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<meta name="DC.Title" content="Immediate Anatomic Results after the Endovascular Treatment of Ruptured Intracranial Aneurysms: Analysis in the CLARITY Series" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1954" />
<meta name="DC.Date" content="2010-05-01" />
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Indicates open access to non-subscribers at www.ajnr.org" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: The efficacy of the endovascular treatment in providing stable occlusion of intracranial aneurysms is still controversial and should be precisely analyzed. A first step is to carefully study immediate anatomical results. CLARITY (Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms) is a prospective multicenter consecutive series including patients treated by coiling for ruptured aneurysms. Immediate anatomic results are presented.

MATERIALS AND METHODS: Postoperative anatomic results were evaluated by DSA by the treating physician and anonymously and independently by 2 experienced neuroradiologists by using the 3-point Montreal Scale. Patients were divided into 2 groups: patients treated with GDC and those treated with Matrix detachable coils.

RESULTS: A total of 773 patients (461 women, 312 men; 19–80 years of age; mean, 51.2 ± 13.2 years) with 773 ruptured aneurysms were included in the study. The rate of occlusion as determined by the treating physician was designated complete for 586 aneurysms (75.8%), neck remnant for 145 aneurysms (18.8%), and aneurysm remnant for 42 aneurysms (5.4%). The same evaluation as reported by the 2 independent reviewers was complete occlusion for 366 aneurysms (47.4%), neck remnant for 324 aneurysms (41.9%), and aneurysm remnant for 83 aneurysms (10.7%). Postoperative anatomic results were significantly linked to age but not to the technique of endovascular treatment or aneurysm characteristics (location, size, dome-to neck ratio). Results were not significantly different between the GDC and Matrix group.

CONCLUSIONS: Endovascular treatment of ruptured intracranial aneurysms resulted in a high rate of satisfactory occlusion (complete occlusion and neck remnant in 89.3%). Patient age was the only factor associated with the rate of occlusion. The rate of aneurysm occlusion differed insignificantly between GDC and Matrix coils.

ACA
:   anterior cerebral artery
AcomA
:   anterior communicating artery
ATENA
:   Analysis of Treatment by Endovascular Approach of Nonruptured Aneurysms
CARAT
:   Cerebral Aneurysm Rerupture After Treatment
CLARITY
:   Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms
CH
:   Centre Hospitalier
CHU
:   Centre Hospitalier Universitaire
DSA
:   digital subtraction angiography
GDC
:   Guglielmi detachable coils
ICA
:   internal carotid artery
ISAT
:   International Subarachnoid Aneurysm Trial
MCA
:   middle cerebral artery
VB
:   vertebrobasilar system" />
<meta name="DC.Contributor" content="L. Pierot" />
<meta name="DC.Contributor" content="C. Cognard" />
<meta name="DC.Contributor" content="F. Ricolfi" />
<meta name="DC.Contributor" content="R. Anxionnat" />
<meta name="DC.Contributor" content="for the CLARITY Investigators" />
<meta name="article:published_time" content="2010-05-01" />
<meta name="article:section" content="Interventional" />
<meta name="citation_title" content="Immediate Anatomic Results after the Endovascular Treatment of Ruptured Intracranial Aneurysms: Analysis in the CLARITY Series" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;The efficacy of the endovascular treatment in providing stable occlusion of intracranial aneurysms is still controversial and should be precisely analyzed. A first step is to carefully study immediate anatomical results. CLARITY (Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms) is a prospective multicenter consecutive series including patients treated by coiling for ruptured aneurysms. Immediate anatomic results are presented.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Postoperative anatomic results were evaluated by DSA by the treating physician and anonymously and independently by 2 experienced neuroradiologists by using the 3-point Montreal Scale. Patients were divided into 2 groups: patients treated with GDC and those treated with Matrix detachable coils.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;A total of 773 patients (461 women, 312 men; 19–80 years of age; mean, 51.2 ± 13.2 years) with 773 ruptured aneurysms were included in the study. The rate of occlusion as determined by the treating physician was designated complete for 586 aneurysms (75.8%), neck remnant for 145 aneurysms (18.8%), and aneurysm remnant for 42 aneurysms (5.4%). The same evaluation as reported by the 2 independent reviewers was complete occlusion for 366 aneurysms (47.4%), neck remnant for 324 aneurysms (41.9%), and aneurysm remnant for 83 aneurysms (10.7%). Postoperative anatomic results were significantly linked to age but not to the technique of endovascular treatment or aneurysm characteristics (location, size, dome-to neck ratio). Results were not significantly different between the GDC and Matrix group.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Endovascular treatment of ruptured intracranial aneurysms resulted in a high rate of satisfactory occlusion (complete occlusion and neck remnant in 89.3%). Patient age was the only factor associated with the rate of occlusion. The rate of aneurysm occlusion differed insignificantly between GDC and Matrix coils.&lt;/p&gt;" />
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<meta name="citation_author" content="L. Pierot" />
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<meta name="citation_author" content="F. Ricolfi" />
<meta name="citation_author" content="R. Anxionnat" />
<meta name="citation_author" content="for the CLARITY Investigators" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: The efficacy of the endovascular treatment in providing stable occlusion of intracranial aneurysms is still controversial and should be precisely analyzed. A first step is to carefully study immediate anatomical results. CLARITY (Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms) is a prospective multicenter consecutive series including patients treated by coiling for ruptured aneurysms. Immediate anatomic results are presented.

MATERIALS AND METHODS: Postoperative anatomic results were evaluated by DSA by the treating physician and anonymously and independently by 2 experienced neuroradiologists by using the 3-point Montreal Scale. Patients were divided into 2 groups: patients treated with GDC and those treated with Matrix detachable coils.

RESULTS: A total of 773 patients (461 women, 312 men; 19–80 years of age; mean, 51.2 ± 13.2 years) with 773 ruptured aneurysms were included in the study. The rate of occlusion as determined by the treating physician was designated complete for 586 aneurysms (75.8%), neck remnant for 145 aneurysms (18.8%), and aneurysm remnant for 42 aneurysms (5.4%). The same evaluation as reported by the 2 independent reviewers was complete occlusion for 366 aneurysms (47.4%), neck remnant for 324 aneurysms (41.9%), and aneurysm remnant for 83 aneurysms (10.7%). Postoperative anatomic results were significantly linked to age but not to the technique of endovascular treatment or aneurysm characteristics (location, size, dome-to neck ratio). Results were not significantly different between the GDC and Matrix group.

CONCLUSIONS: Endovascular treatment of ruptured intracranial aneurysms resulted in a high rate of satisfactory occlusion (complete occlusion and neck remnant in 89.3%). Patient age was the only factor associated with the rate of occlusion. The rate of aneurysm occlusion differed insignificantly between GDC and Matrix coils.

ACA
:   anterior cerebral artery
AcomA
:   anterior communicating artery
ATENA
:   Analysis of Treatment by Endovascular Approach of Nonruptured Aneurysms
CARAT
:   Cerebral Aneurysm Rerupture After Treatment
CLARITY
:   Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms
CH
:   Centre Hospitalier
CHU
:   Centre Hospitalier Universitaire
DSA
:   digital subtraction angiography
GDC
:   Guglielmi detachable coils
ICA
:   internal carotid artery
ISAT
:   International Subarachnoid Aneurysm Trial
MCA
:   middle cerebral artery
VB
:   vertebrobasilar system" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: The efficacy of the endovascular treatment in providing stable occlusion of intracranial aneurysms is still controversial and should be precisely analyzed. A first step is to carefully study immediate anatomical results. CLARITY (Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms) is a prospective multicenter consecutive series including patients treated by coiling for ruptured aneurysms. Immediate anatomic results are presented.

MATERIALS AND METHODS: Postoperative anatomic results were evaluated by DSA by the treating physician and anonymously and independently by 2 experienced neuroradiologists by using the 3-point Montreal Scale. Patients were divided into 2 groups: patients treated with GDC and those treated with Matrix detachable coils.

RESULTS: A total of 773 patients (461 women, 312 men; 19–80 years of age; mean, 51.2 ± 13.2 years) with 773 ruptured aneurysms were included in the study. The rate of occlusion as determined by the treating physician was designated complete for 586 aneurysms (75.8%), neck remnant for 145 aneurysms (18.8%), and aneurysm remnant for 42 aneurysms (5.4%). The same evaluation as reported by the 2 independent reviewers was complete occlusion for 366 aneurysms (47.4%), neck remnant for 324 aneurysms (41.9%), and aneurysm remnant for 83 aneurysms (10.7%). Postoperative anatomic results were significantly linked to age but not to the technique of endovascular treatment or aneurysm characteristics (location, size, dome-to neck ratio). Results were not significantly different between the GDC and Matrix group.

CONCLUSIONS: Endovascular treatment of ruptured intracranial aneurysms resulted in a high rate of satisfactory occlusion (complete occlusion and neck remnant in 89.3%). Patient age was the only factor associated with the rate of occlusion. The rate of aneurysm occlusion differed insignificantly between GDC and Matrix coils.

ACA
:   anterior cerebral artery
AcomA
:   anterior communicating artery
ATENA
:   Analysis of Treatment by Endovascular Approach of Nonruptured Aneurysms
CARAT
:   Cerebral Aneurysm Rerupture After Treatment
CLARITY
:   Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms
CH
:   Centre Hospitalier
CHU
:   Centre Hospitalier Universitaire
DSA
:   digital subtraction angiography
GDC
:   Guglielmi detachable coils
ICA
:   internal carotid artery
ISAT
:   International Subarachnoid Aneurysm Trial
MCA
:   middle cerebral artery
VB
:   vertebrobasilar system" />
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">L. Pierot</span>, <span class="highwire-citation-author" data-delta="1">C. Cognard</span>, <span class="highwire-citation-author" data-delta="2">F. Ricolfi</span>, <span class="highwire-citation-author" data-delta="3">R. Anxionnat</span> and <span class="highwire-citation-author" data-delta="4"><span class="nlm-collab" data-xlink-type="simple" data-hwp-id="collab-1">for the CLARITY Investigators</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">May 2010,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(5) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">907-911; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1954 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-9882--642232726" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">L. Pierot </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.%2BPierot%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Pierot%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AL.%2BPierot%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">C. Cognard </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BCognard%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cognard%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.%2BCognard%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">F. Ricolfi </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BRicolfi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ricolfi%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.%2BRicolfi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">R. Anxionnat </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BAnxionnat%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Anxionnat%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.%2BAnxionnat%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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<p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> The efficacy of the endovascular treatment in providing stable occlusion of intracranial aneurysms is still controversial and should be precisely analyzed. A first step is to carefully study immediate anatomical results. CLARITY (Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms) is a prospective multicenter consecutive series including patients treated by coiling for ruptured aneurysms. Immediate anatomic results are presented.</p>
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<p id="p-3"><strong>MATERIALS AND METHODS:</strong> Postoperative anatomic results were evaluated by DSA by the treating physician and anonymously and independently by 2 experienced neuroradiologists by using the 3-point Montreal Scale. Patients were divided into 2 groups: patients treated with GDC and those treated with Matrix detachable coils.</p>
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<p id="p-4"><strong>RESULTS:</strong> A total of 773 patients (461 women, 312 men; 19–80 years of age; mean, 51.2 ± 13.2 years) with 773 ruptured aneurysms were included in the study. The rate of occlusion as determined by the treating physician was designated complete for 586 aneurysms (75.8%), neck remnant for 145 aneurysms (18.8%), and aneurysm remnant for 42 aneurysms (5.4%). The same evaluation as reported by the 2 independent reviewers was complete occlusion for 366 aneurysms (47.4%), neck remnant for 324 aneurysms (41.9%), and aneurysm remnant for 83 aneurysms (10.7%). Postoperative anatomic results were significantly linked to age but not to the technique of endovascular treatment or aneurysm characteristics (location, size, dome-to neck ratio). Results were not significantly different between the GDC and Matrix group.</p>
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<p id="p-5"><strong>CONCLUSIONS:</strong> Endovascular treatment of ruptured intracranial aneurysms resulted in a high rate of satisfactory occlusion (complete occlusion and neck remnant in 89.3%). Patient age was the only factor associated with the rate of occlusion. The rate of aneurysm occlusion differed insignificantly between GDC and Matrix coils.</p>
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</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">ACA<span class="def-item-dt-sep"></span></dt><dd>anterior cerebral artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">AcomA<span class="def-item-dt-sep"></span></dt><dd>anterior communicating artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">ATENA<span class="def-item-dt-sep"></span></dt><dd>Analysis of Treatment by Endovascular Approach of Nonruptured Aneurysms<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">CARAT<span class="def-item-dt-sep"></span></dt><dd>Cerebral Aneurysm Rerupture After Treatment<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">CLARITY<span class="def-item-dt-sep"></span></dt><dd>Clinical and Anatomical Results in the Treatment of Ruptured Intracranial Aneurysms<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">CH<span class="def-item-dt-sep"></span></dt><dd>Centre Hospitalier<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">CHU<span class="def-item-dt-sep"></span></dt><dd>Centre Hospitalier Universitaire<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">DSA<span class="def-item-dt-sep"></span></dt><dd>digital subtraction angiography<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">GDC<span class="def-item-dt-sep"></span></dt><dd>Guglielmi detachable coils<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">ICA<span class="def-item-dt-sep"></span></dt><dd>internal carotid artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">ISAT<span class="def-item-dt-sep"></span></dt><dd>International Subarachnoid Aneurysm Trial<span class="def-item-dd-sep"></span></dd><dt id="def-item-12">MCA<span class="def-item-dt-sep"></span></dt><dd>middle cerebral artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-13">VB<span class="def-item-dt-sep"></span></dt><dd>vertebrobasilar system</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at <a href="http://www.ajnr.org">www.ajnr.org</a></p></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/31/5/907.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 31</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 5 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 May 2010 </div></div>
      
      
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      <div class="highwire-cite-title">Immediate Anatomic Results after the Endovascular Treatment of Ruptured Intracranial Aneurysms: Analysis in the CLARITY Series</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Pierot</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Cognard</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Ricolfi</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Anxionnat</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-collab" data-xlink-type="simple" data-hwp-id="collab-1">for the CLARITY Investigators</span></span></span></div>
  
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      <div class="highwire-cite-title">Immediate Anatomic Results after the Endovascular Treatment of Ruptured Intracranial Aneurysms: Analysis in the CLARITY Series</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Pierot</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Cognard</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Ricolfi</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Anxionnat</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-collab" data-xlink-type="simple" data-hwp-id="collab-1">for the CLARITY Investigators</span></span></span></div>
  
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