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<meta name="DC.Title" content="Cerebrovascular Reactivity Is a Main Determinant of White Matter Hyperintensity Progression in CADASIL" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1533" />
<meta name="DC.Date" content="2009-06-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Basal total cerebral blood flow (TCBF) and cerebrovascular reactivity (CVR) are assumed to play an important role in the pathophysiology of small-vessel disease. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a unique monogenetic model to study the pathophysiology of arterial small-vessel disease. The aim of this study was to investigate the role of TCBF and CVR in the progression of MR imaging abnormalities in CADASIL.

MATERIALS AND METHODS: Basal TCBF was measured in 25 NOTCH3 mutation carriers and 13 control subjects at baseline. CVR after administration of acetazolamide was measured in 14 NOTCH3 mutation carriers and 9 control subjects. Increase in white matter hyperintensities (WMHs), lacunar infarcts, and microbleeds on MR imaging was measured 7 years later.

RESULTS: Lower CVR at baseline was associated with larger increase of WMHs ( P = .001) but not with a larger increase of lacunar infarcts or microbleeds. TCBF at baseline was not associated with an increase of MR imaging abnormalities.

CONCLUSIONS: Decreased CVR is a potential predictor of disease progression as indicated by increasing WMHs in CADASIL." />
<meta name="DC.Contributor" content="M.K. Liem" />
<meta name="DC.Contributor" content="S.A.J. Lesnik Oberstein" />
<meta name="DC.Contributor" content="J. Haan" />
<meta name="DC.Contributor" content="R.v.d. Boom" />
<meta name="DC.Contributor" content="M.D. Ferrari" />
<meta name="DC.Contributor" content="M.A.v. Buchem" />
<meta name="DC.Contributor" content="J.v.d. Grond" />
<meta name="article:published_time" content="2009-06-01" />
<meta name="article:section" content="BRAIN" />
<meta name="citation_title" content="Cerebrovascular Reactivity Is a Main Determinant of White Matter Hyperintensity Progression in CADASIL" />
<meta name="citation_abstract" lang="en" content="&lt;p&gt;&lt;b&gt;BACKGROUND AND PURPOSE:&lt;/b&gt; Basal total cerebral blood flow (TCBF) and cerebrovascular reactivity (CVR) are assumed to play an important role in the pathophysiology of small-vessel disease. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a unique monogenetic model to study the pathophysiology of arterial small-vessel disease. The aim of this study was to investigate the role of TCBF and CVR in the progression of MR imaging abnormalities in CADASIL.&lt;/p&gt;&lt;p&gt;&lt;b&gt;MATERIALS AND METHODS:&lt;/b&gt; Basal TCBF was measured in 25 &lt;i&gt;NOTCH3&lt;/i&gt; mutation carriers and 13 control subjects at baseline. CVR after administration of acetazolamide was measured in 14 NOTCH3 mutation carriers and 9 control subjects. Increase in white matter hyperintensities (WMHs), lacunar infarcts, and microbleeds on MR imaging was measured 7 years later.&lt;/p&gt;&lt;p&gt;&lt;b&gt;RESULTS:&lt;/b&gt; Lower CVR at baseline was associated with larger increase of WMHs (&lt;i&gt;P&lt;/i&gt; = .001) but not with a larger increase of lacunar infarcts or microbleeds. TCBF at baseline was not associated with an increase of MR imaging abnormalities.&lt;/p&gt;&lt;p&gt;&lt;b&gt;CONCLUSIONS:&lt;/b&gt; Decreased CVR is a potential predictor of disease progression as indicated by increasing WMHs in CADASIL.&lt;/p&gt;" />
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<meta name="twitter:title" content="Cerebrovascular Reactivity Is a Main Determinant of White Matter Hyperintensity Progression in CADASIL" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Basal total cerebral blood flow (TCBF) and cerebrovascular reactivity (CVR) are assumed to play an important role in the pathophysiology of small-vessel disease. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a unique monogenetic model to study the pathophysiology of arterial small-vessel disease. The aim of this study was to investigate the role of TCBF and CVR in the progression of MR imaging abnormalities in CADASIL.

MATERIALS AND METHODS: Basal TCBF was measured in 25 NOTCH3 mutation carriers and 13 control subjects at baseline. CVR after administration of acetazolamide was measured in 14 NOTCH3 mutation carriers and 9 control subjects. Increase in white matter hyperintensities (WMHs), lacunar infarcts, and microbleeds on MR imaging was measured 7 years later.

RESULTS: Lower CVR at baseline was associated with larger increase of WMHs ( P = .001) but not with a larger increase of lacunar infarcts or microbleeds. TCBF at baseline was not associated with an increase of MR imaging abnormalities.

CONCLUSIONS: Decreased CVR is a potential predictor of disease progression as indicated by increasing WMHs in CADASIL." />
<meta name="og-title" property="og:title" content="Cerebrovascular Reactivity Is a Main Determinant of White Matter Hyperintensity Progression in CADASIL" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Basal total cerebral blood flow (TCBF) and cerebrovascular reactivity (CVR) are assumed to play an important role in the pathophysiology of small-vessel disease. Cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL) is a unique monogenetic model to study the pathophysiology of arterial small-vessel disease. The aim of this study was to investigate the role of TCBF and CVR in the progression of MR imaging abnormalities in CADASIL.

MATERIALS AND METHODS: Basal TCBF was measured in 25 NOTCH3 mutation carriers and 13 control subjects at baseline. CVR after administration of acetazolamide was measured in 14 NOTCH3 mutation carriers and 9 control subjects. Increase in white matter hyperintensities (WMHs), lacunar infarcts, and microbleeds on MR imaging was measured 7 years later.

RESULTS: Lower CVR at baseline was associated with larger increase of WMHs ( P = .001) but not with a larger increase of lacunar infarcts or microbleeds. TCBF at baseline was not associated with an increase of MR imaging abnormalities.

CONCLUSIONS: Decreased CVR is a potential predictor of disease progression as indicated by increasing WMHs in CADASIL." />
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">M.K. Liem</span>, <span class="highwire-citation-author" data-delta="1">S.A.J. Lesnik Oberstein</span>, <span class="highwire-citation-author" data-delta="2">J. Haan</span>, <span class="highwire-citation-author" data-delta="3">R.v.d. Boom</span>, <span class="highwire-citation-author" data-delta="4">M.D. Ferrari</span>, <span class="highwire-citation-author" data-delta="5">M.A.v. Buchem</span> and <span class="highwire-citation-author" data-delta="6">J.v.d. Grond</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">June 2009,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1244-1247; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1533 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-7962--61376256377" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">M.K. Liem </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.K.%2BLiem%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Liem%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.K.%2BLiem%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">S.A.J. 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Boom </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.v.d.%2BBoom%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Boom%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.v.d.%2BBoom%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">M.D. Ferrari </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.D.%2BFerrari%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ferrari%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.D.%2BFerrari%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">M.A.v. Buchem </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.A.v.%2BBuchem%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Buchem%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.A.v.%2BBuchem%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">J.v.d. 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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 30</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 6 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">June 2009 </div></div>
      
      
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      <div class="highwire-cite-title">Cerebrovascular Reactivity Is a Main Determinant of White Matter Hyperintensity Progression in CADASIL</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.K.</span> <span class="nlm-surname">Liem</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.A.J.</span> <span class="nlm-surname">Lesnik Oberstein</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Haan</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">R.v.d.</span> <span class="nlm-surname">Boom</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.D.</span> <span class="nlm-surname">Ferrari</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.A.v.</span> <span class="nlm-surname">Buchem</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.v.d.</span> <span class="nlm-surname">Grond</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2009, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1244-1247; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1533 </span></div>
  
  
  
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      <div class="highwire-cite-title">Cerebrovascular Reactivity Is a Main Determinant of White Matter Hyperintensity Progression in CADASIL</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">M.K.</span> <span class="nlm-surname">Liem</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">S.A.J.</span> <span class="nlm-surname">Lesnik Oberstein</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Haan</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">R.v.d.</span> <span class="nlm-surname">Boom</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.D.</span> <span class="nlm-surname">Ferrari</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.A.v.</span> <span class="nlm-surname">Buchem</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.v.d.</span> <span class="nlm-surname">Grond</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2009, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">30 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1244-1247; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1533 </span></div>
  
  
  
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