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<meta name="DC.Title" content="Noninvasive Imaging of Quantitative Cerebral Blood Flow Changes during 100% Oxygen Inhalation Using Arterial Spin-Labeling MR Imaging" />
<meta name="DC.Identifier" content="10.3174/ajnr.A0896" />
<meta name="DC.Date" content="2008-04-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Tracer studies have demonstrated that 100% oxygen inhalation causes a small cerebral blood flow (CBF) decrease. This study was performed to determine whether arterial spin-labeling (ASL), a noninvasive MR imaging technique, could image these changes with clinically reasonable imaging durations.

Materials and METHODS: Continuous ASL imaging was performed in 7 healthy subjects before, during, and after 100% oxygen inhalation. ASL difference signal intensity (ΔM, control − label), CBF, and CBF percentage change were measured. A test-retest paradigm was used to calculate the variability of the initial and final room air CBF measurements.

RESULTS: During oxygen inhalation, ΔM decreased significantly in all regions (eg, global ΔM decreased by 23 ± 11%, P &lt; .01, all values mean ± SD). Accounting for the reduced T1 of hyperoxygenated blood, we found a smaller CBF decrease, which did not reach significance in any of the regions. Global CBF dropped from 50 ± 10 mL per 100 g/minute to 47 ± 10 mL per 100 g/minute following 100% oxygen inhalation, a decrease of 5 ± 14% ( P &gt; .17). The root-mean-square variability of the initial and final room air CBF measurements was 7–8 mL per 100 g/minute.

CONCLUSIONS: The ΔM signal intensity decreased significantly with oxygen inhalation; however, after accounting for changes in blood T1 with oxygen, CBF decreases were small. Such measurements support the use of hyperoxia as an MR imaging contrast agent and may be helpful to interpret hyperoxia-based stroke trials." />
<meta name="DC.Contributor" content="G. Zaharchuk" />
<meta name="DC.Contributor" content="A.J. Martin" />
<meta name="DC.Contributor" content="W.P. Dillon" />
<meta name="article:published_time" content="2008-04-01" />
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<meta name="citation_title" content="Noninvasive Imaging of Quantitative Cerebral Blood Flow Changes during 100% Oxygen Inhalation Using Arterial Spin-Labeling MR Imaging" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; Tracer studies have demonstrated that 100% oxygen inhalation causes a small cerebral blood flow (CBF) decrease. This study was performed to determine whether arterial spin-labeling (ASL), a noninvasive MR imaging technique, could image these changes with clinically reasonable imaging durations.&lt;/p&gt;&lt;p&gt;&lt;b&gt;Materials and METHODS:&lt;/b&gt; Continuous ASL imaging was performed in 7 healthy subjects before, during, and after 100% oxygen inhalation. ASL difference signal intensity (ΔM, control − label), CBF, and CBF percentage change were measured. A test-retest paradigm was used to calculate the variability of the initial and final room air CBF measurements.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; During oxygen inhalation, ΔM decreased significantly in all regions (eg, global ΔM decreased by 23 ± 11%, &lt;i&gt;P&lt;/i&gt; &amp;lt; .01, all values mean ± SD). Accounting for the reduced T1 of hyperoxygenated blood, we found a smaller CBF decrease, which did not reach significance in any of the regions. Global CBF dropped from 50 ± 10 mL per 100 g/minute to 47 ± 10 mL per 100 g/minute following 100% oxygen inhalation, a decrease of 5 ± 14% (&lt;i&gt;P&lt;/i&gt; &amp;gt; .17). The root-mean-square variability of the initial and final room air CBF measurements was 7–8 mL per 100 g/minute.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS:&lt;/b&gt; The ΔM signal intensity decreased significantly with oxygen inhalation; however, after accounting for changes in blood T1 with oxygen, CBF decreases were small. Such measurements support the use of hyperoxia as an MR imaging contrast agent and may be helpful to interpret hyperoxia-based stroke trials.&lt;/p&gt;" />
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<meta name="twitter:title" content="Noninvasive Imaging of Quantitative Cerebral Blood Flow Changes during 100% Oxygen Inhalation Using Arterial Spin-Labeling MR Imaging" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Tracer studies have demonstrated that 100% oxygen inhalation causes a small cerebral blood flow (CBF) decrease. This study was performed to determine whether arterial spin-labeling (ASL), a noninvasive MR imaging technique, could image these changes with clinically reasonable imaging durations.

Materials and METHODS: Continuous ASL imaging was performed in 7 healthy subjects before, during, and after 100% oxygen inhalation. ASL difference signal intensity (ΔM, control − label), CBF, and CBF percentage change were measured. A test-retest paradigm was used to calculate the variability of the initial and final room air CBF measurements.

RESULTS: During oxygen inhalation, ΔM decreased significantly in all regions (eg, global ΔM decreased by 23 ± 11%, P &lt; .01, all values mean ± SD). Accounting for the reduced T1 of hyperoxygenated blood, we found a smaller CBF decrease, which did not reach significance in any of the regions. Global CBF dropped from 50 ± 10 mL per 100 g/minute to 47 ± 10 mL per 100 g/minute following 100% oxygen inhalation, a decrease of 5 ± 14% ( P &gt; .17). The root-mean-square variability of the initial and final room air CBF measurements was 7–8 mL per 100 g/minute.

CONCLUSIONS: The ΔM signal intensity decreased significantly with oxygen inhalation; however, after accounting for changes in blood T1 with oxygen, CBF decreases were small. Such measurements support the use of hyperoxia as an MR imaging contrast agent and may be helpful to interpret hyperoxia-based stroke trials." />
<meta name="og-title" property="og:title" content="Noninvasive Imaging of Quantitative Cerebral Blood Flow Changes during 100% Oxygen Inhalation Using Arterial Spin-Labeling MR Imaging" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/29/4/663" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Tracer studies have demonstrated that 100% oxygen inhalation causes a small cerebral blood flow (CBF) decrease. This study was performed to determine whether arterial spin-labeling (ASL), a noninvasive MR imaging technique, could image these changes with clinically reasonable imaging durations.

Materials and METHODS: Continuous ASL imaging was performed in 7 healthy subjects before, during, and after 100% oxygen inhalation. ASL difference signal intensity (ΔM, control − label), CBF, and CBF percentage change were measured. A test-retest paradigm was used to calculate the variability of the initial and final room air CBF measurements.

RESULTS: During oxygen inhalation, ΔM decreased significantly in all regions (eg, global ΔM decreased by 23 ± 11%, P &lt; .01, all values mean ± SD). Accounting for the reduced T1 of hyperoxygenated blood, we found a smaller CBF decrease, which did not reach significance in any of the regions. Global CBF dropped from 50 ± 10 mL per 100 g/minute to 47 ± 10 mL per 100 g/minute following 100% oxygen inhalation, a decrease of 5 ± 14% ( P &gt; .17). The root-mean-square variability of the initial and final room air CBF measurements was 7–8 mL per 100 g/minute.

CONCLUSIONS: The ΔM signal intensity decreased significantly with oxygen inhalation; however, after accounting for changes in blood T1 with oxygen, CBF decreases were small. Such measurements support the use of hyperoxia as an MR imaging contrast agent and may be helpful to interpret hyperoxia-based stroke trials." />
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      <h1 class="highwire-cite-title" id="page-title">Noninvasive Imaging of Quantitative Cerebral Blood Flow Changes during 100% Oxygen Inhalation Using Arterial Spin-Labeling MR Imaging</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">G. Zaharchuk</span>, <span class="highwire-citation-author" data-delta="1">A.J. Martin</span> and <span class="highwire-citation-author" data-delta="2">W.P. Dillon</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2008,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">663-667; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A0896 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-8168--61512511498" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">G. Zaharchuk </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.%2BZaharchuk%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zaharchuk%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AG.%2BZaharchuk%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">A.J. Martin </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.J.%2BMartin%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Martin%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.J.%2BMartin%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">W.P. Dillon </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.P.%2BDillon%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dillon%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AW.P.%2BDillon%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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      <div class="highwire-cite-title">Noninvasive Imaging of Quantitative Cerebral Blood Flow Changes during 100% Oxygen Inhalation Using Arterial Spin-Labeling MR Imaging</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Zaharchuk</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Martin</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">W.P.</span> <span class="nlm-surname">Dillon</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">663-667; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0896 </span></div>
  
  
  
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      <div class="highwire-cite-title">Noninvasive Imaging of Quantitative Cerebral Blood Flow Changes during 100% Oxygen Inhalation Using Arterial Spin-Labeling MR Imaging</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Zaharchuk</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Martin</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">W.P.</span> <span class="nlm-surname">Dillon</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2008, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">29 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">663-667; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A0896 </span></div>
  
  
  
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