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<meta name="DC.Title" content="High b-Value Diffusion (b = 3000 s/mm2) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with b = 1000 s/mm2" />
<meta name="DC.Identifier" content="10.3174/ajnr.A0842" />
<meta name="DC.Date" content="2008-03-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: High b-value diffusion-weighted imaging (DWI) provides different features not appreciated at lower b-value and have been recently studied in several clinical issues. The purpose of this study was to assess whether DWI at b = 3000 s/mm2 is more useful in discriminating high-grade and low-grade gliomas than DWI at b = 1000 s/mm2 at 3T.

MATERIALS AND METHODS: DWIs at both b = 1000 and 3000 s/mm2 were performed at 3T in 62 patients, 49 high-grade gliomas (20 World Health Organization [WHO] grade III and 29 grade IV) and 13 low-grade gliomas (13 grade II). Visual assessments based on 5-point scaled evaluations, receiver operating characteristic (ROC) curve analysis, and quantitative assessment based on DWI signal intensity (SI) ratio (tumor SI/normal SI) and apparent diffusion coefficient (ADC) values were compared between DWIs at b = 1000 and 3000 s/mm2.

RESULTS: By visual assessment, DWI at b = 3000 s/mm2 showed more conspicuous hyperintensity in high-grade gliomas and hypointensity in low-grade gliomas than DWI at b = 1000 s/mm2. Sensitivity and specificity at b = 3000 s/mm2 were higher than at b = 1000 s/mm2 (83.7%, 84.6% vs 69.4%, 76.9%, respectively). Quantitative assessments showed that mean SI ratio of high-grade gliomas was significantly higher than that of low-grade gliomas at both b-values. The mean ADC value of high-grade gliomas was significantly lower than that of low-grade gliomas at both b-values. The difference between the SI ratios of high-grade and low-grade gliomas was significantly larger at b = 3000 s/mm2 than at b = 1000 s/mm2.

CONCLUSION: DWI at b = 3000 s/mm2 is more useful than DWI at b = 1000 s/mm2 in terms of discriminating high-grade and low-grade gliomas at 3T." />
<meta name="DC.Contributor" content="H.S. Seo" />
<meta name="DC.Contributor" content="K.-H. Chang" />
<meta name="DC.Contributor" content="D.G. Na" />
<meta name="DC.Contributor" content="B.J. Kwon" />
<meta name="DC.Contributor" content="D.H. Lee" />
<meta name="article:published_time" content="2008-03-01" />
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<meta name="citation_title" content="High b-Value Diffusion (b = 3000 s/mm2) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with b = 1000 s/mm2" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; High b-value diffusion-weighted imaging (DWI) provides different features not appreciated at lower b-value and have been recently studied in several clinical issues. The purpose of this study was to assess whether DWI at &lt;i&gt;b&lt;/i&gt; = 3000 s/mm&lt;sup&gt;2&lt;/sup&gt; is more useful in discriminating high-grade and low-grade gliomas than DWI at &lt;i&gt;b&lt;/i&gt; = 1000 s/mm&lt;sup&gt;2&lt;/sup&gt; at 3T.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIALS AND METHODS:&lt;/b&gt; DWIs at both &lt;i&gt;b&lt;/i&gt; = 1000 and 3000 s/mm&lt;sup&gt;2&lt;/sup&gt; were performed at 3T in 62 patients, 49 high-grade gliomas (20 World Health Organization [WHO] grade III and 29 grade IV) and 13 low-grade gliomas (13 grade II). Visual assessments based on 5-point scaled evaluations, receiver operating characteristic (ROC) curve analysis, and quantitative assessment based on DWI signal intensity (SI) ratio (tumor SI/normal SI) and apparent diffusion coefficient (ADC) values were compared between DWIs at &lt;i&gt;b&lt;/i&gt; = 1000 and 3000 s/mm&lt;sup&gt;2&lt;/sup&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; By visual assessment, DWI at &lt;i&gt;b&lt;/i&gt; = 3000 s/mm&lt;sup&gt;2&lt;/sup&gt; showed more conspicuous hyperintensity in high-grade gliomas and hypointensity in low-grade gliomas than DWI at &lt;i&gt;b&lt;/i&gt; = 1000 s/mm&lt;sup&gt;2&lt;/sup&gt;. Sensitivity and specificity at &lt;i&gt;b&lt;/i&gt; = 3000 s/mm&lt;sup&gt;2&lt;/sup&gt; were higher than at &lt;i&gt;b&lt;/i&gt; = 1000 s/mm&lt;sup&gt;2&lt;/sup&gt; (83.7%, 84.6% vs 69.4%, 76.9%, respectively). Quantitative assessments showed that mean SI ratio of high-grade gliomas was significantly higher than that of low-grade gliomas at both b-values. The mean ADC value of high-grade gliomas was significantly lower than that of low-grade gliomas at both b-values. The difference between the SI ratios of high-grade and low-grade gliomas was significantly larger at &lt;i&gt;b&lt;/i&gt; = 3000 s/mm&lt;sup&gt;2&lt;/sup&gt; than at &lt;i&gt;b&lt;/i&gt; = 1000 s/mm&lt;sup&gt;2&lt;/sup&gt;.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSION:&lt;/b&gt; DWI at &lt;i&gt;b&lt;/i&gt; = 3000 s/mm&lt;sup&gt;2&lt;/sup&gt; is more useful than DWI at &lt;i&gt;b&lt;/i&gt; = 1000 s/mm&lt;sup&gt;2&lt;/sup&gt; in terms of discriminating high-grade and low-grade gliomas at 3T.&lt;/p&gt;" />
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<meta name="twitter:title" content="High b-Value Diffusion (b = 3000 s/mm2) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with b = 1000 s/mm2" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: High b-value diffusion-weighted imaging (DWI) provides different features not appreciated at lower b-value and have been recently studied in several clinical issues. The purpose of this study was to assess whether DWI at b = 3000 s/mm2 is more useful in discriminating high-grade and low-grade gliomas than DWI at b = 1000 s/mm2 at 3T.

MATERIALS AND METHODS: DWIs at both b = 1000 and 3000 s/mm2 were performed at 3T in 62 patients, 49 high-grade gliomas (20 World Health Organization [WHO] grade III and 29 grade IV) and 13 low-grade gliomas (13 grade II). Visual assessments based on 5-point scaled evaluations, receiver operating characteristic (ROC) curve analysis, and quantitative assessment based on DWI signal intensity (SI) ratio (tumor SI/normal SI) and apparent diffusion coefficient (ADC) values were compared between DWIs at b = 1000 and 3000 s/mm2.

RESULTS: By visual assessment, DWI at b = 3000 s/mm2 showed more conspicuous hyperintensity in high-grade gliomas and hypointensity in low-grade gliomas than DWI at b = 1000 s/mm2. Sensitivity and specificity at b = 3000 s/mm2 were higher than at b = 1000 s/mm2 (83.7%, 84.6% vs 69.4%, 76.9%, respectively). Quantitative assessments showed that mean SI ratio of high-grade gliomas was significantly higher than that of low-grade gliomas at both b-values. The mean ADC value of high-grade gliomas was significantly lower than that of low-grade gliomas at both b-values. The difference between the SI ratios of high-grade and low-grade gliomas was significantly larger at b = 3000 s/mm2 than at b = 1000 s/mm2.

CONCLUSION: DWI at b = 3000 s/mm2 is more useful than DWI at b = 1000 s/mm2 in terms of discriminating high-grade and low-grade gliomas at 3T." />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: High b-value diffusion-weighted imaging (DWI) provides different features not appreciated at lower b-value and have been recently studied in several clinical issues. The purpose of this study was to assess whether DWI at b = 3000 s/mm2 is more useful in discriminating high-grade and low-grade gliomas than DWI at b = 1000 s/mm2 at 3T.

MATERIALS AND METHODS: DWIs at both b = 1000 and 3000 s/mm2 were performed at 3T in 62 patients, 49 high-grade gliomas (20 World Health Organization [WHO] grade III and 29 grade IV) and 13 low-grade gliomas (13 grade II). Visual assessments based on 5-point scaled evaluations, receiver operating characteristic (ROC) curve analysis, and quantitative assessment based on DWI signal intensity (SI) ratio (tumor SI/normal SI) and apparent diffusion coefficient (ADC) values were compared between DWIs at b = 1000 and 3000 s/mm2.

RESULTS: By visual assessment, DWI at b = 3000 s/mm2 showed more conspicuous hyperintensity in high-grade gliomas and hypointensity in low-grade gliomas than DWI at b = 1000 s/mm2. Sensitivity and specificity at b = 3000 s/mm2 were higher than at b = 1000 s/mm2 (83.7%, 84.6% vs 69.4%, 76.9%, respectively). Quantitative assessments showed that mean SI ratio of high-grade gliomas was significantly higher than that of low-grade gliomas at both b-values. The mean ADC value of high-grade gliomas was significantly lower than that of low-grade gliomas at both b-values. The difference between the SI ratios of high-grade and low-grade gliomas was significantly larger at b = 3000 s/mm2 than at b = 1000 s/mm2.

CONCLUSION: DWI at b = 3000 s/mm2 is more useful than DWI at b = 1000 s/mm2 in terms of discriminating high-grade and low-grade gliomas at 3T." />
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    <title>High b-Value Diffusion (b = 3000 s/mm2) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with b = 1000 s/mm2 | American Journal of Neuroradiology</title>  
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      <h1 class="highwire-cite-title" id="page-title">High b-Value Diffusion (<em>b</em> = 3000 s/mm<sup>2</sup>) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with <em>b</em> = 1000 s/mm<sup>2</sup></h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">H.S. Seo</span>, <span class="highwire-citation-author" data-delta="1">K.-H. Chang</span>, <span class="highwire-citation-author" data-delta="2">D.G. Na</span>, <span class="highwire-citation-author" data-delta="3">B.J. Kwon</span> and <span class="highwire-citation-author" data-delta="4">D.H. Lee</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 2008,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">458-463; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A0842 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-7910--62056630550" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">H.S. Seo </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.S.%2BSeo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Seo%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.S.%2BSeo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">K.-H. Chang </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.-H.%2BChang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chang%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AK.-H.%2BChang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">D.G. Na </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.G.%2BNa%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Na%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.G.%2BNa%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">B.J. Kwon </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B.J.%2BKwon%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kwon%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AB.J.%2BKwon%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">D.H. Lee </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.H.%2BLee%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lee%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.H.%2BLee%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 29</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 3 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">March 2008 </div></div>
      
      
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      <div class="highwire-cite-title">High b-Value Diffusion (<em>b</em> = 3000 s/mm<sup>2</sup>) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with <em>b</em> = 1000 s/mm<sup>2</sup></div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">H.S.</span> <span class="nlm-surname">Seo</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">K.-H.</span> <span class="nlm-surname">Chang</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">D.G.</span> <span class="nlm-surname">Na</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">B.J.</span> <span class="nlm-surname">Kwon</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">D.H.</span> <span class="nlm-surname">Lee</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">458-463; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0842 </span></div>
  
  
  
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      <div class="highwire-cite-title">High b-Value Diffusion (<em>b</em> = 3000 s/mm<sup>2</sup>) MR Imaging in Cerebral Gliomas at 3T: Visual and Quantitative Comparisons with <em>b</em> = 1000 s/mm<sup>2</sup></div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">458-463; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0842 </span></div>
  
  
  
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