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<meta name="DC.Title" content="Multiple Inflow Pulsed Arterial Spin-Labeling Reveals Delays in the Arterial Arrival Time in Minor Stroke and Transient Ischemic Attack" />
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<meta name="DC.Description" content="Our purpose was to use multiple inflow pulsed ASL to investigate whether hemodynamic AAT information is sensitive to hemispheric asymmetry in acute ischemia. The cohorts included 15 patients with acute minor stroke or TIA and 15 age-matched controls. Patients were scanned by using a stroke MR imaging protocol at a median time of 74 hours. DWI lesion volumes were small and functional impairment was low; however, perfusion abnormalities were evident. Prolonged AAT values were more likely to reside in the affected hemisphere (significant when compared with controls, P &lt; .048). An advantage of this ASL technique is the ability to use AAT information in addition to CBF to characterize ischemia.

AAT
:   arterial arrival time
ASL
:   arterial spin-labeling
AUH
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CBF
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DSC
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DWI
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FMRIB
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GRASE
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ICA
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MCA
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NIHSS
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PASL
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TIA
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<meta name="DC.Contributor" content="B.J. MacIntosh" />
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&lt;p&gt;Our purpose was to use multiple inflow pulsed ASL to investigate whether hemodynamic AAT information is sensitive to hemispheric asymmetry in acute ischemia. The cohorts included 15 patients with acute minor stroke or TIA and 15 age-matched controls. Patients were scanned by using a stroke MR imaging protocol at a median time of 74 hours. DWI lesion volumes were small and functional impairment was low; however, perfusion abnormalities were evident. Prolonged AAT values were more likely to reside in the affected hemisphere (significant when compared with controls, &lt;i&gt;P&lt;/i&gt; &amp;lt; .048). An advantage of this ASL technique is the ability to use AAT information in addition to CBF to characterize ischemia.&lt;/p&gt;" />
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<meta name="twitter:title" content="Multiple Inflow Pulsed Arterial Spin-Labeling Reveals Delays in the Arterial Arrival Time in Minor Stroke and Transient Ischemic Attack" />
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<meta name="twitter:description" content="Our purpose was to use multiple inflow pulsed ASL to investigate whether hemodynamic AAT information is sensitive to hemispheric asymmetry in acute ischemia. The cohorts included 15 patients with acute minor stroke or TIA and 15 age-matched controls. Patients were scanned by using a stroke MR imaging protocol at a median time of 74 hours. DWI lesion volumes were small and functional impairment was low; however, perfusion abnormalities were evident. Prolonged AAT values were more likely to reside in the affected hemisphere (significant when compared with controls, P &lt; .048). An advantage of this ASL technique is the ability to use AAT information in addition to CBF to characterize ischemia.

AAT
:   arterial arrival time
ASL
:   arterial spin-labeling
AUH
:   area under the histogram
CBF
:   cerebral blood flow
DSC
:   dynamic susceptibility contrast
DWI
:   diffusion-weighted imaging
FMRIB
:   Functional MRI of the Brain
GRASE
:   gradient and spin-echo
ICA
:   internal carotid artery
MCA
:   middle cerebral artery
NIHSS
:   National Institutes of Health Stroke Scale
PASL
:   pulsed arterial spin-labeling
TIA
:   transient ischemic attack" />
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<meta name="og-description" property="og:description" content="Our purpose was to use multiple inflow pulsed ASL to investigate whether hemodynamic AAT information is sensitive to hemispheric asymmetry in acute ischemia. The cohorts included 15 patients with acute minor stroke or TIA and 15 age-matched controls. Patients were scanned by using a stroke MR imaging protocol at a median time of 74 hours. DWI lesion volumes were small and functional impairment was low; however, perfusion abnormalities were evident. Prolonged AAT values were more likely to reside in the affected hemisphere (significant when compared with controls, P &lt; .048). An advantage of this ASL technique is the ability to use AAT information in addition to CBF to characterize ischemia.

AAT
:   arterial arrival time
ASL
:   arterial spin-labeling
AUH
:   area under the histogram
CBF
:   cerebral blood flow
DSC
:   dynamic susceptibility contrast
DWI
:   diffusion-weighted imaging
FMRIB
:   Functional MRI of the Brain
GRASE
:   gradient and spin-echo
ICA
:   internal carotid artery
MCA
:   middle cerebral artery
NIHSS
:   National Institutes of Health Stroke Scale
PASL
:   pulsed arterial spin-labeling
TIA
:   transient ischemic attack" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node9719--5" data-node-nid="9719" id="top-node-9719--61982530695" data-pisa="ajnr;31/10/1892" data-pisa-master="ajnr;ajnr.A2008" data-apath="/ajnr/31/10/1892.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">Multiple Inflow Pulsed Arterial Spin-Labeling Reveals Delays in the Arterial Arrival Time in Minor Stroke and Transient Ischemic Attack</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">B.J. MacIntosh</span>, <span class="highwire-citation-author" data-delta="1">A.C. Lindsay</span>, <span class="highwire-citation-author" data-delta="2">I. Kylintireas</span>, <span class="highwire-citation-author" data-delta="3">W. Kuker</span>, <span class="highwire-citation-author" data-delta="4">M. Günther</span>, <span class="highwire-citation-author" data-delta="5">M.D. Robson</span>, <span class="highwire-citation-author" data-delta="6">J. Kennedy</span>, <span class="highwire-citation-author" data-delta="7">R.P. Choudhury</span> and <span class="highwire-citation-author" data-delta="8">P. Jezzard</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">November 2010,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1892-1894; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2008 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-9719--61982530695" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">B.J. MacIntosh </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B.J.%2BMacIntosh%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=MacIntosh%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AB.J.%2BMacIntosh%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">A.C. 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<p id="p-2">Our purpose was to use multiple inflow pulsed ASL to investigate whether hemodynamic AAT information is sensitive to hemispheric asymmetry in acute ischemia. The cohorts included 15 patients with acute minor stroke or TIA and 15 age-matched controls. Patients were scanned by using a stroke MR imaging protocol at a median time of 74 hours. DWI lesion volumes were small and functional impairment was low; however, perfusion abnormalities were evident. Prolonged AAT values were more likely to reside in the affected hemisphere (significant when compared with controls, <em>P</em> &lt; .048). An advantage of this ASL technique is the ability to use AAT information in addition to CBF to characterize ischemia.</p>
</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">AAT<span class="def-item-dt-sep"></span></dt><dd>arterial arrival time<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">ASL<span class="def-item-dt-sep"></span></dt><dd>arterial spin-labeling<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">AUH<span class="def-item-dt-sep"></span></dt><dd>area under the histogram<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">CBF<span class="def-item-dt-sep"></span></dt><dd>cerebral blood flow<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">DSC<span class="def-item-dt-sep"></span></dt><dd>dynamic susceptibility contrast<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">DWI<span class="def-item-dt-sep"></span></dt><dd>diffusion-weighted imaging<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">FMRIB<span class="def-item-dt-sep"></span></dt><dd>Functional MRI of the Brain<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">GRASE<span class="def-item-dt-sep"></span></dt><dd>gradient and spin-echo<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">ICA<span class="def-item-dt-sep"></span></dt><dd>internal carotid artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">MCA<span class="def-item-dt-sep"></span></dt><dd>middle cerebral artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">NIHSS<span class="def-item-dt-sep"></span></dt><dd>National Institutes of Health Stroke Scale<span class="def-item-dd-sep"></span></dd><dt id="def-item-12">PASL<span class="def-item-dt-sep"></span></dt><dd>pulsed arterial spin-labeling<span class="def-item-dd-sep"></span></dd><dt id="def-item-13">TIA<span class="def-item-dt-sep"></span></dt><dd>transient ischemic attack</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at 
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 31</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 10 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Nov 2010 </div></div>
      
      
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      <div class="highwire-cite-title">Multiple Inflow Pulsed Arterial Spin-Labeling Reveals Delays in the Arterial Arrival Time in Minor Stroke and Transient Ischemic Attack</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">B.J.</span> <span class="nlm-surname">MacIntosh</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">A.C.</span> <span class="nlm-surname">Lindsay</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">I.</span> <span class="nlm-surname">Kylintireas</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">W.</span> <span class="nlm-surname">Kuker</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Günther</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.D.</span> <span class="nlm-surname">Robson</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Kennedy</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">R.P.</span> <span class="nlm-surname">Choudhury</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Jezzard</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Nov 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(10) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1892-1894; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2008 </span></div>
  
  
  
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