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<meta name="DC.Title" content="White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study" />
<meta name="DC.Identifier" content="10.3174/ajnr.A2195" />
<meta name="DC.Date" content="2010-11-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD.

MATERIALS AND METHODS: FA and MD maps from DTI were obtained in 14 patients with DPD and 18 patients with NDPD. Region-of-interest−guided VBA was conducted on the FA maps to detect possible microstructural differences in the thalamus between these 2 patient groups. Moreover, mean FA and MD in regions with a detected difference were compared between DPD and NDPD groups, and correlations between diffusion quantities and the severity of depression were analyzed.

RESULTS: White matter microstructure differences were found between the patients with DPD and NDPD in the bilateral mediodorsal thalamic regions. In these regions, patients with DPD showed significantly decreased FA values ( P &lt; .005) compared with patients with NDPD, and the mean values of FA were negatively correlated with the scores of depression severity ( P &lt; .05) for patients with PD. No significant differences of MD were found in the mediodorsal thalamus between these 2 groups.

CONCLUSIONS: Our results provide preliminary evidence that the mediodorsal thalamus may play an important role in depression in PD and suggest a relationship between FA in the mediodorsal thalamus and the presence of depressive symptoms in patients with DPD. These findings may be helpful for further understanding the potential mechanisms of depression in PD.

DPD
:   depressed PD
DSM
:   Diagnostic and Statistical Manual of Mental Disorders
DTI
:   diffusion tensor imaging
FA
:   fractional anisotropy
fMRI
:   functional MR imaging
FMRIB
:   Functional MR Imaging of the Brain
FSL
:   FMRIB Software Library
HAMD
:   Hamilton Depression Scale
H-Y
:   Hoehn–Yahr staging
LEDD
:   L-dopa equivalent daily dosage
MD
:   mean diffusivity
MDD
:   major depressive disorder
mFA
:   mean value of FA
mMD
:   mean value of MD
MMSE
:   Mini-Mental State Examination
MNI
:   Montreal Neurological Institute
NDPD
:   nondepressed PD
NS
:   not significant
PD
:   Parkinson disease
UPDRS
:   Unified Parkinson Disease Rating Scale
VBA
:   voxel-based analysis
VBM
:   voxel-based morphometry" />
<meta name="DC.Contributor" content="W. Li" />
<meta name="DC.Contributor" content="J. Liu" />
<meta name="DC.Contributor" content="F. Skidmore" />
<meta name="DC.Contributor" content="Y. Liu" />
<meta name="DC.Contributor" content="J. Tian" />
<meta name="DC.Contributor" content="K. Li" />
<meta name="article:published_time" content="2010-11-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;FA and MD maps from DTI were obtained in 14 patients with DPD and 18 patients with NDPD. Region-of-interest−guided VBA was conducted on the FA maps to detect possible microstructural differences in the thalamus between these 2 patient groups. Moreover, mean FA and MD in regions with a detected difference were compared between DPD and NDPD groups, and correlations between diffusion quantities and the severity of depression were analyzed.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;White matter microstructure differences were found between the patients with DPD and NDPD in the bilateral mediodorsal thalamic regions. In these regions, patients with DPD showed significantly decreased FA values (&lt;i&gt;P&lt;/i&gt; &amp;lt; .005) compared with patients with NDPD, and the mean values of FA were negatively correlated with the scores of depression severity (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05) for patients with PD. No significant differences of MD were found in the mediodorsal thalamus between these 2 groups.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Our results provide preliminary evidence that the mediodorsal thalamus may play an important role in depression in PD and suggest a relationship between FA in the mediodorsal thalamus and the presence of depressive symptoms in patients with DPD. These findings may be helpful for further understanding the potential mechanisms of depression in PD.&lt;/p&gt;" />
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<meta name="twitter:title" content="White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD.

MATERIALS AND METHODS: FA and MD maps from DTI were obtained in 14 patients with DPD and 18 patients with NDPD. Region-of-interest−guided VBA was conducted on the FA maps to detect possible microstructural differences in the thalamus between these 2 patient groups. Moreover, mean FA and MD in regions with a detected difference were compared between DPD and NDPD groups, and correlations between diffusion quantities and the severity of depression were analyzed.

RESULTS: White matter microstructure differences were found between the patients with DPD and NDPD in the bilateral mediodorsal thalamic regions. In these regions, patients with DPD showed significantly decreased FA values ( P &lt; .005) compared with patients with NDPD, and the mean values of FA were negatively correlated with the scores of depression severity ( P &lt; .05) for patients with PD. No significant differences of MD were found in the mediodorsal thalamus between these 2 groups.

CONCLUSIONS: Our results provide preliminary evidence that the mediodorsal thalamus may play an important role in depression in PD and suggest a relationship between FA in the mediodorsal thalamus and the presence of depressive symptoms in patients with DPD. These findings may be helpful for further understanding the potential mechanisms of depression in PD.

DPD
:   depressed PD
DSM
:   Diagnostic and Statistical Manual of Mental Disorders
DTI
:   diffusion tensor imaging
FA
:   fractional anisotropy
fMRI
:   functional MR imaging
FMRIB
:   Functional MR Imaging of the Brain
FSL
:   FMRIB Software Library
HAMD
:   Hamilton Depression Scale
H-Y
:   Hoehn–Yahr staging
LEDD
:   L-dopa equivalent daily dosage
MD
:   mean diffusivity
MDD
:   major depressive disorder
mFA
:   mean value of FA
mMD
:   mean value of MD
MMSE
:   Mini-Mental State Examination
MNI
:   Montreal Neurological Institute
NDPD
:   nondepressed PD
NS
:   not significant
PD
:   Parkinson disease
UPDRS
:   Unified Parkinson Disease Rating Scale
VBA
:   voxel-based analysis
VBM
:   voxel-based morphometry" />
<meta name="og-title" property="og:title" content="White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/31/10/1861" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD.

MATERIALS AND METHODS: FA and MD maps from DTI were obtained in 14 patients with DPD and 18 patients with NDPD. Region-of-interest−guided VBA was conducted on the FA maps to detect possible microstructural differences in the thalamus between these 2 patient groups. Moreover, mean FA and MD in regions with a detected difference were compared between DPD and NDPD groups, and correlations between diffusion quantities and the severity of depression were analyzed.

RESULTS: White matter microstructure differences were found between the patients with DPD and NDPD in the bilateral mediodorsal thalamic regions. In these regions, patients with DPD showed significantly decreased FA values ( P &lt; .005) compared with patients with NDPD, and the mean values of FA were negatively correlated with the scores of depression severity ( P &lt; .05) for patients with PD. No significant differences of MD were found in the mediodorsal thalamus between these 2 groups.

CONCLUSIONS: Our results provide preliminary evidence that the mediodorsal thalamus may play an important role in depression in PD and suggest a relationship between FA in the mediodorsal thalamus and the presence of depressive symptoms in patients with DPD. These findings may be helpful for further understanding the potential mechanisms of depression in PD.

DPD
:   depressed PD
DSM
:   Diagnostic and Statistical Manual of Mental Disorders
DTI
:   diffusion tensor imaging
FA
:   fractional anisotropy
fMRI
:   functional MR imaging
FMRIB
:   Functional MR Imaging of the Brain
FSL
:   FMRIB Software Library
HAMD
:   Hamilton Depression Scale
H-Y
:   Hoehn–Yahr staging
LEDD
:   L-dopa equivalent daily dosage
MD
:   mean diffusivity
MDD
:   major depressive disorder
mFA
:   mean value of FA
mMD
:   mean value of MD
MMSE
:   Mini-Mental State Examination
MNI
:   Montreal Neurological Institute
NDPD
:   nondepressed PD
NS
:   not significant
PD
:   Parkinson disease
UPDRS
:   Unified Parkinson Disease Rating Scale
VBA
:   voxel-based analysis
VBM
:   voxel-based morphometry" />
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      <h1 class="highwire-cite-title" id="page-title">White Matter Microstructure Changes in the Thalamus in Parkinson Disease with Depression: A Diffusion Tensor MR Imaging Study</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">W. Li</span>, <span class="highwire-citation-author" data-delta="1">J. Liu</span>, <span class="highwire-citation-author" data-delta="2">F. Skidmore</span>, <span class="highwire-citation-author" data-delta="3">Y. Liu</span>, <span class="highwire-citation-author" data-delta="4">J. Tian</span> and <span class="highwire-citation-author" data-delta="5">K. Li</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2010,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1861-1866; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2195 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-9720--61873016088" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">W. Li </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.%2BLi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Li%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AW.%2BLi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J. Liu </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BLiu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Liu%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.%2BLiu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">F. Skidmore </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BSkidmore%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Skidmore%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.%2BSkidmore%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">Y. Liu </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=Y.%2BLiu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Liu%20Y&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AY.%2BLiu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">J. Tian </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.%2BTian%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tian%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.%2BTian%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">K. Li </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.%2BLi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Li%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AK.%2BLi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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<p id="p-3"><strong>BACKGROUND AND PURPOSE:</strong> Depression occurs frequently in PD; however the neural basis of depression in PD remains unclear. The aim of this study was to characterize possible depression-related white matter microstructural changes in the thalamus of patients with DPD compared with those with NDPD.</p>
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<p id="p-4"><strong>MATERIALS AND METHODS:</strong> FA and MD maps from DTI were obtained in 14 patients with DPD and 18 patients with NDPD. Region-of-interest−guided VBA was conducted on the FA maps to detect possible microstructural differences in the thalamus between these 2 patient groups. Moreover, mean FA and MD in regions with a detected difference were compared between DPD and NDPD groups, and correlations between diffusion quantities and the severity of depression were analyzed.</p>
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<p id="p-5"><strong>RESULTS:</strong> White matter microstructure differences were found between the patients with DPD and NDPD in the bilateral mediodorsal thalamic regions. In these regions, patients with DPD showed significantly decreased FA values (<em>P</em> &lt; .005) compared with patients with NDPD, and the mean values of FA were negatively correlated with the scores of depression severity (<em>P</em> &lt; .05) for patients with PD. No significant differences of MD were found in the mediodorsal thalamus between these 2 groups.</p>
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<p id="p-6"><strong>CONCLUSIONS:</strong> Our results provide preliminary evidence that the mediodorsal thalamus may play an important role in depression in PD and suggest a relationship between FA in the mediodorsal thalamus and the presence of depressive symptoms in patients with DPD. These findings may be helpful for further understanding the potential mechanisms of depression in PD.</p>
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</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">DPD<span class="def-item-dt-sep"></span></dt><dd>depressed PD<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">DSM<span class="def-item-dt-sep"></span></dt><dd>Diagnostic and Statistical Manual of Mental Disorders<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">DTI<span class="def-item-dt-sep"></span></dt><dd>diffusion tensor imaging<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">FA<span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">fMRI<span class="def-item-dt-sep"></span></dt><dd>functional MR imaging<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">FMRIB<span class="def-item-dt-sep"></span></dt><dd>Functional MR Imaging of the Brain<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">FSL<span class="def-item-dt-sep"></span></dt><dd>FMRIB Software Library<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">HAMD<span class="def-item-dt-sep"></span></dt><dd>Hamilton Depression Scale<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">H-Y<span class="def-item-dt-sep"></span></dt><dd>Hoehn–Yahr staging<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">LEDD<span class="def-item-dt-sep"></span></dt><dd>L-dopa equivalent daily dosage<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">MD<span class="def-item-dt-sep"></span></dt><dd>mean diffusivity<span class="def-item-dd-sep"></span></dd><dt id="def-item-12">MDD<span class="def-item-dt-sep"></span></dt><dd>major depressive disorder<span class="def-item-dd-sep"></span></dd><dt id="def-item-13">mFA<span class="def-item-dt-sep"></span></dt><dd>mean value of FA<span class="def-item-dd-sep"></span></dd><dt id="def-item-14">mMD<span class="def-item-dt-sep"></span></dt><dd>mean value of MD<span class="def-item-dd-sep"></span></dd><dt id="def-item-15">MMSE<span class="def-item-dt-sep"></span></dt><dd>Mini-Mental State Examination<span class="def-item-dd-sep"></span></dd><dt id="def-item-16">MNI<span class="def-item-dt-sep"></span></dt><dd>Montreal Neurological Institute<span class="def-item-dd-sep"></span></dd><dt id="def-item-17">NDPD<span class="def-item-dt-sep"></span></dt><dd>nondepressed PD<span class="def-item-dd-sep"></span></dd><dt id="def-item-18">NS<span class="def-item-dt-sep"></span></dt><dd>not significant<span class="def-item-dd-sep"></span></dd><dt id="def-item-19">PD<span class="def-item-dt-sep"></span></dt><dd>Parkinson disease<span class="def-item-dd-sep"></span></dd><dt id="def-item-20">UPDRS<span class="def-item-dt-sep"></span></dt><dd>Unified Parkinson Disease Rating Scale<span class="def-item-dd-sep"></span></dd><dt id="def-item-21">VBA<span class="def-item-dt-sep"></span></dt><dd>voxel-based analysis<span class="def-item-dd-sep"></span></dd><dt id="def-item-22">VBM<span class="def-item-dt-sep"></span></dt><dd>voxel-based morphometry</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-2">Indicates open access to non-subscribers at <a href="http://www.ajnr.org">www.ajnr.org</a></p></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/31/10/1861.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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