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<meta name="DC.Title" content="The Shrinking Thyroid: How Does Thyroid Size Change Following Radiation Therapy for Laryngeal Cancer?" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1406" />
<meta name="DC.Date" content="2009-03-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: External beam radiation therapy (XRT) for head and neck cancer is known to induce hypothyroidism and cause morphologic changes in the thyroid gland. This retrospective study investigates change in the size of the thyroid gland detectable by CT after XRT for laryngeal cancer.

MATERIALS AND METHODS: The measured width of the thyroid lobes in 61 patients treated nonsurgically with XRT for laryngeal cancer between 2000 and 2003 on posttherapy CT was compared with that on pretherapy CT. Absolute and percentage changes in measured thyroid width following XRT were analyzed according to chemotherapy administration and posttherapy thyroid function.

RESULTS: Eighty-five percent (52/61) of patients had a decrease in the width of the thyroid gland. The average change in width measuring −4.7 mm and −13.8% (SD, 5.7 mm and 19.9%) occurred at an average of 758 days following completion of XRT (mean, 402-1534 days) and was significant ( P = .002). Average change in width between hypothyroid patients ( n = 19, −6.1 mm and −20.0% change) and euthyroid patients ( n = 42, −4.1 mm and −11.1% change) was not significant ( P = .20 absolute change and P = .11 percentage change). The average change in width between patients receiving chemotherapy ( n = 31, −5.5 mm and −16.1% change) and patients not receiving chemotherapy ( n = 30, −3.9 mm and −11.5% change) was not significant ( P = .26 absolute change and P = .37 for percentage change).

CONCLUSIONS: Most nonsurgical patients receiving XRT for laryngeal cancer have a significant decrease in the width of their thyroid glands detected on CT. The average change in the size of the thyroid gland does not differ when development of hypothyroidism or chemotherapy administration are considered." />
<meta name="DC.Contributor" content="M.M. Miller-Thomas" />
<meta name="DC.Contributor" content="A.J. Kumar" />
<meta name="DC.Contributor" content="R.V. Sellin" />
<meta name="DC.Contributor" content="S. Azimpoor" />
<meta name="DC.Contributor" content="K.K. Ang" />
<meta name="article:published_time" content="2009-03-01" />
<meta name="article:section" content="HEAD &amp;amp; NECK" />
<meta name="citation_title" content="The Shrinking Thyroid: How Does Thyroid Size Change Following Radiation Therapy for Laryngeal Cancer?" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; External beam radiation therapy (XRT) for head and neck cancer is known to induce hypothyroidism and cause morphologic changes in the thyroid gland. This retrospective study investigates change in the size of the thyroid gland detectable by CT after XRT for laryngeal cancer.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIALS AND METHODS:&lt;/b&gt; The measured width of the thyroid lobes in 61 patients treated nonsurgically with XRT for laryngeal cancer between 2000 and 2003 on posttherapy CT was compared with that on pretherapy CT. Absolute and percentage changes in measured thyroid width following XRT were analyzed according to chemotherapy administration and posttherapy thyroid function.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Eighty-five percent (52/61) of patients had a decrease in the width of the thyroid gland. The average change in width measuring −4.7 mm and −13.8% (SD, 5.7 mm and 19.9%) occurred at an average of 758 days following completion of XRT (mean, 402-1534 days) and was significant (&lt;i&gt;P&lt;/i&gt; = .002). Average change in width between hypothyroid patients (&lt;i&gt;n&lt;/i&gt; = 19, −6.1 mm and −20.0% change) and euthyroid patients (&lt;i&gt;n&lt;/i&gt; = 42, −4.1 mm and −11.1% change) was not significant (&lt;i&gt;P&lt;/i&gt; = .20 absolute change and &lt;i&gt;P&lt;/i&gt; = .11 percentage change). The average change in width between patients receiving chemotherapy (&lt;i&gt;n&lt;/i&gt; = 31, −5.5 mm and −16.1% change) and patients not receiving chemotherapy (&lt;i&gt;n&lt;/i&gt; = 30, −3.9 mm and −11.5% change) was not significant (&lt;i&gt;P&lt;/i&gt; = .26 absolute change and &lt;i&gt;P&lt;/i&gt; = .37 for percentage change).&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS:&lt;/b&gt; Most nonsurgical patients receiving XRT for laryngeal cancer have a significant decrease in the width of their thyroid glands detected on CT. The average change in the size of the thyroid gland does not differ when development of hypothyroidism or chemotherapy administration are considered.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_publication_date" content="2009/03/01" />
<meta name="citation_mjid" content="ajnr;30/3/613" />
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<meta name="citation_issn" content="0195-6108" />
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<meta name="twitter:title" content="The Shrinking Thyroid: How Does Thyroid Size Change Following Radiation Therapy for Laryngeal Cancer?" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: External beam radiation therapy (XRT) for head and neck cancer is known to induce hypothyroidism and cause morphologic changes in the thyroid gland. This retrospective study investigates change in the size of the thyroid gland detectable by CT after XRT for laryngeal cancer.

MATERIALS AND METHODS: The measured width of the thyroid lobes in 61 patients treated nonsurgically with XRT for laryngeal cancer between 2000 and 2003 on posttherapy CT was compared with that on pretherapy CT. Absolute and percentage changes in measured thyroid width following XRT were analyzed according to chemotherapy administration and posttherapy thyroid function.

RESULTS: Eighty-five percent (52/61) of patients had a decrease in the width of the thyroid gland. The average change in width measuring −4.7 mm and −13.8% (SD, 5.7 mm and 19.9%) occurred at an average of 758 days following completion of XRT (mean, 402-1534 days) and was significant ( P = .002). Average change in width between hypothyroid patients ( n = 19, −6.1 mm and −20.0% change) and euthyroid patients ( n = 42, −4.1 mm and −11.1% change) was not significant ( P = .20 absolute change and P = .11 percentage change). The average change in width between patients receiving chemotherapy ( n = 31, −5.5 mm and −16.1% change) and patients not receiving chemotherapy ( n = 30, −3.9 mm and −11.5% change) was not significant ( P = .26 absolute change and P = .37 for percentage change).

CONCLUSIONS: Most nonsurgical patients receiving XRT for laryngeal cancer have a significant decrease in the width of their thyroid glands detected on CT. The average change in the size of the thyroid gland does not differ when development of hypothyroidism or chemotherapy administration are considered." />
<meta name="og-title" property="og:title" content="The Shrinking Thyroid: How Does Thyroid Size Change Following Radiation Therapy for Laryngeal Cancer?" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: External beam radiation therapy (XRT) for head and neck cancer is known to induce hypothyroidism and cause morphologic changes in the thyroid gland. This retrospective study investigates change in the size of the thyroid gland detectable by CT after XRT for laryngeal cancer.

MATERIALS AND METHODS: The measured width of the thyroid lobes in 61 patients treated nonsurgically with XRT for laryngeal cancer between 2000 and 2003 on posttherapy CT was compared with that on pretherapy CT. Absolute and percentage changes in measured thyroid width following XRT were analyzed according to chemotherapy administration and posttherapy thyroid function.

RESULTS: Eighty-five percent (52/61) of patients had a decrease in the width of the thyroid gland. The average change in width measuring −4.7 mm and −13.8% (SD, 5.7 mm and 19.9%) occurred at an average of 758 days following completion of XRT (mean, 402-1534 days) and was significant ( P = .002). Average change in width between hypothyroid patients ( n = 19, −6.1 mm and −20.0% change) and euthyroid patients ( n = 42, −4.1 mm and −11.1% change) was not significant ( P = .20 absolute change and P = .11 percentage change). The average change in width between patients receiving chemotherapy ( n = 31, −5.5 mm and −16.1% change) and patients not receiving chemotherapy ( n = 30, −3.9 mm and −11.5% change) was not significant ( P = .26 absolute change and P = .37 for percentage change).

CONCLUSIONS: Most nonsurgical patients receiving XRT for laryngeal cancer have a significant decrease in the width of their thyroid glands detected on CT. The average change in the size of the thyroid gland does not differ when development of hypothyroidism or chemotherapy administration are considered." />
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 30</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 3 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">March 2009 </div></div>
      
      
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      <div class="highwire-cite-title">The Shrinking Thyroid: How Does Thyroid Size Change Following Radiation Therapy for Laryngeal Cancer?</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Miller-Thomas</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Kumar</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">R.V.</span> <span class="nlm-surname">Sellin</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Azimpoor</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">K.K.</span> <span class="nlm-surname">Ang</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2009, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">613-616; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1406 </span></div>
  
  
  
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      <div class="highwire-cite-title">The Shrinking Thyroid: How Does Thyroid Size Change Following Radiation Therapy for Laryngeal Cancer?</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Miller-Thomas</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Kumar</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">R.V.</span> <span class="nlm-surname">Sellin</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Azimpoor</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">K.K.</span> <span class="nlm-surname">Ang</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2009, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">613-616; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1406 </span></div>
  
  
  
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