) with a common normal data base between patients with very early AD at the stage of mild cognitive impairment and age-matched healthy controls.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIALS AND METHODS:&lt;/b&gt; For a multicenter study, SPECT images of 40 patients with AD and 40 healthy volunteers were acquired from 4 gamma camera systems in 4 different institutions. Systematic differences of SPECT images between gamma cameras were corrected by using conversion maps calculated from the SPECT images of the same brain phantom. Receiver operating characteristic (ROC) analysis was performed to discriminate patients and controls by using a &lt;i&gt;Z&lt;/i&gt;-score in the volume of interest (VOI), which had been defined as a region related to AD in subjects other than those in a multicenter study.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Bilateral posterior cingulate gyri, precunei, and parietal cortices were defined as a VOI showing rCBF reduction in very early AD. A new indicator of rCBF abnormality in the VOI provided 86% accuracy for distinction of AD and healthy controls in the multicenter study. The area under the ROC curve was 0.934.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION:&lt;/b&gt; Because an eZIS can use a common normal data base by converting site-specific SPECT data to the core data, the eZIS was useful for automated diagnosis of very early AD in routine studies in multiple institutions.&lt;/p&gt;" />
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<meta name="twitter:title" content="Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy Z-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: In Alzheimer disease (AD), a peculiar regional cerebral blood flow (rCBF) abnormality has been reported in the posterior cingulate gyri and precunei, even at a very early stage. We performed a multicenter brain perfusion single-photon emission tomography (SPECT) study to evaluate the discrimination ability of an easy Z -score imaging system (eZIS) with a common normal data base between patients with very early AD at the stage of mild cognitive impairment and age-matched healthy controls.

MATERIALS AND METHODS: For a multicenter study, SPECT images of 40 patients with AD and 40 healthy volunteers were acquired from 4 gamma camera systems in 4 different institutions. Systematic differences of SPECT images between gamma cameras were corrected by using conversion maps calculated from the SPECT images of the same brain phantom. Receiver operating characteristic (ROC) analysis was performed to discriminate patients and controls by using a Z -score in the volume of interest (VOI), which had been defined as a region related to AD in subjects other than those in a multicenter study.

RESULTS: Bilateral posterior cingulate gyri, precunei, and parietal cortices were defined as a VOI showing rCBF reduction in very early AD. A new indicator of rCBF abnormality in the VOI provided 86% accuracy for distinction of AD and healthy controls in the multicenter study. The area under the ROC curve was 0.934.

CONCLUSION: Because an eZIS can use a common normal data base by converting site-specific SPECT data to the core data, the eZIS was useful for automated diagnosis of very early AD in routine studies in multiple institutions." />
<meta name="og-title" property="og:title" content="Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy Z-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: In Alzheimer disease (AD), a peculiar regional cerebral blood flow (rCBF) abnormality has been reported in the posterior cingulate gyri and precunei, even at a very early stage. We performed a multicenter brain perfusion single-photon emission tomography (SPECT) study to evaluate the discrimination ability of an easy Z -score imaging system (eZIS) with a common normal data base between patients with very early AD at the stage of mild cognitive impairment and age-matched healthy controls.

MATERIALS AND METHODS: For a multicenter study, SPECT images of 40 patients with AD and 40 healthy volunteers were acquired from 4 gamma camera systems in 4 different institutions. Systematic differences of SPECT images between gamma cameras were corrected by using conversion maps calculated from the SPECT images of the same brain phantom. Receiver operating characteristic (ROC) analysis was performed to discriminate patients and controls by using a Z -score in the volume of interest (VOI), which had been defined as a region related to AD in subjects other than those in a multicenter study.

RESULTS: Bilateral posterior cingulate gyri, precunei, and parietal cortices were defined as a VOI showing rCBF reduction in very early AD. A new indicator of rCBF abnormality in the VOI provided 86% accuracy for distinction of AD and healthy controls in the multicenter study. The area under the ROC curve was 0.934.

CONCLUSION: Because an eZIS can use a common normal data base by converting site-specific SPECT data to the core data, the eZIS was useful for automated diagnosis of very early AD in routine studies in multiple institutions." />
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    <title>Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy Z-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography | American Journal of Neuroradiology</title>  
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">BRAIN</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy <em>Z</em>-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">H. Matsuda</span>, <span class="highwire-citation-author" data-delta="1">S. Mizumura</span>, <span class="highwire-citation-author" data-delta="2">T. Nagao</span>, <span class="highwire-citation-author" data-delta="3">T. Ota</span>, <span class="highwire-citation-author" data-delta="4">T. Iizuka</span>, <span class="highwire-citation-author" data-delta="5">K. Nemoto</span>, <span class="highwire-citation-author" data-delta="6">N. Takemura</span>, <span class="highwire-citation-author" data-delta="7">H. Arai</span> and <span class="highwire-citation-author" data-delta="8">A. Homma</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2007,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">28 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">731-736; </span></div>
  
  
  
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      <div class="highwire-cite-title">Automated Discrimination Between Very Early Alzheimer Disease and Controls Using an Easy <em>Z</em>-Score Imaging System for Multicenter Brain Perfusion Single-Photon Emission Tomography</div>  
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