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<meta name="DC.Title" content="Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas" />
<meta name="DC.Identifier" content="10.3174/ajnr.A0673" />
<meta name="DC.Date" content="2007-10-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Noninvasive grading of gliomas remains a challenge despite its important role in the prognosis and management of patients with intracranial neoplasms. In this study, we evaluated the ability of cerebral blood flow (CBF)-guided voxel-by-voxel analysis of multivoxel proton MR spectroscopic imaging (1H-MRSI) to differentiate low-grade from high-grade gliomas.

MATERIALS AND METHODS: A total of 35 patients with primary gliomas (22 high grade and 13 low grade) underwent continuous arterial spin-labeling perfusion-weighted imaging (PWI) and 1H-MRSI. Different regions of the gliomas were categorized as “hypoperfused,” “isoperfused,” and “hyperperfused” on the basis of the average CBF obtained from contralateral healthy white matter. 1H-MRSI indices were computed from these regions and compared between low- and high-grade gliomas. Using a similar approach, we applied a subgroup analysis to differentiate low- from high-grade oligodendrogliomas because they show different physiologic and genetic characteristics.

RESULTS: Choglioma (G)/white matter (WM), GlxG/WM, and Lip+LacG/CrWM were significantly higher in the “hyperperfused” regions of high-grade gliomas compared with low-grade gliomas. ChoG/WM and Lip+LacG/CrWM were also significantly higher in the “hyperperfused” regions of high-grade oligodendrogliomas. However, metabolite ratios from the “hypoperfused” or “isoperfused” regions did not exhibit any significant differences between high-grade and low-grade gliomas.

CONCLUSION: The results suggest that 1H-MRSI indices from the “hyperperfused” regions of gliomas, on the basis of PWI, may be helpful in distinguishing high-grade from low-grade gliomas including oligodendrogliomas." />
<meta name="DC.Contributor" content="S. Chawla" />
<meta name="DC.Contributor" content="S. Wang" />
<meta name="DC.Contributor" content="R.L. Wolf" />
<meta name="DC.Contributor" content="J.H. Woo" />
<meta name="DC.Contributor" content="J. Wang" />
<meta name="DC.Contributor" content="D.M. O'Rourke" />
<meta name="DC.Contributor" content="K.D. Judy" />
<meta name="DC.Contributor" content="M.S. Grady" />
<meta name="DC.Contributor" content="E.R. Melhem" />
<meta name="DC.Contributor" content="H. Poptani" />
<meta name="article:published_time" content="2007-10-01" />
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<meta name="citation_title" content="Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; Noninvasive grading of gliomas remains a challenge despite its important role in the prognosis and management of patients with intracranial neoplasms. In this study, we evaluated the ability of cerebral blood flow (CBF)-guided voxel-by-voxel analysis of multivoxel proton MR spectroscopic imaging (&lt;sup&gt;1&lt;/sup&gt;H-MRSI) to differentiate low-grade from high-grade gliomas.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIALS AND METHODS:&lt;/b&gt; A total of 35 patients with primary gliomas (22 high grade and 13 low grade) underwent continuous arterial spin-labeling perfusion-weighted imaging (PWI) and &lt;sup&gt;1&lt;/sup&gt;H-MRSI. Different regions of the gliomas were categorized as “hypoperfused,” “isoperfused,” and “hyperperfused” on the basis of the average CBF obtained from contralateral healthy white matter. &lt;sup&gt;1&lt;/sup&gt;H-MRSI indices were computed from these regions and compared between low- and high-grade gliomas. Using a similar approach, we applied a subgroup analysis to differentiate low- from high-grade oligodendrogliomas because they show different physiologic and genetic characteristics.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Cho&lt;sub&gt;glioma (G)/white matter (WM)&lt;/sub&gt;, Glx&lt;sub&gt;G/WM&lt;/sub&gt;, and Lip+Lac&lt;sub&gt;G&lt;/sub&gt;/Cr&lt;sub&gt;WM&lt;/sub&gt; were significantly higher in the “hyperperfused” regions of high-grade gliomas compared with low-grade gliomas. Cho&lt;sub&gt;G/WM&lt;/sub&gt; and Lip+Lac&lt;sub&gt;G&lt;/sub&gt;/Cr&lt;sub&gt;WM&lt;/sub&gt; were also significantly higher in the “hyperperfused” regions of high-grade oligodendrogliomas. However, metabolite ratios from the “hypoperfused” or “isoperfused” regions did not exhibit any significant differences between high-grade and low-grade gliomas.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION:&lt;/b&gt; The results suggest that &lt;sup&gt;1&lt;/sup&gt;H-MRSI indices from the “hyperperfused” regions of gliomas, on the basis of PWI, may be helpful in distinguishing high-grade from low-grade gliomas including oligodendrogliomas.&lt;/p&gt;" />
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<meta name="twitter:title" content="Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Noninvasive grading of gliomas remains a challenge despite its important role in the prognosis and management of patients with intracranial neoplasms. In this study, we evaluated the ability of cerebral blood flow (CBF)-guided voxel-by-voxel analysis of multivoxel proton MR spectroscopic imaging (1H-MRSI) to differentiate low-grade from high-grade gliomas.

MATERIALS AND METHODS: A total of 35 patients with primary gliomas (22 high grade and 13 low grade) underwent continuous arterial spin-labeling perfusion-weighted imaging (PWI) and 1H-MRSI. Different regions of the gliomas were categorized as “hypoperfused,” “isoperfused,” and “hyperperfused” on the basis of the average CBF obtained from contralateral healthy white matter. 1H-MRSI indices were computed from these regions and compared between low- and high-grade gliomas. Using a similar approach, we applied a subgroup analysis to differentiate low- from high-grade oligodendrogliomas because they show different physiologic and genetic characteristics.

RESULTS: Choglioma (G)/white matter (WM), GlxG/WM, and Lip+LacG/CrWM were significantly higher in the “hyperperfused” regions of high-grade gliomas compared with low-grade gliomas. ChoG/WM and Lip+LacG/CrWM were also significantly higher in the “hyperperfused” regions of high-grade oligodendrogliomas. However, metabolite ratios from the “hypoperfused” or “isoperfused” regions did not exhibit any significant differences between high-grade and low-grade gliomas.

CONCLUSION: The results suggest that 1H-MRSI indices from the “hyperperfused” regions of gliomas, on the basis of PWI, may be helpful in distinguishing high-grade from low-grade gliomas including oligodendrogliomas." />
<meta name="og-title" property="og:title" content="Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/28/9/1683" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Noninvasive grading of gliomas remains a challenge despite its important role in the prognosis and management of patients with intracranial neoplasms. In this study, we evaluated the ability of cerebral blood flow (CBF)-guided voxel-by-voxel analysis of multivoxel proton MR spectroscopic imaging (1H-MRSI) to differentiate low-grade from high-grade gliomas.

MATERIALS AND METHODS: A total of 35 patients with primary gliomas (22 high grade and 13 low grade) underwent continuous arterial spin-labeling perfusion-weighted imaging (PWI) and 1H-MRSI. Different regions of the gliomas were categorized as “hypoperfused,” “isoperfused,” and “hyperperfused” on the basis of the average CBF obtained from contralateral healthy white matter. 1H-MRSI indices were computed from these regions and compared between low- and high-grade gliomas. Using a similar approach, we applied a subgroup analysis to differentiate low- from high-grade oligodendrogliomas because they show different physiologic and genetic characteristics.

RESULTS: Choglioma (G)/white matter (WM), GlxG/WM, and Lip+LacG/CrWM were significantly higher in the “hyperperfused” regions of high-grade gliomas compared with low-grade gliomas. ChoG/WM and Lip+LacG/CrWM were also significantly higher in the “hyperperfused” regions of high-grade oligodendrogliomas. However, metabolite ratios from the “hypoperfused” or “isoperfused” regions did not exhibit any significant differences between high-grade and low-grade gliomas.

CONCLUSION: The results suggest that 1H-MRSI indices from the “hyperperfused” regions of gliomas, on the basis of PWI, may be helpful in distinguishing high-grade from low-grade gliomas including oligodendrogliomas." />
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      <h1 class="highwire-cite-title" id="page-title">Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">S. Chawla</span>, <span class="highwire-citation-author" data-delta="1">S. Wang</span>, <span class="highwire-citation-author" data-delta="2">R.L. Wolf</span>, <span class="highwire-citation-author" data-delta="3">J.H. Woo</span>, <span class="highwire-citation-author" data-delta="4">J. Wang</span>, <span class="highwire-citation-author" data-delta="5">D.M. O'Rourke</span>, <span class="highwire-citation-author" data-delta="6">K.D. Judy</span>, <span class="highwire-citation-author" data-delta="7">M.S. Grady</span>, <span class="highwire-citation-author" data-delta="8">E.R. Melhem</span> and <span class="highwire-citation-author" data-delta="9">H. Poptani</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">October 2007,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">28 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1683-1689; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A0673 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-7229--61923752107" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">S. Chawla </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BChawla%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chawla%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.%2BChawla%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">S. 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      <div class="highwire-cite-title">Arterial Spin-Labeling and MR Spectroscopy in the Differentiation of Gliomas</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Chawla</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">R.L.</span> <span class="nlm-surname">Wolf</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.H.</span> <span class="nlm-surname">Woo</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">D.M.</span> <span class="nlm-surname">O'Rourke</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">K.D.</span> <span class="nlm-surname">Judy</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">M.S.</span> <span class="nlm-surname">Grady</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">E.R.</span> <span class="nlm-surname">Melhem</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Poptani</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2007, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">28 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1683-1689; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0673 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Chawla</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">R.L.</span> <span class="nlm-surname">Wolf</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.H.</span> <span class="nlm-surname">Woo</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">D.M.</span> <span class="nlm-surname">O'Rourke</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">K.D.</span> <span class="nlm-surname">Judy</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">M.S.</span> <span class="nlm-surname">Grady</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">E.R.</span> <span class="nlm-surname">Melhem</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Poptani</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Oct 2007, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">28 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(9) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1683-1689; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0673 </span></div>
  
  
  
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