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<meta name="DC.Title" content="Preoperative Embolization of Cerebral Arteriovenous Malformations with Onyx" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1376" />
<meta name="DC.Date" content="2009-03-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Preoperative embolization facilitates the surgical management of complex cerebral arteriovenous malformations (cAVMs). This analysis aims to investigate the risks for preoperative cAVM embolization with Onyx.

MATERIALS AND METHODS: We retrospectively analyzed clinical data of all patients who underwent embolization with Onyx as a preoperative treatment of cAVMs at our institution since 2005 (US Food and Drug Administration [FDA] approval). Patients with arteriovenous fistulas were excluded. A total of 107 patients were treated for cAVMs during the study period. Of those patients, 41 underwent cAVM embolizations with Onyx in 82 procedures.

RESULTS: After the embolization, the cAVM diameter was reduced from 3.71 ± 1.55 cm to 3.06 ± 1.89 cm ( P &lt; .05). Median volume reduction was 75%. Complete occlusion with embolization alone was achieved in 4 (10%) cAVMs. The recurrence rate for completely occluded cAVMs was 50% (2 patients). A total of 71% of the 41 patients treated with Onyx underwent surgery, and 15% underwent radiosurgery. There were 9% who have not yet received definitive treatment of their residual cAVMs. A new permanent neurologic deficit occurred in 5 patients (6.1% per procedure or 12.2% per patient).

CONCLUSIONS: A considerable risk for a permanent neurologic deficit remains for cAVM embolization with Onyx. The risk has to be carefully weighted against the benefit of volume reduction in the treatment of cAVMs." />
<meta name="DC.Contributor" content="E.F. Hauck" />
<meta name="DC.Contributor" content="B.G. Welch" />
<meta name="DC.Contributor" content="J.A. White" />
<meta name="DC.Contributor" content="P.D. Purdy" />
<meta name="DC.Contributor" content="L.G. Pride" />
<meta name="DC.Contributor" content="D. Samson" />
<meta name="article:published_time" content="2009-03-01" />
<meta name="article:section" content="INTERVENTIONAL" />
<meta name="citation_title" content="Preoperative Embolization of Cerebral Arteriovenous Malformations with Onyx" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; Preoperative embolization facilitates the surgical management of complex cerebral arteriovenous malformations (cAVMs). This analysis aims to investigate the risks for preoperative cAVM embolization with Onyx.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIALS AND METHODS:&lt;/b&gt; We retrospectively analyzed clinical data of all patients who underwent embolization with Onyx as a preoperative treatment of cAVMs at our institution since 2005 (US Food and Drug Administration [FDA] approval). Patients with arteriovenous fistulas were excluded. A total of 107 patients were treated for cAVMs during the study period. Of those patients, 41 underwent cAVM embolizations with Onyx in 82 procedures.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; After the embolization, the cAVM diameter was reduced from 3.71 ± 1.55 cm to 3.06 ± 1.89 cm (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05). Median volume reduction was 75%. Complete occlusion with embolization alone was achieved in 4 (10%) cAVMs. The recurrence rate for completely occluded cAVMs was 50% (2 patients). A total of 71% of the 41 patients treated with Onyx underwent surgery, and 15% underwent radiosurgery. There were 9% who have not yet received definitive treatment of their residual cAVMs. A new permanent neurologic deficit occurred in 5 patients (6.1% per procedure or 12.2% per patient).&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS:&lt;/b&gt; A considerable risk for a permanent neurologic deficit remains for cAVM embolization with Onyx. The risk has to be carefully weighted against the benefit of volume reduction in the treatment of cAVMs.&lt;/p&gt;" />
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<meta name="citation_author" content="E.F. Hauck" />
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<meta name="citation_author" content="P.D. Purdy" />
<meta name="citation_author" content="L.G. Pride" />
<meta name="citation_author" content="D. Samson" />
<meta name="twitter:title" content="Preoperative Embolization of Cerebral Arteriovenous Malformations with Onyx" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Preoperative embolization facilitates the surgical management of complex cerebral arteriovenous malformations (cAVMs). This analysis aims to investigate the risks for preoperative cAVM embolization with Onyx.

MATERIALS AND METHODS: We retrospectively analyzed clinical data of all patients who underwent embolization with Onyx as a preoperative treatment of cAVMs at our institution since 2005 (US Food and Drug Administration [FDA] approval). Patients with arteriovenous fistulas were excluded. A total of 107 patients were treated for cAVMs during the study period. Of those patients, 41 underwent cAVM embolizations with Onyx in 82 procedures.

RESULTS: After the embolization, the cAVM diameter was reduced from 3.71 ± 1.55 cm to 3.06 ± 1.89 cm ( P &lt; .05). Median volume reduction was 75%. Complete occlusion with embolization alone was achieved in 4 (10%) cAVMs. The recurrence rate for completely occluded cAVMs was 50% (2 patients). A total of 71% of the 41 patients treated with Onyx underwent surgery, and 15% underwent radiosurgery. There were 9% who have not yet received definitive treatment of their residual cAVMs. A new permanent neurologic deficit occurred in 5 patients (6.1% per procedure or 12.2% per patient).

CONCLUSIONS: A considerable risk for a permanent neurologic deficit remains for cAVM embolization with Onyx. The risk has to be carefully weighted against the benefit of volume reduction in the treatment of cAVMs." />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Preoperative embolization facilitates the surgical management of complex cerebral arteriovenous malformations (cAVMs). This analysis aims to investigate the risks for preoperative cAVM embolization with Onyx.

MATERIALS AND METHODS: We retrospectively analyzed clinical data of all patients who underwent embolization with Onyx as a preoperative treatment of cAVMs at our institution since 2005 (US Food and Drug Administration [FDA] approval). Patients with arteriovenous fistulas were excluded. A total of 107 patients were treated for cAVMs during the study period. Of those patients, 41 underwent cAVM embolizations with Onyx in 82 procedures.

RESULTS: After the embolization, the cAVM diameter was reduced from 3.71 ± 1.55 cm to 3.06 ± 1.89 cm ( P &lt; .05). Median volume reduction was 75%. Complete occlusion with embolization alone was achieved in 4 (10%) cAVMs. The recurrence rate for completely occluded cAVMs was 50% (2 patients). A total of 71% of the 41 patients treated with Onyx underwent surgery, and 15% underwent radiosurgery. There were 9% who have not yet received definitive treatment of their residual cAVMs. A new permanent neurologic deficit occurred in 5 patients (6.1% per procedure or 12.2% per patient).

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    <div class="highwire-article-citation highwire-citation-type-highwire-article node7830" data-node-nid="7830" id="top-node-7830--21168129003" data-pisa="ajnr;30/3/492" data-pisa-master="ajnr;ajnr.A1376" data-apath="/ajnr/30/3/492.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">Preoperative Embolization of Cerebral Arteriovenous Malformations with Onyx</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">E.F. Hauck</span>, <span class="highwire-citation-author" data-delta="1">B.G. Welch</span>, <span class="highwire-citation-author" data-delta="2">J.A. White</span>, <span class="highwire-citation-author" data-delta="3">P.D. Purdy</span>, <span class="highwire-citation-author" data-delta="4">L.G. Pride</span> and <span class="highwire-citation-author" data-delta="5">D. Samson</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 2009,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">492-495; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1376 </span></div>
  
  
  
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