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<meta name="DC.Title" content="In Vivo Demonstration of Neuroinflammatory Molecule Expression in Brain Abscess with Diffusion Tensor Imaging" />
<meta name="DC.Identifier" content="10.3174/ajnr.A0826" />
<meta name="DC.Date" content="2008-02-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Neuroinflammatory molecules, including tumor necrosis factor-α, interleukin1-β, lymphocyte function associated molecule-1, and intercellular cell adhesion molecule-1 contribute to the development of brain abscess. We hypothesized that the high fractional anisotropy (FA) in the brain abscess cavity reflects the upregulation of these neuroinflammatory molecules.

Materials and METHODS: Diffusion tensor imaging (DTI) was performed in 24 patients with brain abscess and Staphylococcus aureus –treated as well as nontreated Jurket cell lines (at 4 time points: 1, 24, 48, and 72 hours). Neuroinflammatory molecules were quantified from the brain abscess cavity aspirate of the patients as well as from the heat-killed S aureus –treated and nontreated cell lines and correlated with DTI measures.

RESULTS: The DTI-derived FA strongly correlated with the presence of neuroinflammatory molecules in the pus as well as in S aureus –treated cell lines; no such correlation was observed in nontreated cell lines.

CONCLUSIONS: These data indicate that neuroinflammatory molecules confer high diffusion anisotropy inside the brain abscess cavity. We propose that increased FA reflects upregulated inflammatory response in brain abscess." />
<meta name="DC.Contributor" content="R.K. Gupta" />
<meta name="DC.Contributor" content="K. Nath" />
<meta name="DC.Contributor" content="A. Prasad" />
<meta name="DC.Contributor" content="K.N. Prasad" />
<meta name="DC.Contributor" content="M. Husain" />
<meta name="DC.Contributor" content="R.K.S. Rathore" />
<meta name="DC.Contributor" content="N. Husain" />
<meta name="DC.Contributor" content="C. Srivastava" />
<meta name="DC.Contributor" content="P. Khetan" />
<meta name="DC.Contributor" content="R. Trivedi" />
<meta name="DC.Contributor" content="P.A. Narayana" />
<meta name="article:published_time" content="2008-02-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="In Vivo Demonstration of Neuroinflammatory Molecule Expression in Brain Abscess with Diffusion Tensor Imaging" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; Neuroinflammatory molecules, including tumor necrosis factor-α, interleukin1-β, lymphocyte function associated molecule-1, and intercellular cell adhesion molecule-1 contribute to the development of brain abscess. We hypothesized that the high fractional anisotropy (FA) in the brain abscess cavity reflects the upregulation of these neuroinflammatory molecules.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Materials and METHODS:&lt;/b&gt; Diffusion tensor imaging (DTI) was performed in 24 patients with brain abscess and &lt;i&gt;Staphylococcus aureus&lt;/i&gt;–treated as well as nontreated Jurket cell lines (at 4 time points: 1, 24, 48, and 72 hours). Neuroinflammatory molecules were quantified from the brain abscess cavity aspirate of the patients as well as from the heat-killed &lt;i&gt;S aureus&lt;/i&gt;–treated and nontreated cell lines and correlated with DTI measures.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; The DTI-derived FA strongly correlated with the presence of neuroinflammatory molecules in the pus as well as in &lt;i&gt;S aureus&lt;/i&gt;–treated cell lines; no such correlation was observed in nontreated cell lines.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS:&lt;/b&gt; These data indicate that neuroinflammatory molecules confer high diffusion anisotropy inside the brain abscess cavity. We propose that increased FA reflects upregulated inflammatory response in brain abscess.&lt;/p&gt;" />
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<meta name="citation_publication_date" content="2008/02/01" />
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<meta name="twitter:title" content="In Vivo Demonstration of Neuroinflammatory Molecule Expression in Brain Abscess with Diffusion Tensor Imaging" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Neuroinflammatory molecules, including tumor necrosis factor-α, interleukin1-β, lymphocyte function associated molecule-1, and intercellular cell adhesion molecule-1 contribute to the development of brain abscess. We hypothesized that the high fractional anisotropy (FA) in the brain abscess cavity reflects the upregulation of these neuroinflammatory molecules.

Materials and METHODS: Diffusion tensor imaging (DTI) was performed in 24 patients with brain abscess and Staphylococcus aureus –treated as well as nontreated Jurket cell lines (at 4 time points: 1, 24, 48, and 72 hours). Neuroinflammatory molecules were quantified from the brain abscess cavity aspirate of the patients as well as from the heat-killed S aureus –treated and nontreated cell lines and correlated with DTI measures.

RESULTS: The DTI-derived FA strongly correlated with the presence of neuroinflammatory molecules in the pus as well as in S aureus –treated cell lines; no such correlation was observed in nontreated cell lines.

CONCLUSIONS: These data indicate that neuroinflammatory molecules confer high diffusion anisotropy inside the brain abscess cavity. We propose that increased FA reflects upregulated inflammatory response in brain abscess." />
<meta name="og-title" property="og:title" content="In Vivo Demonstration of Neuroinflammatory Molecule Expression in Brain Abscess with Diffusion Tensor Imaging" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/29/2/326" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Neuroinflammatory molecules, including tumor necrosis factor-α, interleukin1-β, lymphocyte function associated molecule-1, and intercellular cell adhesion molecule-1 contribute to the development of brain abscess. We hypothesized that the high fractional anisotropy (FA) in the brain abscess cavity reflects the upregulation of these neuroinflammatory molecules.

Materials and METHODS: Diffusion tensor imaging (DTI) was performed in 24 patients with brain abscess and Staphylococcus aureus –treated as well as nontreated Jurket cell lines (at 4 time points: 1, 24, 48, and 72 hours). Neuroinflammatory molecules were quantified from the brain abscess cavity aspirate of the patients as well as from the heat-killed S aureus –treated and nontreated cell lines and correlated with DTI measures.

RESULTS: The DTI-derived FA strongly correlated with the presence of neuroinflammatory molecules in the pus as well as in S aureus –treated cell lines; no such correlation was observed in nontreated cell lines.

CONCLUSIONS: These data indicate that neuroinflammatory molecules confer high diffusion anisotropy inside the brain abscess cavity. We propose that increased FA reflects upregulated inflammatory response in brain abscess." />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node7873--5" data-node-nid="7873" id="top-node-7873--61382314102" data-pisa="ajnr;29/2/326" data-pisa-master="ajnr;ajnr.A0826" data-apath="/ajnr/29/2/326.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">BRAIN</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">In Vivo Demonstration of Neuroinflammatory Molecule Expression in Brain Abscess with Diffusion Tensor Imaging</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">R.K. Gupta</span>, <span class="highwire-citation-author" data-delta="1">K. Nath</span>, <span class="highwire-citation-author" data-delta="2">A. Prasad</span>, <span class="highwire-citation-author" data-delta="3">K.N. Prasad</span>, <span class="highwire-citation-author" data-delta="4">M. Husain</span>, <span class="highwire-citation-author" data-delta="5">R.K.S. Rathore</span>, <span class="highwire-citation-author" data-delta="6">N. Husain</span>, <span class="highwire-citation-author" data-delta="7">C. Srivastava</span>, <span class="highwire-citation-author" data-delta="8">P. Khetan</span>, <span class="highwire-citation-author" data-delta="9">R. Trivedi</span> and <span class="highwire-citation-author" data-delta="10">P.A. Narayana</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 2008,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">326-332; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A0826 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-7873--61382314102" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">R.K. Gupta </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.K.%2BGupta%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Gupta%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.K.%2BGupta%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">K. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 29</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 2 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">February 2008 </div></div>
      
      
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      <div class="highwire-cite-title">In Vivo Demonstration of Neuroinflammatory Molecule Expression in Brain Abscess with Diffusion Tensor Imaging</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Feb 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">326-332; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0826 </span></div>
  
  
  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Feb 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">326-332; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0826 </span></div>
  
  
  
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