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<meta name="DC.Title" content="Diffusion Tensor Imaging Study of the Cortical Origin and Course of the Corticospinal Tract in Healthy Children" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1742" />
<meta name="DC.Date" content="2009-11-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology. 
Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Several studies have questioned the traditional belief that the corticospinal tract (CST) arises exclusively from the precentral gyrus and passes through the anterior half of the posterior limb of the internal capsule (PLIC) in humans; however, no direct evidence existed from structural imaging, and developmental aspects of CST origin have not been clarified. We used diffusion tensor imaging (DTI) tractography to test the hypotheses that CST can originate from both pre- and postcentral gyri and is located posteriorly in the PLIC, and we also determined how age, sex, or handedness affected these locations.

MATERIALS AND METHODS: Forty-two healthy children (2.6–17.5 years of age; 20 girls) underwent DTI. Subsequently, tractography was performed on the basis of fiber assignment by continuous tracking (FACT) algorithm and brute force approach, with a fractional anisotropy (FA) threshold of &lt;0.2 and an angle threshold of &gt;50°. The CST was isolated by using a knowledge-based region-of-interest approach, and its cortical origin and location on the PLIC was determined.

RESULTS: DTI revealed that the CST originated from both pre- and postcentral gyri in 71.4% of hemispheres, from the precentral gyrus only in 19%, and from the postcentral gyrus only in 7.1%. The overall distribution was similar in both hemispheres. However, children with CST originating from both pre- and postcentral gyri were older (mean, 11.1 years of age) than those with precentral origin (mean, 5.8 years of age) or postcentral origin (mean, 7.8 years of age) only ( P = .00003). The center of the CST was localized at 65% of the length (from its anterior margin) of the PLIC, and the CST occupied 26.5% of its anteroposterior length. There was a significant positive correlation between age and FA of the CST ( r = 0.49; P = .002). The volume of the precentral portion of the left CST was significantly higher than that of its postcentral portion ( P = .01) and that of the right CST ( P = .0002). The pattern of cortical origin of CST, its location at the level of PLIC, and its volume and FA were unaffected by sex or handedness.

CONCLUSIONS: The CST most frequently originates from both pre- and postcentral gyri, especially in older children, and is typically centered approximately two thirds of the distance from the anterior margin of the PLIC and occupies about a quarter of its anteroposterior length. In young children, the CST can often be seen originating exclusively from the precentral gyrus by DTI." />
<meta name="DC.Contributor" content="A. Kumar" />
<meta name="DC.Contributor" content="C. Juhasz" />
<meta name="DC.Contributor" content="E. Asano" />
<meta name="DC.Contributor" content="S.K. Sundaram" />
<meta name="DC.Contributor" content="M.I. Makki" />
<meta name="DC.Contributor" content="D.C. Chugani" />
<meta name="DC.Contributor" content="H.T. Chugani" />
<meta name="article:published_time" content="2009-11-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="Diffusion Tensor Imaging Study of the Cortical Origin and Course of the Corticospinal Tract in Healthy Children" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Several studies have questioned the traditional belief that the corticospinal tract (CST) arises exclusively from the precentral gyrus and passes through the anterior half of the posterior limb of the internal capsule (PLIC) in humans; however, no direct evidence existed from structural imaging, and developmental aspects of CST origin have not been clarified. We used diffusion tensor imaging (DTI) tractography to test the hypotheses that CST can originate from both pre- and postcentral gyri and is located posteriorly in the PLIC, and we also determined how age, sex, or handedness affected these locations.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Forty-two healthy children (2.6–17.5 years of age; 20 girls) underwent DTI. Subsequently, tractography was performed on the basis of fiber assignment by continuous tracking (FACT) algorithm and brute force approach, with a fractional anisotropy (FA) threshold of &amp;lt;0.2 and an angle threshold of &amp;gt;50°. The CST was isolated by using a knowledge-based region-of-interest approach, and its cortical origin and location on the PLIC was determined.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;DTI revealed that the CST originated from both pre- and postcentral gyri in 71.4% of hemispheres, from the precentral gyrus only in 19%, and from the postcentral gyrus only in 7.1%. The overall distribution was similar in both hemispheres. However, children with CST originating from both pre- and postcentral gyri were older (mean, 11.1 years of age) than those with precentral origin (mean, 5.8 years of age) or postcentral origin (mean, 7.8 years of age) only (&lt;i&gt;P&lt;/i&gt; = .00003). The center of the CST was localized at 65% of the length (from its anterior margin) of the PLIC, and the CST occupied 26.5% of its anteroposterior length. There was a significant positive correlation between age and FA of the CST (&lt;i&gt;r&lt;/i&gt; = 0.49; &lt;i&gt;P&lt;/i&gt; = .002). The volume of the precentral portion of the left CST was significantly higher than that of its postcentral portion (&lt;i&gt;P&lt;/i&gt; = .01) and that of the right CST (&lt;i&gt;P&lt;/i&gt; = .0002). The pattern of cortical origin of CST, its location at the level of PLIC, and its volume and FA were unaffected by sex or handedness.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;The CST most frequently originates from both pre- and postcentral gyri, especially in older children, and is typically centered approximately two thirds of the distance from the anterior margin of the PLIC and occupies about a quarter of its anteroposterior length. In young children, the CST can often be seen originating exclusively from the precentral gyrus by DTI.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2009/11/01" />
<meta name="citation_mjid" content="ajnr;30/10/1963" />
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<meta name="citation_issn" content="0195-6108" />
<meta name="citation_issn" content="1936-959X" />
<meta name="citation_doi" content="10.3174/ajnr.A1742" />
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<meta name="citation_volume" content="30" />
<meta name="citation_issue" content="10" />
<meta name="citation_article_type" content="Research Article" />
<meta name="citation_section" content="Pediatrics" />
<meta name="citation_firstpage" content="1963" />
<meta name="citation_lastpage" content="1970" />
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<meta name="citation_author" content="A. Kumar" />
<meta name="citation_author" content="C. Juhasz" />
<meta name="citation_author" content="E. Asano" />
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<meta name="citation_author" content="M.I. Makki" />
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<meta name="citation_reference" content="citation_journal_title=Brain;citation_journal_abbrev=Brain;citation_author=W. Penfield;citation_author=E. Boldrey;citation_title=SOMATIC MOTOR AND SENSORY REPRESENTATION IN THE CEREBRAL CORTEX OF MAN AS STUDIED BY ELECTRICAL STIMULATION;citation_pages=389-443;citation_volume=60;citation_year=1937;citation_issue=4;citation_issn=0006-8950;citation_doi=10.1093/brain/60.4.389" />
<meta name="citation_reference" content="citation_journal_title=Brain;citation_author=M. Fukuda;citation_author=M. Nishida;citation_author=C. Juhasz;citation_title=Short-latency median-nerve somatosensory-evoked potentials and induced gamma-oscillations in humans;citation_volume=131;citation_year=2008;citation_pmid=18508784;citation_doi=10.1093/brain/awn100" />
<meta name="citation_reference" content="citation_journal_title=Epilepsy research;citation_journal_abbrev=Epilepsy Res;citation_author=A. Haseeb;citation_author=E. Asano;citation_author=C. Juhasz;citation_title=Young patients with focal seizures may have the primary motor area for the hand in the postcentral gyrus.;citation_pages=131-139;citation_volume=76;citation_year=2007;citation_issue=2-3;citation_pmid=17723289;citation_doi=10.1016/j.eplepsyres.2007.07.007" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=Y. Nii;citation_author=S. Uematsu;citation_author=RP. Lesser;citation_title=Does the central sulcus divide motor and sensory functions: Cortical mapping of human hand areas as revealed by electrical stimulation through subdural grid electrodes;citation_pages=360-367;citation_volume=46;citation_year=1996;citation_issue=2;citation_issn=0028-3878;citation_pmid=8614495" />
<meta name="citation_reference" content="citation_journal_title=Neurosurgery;citation_journal_abbrev=Neurosurgery;citation_author=S. Uematsu;citation_author=R. Lesser;citation_author=RS. Fisher;citation_title=Motor and sensory cortex in humans: topography studied with chronic subdural stimulation.;citation_pages=59-71;citation_volume=31;citation_year=1992;citation_issue=1;citation_pmid=1641111;citation_doi=10.1227/00006123-199207000-00009" />
<meta name="citation_reference" content="citation_title=Lectures on the Localization of Cerebral and Spinal Diseases;citation_author=JM. Charcot;citation_author=WM. Hadden;citation_pages=186-89;citation_year=1883" />
<meta name="citation_reference" content="citation_title=Anatomie des Centres Nerveaux;citation_author=J. Dejerine;citation_pages=720;citation_year=1901" />
<meta name="citation_reference" content="citation_title=Motorische Felder und Bahnen;citation_author=O. Foerster;citation_year=1936" />
<meta name="citation_reference" content="citation_journal_title=Brain;citation_journal_abbrev=Brain;citation_author=E. Beck;citation_author=A. Bignami;citation_title=SOME NEURO-ANATOMICAL OBSERVATIONS IN CASES WITH STEREOTACTIC LESIONS FOR THE RELIEF OF PARKINSONISM;citation_pages=589-618;citation_volume=91;citation_year=1968;citation_issue=4;citation_issn=0006-8950;citation_pmid=4883843;citation_doi=10.1093/brain/91.4.589" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=G. Bertrand;citation_author=J. Blundell;citation_author=R. Musella;citation_title=ELECTRICAL EXPLORATION OF THE INTERNAL CAPSULE AND NEIGHBOURING STRUCTURES DURING STEREOTAXIC PROCEDURES.;citation_pages=333-343;citation_volume=22;citation_year=1965;citation_pmid=14318109" />
<meta name="citation_reference" content="citation_journal_title=Confinia neurologica;citation_journal_abbrev=Confin Neurol;citation_author=FJ. Gillingham;citation_title=Small localised surgical lesions of the internal capsule in the treatment of the dyskinesias.;citation_pages=385-392;citation_volume=22;citation_year=1962;citation_pmid=13947938;citation_doi=10.1159/000104390" />
<meta name="citation_reference" content="citation_journal_title=Revue neurologique;citation_journal_abbrev=Rev Neurol (Paris);citation_author=G. Guiot;citation_author=J. Rougerie;citation_author=M. Sachs;citation_title=[Capsular stimulation in man; its importance in pallidal stereotaxy for parkinsonian syndromes.];citation_pages=222-224;citation_volume=98;citation_year=1958;citation_issue=3;citation_pmid=13579800" />
<meta name="citation_reference" content="citation_journal_title=Applied neurophysiology;citation_journal_abbrev=Appl Neurophysiol;citation_author=TL. Hardy;citation_author=G. Bertrand;citation_author=CJ. Thompson;citation_title=The position and organization of motor fibers in the internal capsule found during stereotactic surgery.;citation_pages=160-170;citation_volume=42;citation_year=1979;citation_issue=3;citation_pmid=380467" />
<meta name="citation_reference" content="citation_journal_title=Journal of Anatomy;citation_journal_abbrev=Journal of Anatomy;citation_author=HJ. Kretschmann;citation_title=Localisation of the corticospinal fibres in the internal capsule in man.;citation_pages=219-225;citation_volume=160;citation_year=1988;citation_pmid=3253257" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=DA. Rottenberg;citation_author=W. Talman;citation_author=NL. Chernik;citation_title=Location of pyramidal tract questioned;citation_pages=291-291;citation_volume=26;citation_year=1976;citation_issue=3;citation_issn=0028-3878;citation_pmid=943058" />
<meta name="citation_reference" content="citation_title=Gray's Anatomy: The Anatomical Basis of Clinical Practice;citation_title=Cerebral hemisphere;citation_author=S. Standring;citation_pages=387-418;citation_year=2005" />
<meta name="citation_reference" content="citation_journal_title=The Anatomical Record;citation_journal_abbrev=The Anatomical Record;citation_author=S. Mori;citation_author=PB. Barker;citation_title=Diffusion magnetic resonance imaging: its principle and applications.;citation_pages=102-109;citation_volume=257;citation_year=1999;citation_issue=3;citation_pmid=10397783;citation_doi=10.1002/(SICI)1097-0185(19990615)257:3&lt;102::AID-AR7&gt;3.0.CO;2-6" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=JI. Berman;citation_author=MS. Berger;citation_author=P. Mukherjee;citation_title=Diffusion-tensor imaging-guided tracking of fibers of the pyramidal tract combined with intraoperative cortical stimulation mapping in patients with gliomas.;citation_pages=66-72;citation_volume=101;citation_year=2004;citation_issue=1;citation_pmid=15255253;citation_doi=10.3171/jns.2004.101.1.0066" />
<meta name="citation_reference" content="citation_journal_title=Surgical neurology;citation_journal_abbrev=Surg Neurol;citation_author=VA. Coenen;citation_author=T. Krings;citation_author=H. Axer;citation_title=Intraoperative three-dimensional visualization of the pyramidal tract in a neuronavigation system (PTV) reliably predicts true position of principal motor pathways.;citation_pages=381-390;citation_volume=60;citation_year=2003;citation_issue=5;citation_pmid=14572954;citation_doi=10.1016/S0090-3019(03)00392-6" />
<meta name="citation_reference" content="citation_journal_title=Radiology;citation_author=AI. Holodny;citation_author=DM. Gor;citation_author=R. Watts;citation_title=Diffusion-tensor MR tractography of somatotopic organization of corticospinal tracts in the internal capsule: initial anatomic results in contradistinction to prior reports;citation_volume=234;citation_year=2005;citation_pmid=15665224" />
<meta name="citation_reference" content="citation_journal_title=Neurosurgery;citation_journal_abbrev=Neurosurgery;citation_author=K. Kamada;citation_author=Y. Sawamura;citation_author=F. Takeuchi;citation_title=Functional identification of the primary motor area by corticospinal tractography.;citation_pages=98-109;citation_volume=56;citation_year=2005;citation_issue=1 Suppl;citation_pmid=15799797" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=N. Mikuni;citation_author=T. Okada;citation_author=N. Nishida;citation_title=Comparison between motor evoked potential recording and fiber tracking for estimating pyramidal tracts near brain tumors.;citation_pages=128-133;citation_volume=106;citation_year=2007;citation_issue=1;citation_pmid=17236498" />
<meta name="citation_reference" content="citation_journal_title=Brain;citation_author=JM. Newton;citation_author=NS. Ward;citation_author=GJ. Parker;citation_title=Non-invasive mapping of corticofugal fibres from multiple motor areas: relevance to stroke recovery;citation_volume=129;citation_year=2006;citation_pmid=16702192;citation_doi=10.1093/brain/awl106" />
<meta name="citation_reference" content="citation_journal_title=Radiology;citation_author=T. Okada;citation_author=N. Mikuni;citation_author=Y. Miki;citation_title=Corticospinal tract localization: integration of diffusion-tensor tractography at 3-T MR imaging with intraoperative white matter stimulation mapping—preliminary results;citation_volume=240;citation_year=2006;citation_pmid=16857980;citation_doi=10.1148/radiol.2403050916" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=DK. Jones;citation_title=The effect of gradient sampling schemes on measures derived from diffusion tensor MRI: a Monte Carlo study.;citation_pages=807-815;citation_volume=51;citation_year=2004;citation_issue=4;citation_pmid=15065255;citation_doi=10.1002/mrm.20033" />
<meta name="citation_reference" content="citation_journal_title=Human brain mapping;citation_journal_abbrev=Hum Brain Mapp;citation_author=DK. Jones;citation_author=SC. Williams;citation_author=D. Gasston;citation_title=Isotropic resolution diffusion tensor imaging with whole brain acquisition in a clinically acceptable time.;citation_pages=216-230;citation_volume=15;citation_year=2002;citation_issue=4;citation_pmid=11835610;citation_doi=10.1002/hbm.10018" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance imaging :  JMRI;citation_journal_abbrev=J Magn Reson Imaging;citation_author=T. Zhu;citation_author=X. Liu;citation_author=MD. Gaugh;citation_title=Evaluation of measurement uncertainties in human diffusion tensor imaging (DTI)-derived parameters and optimization of clinical DTI protocols with a wild bootstrap analysis.;citation_pages=422-435;citation_volume=29;citation_year=2009;citation_issue=2;citation_pmid=19161198;citation_doi=10.1002/jmri.21647" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=TG. Reese;citation_author=DA. Feinberg;citation_author=J. Dou;citation_title=Phase contrast MRI of myocardial 3D strain by encoding contiguous slices in a single shot.;citation_pages=665-676;citation_volume=47;citation_year=2002;citation_issue=4;citation_pmid=11948727;citation_doi=10.1002/mrm.10111" />
<meta name="citation_reference" content="citation_journal_title=Journal of computer assisted tomography;citation_journal_abbrev=J Comput Assist Tomogr;citation_author=RP. Woods;citation_author=ST. Grafton;citation_author=CJ. Holmes;citation_title=Automated image registration: I. General methods and intrasubject, intramodality validation.;citation_pages=139-152;citation_volume=22;citation_year=1998;citation_issue=1;citation_pmid=9448779;citation_doi=10.1097/00004728-199801000-00027" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance. Series B;citation_journal_abbrev=J Magn Reson B;citation_author=PJ. Basser;citation_author=J. Mattiello;citation_author=D. LeBihan;citation_title=Estimation of the effective self-diffusion tensor from the NMR spin echo.;citation_pages=247-254;citation_volume=103;citation_year=1994;citation_issue=3;citation_pmid=8019776;citation_doi=10.1006/jmrb.1994.1037" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=MS. Berger;citation_author=WA. Cohen;citation_author=GA. Ojemann;citation_title=Correlation of motor cortex brain mapping data with magnetic resonance imaging.;citation_pages=383-387;citation_volume=72;citation_year=1990;citation_issue=3;citation_pmid=2303872;citation_doi=10.3171/jns.1990.72.3.0383" />
<meta name="citation_reference" content="citation_journal_title=Journal of neurosurgery;citation_journal_abbrev=J Neurosurg;citation_author=S. Lehericy;citation_author=H. Duffau;citation_author=P. Cornu;citation_title=Correspondence between functional magnetic resonance imaging somatotopy and individual brain anatomy of the central region: comparison with intraoperative stimulation in patients with brain tumors.;citation_pages=589-598;citation_volume=92;citation_year=2000;citation_issue=4;citation_pmid=10761647;citation_doi=10.3171/jns.2000.92.4.0589" />
<meta name="citation_reference" content="citation_journal_title=Human brain mapping;citation_journal_abbrev=Hum Brain Mapp;citation_author=JP. Makela;citation_author=E. Kirveskari;citation_author=M. Seppa;citation_title=Three-dimensional integration of brain anatomy and function to facilitate intraoperative navigation around the sensorimotor strip.;citation_pages=180-192;citation_volume=12;citation_year=2001;citation_issue=3;citation_pmid=11170309;citation_doi=10.1002/1097-0193(200103)12:3&lt;180::AID-HBM1014&gt;3.0.CO;2-N" />
<meta name="citation_reference" content="citation_journal_title=Brain;citation_journal_abbrev=Brain;citation_author=TA. Yousry;citation_author=UD. Schmid;citation_author=H. Alkadhi;citation_title=Localization of the motor hand area to a knob on the precentral gyrus. A new landmark;citation_pages=141-157;citation_volume=120;citation_year=1997;citation_issue=Pt 1;citation_issn=0006-8950;citation_pmid=9055804;citation_doi=10.1093/brain/120.1.141" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=HM. von Stockhausen;citation_author=A. Thiel;citation_author=K. Herholz;citation_title=A convenient method for topographical localization of intracranial electrodes with MRI and a conventional radiograph;citation_pages=S514;citation_volume=5;citation_year=1997" />
<meta name="citation_reference" content="citation_journal_title=Journal fur Hirnforschung;citation_journal_abbrev=Journal fur Hirnforschung;citation_author=K. Toyoshima;citation_author=H. Sakai;citation_title=Exact cortical extent of the origin of the corticospinal tract (CST) and the quantitative contribution to the CST in different cytoarchitectonic areas. A study with horseradish peroxidase in the monkey.;citation_pages=257-269;citation_volume=23;citation_year=1982;citation_issue=3;citation_pmid=7130676" />
<meta name="citation_reference" content="citation_journal_title=Journal of Neurophysiology;citation_journal_abbrev=J. Neurophysiol.;citation_author=C. Xerri;citation_author=MM. Merzenich;citation_author=BE. Peterson;citation_title=Plasticity of Primary Somatosensory Cortex Paralleling Sensorimotor Skill Recovery From Stroke in Adult Monkeys;citation_pages=2119-2148;citation_volume=79;citation_year=1998;citation_issue=4;citation_issn=0022-3077;citation_pmid=9535973" />
<meta name="citation_reference" content="citation_journal_title=The Journal of Physiology;citation_journal_abbrev=J. Physiol.;citation_author=J. Brinkman;citation_author=JG. Colebatch;citation_author=R. Porter;citation_title=Responses of precentral cells during cooling of post-central cortex in conscious monkeys.;citation_pages=611-625;citation_volume=368;citation_year=1985;citation_issue=1;citation_issn=0022-3751;citation_pmid=4078751" />
<meta name="citation_reference" content="citation_journal_title=Academic radiology;citation_journal_abbrev=Acad Radiol;citation_author=T. Yoshiura;citation_author=S. Kumazawa;citation_author=T. Noguchi;citation_title=MR tractography based on directional diffusion function validation in somatotopic organization of the pyramidal tract.;citation_pages=186-192;citation_volume=15;citation_year=2008;citation_issue=2;citation_pmid=18206617;citation_doi=10.1016/j.acra.2007.09.009" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance imaging :  JMRI;citation_journal_abbrev=J Magn Reson Imaging;citation_author=M. Zarei;citation_author=H. Johansen-Berg;citation_author=M. Jenkinson;citation_title=Two-dimensional population map of cortical connections in the human internal capsule.;citation_pages=48-54;citation_volume=25;citation_year=2007;citation_issue=1;citation_pmid=17152053;citation_doi=10.1002/jmri.20810" />
<meta name="citation_reference" content="citation_journal_title=Brain;citation_journal_abbrev=Brain;citation_author=J. Rademacher;citation_author=U. Burgel;citation_author=S. Geyer;citation_title=Variability and asymmetry in the human precentral motor system: A cytoarchitectonic and myeloarchitectonic brain mapping study;citation_pages=2232-2258;citation_volume=124;citation_year=2001;citation_issue=11;citation_issn=0006-8950;citation_pmid=11673325;citation_doi=10.1093/brain/124.11.2232" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=PY. Herve;citation_author=F. Crivello;citation_author=G. Perchey;citation_title=Handedness and cerebral anatomical asymmetries in young adult males;citation_pages=1066-79;citation_volume=29;citation_year=2006;citation_pmid=16198126;citation_doi=10.1016/j.neuroimage.2005.08.031" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=R. Westerhausen;citation_author=RJ. Huster;citation_author=F. Kreuder;citation_title=Corticospinal tract asymmetries at the level of the internal capsule: is there an association with handedness?;citation_pages=379-86;citation_volume=37;citation_year=2007;citation_pmid=17601751;citation_doi=10.1016/j.neuroimage.2007.05.047" />
<meta name="citation_reference" content="citation_journal_title=Cereb Cortex;citation_author=N. Barnea-Goraly;citation_author=V. Menon;citation_author=M. Eckert;citation_title=White matter development during childhood and adolescence: a cross-sectional diffusion tensor imaging study;citation_volume=15;citation_year=2005;citation_pmid=15758200;citation_doi=10.1093/cercor/bhi062" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance imaging :  JMRI;citation_journal_abbrev=J Magn Reson Imaging;citation_author=D. Ben Bashat;citation_author=L. Ben Sira;citation_author=M. Graif;citation_title=Normal white matter development from infancy to adulthood: comparing diffusion tensor and high b value diffusion weighted MR images.;citation_pages=503-511;citation_volume=21;citation_year=2005;citation_issue=5;citation_pmid=15834918;citation_doi=10.1002/jmri.20281" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=D. Bonekamp;citation_author=LM. Nagae;citation_author=M. Degaonkar;citation_title=Diffusion tensor imaging in children and adolescents: reproducibility, hemispheric, and age-related differences;citation_pages=733-42;citation_volume=34;citation_year=2007;citation_pmid=17092743;citation_doi=10.1016/j.neuroimage.2006.09.020" />
<meta name="citation_reference" content="citation_journal_title=Cereb Cortex;citation_author=TJ. Eluvathingal;citation_author=KM. Hasan;citation_author=L. Kramer;citation_title=Quantitative diffusion tensor tractography of association and projection fibers in normally developing children and adolescents;citation_volume=17;citation_year=2007;citation_pmid=17307759;citation_doi=10.1093/cercor/bhm003" />
<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=L. Hermoye;citation_author=C. Saint-Martin;citation_author=G. Cosnard;citation_title=Pediatric diffusion tensor imaging: normal database and observation of the white matter maturation in early childhood;citation_pages=493-504;citation_volume=29;citation_year=2006;citation_pmid=16194615;citation_doi=10.1016/j.neuroimage.2005.08.017" />
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<meta name="citation_reference" content="citation_journal_title=PNAS;citation_journal_abbrev=Proc. Natl. Acad. Sci. USA;citation_author=P. Dassonville;citation_author=XH. Zhu;citation_author=K. Uurbil;citation_title=Functional activation in motor cortex reflects the direction and the degree of handedness;citation_pages=14015-14018;citation_volume=94;citation_year=1997;citation_issue=25;citation_issn=0027-8424;citation_pmid=9391144;citation_doi=10.1073/pnas.94.25.14015" />
<meta name="citation_reference" content="citation_journal_title=Trans Am Neurol Ass;citation_author=PI. Yakolev;citation_author=P. Rakic;citation_title=Patterns of decussation of bulbar pyramids and distribution of pyramidal tracts on two sides of the spinal cord;citation_pages=366-67;citation_volume=91;citation_year=1966" />
<meta name="citation_reference" content="citation_journal_title=Brain;citation_journal_abbrev=Brain;citation_author=PW. Nathan;citation_author=MC. Smith;citation_author=P. Deacon;citation_title=THE CORTICOSPINAL TRACTS IN MAN: COURSE AND LOCATION OF FIBRES AT DIFFERENT SEGMENTAL LEVELS;citation_pages=303-324;citation_volume=113;citation_year=1990;citation_issue=Pt 2;citation_issn=0006-8950;citation_pmid=2328407;citation_doi=10.1093/brain/113.2.303" />
<meta name="citation_reference" content="citation_journal_title=Cereb Cortex;citation_author=K. Hua;citation_author=K. Oishi;citation_author=J. Zhang;citation_title=Mapping of functional areas in the human cortex based on connectivity through association fibers;citation_volume=19;citation_year=2009;citation_pmid=19068488;citation_doi=10.1093/cercor/bhn215" />
<meta name="citation_fulltext_world_readable" content="" />
<meta name="twitter:title" content="Diffusion Tensor Imaging Study of the Cortical Origin and Course of the Corticospinal Tract in Healthy Children" />
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<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/30/10.cover.gif" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Several studies have questioned the traditional belief that the corticospinal tract (CST) arises exclusively from the precentral gyrus and passes through the anterior half of the posterior limb of the internal capsule (PLIC) in humans; however, no direct evidence existed from structural imaging, and developmental aspects of CST origin have not been clarified. We used diffusion tensor imaging (DTI) tractography to test the hypotheses that CST can originate from both pre- and postcentral gyri and is located posteriorly in the PLIC, and we also determined how age, sex, or handedness affected these locations.

MATERIALS AND METHODS: Forty-two healthy children (2.6–17.5 years of age; 20 girls) underwent DTI. Subsequently, tractography was performed on the basis of fiber assignment by continuous tracking (FACT) algorithm and brute force approach, with a fractional anisotropy (FA) threshold of &lt;0.2 and an angle threshold of &gt;50°. The CST was isolated by using a knowledge-based region-of-interest approach, and its cortical origin and location on the PLIC was determined.

RESULTS: DTI revealed that the CST originated from both pre- and postcentral gyri in 71.4% of hemispheres, from the precentral gyrus only in 19%, and from the postcentral gyrus only in 7.1%. The overall distribution was similar in both hemispheres. However, children with CST originating from both pre- and postcentral gyri were older (mean, 11.1 years of age) than those with precentral origin (mean, 5.8 years of age) or postcentral origin (mean, 7.8 years of age) only ( P = .00003). The center of the CST was localized at 65% of the length (from its anterior margin) of the PLIC, and the CST occupied 26.5% of its anteroposterior length. There was a significant positive correlation between age and FA of the CST ( r = 0.49; P = .002). The volume of the precentral portion of the left CST was significantly higher than that of its postcentral portion ( P = .01) and that of the right CST ( P = .0002). The pattern of cortical origin of CST, its location at the level of PLIC, and its volume and FA were unaffected by sex or handedness.

CONCLUSIONS: The CST most frequently originates from both pre- and postcentral gyri, especially in older children, and is typically centered approximately two thirds of the distance from the anterior margin of the PLIC and occupies about a quarter of its anteroposterior length. In young children, the CST can often be seen originating exclusively from the precentral gyrus by DTI." />
<meta name="og-title" property="og:title" content="Diffusion Tensor Imaging Study of the Cortical Origin and Course of the Corticospinal Tract in Healthy Children" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/30/10/1963" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Several studies have questioned the traditional belief that the corticospinal tract (CST) arises exclusively from the precentral gyrus and passes through the anterior half of the posterior limb of the internal capsule (PLIC) in humans; however, no direct evidence existed from structural imaging, and developmental aspects of CST origin have not been clarified. We used diffusion tensor imaging (DTI) tractography to test the hypotheses that CST can originate from both pre- and postcentral gyri and is located posteriorly in the PLIC, and we also determined how age, sex, or handedness affected these locations.

MATERIALS AND METHODS: Forty-two healthy children (2.6–17.5 years of age; 20 girls) underwent DTI. Subsequently, tractography was performed on the basis of fiber assignment by continuous tracking (FACT) algorithm and brute force approach, with a fractional anisotropy (FA) threshold of &lt;0.2 and an angle threshold of &gt;50°. The CST was isolated by using a knowledge-based region-of-interest approach, and its cortical origin and location on the PLIC was determined.

RESULTS: DTI revealed that the CST originated from both pre- and postcentral gyri in 71.4% of hemispheres, from the precentral gyrus only in 19%, and from the postcentral gyrus only in 7.1%. The overall distribution was similar in both hemispheres. However, children with CST originating from both pre- and postcentral gyri were older (mean, 11.1 years of age) than those with precentral origin (mean, 5.8 years of age) or postcentral origin (mean, 7.8 years of age) only ( P = .00003). The center of the CST was localized at 65% of the length (from its anterior margin) of the PLIC, and the CST occupied 26.5% of its anteroposterior length. There was a significant positive correlation between age and FA of the CST ( r = 0.49; P = .002). The volume of the precentral portion of the left CST was significantly higher than that of its postcentral portion ( P = .01) and that of the right CST ( P = .0002). The pattern of cortical origin of CST, its location at the level of PLIC, and its volume and FA were unaffected by sex or handedness.

CONCLUSIONS: The CST most frequently originates from both pre- and postcentral gyri, especially in older children, and is typically centered approximately two thirds of the distance from the anterior margin of the PLIC and occupies about a quarter of its anteroposterior length. In young children, the CST can often be seen originating exclusively from the precentral gyrus by DTI." />
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Diffusion Tensor Imaging Study of the Cortical Origin and Course of the Corticospinal Tract in Healthy Children</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">A. Kumar</span>, <span class="highwire-citation-author" data-delta="1">C. Juhasz</span>, <span class="highwire-citation-author" data-delta="2">E. Asano</span>, <span class="highwire-citation-author" data-delta="3">S.K. Sundaram</span>, <span class="highwire-citation-author" data-delta="4">M.I. Makki</span>, <span class="highwire-citation-author" data-delta="5">D.C. Chugani</span> and <span class="highwire-citation-author" data-delta="6">H.T. Chugani</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2009,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1963-1970; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1742 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-8366--6636509120" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">A. Kumar </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.%2BKumar%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kumar%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.%2BKumar%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">C. 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<p id="p-3"><strong>BACKGROUND AND PURPOSE:</strong> Several studies have questioned the traditional belief that the corticospinal tract (CST) arises exclusively from the precentral gyrus and passes through the anterior half of the posterior limb of the internal capsule (PLIC) in humans; however, no direct evidence existed from structural imaging, and developmental aspects of CST origin have not been clarified. We used diffusion tensor imaging (DTI) tractography to test the hypotheses that CST can originate from both pre- and postcentral gyri and is located posteriorly in the PLIC, and we also determined how age, sex, or handedness affected these locations.</p>
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<p id="p-4"><strong>MATERIALS AND METHODS:</strong> Forty-two healthy children (2.6–17.5 years of age; 20 girls) underwent DTI. Subsequently, tractography was performed on the basis of fiber assignment by continuous tracking (FACT) algorithm and brute force approach, with a fractional anisotropy (FA) threshold of &lt;0.2 and an angle threshold of &gt;50°. The CST was isolated by using a knowledge-based region-of-interest approach, and its cortical origin and location on the PLIC was determined.</p>
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<p id="p-5"><strong>RESULTS:</strong> DTI revealed that the CST originated from both pre- and postcentral gyri in 71.4% of hemispheres, from the precentral gyrus only in 19%, and from the postcentral gyrus only in 7.1%. The overall distribution was similar in both hemispheres. However, children with CST originating from both pre- and postcentral gyri were older (mean, 11.1 years of age) than those with precentral origin (mean, 5.8 years of age) or postcentral origin (mean, 7.8 years of age) only (<em>P</em> = .00003). The center of the CST was localized at 65% of the length (from its anterior margin) of the PLIC, and the CST occupied 26.5% of its anteroposterior length. There was a significant positive correlation between age and FA of the CST (<em>r</em> = 0.49; <em>P</em> = .002). The volume of the precentral portion of the left CST was significantly higher than that of its postcentral portion (<em>P</em> = .01) and that of the right CST (<em>P</em> = .0002). The pattern of cortical origin of CST, its location at the level of PLIC, and its volume and FA were unaffected by sex or handedness.</p>
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<p id="p-6"><strong>CONCLUSIONS:</strong> The CST most frequently originates from both pre- and postcentral gyri, especially in older children, and is typically centered approximately two thirds of the distance from the anterior margin of the PLIC and occupies about a quarter of its anteroposterior length. In young children, the CST can often be seen originating exclusively from the precentral gyrus by DTI.</p>
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