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<meta name="DC.Title" content="Assessment of Sulcation of the Fetal Brain in Cases of Isolated Agenesis of the Corpus Callosum Using In Utero MR Imaging" />
<meta name="DC.Identifier" content="10.3174/ajnr.A1982" />
<meta name="DC.Date" content="2010-06-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: There is gathering evidence to suggest that agenesis of the corpus callosum is associated with delayed fetal sulcation; it is possible that the corpus callosum facilitates normal gyral development. In this paper we sought to confirm whether delayed sulcation is found in fetuses with isolated agenesis of the corpus callosum as judged by in utero MR imaging.

MATERIALS AND METHODS: Retrospective analysis of 20 fetuses with isolated corpus callosum agenesis investigated by in utero MR imaging and 20 aged-matched normal fetuses was performed in the second or third trimester. All fetuses were singleton pregnancies with known gestational age, imaged on a 1.5T superconducting MR system. Estimation of sulcation maturity was made with reference to a standard atlas and subgroup analysis of earlier gestation (group 1, 21–26 weeks) and later gestation (group 2, 30–34 weeks) fetuses was performed.

RESULTS: Group 1 ( n = 12) did not show a statistically significant difference between the 2 subgroups ( P = .44) in terms of sulcation. A significant difference was demonstrated in the later gestation, group 2 ( n = 8) fetal analyses; mean difference between consensus and actual gestation for normal fetuses was 0.9 weeks (SD of 1.5 weeks) versus −0.5 weeks (SD of 1.1 weeks) for the agenesis of corpus callosum cases ( P = .046), suggestive of delayed sulcation in callosal agenesis.

CONCLUSIONS: Delayed sulcation encountered in third trimester fetuses with agenesis of the corpus callosum may be seen and does not in itself imply an additional brain abnormality.

ACC
:   agenesis of the corpus callosum
CNS
:   central nervous system
GA
:   gestational age
iuMR
:   in utero MR
SSFSE
:   single shot fast spin-echo" />
<meta name="DC.Contributor" content="D.J. Warren" />
<meta name="DC.Contributor" content="D.J.A. Connolly" />
<meta name="DC.Contributor" content="P.D. Griffiths" />
<meta name="article:published_time" content="2010-06-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="Assessment of Sulcation of the Fetal Brain in Cases of Isolated Agenesis of the Corpus Callosum Using In Utero MR Imaging" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;There is gathering evidence to suggest that agenesis of the corpus callosum is associated with delayed fetal sulcation; it is possible that the corpus callosum facilitates normal gyral development. In this paper we sought to confirm whether delayed sulcation is found in fetuses with isolated agenesis of the corpus callosum as judged by in utero MR imaging.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Retrospective analysis of 20 fetuses with isolated corpus callosum agenesis investigated by in utero MR imaging and 20 aged-matched normal fetuses was performed in the second or third trimester. All fetuses were singleton pregnancies with known gestational age, imaged on a 1.5T superconducting MR system. Estimation of sulcation maturity was made with reference to a standard atlas and subgroup analysis of earlier gestation (group 1, 21–26 weeks) and later gestation (group 2, 30–34 weeks) fetuses was performed.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Group 1 (&lt;i&gt;n&lt;/i&gt; = 12) did not show a statistically significant difference between the 2 subgroups (&lt;i&gt;P&lt;/i&gt; = .44) in terms of sulcation. A significant difference was demonstrated in the later gestation, group 2 (&lt;i&gt;n&lt;/i&gt; = 8) fetal analyses; mean difference between consensus and actual gestation for normal fetuses was 0.9 weeks (SD of 1.5 weeks) versus −0.5 weeks (SD of 1.1 weeks) for the agenesis of corpus callosum cases (&lt;i&gt;P&lt;/i&gt; = .046), suggestive of delayed sulcation in callosal agenesis.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Delayed sulcation encountered in third trimester fetuses with agenesis of the corpus callosum may be seen and does not in itself imply an additional brain abnormality.&lt;/p&gt;" />
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<meta name="twitter:title" content="Assessment of Sulcation of the Fetal Brain in Cases of Isolated Agenesis of the Corpus Callosum Using In Utero MR Imaging" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: There is gathering evidence to suggest that agenesis of the corpus callosum is associated with delayed fetal sulcation; it is possible that the corpus callosum facilitates normal gyral development. In this paper we sought to confirm whether delayed sulcation is found in fetuses with isolated agenesis of the corpus callosum as judged by in utero MR imaging.

MATERIALS AND METHODS: Retrospective analysis of 20 fetuses with isolated corpus callosum agenesis investigated by in utero MR imaging and 20 aged-matched normal fetuses was performed in the second or third trimester. All fetuses were singleton pregnancies with known gestational age, imaged on a 1.5T superconducting MR system. Estimation of sulcation maturity was made with reference to a standard atlas and subgroup analysis of earlier gestation (group 1, 21–26 weeks) and later gestation (group 2, 30–34 weeks) fetuses was performed.

RESULTS: Group 1 ( n = 12) did not show a statistically significant difference between the 2 subgroups ( P = .44) in terms of sulcation. A significant difference was demonstrated in the later gestation, group 2 ( n = 8) fetal analyses; mean difference between consensus and actual gestation for normal fetuses was 0.9 weeks (SD of 1.5 weeks) versus −0.5 weeks (SD of 1.1 weeks) for the agenesis of corpus callosum cases ( P = .046), suggestive of delayed sulcation in callosal agenesis.

CONCLUSIONS: Delayed sulcation encountered in third trimester fetuses with agenesis of the corpus callosum may be seen and does not in itself imply an additional brain abnormality.

ACC
:   agenesis of the corpus callosum
CNS
:   central nervous system
GA
:   gestational age
iuMR
:   in utero MR
SSFSE
:   single shot fast spin-echo" />
<meta name="og-title" property="og:title" content="Assessment of Sulcation of the Fetal Brain in Cases of Isolated Agenesis of the Corpus Callosum Using In Utero MR Imaging" />
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<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: There is gathering evidence to suggest that agenesis of the corpus callosum is associated with delayed fetal sulcation; it is possible that the corpus callosum facilitates normal gyral development. In this paper we sought to confirm whether delayed sulcation is found in fetuses with isolated agenesis of the corpus callosum as judged by in utero MR imaging.

MATERIALS AND METHODS: Retrospective analysis of 20 fetuses with isolated corpus callosum agenesis investigated by in utero MR imaging and 20 aged-matched normal fetuses was performed in the second or third trimester. All fetuses were singleton pregnancies with known gestational age, imaged on a 1.5T superconducting MR system. Estimation of sulcation maturity was made with reference to a standard atlas and subgroup analysis of earlier gestation (group 1, 21–26 weeks) and later gestation (group 2, 30–34 weeks) fetuses was performed.

RESULTS: Group 1 ( n = 12) did not show a statistically significant difference between the 2 subgroups ( P = .44) in terms of sulcation. A significant difference was demonstrated in the later gestation, group 2 ( n = 8) fetal analyses; mean difference between consensus and actual gestation for normal fetuses was 0.9 weeks (SD of 1.5 weeks) versus −0.5 weeks (SD of 1.1 weeks) for the agenesis of corpus callosum cases ( P = .046), suggestive of delayed sulcation in callosal agenesis.

CONCLUSIONS: Delayed sulcation encountered in third trimester fetuses with agenesis of the corpus callosum may be seen and does not in itself imply an additional brain abnormality.

ACC
:   agenesis of the corpus callosum
CNS
:   central nervous system
GA
:   gestational age
iuMR
:   in utero MR
SSFSE
:   single shot fast spin-echo" />
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      <h1 class="highwire-cite-title" id="page-title">Assessment of Sulcation of the Fetal Brain in Cases of Isolated Agenesis of the Corpus Callosum Using In Utero MR Imaging</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">D.J. Warren</span>, <span class="highwire-citation-author" data-delta="1">D.J.A. Connolly</span> and <span class="highwire-citation-author" data-delta="2">P.D. Griffiths</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">June 2010,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1085-1090; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A1982 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-9913--6568188410" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">D.J. Warren </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.J.%2BWarren%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Warren%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.J.%2BWarren%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">D.J.A. Connolly </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=D.J.A.%2BConnolly%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Connolly%20D&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AD.J.A.%2BConnolly%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">P.D. Griffiths </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=P.D.%2BGriffiths%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Griffiths%20P&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AP.D.%2BGriffiths%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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<p id="p-1"><strong>BACKGROUND AND PURPOSE:</strong> There is gathering evidence to suggest that agenesis of the corpus callosum is associated with delayed fetal sulcation; it is possible that the corpus callosum facilitates normal gyral development. In this paper we sought to confirm whether delayed sulcation is found in fetuses with isolated agenesis of the corpus callosum as judged by in utero MR imaging.</p>
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<p id="p-2"><strong>MATERIALS AND METHODS:</strong> Retrospective analysis of 20 fetuses with isolated corpus callosum agenesis investigated by in utero MR imaging and 20 aged-matched normal fetuses was performed in the second or third trimester. All fetuses were singleton pregnancies with known gestational age, imaged on a 1.5T superconducting MR system. Estimation of sulcation maturity was made with reference to a standard atlas and subgroup analysis of earlier gestation (group 1, 21–26 weeks) and later gestation (group 2, 30–34 weeks) fetuses was performed.</p>
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<p id="p-3"><strong>RESULTS:</strong> Group 1 (<em>n</em> = 12) did not show a statistically significant difference between the 2 subgroups (<em>P</em> = .44) in terms of sulcation. A significant difference was demonstrated in the later gestation, group 2 (<em>n</em> = 8) fetal analyses; mean difference between consensus and actual gestation for normal fetuses was 0.9 weeks (SD of 1.5 weeks) versus −0.5 weeks (SD of 1.1 weeks) for the agenesis of corpus callosum cases (<em>P</em> = .046), suggestive of delayed sulcation in callosal agenesis.</p>
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<p id="p-4"><strong>CONCLUSIONS:</strong> Delayed sulcation encountered in third trimester fetuses with agenesis of the corpus callosum may be seen and does not in itself imply an additional brain abnormality.</p>
</div></div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">ACC<span class="def-item-dt-sep"></span></dt><dd>agenesis of the corpus callosum<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">CNS<span class="def-item-dt-sep"></span></dt><dd>central nervous system<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">GA<span class="def-item-dt-sep"></span></dt><dd>gestational age<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">iuMR<span class="def-item-dt-sep"></span></dt><dd>in utero MR<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">SSFSE<span class="def-item-dt-sep"></span></dt><dd>single shot fast spin-echo</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/31/6/1085.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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      <div class="highwire-cite-title">Assessment of Sulcation of the Fetal Brain in Cases of Isolated Agenesis of the Corpus Callosum Using In Utero MR Imaging</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jun 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(6) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1085-1090; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1982 </span></div>
  
  
  
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