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<meta name="citation_reference" content="citation_title=Stroke;citation_volume=37;citation_year=2006;citation_pmid=16888269;citation_doi=10.1161/01.STR.0000237060.21472.47" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=36;citation_year=2005;citation_pmid=15569865;citation_doi=10.1161/01.STR.0000150515.15576.29" />
<meta name="citation_reference" content="citation_title=Neurology;citation_journal_abbrev=Neurology;citation_title=Cerebral hemorrhage after intra-arterial thrombolysis for ischemic stroke: The PROACT II trial;citation_pages=1603-1610;citation_volume=57;citation_year=2001;citation_issue=9;citation_issn=0028-3878;citation_pmid=11706099" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=38;citation_year=2007;citation_pmid=17702956;citation_doi=10.1161/STROKEAHA.107.490417" />
<meta name="citation_reference" content="citation_title=Journal of Neurology, Neurosurgery &amp; Psychiatry;citation_journal_abbrev=J. Neurol. Neurosurg. Psychiatry;citation_title=Intra-arterial thrombolysis in 24 consecutive patients with internal carotid artery T occlusions;citation_pages=739-742;citation_volume=74;citation_year=2003;citation_issue=6;citation_issn=0022-3050;citation_pmid=12754342;citation_doi=10.1136/jnnp.74.6.739" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Thrombolytic therapy in acute occlusion of the intracranial internal carotid artery bifurcation;citation_pages=1977-1986;citation_volume=16;citation_year=1995;citation_issue=10;citation_issn=0195-6108;citation_pmid=8585483" />
<meta name="citation_reference" content="citation_title=Stroke;citation_journal_abbrev=Stroke;citation_title=Response to Intra-Arterial and Combined Intravenous and Intra-Arterial Thrombolytic Therapy in Patients With Distal Internal Carotid Artery Occlusion * Editorial Comment;citation_pages=1821-1827;citation_volume=33;citation_year=2002;citation_issue=7;citation_issn=0039-2499;citation_pmid=12105360;citation_doi=10.1161/01.STR.0000020363.23725.67" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Recanalization by Mechanical Embolus Disruption during Intra-Arterial Thrombolysis in the Carotid Territory;citation_pages=1391-1402;citation_volume=25;citation_year=2004;citation_issue=8;citation_issn=0195-6108;citation_pmid=15466340" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=38;citation_year=2007;citation_pmid=17332445;citation_doi=10.1161/01.STR.0000260187.33864.a7" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=36;citation_year=2005;citation_pmid=16224082;citation_doi=10.1161/01.STR.0000185924.22918.51" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=39;citation_year=2008;citation_pmid=18420951;citation_doi=10.1161/STROKEAHA.107.505404" />
<meta name="citation_reference" content="citation_title=Journal of Neurology, Neurosurgery &amp; Psychiatry;citation_journal_abbrev=J. Neurol. Neurosurg. Psychiatry;citation_title=Comparison of intra-arterial thrombolysis with conventional treatment in patients with acute central retinal artery occlusion;citation_pages=196-199;citation_volume=76;citation_year=2005;citation_issue=2;citation_issn=0022-3050;citation_pmid=15654031;citation_doi=10.1136/jnnp.2004.037135" />
<meta name="citation_reference" content="citation_title=British Journal of Ophthalmology;citation_journal_abbrev=Br J Ophthalmol;citation_title=Intra-arterial thrombolysis for central retinal artery occlusion: a systematic review;citation_pages=588-593;citation_volume=92;citation_year=2008;citation_issue=5;citation_issn=0007-1161;citation_pmid=18441166;citation_doi=10.1136/bjo.2007.133488" />
<meta name="citation_reference" content="citation_title=Stroke;citation_journal_abbrev=Stroke;citation_title=Intra-Arterial Thrombolysis for Basilar Artery Thrombosis: Trial It;citation_pages=704-706;citation_volume=38;citation_year=2007;citation_issue=2;citation_issn=0039-2499;citation_pmid=17261721;citation_doi=10.1161/01.STR.0000254128.05122.a2" />
<meta name="citation_reference" content="citation_title=Stroke;citation_journal_abbrev=Stroke;citation_title=Intra-Arterial Thrombolytic Therapy for Acute Basilar Occlusion: Pro;citation_pages=701-703;citation_volume=38;citation_year=2007;citation_issue=2;citation_issn=0039-2499;citation_pmid=17261720;citation_doi=10.1161/01.STR.0000247897.33267.42" />
<meta name="citation_reference" content="citation_title=Cerebrovascular diseases (Basel, Switzerland);citation_journal_abbrev=Cerebrovasc Dis;citation_title=Results of a multicentre, randomised controlled trial of intra-arterial urokinase in the treatment of acute posterior circulation ischaemic stroke.;citation_pages=12-17;citation_volume=20;citation_year=2005;citation_issue=1;citation_pmid=15925877;citation_doi=10.1159/000086121" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Local intraarterial thrombolysis in vertebrobasilar thromboembolic disease.;citation_pages=401-404;citation_volume=4;citation_year=1983;citation_issue=3;citation_issn=0195-6108;citation_pmid=6410756" />
<meta name="citation_reference" content="citation_title=Stroke: Pathophysiology, Diagnosis, and Management.;citation_pages=943;citation_year=2004" />
<meta name="citation_reference" content="citation_title=Stroke;citation_pages=9authorreply10;citation_volume=38;citation_year=2007;citation_issn=0039-2499" />
<meta name="citation_reference" content="citation_journal_abbrev=Int J Stroke;citation_title=The basilar artery international cooperation study (BASICS).;citation_pages=220-223;citation_volume=2;citation_year=2007;citation_issue=3;citation_pmid=18705948;citation_doi=10.1111/j.1747-4949.2007.00145.x" />
<meta name="citation_reference" content="citation_title=Proceedings of the 17th European Stroke Conference;citation_year=2008" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=40;citation_year=2009;citation_pmid=18927446;citation_doi=10.1161/STROKEAHA.108.526566" />
<meta name="citation_reference" content="citation_journal_abbrev=J Stroke Cerebrovasc Dis;citation_title=Vertebrobasilar revascularization rates and outcomes in the MERCI and multi-MERCI trials.;citation_pages=55-57;citation_volume=17;citation_year=2008;citation_issue=2;citation_pmid=18346645;citation_doi=10.1016/j.jstrokecerebrovasdis.2007.11.003" />
<meta name="citation_reference" content="citation_title=Neurosurgery;citation_journal_abbrev=Neurosurgery;citation_title=Factors affecting survival rates for acute vertebrobasilar artery occlusions treated with intra-arterial thrombolytic therapy: a meta-analytical approach.;citation_pages=539-545;citation_volume=45;citation_year=1999;citation_issue=3;citation_pmid=10493376;citation_doi=10.1097/00006123-199909000-00025" />
<meta name="citation_reference" content="citation_title=Journal of Neuroimaging;citation_journal_abbrev=J Neuroimaging;citation_title=Extensive brainstem ischemia on neuroimaging does not preclude meaningful recovery from locked-in syndrome: two cases of endovascularly managed basilar thrombosis.;citation_pages=15-17;citation_volume=18;citation_year=2008;citation_issue=1;citation_issn=1051-2284;citation_pmid=18190490" />
<meta name="citation_reference" content="citation_title=Stroke;citation_journal_abbrev=Stroke;citation_title=Combined Intravenous and Intra-Arterial r-TPA Versus Intra-Arterial Therapy of Acute Ischemic Stroke : Emergency Management of Stroke (EMS) Bridging Trial;citation_pages=2598-2605;citation_volume=30;citation_year=1999;citation_issue=12;citation_issn=0039-2499;citation_pmid=10582984;citation_doi=10.1161/01.STR.30.12.2598" />
<meta name="citation_reference" content="citation_journal_abbrev=J Stroke Cerebrovasc Dis;citation_title=Comparison of combined venous and arterial thrombolysis with primary arterial therapy using recombinant tissue plasminogen activator in acute ischemic stroke.;citation_pages=121-128;citation_volume=17;citation_year=2008;citation_issue=3;citation_pmid=18436152;citation_doi=10.1016/j.jstrokecerebrovasdis.2007.12.004" />
<meta name="citation_reference" content="citation_title=Stroke;citation_journal_abbrev=Stroke;citation_title=Combined Intravenous and Intra-Arterial Recombinant Tissue Plasminogen Activator in Acute Ischemic Stroke;citation_pages=2552-2557;citation_volume=31;citation_year=2000;citation_issue=11;citation_issn=0039-2499;citation_pmid=11062274" />
<meta name="citation_reference" content="citation_title=Neurosurgery;citation_journal_abbrev=Neurosurgery;citation_title=Endovascular administration after intravenous infusion of thrombolytic agents for the treatment of patients with acute ischemic strokes.;citation_pages=251-259;citation_volume=50;citation_year=2002;citation_issue=2;citation_pmid=11844259;citation_doi=10.1097/00006123-200202000-00005" />
<meta name="citation_reference" content="citation_title=Stroke;citation_journal_abbrev=Stroke;citation_title=Acute Intravenous-Intra-Arterial Revascularization Therapy for Severe Ischemic Stroke;citation_pages=279-282;citation_volume=33;citation_year=2002;citation_issue=1;citation_issn=0039-2499;citation_pmid=11779923;citation_doi=10.1161/hs0102.101900" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=38;citation_year=2007;citation_pmid=17122433;citation_doi=10.1161/01.STR.0000251720.25337.b0" />
<meta name="citation_reference" content="citation_title=AJNR Am J Neuroradiol;citation_volume=29;citation_year=2008;citation_pmid=18784214;citation_doi=10.3174/ajnr.A1236" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Combined Intraarterial/Intravenous Thrombolysis for Acute Ischemic Stroke;citation_pages=352-358;citation_volume=22;citation_year=2001;citation_issue=2;citation_issn=0195-6108;citation_pmid=11156782" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=35;citation_year=2004;citation_pmid=15017018;citation_doi=10.1161/01.STR.0000121641.77121.98" />
<meta name="citation_reference" content="citation_title=New England Journal of Medicine;citation_journal_abbrev=NEJM;citation_title=Tissue Plasminogen Activator for Acute Ischemic Stroke;citation_pages=1581-1588;citation_volume=333;citation_year=1995;citation_issue=24;citation_issn=0028-4793;citation_pmid=7477192;citation_doi=10.1056/NEJM199512143332401" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=37;citation_year=2006;citation_pmid=16439694;citation_doi=10.1161/01.STR.0000202586.69525.ae" />
<meta name="citation_reference" content="citation_title=Stroke;citation_volume=36;citation_year=2005;citation_pmid=16224088;citation_doi=10.1161/01.STR.0000185698.45720.58" />
<meta name="citation_reference" content="citation_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_title=Using the Baseline CT Scan to Select Acute Stroke Patients for IV-IA Therapy.;citation_pages=1612-1616;citation_volume=27;citation_year=2006;citation_issue=8;citation_issn=0195-6108;citation_pmid=16971597" />
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<meta name="twitter:title" content="Endovascular Approaches to Acute Stroke, Part 2: A Comprehensive Review of Studies and Trials" />
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<meta name="twitter:description" content="SUMMARY: Reperfusion remains the mainstay of acute ischemic stroke treatment. Endovascular therapy has become a promising alternative for patients who are ineligible for or have failed intravenous (IV) thrombolysis. The conviction that recanalization of properly selected patients is essential for the achievement of good clinical outcomes has led to the rapid and widespread growth in the adoption of endovascular stroke therapies. However, comparisons of the recent reperfusion studies have brought into question the strength of the association between revascularization and improved clinical outcome. Despite higher rates of recanalization, the mechanical thrombectomy studies have demonstrated substantially lower rates of good outcomes compared with IV and/or intra-arterial thrombolytic trials. However, such analyses disregard important differences in clot location and burden, baseline stroke severity, time from stroke onset to treatment, and patient selection in these studies. Many clinical trials are testing novel devices and drugs as well as the paradigm of physiology-based stroke imaging as a treatment-selection tool. The objective of this article is to provide a comprehensive review of the relevant past, current, and upcoming data on endovascular stroke therapy with a special focus on the prospective studies and randomized clinical trials." />
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<meta name="og-description" property="og:description" content="SUMMARY: Reperfusion remains the mainstay of acute ischemic stroke treatment. Endovascular therapy has become a promising alternative for patients who are ineligible for or have failed intravenous (IV) thrombolysis. The conviction that recanalization of properly selected patients is essential for the achievement of good clinical outcomes has led to the rapid and widespread growth in the adoption of endovascular stroke therapies. However, comparisons of the recent reperfusion studies have brought into question the strength of the association between revascularization and improved clinical outcome. Despite higher rates of recanalization, the mechanical thrombectomy studies have demonstrated substantially lower rates of good outcomes compared with IV and/or intra-arterial thrombolytic trials. However, such analyses disregard important differences in clot location and burden, baseline stroke severity, time from stroke onset to treatment, and patient selection in these studies. Many clinical trials are testing novel devices and drugs as well as the paradigm of physiology-based stroke imaging as a treatment-selection tool. The objective of this article is to provide a comprehensive review of the relevant past, current, and upcoming data on endovascular stroke therapy with a special focus on the prospective studies and randomized clinical trials." />
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      <h1 class="highwire-cite-title" id="page-title">Endovascular Approaches to Acute Stroke, Part 2: A Comprehensive Review of Studies and Trials</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">R.G. Nogueira</span>, <span class="highwire-citation-author" data-delta="1">A.J. Yoo</span>, <span class="highwire-citation-author" data-delta="2">F.S. Buonanno</span> and <span class="highwire-citation-author" data-delta="3">J.A. Hirsch</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2009,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">859-875; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1604 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">R.G.</span> <span class="nlm-surname">Nogueira</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.J.</span> <span class="nlm-surname">Yoo</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">F.S.</span> <span class="nlm-surname">Buonanno</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.A.</span> <span class="nlm-surname">Hirsch</span></span></span></div>
  
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