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<meta name="DC.Title" content="A Novel Association between RASA1 Mutations and Spinal Arteriovenous Anomalies" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1907" />
<meta name="DC.Date" content="2010-04-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: CM-AVM is a recently recognized autosomal dominant disorder associated with mutations in RASA1 . Arteriovenous lesions have been reported in the brain, limbs, and the face in 18.5% of patients. We report a novel association between RASA1 mutations and spinal arteriovenous anomalies.

MATERIALS AND METHODS: In a collaborative study, 5 index patients (2 females, 3 males) with spinal AVMs or AVFs and cutaneous multifocal capillary lesions were investigated for the RASA1 gene mutation.

RESULTS: All 5 patients were found to have RASA1 mutation (2 de novo, 3 familial), and all had multifocal capillary malformations at birth. Neurologic deficits developed at ages ranging from infancy to early adulthood. All spinal anomalies (2 AVMs at the conus, 1 AVM at the lumbosacral junction, and 1 cervical and 1 cervicothoracic AVF) were complex, extensive, and fast-flow lesions. All patients required treatment based on the clinical and/or radiologic appearance of the lesions.

CONCLUSIONS: To our knowledge, an association of RASA1 mutation and spinal AVM/AVF has not been described. MR imaging screening of patients with characteristic CMs and neurologic symptoms presenting at a young age may be useful in detecting the presence of fast-flow intracranial or intraspinal arteriovenous anomalies before potentially significant neurologic insult has occurred.

ASA
:   anterior spinal artery
AVF
:   arteriovenous fistula
AVM
:   arteriovenous malformation
CM
:   capillary malformation
GTP
:   guanosine 5′-triphosphate
HHT
:   hereditary hemorrhagic telangiectasia
n -BCA
:   n -butyl 2-cyanoacrylate
R
:   right
SWS
:   Sturge-Weber syndrome" />
<meta name="DC.Contributor" content="R. Thiex" />
<meta name="DC.Contributor" content="J.B. Mulliken" />
<meta name="DC.Contributor" content="N. Revencu" />
<meta name="DC.Contributor" content="L.M. Boon" />
<meta name="DC.Contributor" content="P.E. Burrows" />
<meta name="DC.Contributor" content="M. Cordisco" />
<meta name="DC.Contributor" content="Y. Dwight" />
<meta name="DC.Contributor" content="E.R. Smith" />
<meta name="DC.Contributor" content="M. Vikkula" />
<meta name="DC.Contributor" content="D.B. Orbach" />
<meta name="article:published_time" content="2010-04-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="A Novel Association between RASA1 Mutations and Spinal Arteriovenous Anomalies" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;CM-AVM is a recently recognized autosomal dominant disorder associated with mutations in &lt;i&gt;RASA1&lt;/i&gt;. Arteriovenous lesions have been reported in the brain, limbs, and the face in 18.5% of patients. We report a novel association between &lt;i&gt;RASA1&lt;/i&gt; mutations and spinal arteriovenous anomalies.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;In a collaborative study, 5 index patients (2 females, 3 males) with spinal AVMs or AVFs and cutaneous multifocal capillary lesions were investigated for the &lt;i&gt;RASA1&lt;/i&gt; gene mutation.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;All 5 patients were found to have &lt;i&gt;RASA1&lt;/i&gt; mutation (2 de novo, 3 familial), and all had multifocal capillary malformations at birth. Neurologic deficits developed at ages ranging from infancy to early adulthood. All spinal anomalies (2 AVMs at the conus, 1 AVM at the lumbosacral junction, and 1 cervical and 1 cervicothoracic AVF) were complex, extensive, and fast-flow lesions. All patients required treatment based on the clinical and/or radiologic appearance of the lesions.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;To our knowledge, an association of &lt;i&gt;RASA1&lt;/i&gt; mutation and spinal AVM/AVF has not been described. MR imaging screening of patients with characteristic CMs and neurologic symptoms presenting at a young age may be useful in detecting the presence of fast-flow intracranial or intraspinal arteriovenous anomalies before potentially significant neurologic insult has occurred.&lt;/p&gt;" />
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<meta name="citation_reference" content="citation_journal_title=Human mutation;citation_journal_title=Hum Mutat;citation_author=N. Revencu;citation_author=LM. Boon;citation_author=JB. Mulliken;citation_title=Parkes Weber syndrome, vein of Galen aneurysmal malformation, and other fast-flow vascular anomalies are caused by RASA1 mutations.;citation_pages=959-965;citation_volume=29;citation_year=2008;citation_issue=7;citation_pmid=18446851;citation_doi=10.1002/humu.20746" />
<meta name="citation_reference" content="citation_journal_title=Child's nervous system :  ChNS : official journal of the International Society for Pediatric Neurosurgery;citation_journal_title=Childs Nerv Syst;citation_author=JL. Mandzia;citation_author=KG. terBrugge;citation_author=ME. Faughnan;citation_title=Spinal cord arteriovenous malformations in two patients with hereditary hemorrhagic telangiectasia.;citation_pages=80-83;citation_volume=15;citation_year=1999;citation_issue=2-3;citation_pmid=10230660;citation_doi=10.1007/s003810050336" />
<meta name="citation_reference" content="citation_journal_title=Neuropediatrics;citation_journal_title=Neuropediatrics;citation_author=P. Terdjman;citation_author=J. Aicardi;citation_author=C. Sainte-Rose;citation_title=Neuroradiological findings in Sturge-Weber syndrome (SWS) and isolated pial angiomatosis.;citation_pages=115-120;citation_volume=22;citation_year=1991;citation_issue=3;citation_pmid=1944817" />
<meta name="citation_reference" content="citation_journal_title=Journal of clinical neuro-ophthalmology;citation_journal_title=J Clin Neuroophthalmol;citation_author=M. Uram;citation_author=C. Zubillaga;citation_title=The cutaneous manifestations of Sturge-Weber syndrome.;citation_pages=245-248;citation_volume=2;citation_year=1982;citation_issue=4;citation_pmid=6226707" />
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<meta name="citation_reference" content="citation_journal_title=Plast Reconstr Surg;citation_author=GF. Rogers;citation_author=JB. Mulliken;citation_author=HP. Kozakewich;citation_pages=376-82;citation_volume=115;citation_year=2005;citation_pmid=15692339;citation_doi=10.1097/01.PRS.0000148412.89532.76" />
<meta name="citation_reference" content="citation_journal_title=Pediatric dermatology;citation_journal_title=Pediatr Dermatol;citation_author=O. Enjolras;citation_author=M. Boukobza;citation_author=R. Jdid;citation_title=Cervical occult spinal dysraphism: MRI findings and the value of a vascular birthmark.;citation_pages=256-259;citation_volume=12;citation_year=1995;citation_issue=3;citation_pmid=7501560" />
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<meta name="citation_reference" content="citation_journal_title=Archives of Dermatology;citation_journal_title=Arch Dermatol;citation_author=D. Guggisberg;citation_author=S. Hadj-Rabia;citation_author=C. Viney;citation_title=Skin Markers of Occult Spinal Dysraphism in Children: A Review of 54 Cases;citation_pages=1109-1115;citation_volume=140;citation_year=2004;citation_issue=9;citation_issn=0003-987X;citation_pmid=15381552;citation_doi=10.1001/archderm.140.9.1109" />
<meta name="citation_reference" content="citation_journal_title=Surgical neurology;citation_journal_title=Surg Neurol;citation_author=C. Kadoya;citation_author=Y. Momota;citation_author=Y. Ikegami;citation_title=Central nervous system arteriovenous malformations with hereditary hemorrhagic telangiectasia: report of a family with three cases.;citation_pages=234-239;citation_volume=42;citation_year=1994;citation_issue=3;citation_pmid=7940111;citation_doi=10.1016/0090-3019(94)90269-0" />
<meta name="citation_reference" content="citation_journal_title=Pediatrics;citation_author=T. Morgan;citation_author=J. McDonald;citation_author=C. Anderson;citation_pages=E12;citation_volume=109;citation_year=2002;citation_issn=0031-4005;citation_pmid=11773580;citation_doi=10.1542/peds.109.1.e12" />
<meta name="citation_reference" content="citation_journal_title=Neurosurgery;citation_journal_title=Neurosurgery;citation_author=G. Rodesch;citation_author=M. Hurth;citation_author=H. Alvarez;citation_title=Spinal cord intradural arteriovenous fistulae: anatomic, clinical, and therapeutic considerations in a series of 32 consecutive patients seen between 1981 and 2000 with emphasis on endovascular therapy.;citation_pages=973-983;citation_volume=57;citation_year=2005;citation_issue=5;citation_pmid=16284566;citation_doi=10.1227/01.NEU.0000181314.94000.CD" />
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<meta name="twitter:title" content="A Novel Association between RASA1 Mutations and Spinal Arteriovenous Anomalies" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: CM-AVM is a recently recognized autosomal dominant disorder associated with mutations in RASA1 . Arteriovenous lesions have been reported in the brain, limbs, and the face in 18.5% of patients. We report a novel association between RASA1 mutations and spinal arteriovenous anomalies.

MATERIALS AND METHODS: In a collaborative study, 5 index patients (2 females, 3 males) with spinal AVMs or AVFs and cutaneous multifocal capillary lesions were investigated for the RASA1 gene mutation.

RESULTS: All 5 patients were found to have RASA1 mutation (2 de novo, 3 familial), and all had multifocal capillary malformations at birth. Neurologic deficits developed at ages ranging from infancy to early adulthood. All spinal anomalies (2 AVMs at the conus, 1 AVM at the lumbosacral junction, and 1 cervical and 1 cervicothoracic AVF) were complex, extensive, and fast-flow lesions. All patients required treatment based on the clinical and/or radiologic appearance of the lesions.

CONCLUSIONS: To our knowledge, an association of RASA1 mutation and spinal AVM/AVF has not been described. MR imaging screening of patients with characteristic CMs and neurologic symptoms presenting at a young age may be useful in detecting the presence of fast-flow intracranial or intraspinal arteriovenous anomalies before potentially significant neurologic insult has occurred.

ASA
:   anterior spinal artery
AVF
:   arteriovenous fistula
AVM
:   arteriovenous malformation
CM
:   capillary malformation
GTP
:   guanosine 5′-triphosphate
HHT
:   hereditary hemorrhagic telangiectasia
n -BCA
:   n -butyl 2-cyanoacrylate
R
:   right
SWS
:   Sturge-Weber syndrome" />
<meta name="og-title" property="og:title" content="A Novel Association between RASA1 Mutations and Spinal Arteriovenous Anomalies" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/31/4/775" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: CM-AVM is a recently recognized autosomal dominant disorder associated with mutations in RASA1 . Arteriovenous lesions have been reported in the brain, limbs, and the face in 18.5% of patients. We report a novel association between RASA1 mutations and spinal arteriovenous anomalies.

MATERIALS AND METHODS: In a collaborative study, 5 index patients (2 females, 3 males) with spinal AVMs or AVFs and cutaneous multifocal capillary lesions were investigated for the RASA1 gene mutation.

RESULTS: All 5 patients were found to have RASA1 mutation (2 de novo, 3 familial), and all had multifocal capillary malformations at birth. Neurologic deficits developed at ages ranging from infancy to early adulthood. All spinal anomalies (2 AVMs at the conus, 1 AVM at the lumbosacral junction, and 1 cervical and 1 cervicothoracic AVF) were complex, extensive, and fast-flow lesions. All patients required treatment based on the clinical and/or radiologic appearance of the lesions.

CONCLUSIONS: To our knowledge, an association of RASA1 mutation and spinal AVM/AVF has not been described. MR imaging screening of patients with characteristic CMs and neurologic symptoms presenting at a young age may be useful in detecting the presence of fast-flow intracranial or intraspinal arteriovenous anomalies before potentially significant neurologic insult has occurred.

ASA
:   anterior spinal artery
AVF
:   arteriovenous fistula
AVM
:   arteriovenous malformation
CM
:   capillary malformation
GTP
:   guanosine 5′-triphosphate
HHT
:   hereditary hemorrhagic telangiectasia
n -BCA
:   n -butyl 2-cyanoacrylate
R
:   right
SWS
:   Sturge-Weber syndrome" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node9852--5" data-node-nid="9852" id="top-node-9852--6901894429" data-pisa="ajnr;31/4/775" data-pisa-master="ajnr;ajnr.A1907" data-apath="/ajnr/31/4/775.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-series highwire-cite-metadata">E</span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">A Novel Association between <em>RASA1</em> Mutations and Spinal Arteriovenous Anomalies</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">R. Thiex</span>, <span class="highwire-citation-author" data-delta="1">J.B. Mulliken</span>, <span class="highwire-citation-author" data-delta="2">N. Revencu</span>, <span class="highwire-citation-author" data-delta="3">L.M. Boon</span>, <span class="highwire-citation-author" data-delta="4">P.E. Burrows</span>, <span class="highwire-citation-author" data-delta="5">M. Cordisco</span>, <span class="highwire-citation-author" data-delta="6">Y. Dwight</span>, <span class="highwire-citation-author" data-delta="7">E.R. Smith</span>, <span class="highwire-citation-author" data-delta="8">M. Vikkula</span> and <span class="highwire-citation-author" data-delta="9">D.B. Orbach</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2010,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">775-779; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1907 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-9852--6901894429" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">R. Thiex </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BThiex%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Thiex%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.%2BThiex%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J.B. 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Revencu </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=N.%2BRevencu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Revencu%20N&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AN.%2BRevencu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">L.M. 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<p id="p-3"><strong>BACKGROUND AND PURPOSE:</strong> CM-AVM is a recently recognized autosomal dominant disorder associated with mutations in <em>RASA1</em>. Arteriovenous lesions have been reported in the brain, limbs, and the face in 18.5% of patients. We report a novel association between <em>RASA1</em> mutations and spinal arteriovenous anomalies.</p>
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<p id="p-4"><strong>MATERIALS AND METHODS:</strong> In a collaborative study, 5 index patients (2 females, 3 males) with spinal AVMs or AVFs and cutaneous multifocal capillary lesions were investigated for the <em>RASA1</em> gene mutation.</p>
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<p id="p-5"><strong>RESULTS:</strong> All 5 patients were found to have <em>RASA1</em> mutation (2 de novo, 3 familial), and all had multifocal capillary malformations at birth. Neurologic deficits developed at ages ranging from infancy to early adulthood. All spinal anomalies (2 AVMs at the conus, 1 AVM at the lumbosacral junction, and 1 cervical and 1 cervicothoracic AVF) were complex, extensive, and fast-flow lesions. All patients required treatment based on the clinical and/or radiologic appearance of the lesions.</p>
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<p id="p-6"><strong>CONCLUSIONS:</strong> To our knowledge, an association of <em>RASA1</em> mutation and spinal AVM/AVF has not been described. MR imaging screening of patients with characteristic CMs and neurologic symptoms presenting at a young age may be useful in detecting the presence of fast-flow intracranial or intraspinal arteriovenous anomalies before potentially significant neurologic insult has occurred.</p>
</div></div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">ASA<span class="def-item-dt-sep"></span></dt><dd>anterior spinal artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">AVF<span class="def-item-dt-sep"></span></dt><dd>arteriovenous fistula<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">AVM<span class="def-item-dt-sep"></span></dt><dd>arteriovenous malformation<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">CM<span class="def-item-dt-sep"></span></dt><dd>capillary malformation<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">GTP<span class="def-item-dt-sep"></span></dt><dd>guanosine 5′-triphosphate<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">HHT<span class="def-item-dt-sep"></span></dt><dd>hereditary hemorrhagic telangiectasia<span class="def-item-dd-sep"></span></dd><dt id="def-item-7"><em>n</em>-BCA<span class="def-item-dt-sep"></span></dt><dd><em>n</em>-butyl 2-cyanoacrylate<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">R<span class="def-item-dt-sep"></span></dt><dd>right<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">SWS<span class="def-item-dt-sep"></span></dt><dd>Sturge-Weber syndrome</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/31/4/775.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 31</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 4 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Apr 2010 </div></div>
      
      
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      <div class="highwire-cite-title">A Novel Association between <em>RASA1</em> Mutations and Spinal Arteriovenous Anomalies</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Thiex</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.B.</span> <span class="nlm-surname">Mulliken</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Revencu</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">L.M.</span> <span class="nlm-surname">Boon</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">P.E.</span> <span class="nlm-surname">Burrows</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Cordisco</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Dwight</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">E.R.</span> <span class="nlm-surname">Smith</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Vikkula</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">D.B.</span> <span class="nlm-surname">Orbach</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">775-779; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1907 </span></div>
  
  
  
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      <div class="highwire-cite-title">A Novel Association between <em>RASA1</em> Mutations and Spinal Arteriovenous Anomalies</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Thiex</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.B.</span> <span class="nlm-surname">Mulliken</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Revencu</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">L.M.</span> <span class="nlm-surname">Boon</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">P.E.</span> <span class="nlm-surname">Burrows</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Cordisco</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Dwight</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">E.R.</span> <span class="nlm-surname">Smith</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Vikkula</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">D.B.</span> <span class="nlm-surname">Orbach</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">775-779; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1907 </span></div>
  
  
  
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