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<meta name="DC.Title" content="Posterior Reversible Encephalopathy Syndrome, Part 2: Controversies Surrounding Pathophysiology of Vasogenic Edema" />
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<meta name="DC.Description" content="SUMMARY: Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state accompanied by a unique brain imaging pattern typically associated with a number of complex clinical conditions including: preeclampsia/eclampsia, allogeneic bone marrow transplantation, solid organ transplantation, autoimmune diseases and high dose cancer chemotherapy. The mechanism behind the developing vasogenic edema and CT or MR imaging appearance of PRES is not known. Two theories have historically been proposed: 1) Severe hypertension leads to failed auto-regulation, subsequent hyperperfusion, with endothelial injury/vasogenic edema and; 2) vasoconstriction and hypoperfusion leads to brain ischemia and subsequent vasogenic edema. The strengths/weaknesses of these hypotheses are reviewed in a translational fashion including supporting evidence and current available imaging/clinical data related to the conditions that develop PRES. While the hypertension/hyperperfusion theory has been most popular, the conditions associated with PRES have a similar immune challenge present and develop a similar state of T-cell/endothelial cell activation that may be the basis of leukocyte trafficking and systemic/cerebral vasoconstriction. These systemic features along with current vascular and perfusion imaging features in PRES appear to render strong support for the older theory of vasoconstriction coupled with hypoperfusion as the mechanism." />
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<meta name="citation_reference" content="citation_title=American Journal of Roentgenology;citation_journal_abbrev=Am. J. Roentgenol.;citation_title=Acute hypertensive encephalopathy: findings on spin-echo and gradient- echo MR imaging;citation_pages=665-670;citation_volume=162;citation_year=1994;citation_issue=3;citation_issn=0361-803X;citation_pmid=8109519;citation_doi=10.2214/ajr.162.3.8109519" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Computed tomographic changes of hypertensive encephalopathy.;citation_pages=395-398;citation_volume=6;citation_year=1985;citation_issue=3;citation_issn=0195-6108;citation_pmid=3923795" />
<meta name="citation_reference" content="citation_title=Obstetrics &amp; Gynecology;citation_journal_abbrev=Obstet Gynecol;citation_title=Cortical blindness in severe preeclampsia: computed tomography, magnetic resonance imaging, and single-photon-emission computed tomography findings.;citation_pages=1017-1019;citation_volume=95;citation_year=2000;citation_issue=6 Pt 2;citation_issn=0029-7844;citation_pmid=10808010;citation_doi=10.1016/S0029-7844(00)00878-4" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Distinct Imaging Patterns and Lesion Distribution in Posterior Reversible Encephalopathy Syndrome;citation_pages=1320-1327;citation_volume=28;citation_year=2007;citation_issue=7;citation_issn=0195-6108;citation_pmid=17698535;citation_doi=10.3174/ajnr.A0549" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Etiology of Cortical and White Matter Lesions in Cyclosporin-A and FK-506 Neurotoxicity;citation_pages=1901-1914;citation_volume=22;citation_year=2001;citation_issue=10;citation_issn=0195-6108;citation_pmid=11733324" />
<meta name="citation_reference" content="citation_title=American journal of obstetrics and gynecology;citation_journal_abbrev=Am J Obstet Gynecol;citation_title=Eclampsia. VI. Maternal-perinatal outcome in 254 consecutive cases.;citation_pages=1049-1054;citation_volume=163;citation_year=1990;citation_issue=3;citation_pmid=2403130;citation_doi=10.1016/0002-9378(90)91123-T" />
<meta name="citation_reference" content="citation_title=AJNR Am J Neuroradiol;citation_year=2008" />
<meta name="citation_reference" content="citation_title=AJNR Am J Neuroradiol.;citation_volume=29;citation_year=2008;citation_pmid=18079186;citation_doi=10.3174/ajnr.A0839" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Pretransplantation Conditioning Influence on the Occurrence of Cyclosporine or FK-506 Neurotoxicity in Allogeneic Bone Marrow Transplantation;citation_pages=261-269;citation_volume=25;citation_year=2004;citation_issue=2;citation_issn=0195-6108;citation_pmid=14970028" />
<meta name="citation_reference" content="citation_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_title=A Reversible Posterior Leukoencephalopathy Syndrome;citation_pages=494-500;citation_volume=334;citation_year=1996;citation_issue=8;citation_issn=0028-4793;citation_pmid=8559202;citation_doi=10.1056/NEJM199602223340803" />
<meta name="citation_reference" content="citation_title=Radiology;citation_journal_abbrev=Radiology;citation_title=Reversible Posterior Leukoencephalopathy Syndrome: Evaluation with Diffusion-Tensor MR Imaging;citation_pages=756-765;citation_volume=219;citation_year=2001;citation_issue=3;citation_issn=0033-8419;citation_pmid=11376265;citation_doi=10.1148/radiology.219.3.r01jn48756" />
<meta name="citation_reference" content="citation_title=Bone marrow transplantation;citation_journal_abbrev=Bone Marrow Transplant;citation_title=Neurologic complications in allogeneic bone marrow transplant patients receiving cyclosporin.;citation_pages=393-401;citation_volume=8;citation_year=1991;citation_issue=5;citation_pmid=1768975" />
<meta name="citation_reference" content="citation_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_title=Cyclosporine, sympathetic activity, and hypertension;citation_pages=748-750;citation_volume=323;citation_year=1990;citation_issue=11;citation_issn=0028-4793;citation_pmid=2388672" />
<meta name="citation_reference" content="citation_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_title=Cyclosporine-induced sympathetic activation and hypertension after heart transplantation;citation_pages=693-699;citation_volume=323;citation_year=1990;citation_issue=11;citation_issn=0028-4793;citation_pmid=2388667;citation_doi=10.1056/NEJM199009133231101" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Hemodynamic and Permeability Changes in Posterior Reversible Encephalopathy Syndrome Measured by Dynamic Susceptibility Perfusion-Weighted MR Imaging;citation_pages=825-830;citation_volume=26;citation_year=2005;citation_issue=4;citation_issn=0195-6108;citation_pmid=15814928" />
<meta name="citation_reference" content="citation_title=American Journal of Roentgenology;citation_journal_abbrev=Am. J. Roentgenol.;citation_title=Assessment of cerebral microcirculation in a patient with hypertensive encephalopathy using MR perfusion imaging;citation_pages=1491-1493;citation_volume=173;citation_year=1999;citation_issue=6;citation_issn=0361-803X;citation_pmid=10584788" />
<meta name="citation_reference" content="citation_title=British journal of obstetrics and gynaecology;citation_journal_abbrev=Br J Obstet Gynaecol;citation_title=Single photon emission and cerebral computerised tomographic scan and transcranial Doppler sonographic findings in eclampsia.;citation_pages=1165-1172;citation_volume=104;citation_year=1997;citation_issue=10;citation_pmid=9332995" />
<meta name="citation_reference" content="citation_title=Journal of Nuclear Medicine;citation_journal_abbrev=JNM;citation_title=Brain SPECT in Neurology and Psychiatry;citation_pages=611-623;citation_volume=42;citation_year=2001;citation_issue=4;citation_issn=0161-5505;citation_pmid=11337551" />
<meta name="citation_reference" content="citation_title=Williams Obstetrics.;citation_pages=567;citation_year=2001" />
<meta name="citation_reference" content="citation_title=American journal of obstetrics and gynecology;citation_journal_abbrev=Am J Obstet Gynecol;citation_title=Etiology and pathogenesis of preeclampsia: current concepts.;citation_pages=1359-1375;citation_volume=179;citation_year=1998;citation_issue=5;citation_pmid=9822529;citation_doi=10.1016/S0002-9378(98)70160-7" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Posterior Reversible Encephalopathy Syndrome in Infection, Sepsis, and Shock;citation_pages=2179-2190;citation_volume=27;citation_year=2006;citation_issue=10;citation_issn=0195-6108;citation_pmid=17110690" />
<meta name="citation_reference" content="citation_title=AJNR Am J Neuroradiol;citation_volume=29;citation_year=2008;citation_pmid=18272559;citation_doi=10.3174/ajnr.A0960" />
<meta name="citation_reference" content="citation_title=Journal of computer assisted tomography;citation_journal_abbrev=J Comput Assist Tomogr;citation_title=MR imaging of postpartum cortical blindness.;citation_pages=572-576;citation_volume=13;citation_year=1989;citation_issue=4;citation_pmid=2745774" />
<meta name="citation_reference" content="citation_title=Stroke;citation_journal_abbrev=Stroke;citation_title=Cerebral vasospasm and eclampsia;citation_pages=326-329;citation_volume=19;citation_year=1988;citation_issue=3;citation_issn=0039-2499;citation_pmid=3354016" />
<meta name="citation_reference" content="citation_title=Cerebrovascular Disorders.;citation_pages=342;citation_year=1999" />
<meta name="citation_reference" content="citation_title=European radiology;citation_journal_abbrev=Eur Radiol;citation_title=MR imaging with quantitative diffusion mapping of tacrolimus-induced neurotoxicity in organ transplant patients.;citation_pages=986-993;citation_volume=13;citation_year=2003;citation_issue=5;citation_pmid=12695819" />
<meta name="citation_reference" content="citation_title=Gerontology;citation_pages=29;citation_volume=38(suppl 1);citation_year=1992" />
<meta name="citation_reference" content="citation_title=The FASEB Journal;citation_journal_abbrev=FASEB J.;citation_title=Cytokine regulation of endothelial cell function;citation_pages=2591-2599;citation_volume=6;citation_year=1992;citation_issue=8;citation_issn=0892-6638;citation_pmid=1592209" />
<meta name="citation_reference" content="citation_title=Am J Physiol;citation_pages=C854;citation_volume=262;citation_year=1992;citation_pmid=1566813" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Fatal puerperal cerebral vasospasm and stroke in a young woman;citation_pages=1145-1145;citation_volume=41;citation_year=1991;citation_issue=7;citation_issn=0028-3878;citation_pmid=2067647" />
<meta name="citation_reference" content="citation_title=Neuroradiology;citation_journal_abbrev=Neuroradiology;citation_title=CT and angiographic correlation of severe neurological disease in toxemia of pregnancy.;citation_pages=59-64;citation_volume=30;citation_year=1988;citation_issue=1;citation_pmid=3357569;citation_doi=10.1007/BF00341945" />
<meta name="citation_reference" content="citation_title=British journal of obstetrics and gynaecology;citation_journal_abbrev=Br J Obstet Gynaecol;citation_title=Association of cerebral perfusion pressure with headache in women with pre-eclampsia.;citation_pages=814-821;citation_volume=106;citation_year=1999;citation_issue=8;citation_pmid=10453832" />
<meta name="citation_reference" content="citation_title=Archives of Neurology;citation_journal_abbrev=Arch Neurol;citation_title=Cerebral Hemodynamics in Preeclampsia and Eclampsia;citation_pages=1226-1231;citation_volume=53;citation_year=1996;citation_issue=12;citation_issn=0003-9942;citation_pmid=8970450;citation_doi=10.1001/archneur.1996.00550120034013" />
<meta name="citation_reference" content="citation_title=American journal of obstetrics and gynecology;citation_journal_abbrev=Am J Obstet Gynecol;citation_title=Persistence of cerebral hemodynamic changes in patients with eclampsia: A report of three cases.;citation_pages=1162-1165;citation_volume=181;citation_year=1999;citation_issue=5 Pt 1;citation_pmid=10561638;citation_doi=10.1016/S0002-9378(99)70101-8" />
<meta name="citation_reference" content="citation_title=Williams Obstetrics.;citation_pages=85;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Blood;citation_journal_abbrev=Blood;citation_title=Total Body Irradiation and Acute Graft-Versus-Host Disease: The Role of Gastrointestinal Damage and Inflammatory Cytokines;citation_pages=3204-3213;citation_volume=90;citation_year=1997;citation_issue=8;citation_issn=0006-4971;citation_pmid=9376604" />
<meta name="citation_reference" content="citation_title=Blood;citation_journal_abbrev=Blood;citation_title=Cytokine dysregulation and acute graft-versus-host disease;citation_pages=2964-2968;citation_volume=80;citation_year=1992;citation_issue=12;citation_issn=0006-4971;citation_pmid=1467511" />
<meta name="citation_reference" content="citation_journal_abbrev=Neurocrit Care;citation_title=Variable incidence of cyclosporine and FK-506 neurotoxicity in hematopoeitic malignancies and marrow conditions after allogeneic bone marrow transplantation.;citation_pages=33-45;citation_volume=3;citation_year=2005;citation_issue=1;citation_pmid=16159093;citation_doi=10.1385/NCC:3:1:033" />
<meta name="citation_reference" content="citation_title=Journal of hematotherapy &amp; stem cell research;citation_journal_abbrev=J Hematother Stem Cell Res;citation_title=Pathogenesis of acute graft-versus-host disease: cytokines and cellular effectors.;citation_pages=299-306;citation_volume=9;citation_year=2000;citation_issue=3;citation_pmid=10894351;citation_doi=10.1089/15258160050079407" />
<meta name="citation_reference" content="citation_title=Blood;citation_journal_abbrev=Blood;citation_title=Increased serum levels of tumor necrosis factor alpha precede major complications of bone marrow transplantation [see comments];citation_pages=1011-1016;citation_volume=75;citation_year=1990;citation_issue=4;citation_issn=0006-4971;citation_pmid=2405918" />
<meta name="citation_reference" content="citation_title=Leukemia :  official journal of the Leukemia Society of America, Leukemia Research Fund, U.K;citation_journal_abbrev=Leukemia;citation_title=Proinflammatory cytokines and their role in the development of major transplant-related complications in the early phase after allogeneic bone marrow transplantation.;citation_pages=1150-1156;citation_volume=17;citation_year=2003;citation_issue=6;citation_pmid=12764383;citation_doi=10.1038/sj.leu.2402946" />
<meta name="citation_reference" content="citation_title=American journal of hematology;citation_journal_abbrev=Am J Hematol;citation_title=Plasma von Willebrand Factor Antigen (vWF:AG) and thrombomodulin (TM) levels in Adult Thrombotic Thrombocytopenic Purpura/Hemolytic Uremic Syndromes (TTP/HUS) and bone marrow transplant-associated thrombotic microangiopathy (BMT-TM).;citation_pages=213-220;citation_volume=53;citation_year=1996;citation_issue=4;citation_pmid=8948657;citation_doi=10.1002/(SICI)1096-8652(199612)53:4&lt;213::AID-AJH1&gt;3.0.CO;2-0" />
<meta name="citation_reference" content="citation_title=Current and Future Immunosuppressive Therapies Following Transplantation.;citation_pages=111;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Current and Future Immunosuppressive Therapies Following Transplantation.;citation_pages=123;citation_year=2001" />
<meta name="citation_reference" content="citation_title=Blood;citation_journal_abbrev=Blood;citation_title=Microangiopathy in patients on cyclosporine prophylaxis who developed acute graft-versus-host disease after HLA-identical bone marrow transplantation;citation_pages=2018-2024;citation_volume=73;citation_year=1989;citation_issue=7;citation_issn=0006-4971;citation_pmid=2496776" />
<meta name="citation_reference" content="citation_title=Kidney international;citation_journal_abbrev=Kidney Int;citation_title=Role of endothelin in cyclosporine-induced glomerular dysfunction.;citation_pages=1487-1491;citation_volume=37;citation_year=1990;citation_issue=6;citation_pmid=2194067" />
<meta name="citation_reference" content="citation_title=British journal of haematology;citation_journal_abbrev=Br J Haematol;citation_title=Autoimmunity in 28 patients after allogeneic bone marrow transplantation: comparison with Sjogren syndrome and scleroderma.;citation_pages=45-47;citation_volume=66;citation_year=1987;citation_issue=1;citation_pmid=3297128" />
<meta name="citation_reference" content="citation_title=Principles and Practice of Infectious Disease.;citation_pages=906;citation_year=2005" />
<meta name="citation_reference" content="citation_title=Irwin and Rippe's Intensive Care Medicine.;citation_pages=1834;citation_year=2003" />
<meta name="citation_reference" content="citation_title=Intensive care medicine;citation_journal_abbrev=Intensive Care Med;citation_title=The SOFA (Sepsis-related Organ Failure Assessment) score to describe organ dysfunction/failure. On behalf of the Working Group on Sepsis-Related Problems of the European Society of Intensive Care Medicine.;citation_pages=707-710;citation_volume=22;citation_year=1996;citation_issue=7;citation_pmid=8844239;citation_doi=10.1007/BF01709751" />
<meta name="citation_reference" content="citation_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_title=Acute-Phase Proteins and Other Systemic Responses to Inflammation;citation_pages=448-454;citation_volume=340;citation_year=1999;citation_issue=6;citation_issn=0028-4793;citation_pmid=9971870;citation_doi=10.1056/NEJM199902113400607" />
<meta name="citation_reference" content="citation_title=Bone marrow transplantation;citation_journal_abbrev=Bone Marrow Transplant;citation_title=Organ dysfunction following stem cell transplantation: relationship to plasma cytokine concentrations.;citation_pages=889-893;citation_volume=28;citation_year=2001;citation_issue=9;citation_pmid=11781651;citation_doi=10.1038/sj.bmt.1703238" />
<meta name="citation_reference" content="citation_title=Blood;citation_volume=101;citation_year=2003;citation_pmid=12543869;citation_doi=10.1182/blood-2002-06-1887" />
<meta name="citation_reference" content="citation_title=American Journal of Respiratory and Critical Care Medicine;citation_journal_abbrev=Am. J. Respir. Crit. Care Med.;citation_title=Circulating Endothelial Cells in Patients with Septic Shock;citation_pages=195-200;citation_volume=163;citation_year=2001;citation_issue=1;citation_issn=1073-449X;citation_pmid=11208646;citation_doi=10.1164/ajrccm.163.1.9912036" />
<meta name="citation_reference" content="citation_title=Infectious disease clinics of North America;citation_journal_abbrev=Infect Dis Clin North Am;citation_title=Neutrophil and endothelial cell interactions in sepsis. The role of adhesion molecules.;citation_pages=427-47, x;citation_volume=13;citation_year=1999;citation_issue=2;citation_pmid=10340176;citation_doi=10.1016/S0891-5520(05)70084-2" />
<meta name="citation_reference" content="citation_title=Cardiovasc Res;citation_volume=32;citation_year=1996;citation_pmid=8915193;citation_doi=10.1016/S0008-6363(96)00113-7" />
<meta name="citation_reference" content="citation_title=Infectious disease clinics of North America;citation_journal_abbrev=Infect Dis Clin North Am;citation_title=Nitric oxide in the pathogenesis of sepsis.;citation_pages=449- x;citation_volume=13;citation_year=1999;citation_issue=2;citation_pmid=10340177;citation_doi=10.1016/S0891-5520(05)70085-4" />
<meta name="citation_reference" content="citation_title=JAMA;citation_journal_abbrev=JAMA;citation_title=Epidemiology of Sepsis Syndrome in 8 Academic Medical Centers;citation_pages=234-240;citation_volume=278;citation_year=1997;citation_issue=3;citation_issn=0002-9955;citation_pmid=9218672;citation_doi=10.1001/jama.1997.03550030074038" />
<meta name="citation_reference" content="citation_title=European journal of pharmacology;citation_journal_abbrev=Eur J Pharmacol;citation_title=The endothelin system in septic and endotoxin shock.;citation_pages=1-15;citation_volume=407;citation_year=2000;citation_issue=1-2;citation_pmid=11050285;citation_doi=10.1016/S0014-2999(00)00675-0" />
<meta name="citation_reference" content="citation_title=Biochemical and biophysical research communications;citation_journal_abbrev=Biochem Biophys Res Commun;citation_title=Endotoxin stimulates endothelin-release in vivo and in vitro as determined by radioimmunoassay.;citation_pages=1220-1227;citation_volume=161;citation_year=1989;citation_issue=3;citation_pmid=2662974;citation_doi=10.1016/0006-291X(89)91372-7" />
<meta name="citation_reference" content="citation_title=Infectious disease clinics of North America;citation_journal_abbrev=Infect Dis Clin North Am;citation_title=Structure and function of streptococcal and staphylococcal superantigens in septic shock.;citation_pages=387-96, ix;citation_volume=13;citation_year=1999;citation_issue=2;citation_pmid=10340173;citation_doi=10.1016/S0891-5520(05)70081-7" />
<meta name="citation_reference" content="citation_title=Clinical Microbiology Reviews;citation_journal_abbrev=Clin. Microbiol. Rev.;citation_title=Bacterial pyrogenic exotoxins as superantigens;citation_pages=411-426;citation_volume=8;citation_year=1995;citation_issue=3;citation_issn=0893-8512;citation_pmid=7553574" />
<meta name="citation_reference" content="citation_title=Infectious disease clinics of North America;citation_journal_abbrev=Infect Dis Clin North Am;citation_title=Gram-positive sepsis. Mechanisms and differences from gram-negative sepsis.;citation_pages=397-412;citation_volume=13;citation_year=1999;citation_issue=2;citation_pmid=10340174;citation_doi=10.1016/S0891-5520(05)70082-9" />
<meta name="citation_reference" content="citation_title=Organ Transplantation.;citation_pages=1;citation_year=2003" />
<meta name="citation_reference" content="citation_title=Transplantation;citation_journal_abbrev=Transplantation;citation_title=The vascular endothelial cell antigen system.;citation_pages=286-289;citation_volume=39;citation_year=1985;citation_issue=3;citation_pmid=3919480" />
<meta name="citation_reference" content="citation_title=Cellular and Molecular Immunology 5th ed.;citation_pages=391;citation_year=2005" />
<meta name="citation_reference" content="citation_title=Transplantation of the Liver.;citation_pages=274;citation_year=1996" />
<meta name="citation_reference" content="citation_title=PNAS;citation_journal_abbrev=Proc. Natl. Acad. Sci. USA;citation_title=Male fetal progenitor cells persist in maternal blood for as long as 27 years postpartum.;citation_pages=705-708;citation_volume=93;citation_year=1996;citation_issue=2;citation_issn=0027-8424;citation_pmid=8570620;citation_doi=10.1073/pnas.93.2.705" />
<meta name="citation_reference" content="citation_title=Lancet;citation_journal_abbrev=Lancet;citation_title=Clinical endovascular placement of bifurcated graft in abdominal aortic aneurysm without laparotomy.;citation_pages=413-413;citation_volume=343;citation_year=1994;citation_issue=8894;citation_pmid=7905561" />
<meta name="citation_reference" content="citation_title=Obstetrics &amp; Gynecology;citation_journal_abbrev=Obstet Gynecol;citation_title=Disturbed feto-maternal cell traffic in preeclampsia.;citation_pages=669-672;citation_volume=91;citation_year=1998;citation_issue=5 Pt 1;citation_issn=0029-7844;citation_pmid=9572208;citation_doi=10.1016/S0029-7844(98)00068-4" />
<meta name="citation_reference" content="citation_title=Rheumatology.;citation_pages=1481;citation_year=2003" />
<meta name="citation_reference" content="citation_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_title=Identification of Fetal DNA and Cells in Skin Lesions from Women with Systemic Sclerosis;citation_pages=1186-1191;citation_volume=338;citation_year=1998;citation_issue=17;citation_issn=0028-4793;citation_pmid=9554859;citation_doi=10.1056/NEJM199804233381704" />
<meta name="citation_reference" content="citation_title=Lancet;citation_journal_abbrev=Lancet;citation_title=Microchimerism and HLA-compatible relationships of pregnancy in scleroderma.;citation_pages=559-562;citation_volume=351;citation_year=1998;citation_issue=9102;citation_pmid=9492775;citation_doi=10.1016/S0140-6736(97)08357-8" />
<meta name="citation_reference" content="citation_title=Arthritis and rheumatism;citation_journal_abbrev=Arthritis Rheum;citation_title=A syndrome resembling progressive systemic sclerosis after bone marrow transplantation. A model for scleroderma?;citation_pages=904-910;citation_volume=22;citation_year=1979;citation_issue=8;citation_pmid=37843" />
<meta name="citation_reference" content="citation_title=The Journal of Immunology;citation_journal_abbrev=J. Immunol.;citation_title=Anti-TGF-{beta} Treatment Prevents Skin and Lung Fibrosis in Murine Sclerodermatous Graft-Versus-Host Disease: A Model for Human Scleroderma;citation_pages=5693-5699;citation_volume=163;citation_year=1999;citation_issue=10;citation_issn=0022-1767;citation_pmid=10553100" />
<meta name="citation_reference" content="citation_title=Rheumatology.;citation_pages=1347;citation_year=2003" />
<meta name="citation_reference" content="citation_title=Rheumatology.;citation_pages=1624;citation_year=2003" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=MR angiography of cerebral vasospasm in preeclampsia;citation_pages=1344-1346;citation_volume=16;citation_year=1995;citation_issue=6;citation_issn=0195-6108;citation_pmid=7677037" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Prolonged Reversible Vasospasm in Cyclosporin A-Induced Encephalopathy;citation_pages=102-104;citation_volume=24;citation_year=2003;citation_issue=1;citation_issn=0195-6108;citation_pmid=12533334" />
<meta name="citation_reference" content="citation_title=Bone marrow transplantation;citation_journal_abbrev=Bone Marrow Transplant;citation_title=Cyclosporin A-related cerebral vasculopathy.;citation_pages=801-804;citation_volume=26;citation_year=2000;citation_issue=7;citation_pmid=11042665;citation_doi=10.1038/sj.bmt.1702603" />
<meta name="citation_reference" content="citation_title=Journal of computer assisted tomography;citation_journal_abbrev=J Comput Assist Tomogr;citation_title=Watershed imaging features and clinical vascular injury in cyclosporin A neurotoxicity.;citation_pages=872-880;citation_volume=21;citation_year=1997;citation_issue=6;citation_pmid=9386275;citation_doi=10.1097/00004728-199711000-00005" />
<meta name="citation_reference" content="citation_title=Journal of Biological Chemistry;citation_journal_abbrev=J Biol Chem;citation_title=Vascular Permeability Factor/Vascular Endothelial Cell Growth Factor-mediated Permeability Occurs through Disorganization of Endothelial Junctional Proteins;citation_pages=15099-15103;citation_volume=273;citation_year=1998;citation_issue=24;citation_issn=0021-9258;citation_pmid=9614120;citation_doi=10.1074/jbc.273.24.15099" />
<meta name="citation_reference" content="citation_title=Journal of Biological Chemistry;citation_journal_abbrev=J Biol Chem;citation_title=Transcriptional Regulation of the Rat Vascular Endothelial Growth Factor Gene by Hypoxia;citation_pages=13333-13340;citation_volume=270;citation_year=1995;citation_issue=22;citation_issn=0021-9258;citation_pmid=7768934;citation_doi=10.1074/jbc.270.22.13333" />
<meta name="citation_reference" content="citation_title=Nature; Physical Science (London);citation_journal_abbrev=Nature; Physical Science (London);citation_title=Vascular endothelial growth factor induced by hypoxia may mediate hypoxia-initiated angiogenesis.;citation_pages=843-845;citation_volume=359;citation_year=1992;citation_issue=6398;citation_pmid=1279431;citation_doi=10.1038/359843a0" />
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<meta name="twitter:title" content="Posterior Reversible Encephalopathy Syndrome, Part 2: Controversies Surrounding Pathophysiology of Vasogenic Edema" />
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<meta name="twitter:description" content="SUMMARY: Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state accompanied by a unique brain imaging pattern typically associated with a number of complex clinical conditions including: preeclampsia/eclampsia, allogeneic bone marrow transplantation, solid organ transplantation, autoimmune diseases and high dose cancer chemotherapy. The mechanism behind the developing vasogenic edema and CT or MR imaging appearance of PRES is not known. Two theories have historically been proposed: 1) Severe hypertension leads to failed auto-regulation, subsequent hyperperfusion, with endothelial injury/vasogenic edema and; 2) vasoconstriction and hypoperfusion leads to brain ischemia and subsequent vasogenic edema. The strengths/weaknesses of these hypotheses are reviewed in a translational fashion including supporting evidence and current available imaging/clinical data related to the conditions that develop PRES. While the hypertension/hyperperfusion theory has been most popular, the conditions associated with PRES have a similar immune challenge present and develop a similar state of T-cell/endothelial cell activation that may be the basis of leukocyte trafficking and systemic/cerebral vasoconstriction. These systemic features along with current vascular and perfusion imaging features in PRES appear to render strong support for the older theory of vasoconstriction coupled with hypoperfusion as the mechanism." />
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<meta name="og-description" property="og:description" content="SUMMARY: Posterior reversible encephalopathy syndrome (PRES) is a neurotoxic state accompanied by a unique brain imaging pattern typically associated with a number of complex clinical conditions including: preeclampsia/eclampsia, allogeneic bone marrow transplantation, solid organ transplantation, autoimmune diseases and high dose cancer chemotherapy. The mechanism behind the developing vasogenic edema and CT or MR imaging appearance of PRES is not known. Two theories have historically been proposed: 1) Severe hypertension leads to failed auto-regulation, subsequent hyperperfusion, with endothelial injury/vasogenic edema and; 2) vasoconstriction and hypoperfusion leads to brain ischemia and subsequent vasogenic edema. The strengths/weaknesses of these hypotheses are reviewed in a translational fashion including supporting evidence and current available imaging/clinical data related to the conditions that develop PRES. While the hypertension/hyperperfusion theory has been most popular, the conditions associated with PRES have a similar immune challenge present and develop a similar state of T-cell/endothelial cell activation that may be the basis of leukocyte trafficking and systemic/cerebral vasoconstriction. These systemic features along with current vascular and perfusion imaging features in PRES appear to render strong support for the older theory of vasoconstriction coupled with hypoperfusion as the mechanism." />
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 29</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 6 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">June 2008 </div></div>
      
      
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