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<meta name="DC.Title" content="Effects of Age on the Glucose Metabolic Changes in Mild Cognitive Impairment" />
<meta name="DC.Identifier" content="10.3174/ajnr.A2070" />
<meta name="DC.Date" content="2010-08-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
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www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Decreased glucose metabolism in the temporal and parietal lobes on FDG-PET is recognized as an early imaging marker for the AD pathology. Our objective was to investigate the effects of age on FDG-PET findings in aMCI.

MATERIALS AND METHODS: Twenty-five patients with aMCI at 55–86 years of age (median = 73 years) and 25 age- and sex-matched CN subjects underwent FDG-PET. SPM5 was used to compare the FDG uptake in patients in aMCI-old (&gt;73 years) and aMCI-young (≤73 years) groups with CN subjects. The findings in the aMCI-old patients were independently validated in a separate cohort of 10 aMCI and 13 CN subjects older than 73 years of age.

RESULTS: The pattern of decreased glucose metabolism and gray matter atrophy in the medial temporal, posterior cingulate, precuneus, lateral parietal, and temporal lobes in aMCI-young subjects was consistent with the typical pattern observed in AD. The pattern of glucose metabolic changes in aMCI-old subjects was different, predominantly involving the frontal lobes and the left parietal lobe. Gray matter atrophy in aMCI-old subjects was less pronounced than that in the aMCI-young subjects, involving the hippocampus and the basal forebrain in both hemispheres

CONCLUSIONS: Pathologic heterogeneity may be underlying the absence of AD-like glucose metabolic changes in older compared with younger patients with aMCI. This may be an important consideration for the clinical use of temporoparietal hypometabolism on FDG-PET as a marker for early diagnosis of AD in aMCI.

AAL
:   automated anatomic labeling
AD
:   Alzheimer disease
ADRC/ADPR
:   Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry
aMCI
:   amnestic mild cognitive impairment
CDR
:   Clinical Dementia Rating
CN
:   cognitively normal
DCT
:   discrete cosine transformation
FDG-PET
:   fluorodeoxyglucose–positron-emission tomography
FLAIR
:   fluid-attenuated inversion recovery
IQR
:   interquartile range
MCI
:   mild cognitive impairment
MMSE
:   Mini-Mental State Examination
SPM
:   statistical parametric mapping
VBM
:   voxel-based morphometry
WMH
:   white matter hyperintensities" />
<meta name="DC.Contributor" content="K. Kantarci" />
<meta name="DC.Contributor" content="M.L. Senjem" />
<meta name="DC.Contributor" content="V.J. Lowe" />
<meta name="DC.Contributor" content="H.J. Wiste" />
<meta name="DC.Contributor" content="S.D. Weigand" />
<meta name="DC.Contributor" content="B.J. Kemp" />
<meta name="DC.Contributor" content="A.R. Frank" />
<meta name="DC.Contributor" content="M.M. Shiung" />
<meta name="DC.Contributor" content="B.F. Boeve" />
<meta name="DC.Contributor" content="D.S. Knopman" />
<meta name="DC.Contributor" content="R.C. Petersen" />
<meta name="DC.Contributor" content="C.R. Jack" />
<meta name="article:published_time" content="2010-08-01" />
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<meta name="citation_title" content="Effects of Age on the Glucose Metabolic Changes in Mild Cognitive Impairment" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Decreased glucose metabolism in the temporal and parietal lobes on FDG-PET is recognized as an early imaging marker for the AD pathology. Our objective was to investigate the effects of age on FDG-PET findings in aMCI.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Twenty-five patients with aMCI at 55–86 years of age (median = 73 years) and 25 age- and sex-matched CN subjects underwent FDG-PET. SPM5 was used to compare the FDG uptake in patients in aMCI-old (&amp;gt;73 years) and aMCI-young (≤73 years) groups with CN subjects. The findings in the aMCI-old patients were independently validated in a separate cohort of 10 aMCI and 13 CN subjects older than 73 years of age.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The pattern of decreased glucose metabolism and gray matter atrophy in the medial temporal, posterior cingulate, precuneus, lateral parietal, and temporal lobes in aMCI-young subjects was consistent with the typical pattern observed in AD. The pattern of glucose metabolic changes in aMCI-old subjects was different, predominantly involving the frontal lobes and the left parietal lobe. Gray matter atrophy in aMCI-old subjects was less pronounced than that in the aMCI-young subjects, involving the hippocampus and the basal forebrain in both hemispheres&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Pathologic heterogeneity may be underlying the absence of AD-like glucose metabolic changes in older compared with younger patients with aMCI. This may be an important consideration for the clinical use of temporoparietal hypometabolism on FDG-PET as a marker for early diagnosis of AD in aMCI.&lt;/p&gt;" />
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<meta name="twitter:title" content="Effects of Age on the Glucose Metabolic Changes in Mild Cognitive Impairment" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Decreased glucose metabolism in the temporal and parietal lobes on FDG-PET is recognized as an early imaging marker for the AD pathology. Our objective was to investigate the effects of age on FDG-PET findings in aMCI.

MATERIALS AND METHODS: Twenty-five patients with aMCI at 55–86 years of age (median = 73 years) and 25 age- and sex-matched CN subjects underwent FDG-PET. SPM5 was used to compare the FDG uptake in patients in aMCI-old (&gt;73 years) and aMCI-young (≤73 years) groups with CN subjects. The findings in the aMCI-old patients were independently validated in a separate cohort of 10 aMCI and 13 CN subjects older than 73 years of age.

RESULTS: The pattern of decreased glucose metabolism and gray matter atrophy in the medial temporal, posterior cingulate, precuneus, lateral parietal, and temporal lobes in aMCI-young subjects was consistent with the typical pattern observed in AD. The pattern of glucose metabolic changes in aMCI-old subjects was different, predominantly involving the frontal lobes and the left parietal lobe. Gray matter atrophy in aMCI-old subjects was less pronounced than that in the aMCI-young subjects, involving the hippocampus and the basal forebrain in both hemispheres

CONCLUSIONS: Pathologic heterogeneity may be underlying the absence of AD-like glucose metabolic changes in older compared with younger patients with aMCI. This may be an important consideration for the clinical use of temporoparietal hypometabolism on FDG-PET as a marker for early diagnosis of AD in aMCI.

AAL
:   automated anatomic labeling
AD
:   Alzheimer disease
ADRC/ADPR
:   Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry
aMCI
:   amnestic mild cognitive impairment
CDR
:   Clinical Dementia Rating
CN
:   cognitively normal
DCT
:   discrete cosine transformation
FDG-PET
:   fluorodeoxyglucose–positron-emission tomography
FLAIR
:   fluid-attenuated inversion recovery
IQR
:   interquartile range
MCI
:   mild cognitive impairment
MMSE
:   Mini-Mental State Examination
SPM
:   statistical parametric mapping
VBM
:   voxel-based morphometry
WMH
:   white matter hyperintensities" />
<meta name="og-title" property="og:title" content="Effects of Age on the Glucose Metabolic Changes in Mild Cognitive Impairment" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/31/7/1247" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Decreased glucose metabolism in the temporal and parietal lobes on FDG-PET is recognized as an early imaging marker for the AD pathology. Our objective was to investigate the effects of age on FDG-PET findings in aMCI.

MATERIALS AND METHODS: Twenty-five patients with aMCI at 55–86 years of age (median = 73 years) and 25 age- and sex-matched CN subjects underwent FDG-PET. SPM5 was used to compare the FDG uptake in patients in aMCI-old (&gt;73 years) and aMCI-young (≤73 years) groups with CN subjects. The findings in the aMCI-old patients were independently validated in a separate cohort of 10 aMCI and 13 CN subjects older than 73 years of age.

RESULTS: The pattern of decreased glucose metabolism and gray matter atrophy in the medial temporal, posterior cingulate, precuneus, lateral parietal, and temporal lobes in aMCI-young subjects was consistent with the typical pattern observed in AD. The pattern of glucose metabolic changes in aMCI-old subjects was different, predominantly involving the frontal lobes and the left parietal lobe. Gray matter atrophy in aMCI-old subjects was less pronounced than that in the aMCI-young subjects, involving the hippocampus and the basal forebrain in both hemispheres

CONCLUSIONS: Pathologic heterogeneity may be underlying the absence of AD-like glucose metabolic changes in older compared with younger patients with aMCI. This may be an important consideration for the clinical use of temporoparietal hypometabolism on FDG-PET as a marker for early diagnosis of AD in aMCI.

AAL
:   automated anatomic labeling
AD
:   Alzheimer disease
ADRC/ADPR
:   Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry
aMCI
:   amnestic mild cognitive impairment
CDR
:   Clinical Dementia Rating
CN
:   cognitively normal
DCT
:   discrete cosine transformation
FDG-PET
:   fluorodeoxyglucose–positron-emission tomography
FLAIR
:   fluid-attenuated inversion recovery
IQR
:   interquartile range
MCI
:   mild cognitive impairment
MMSE
:   Mini-Mental State Examination
SPM
:   statistical parametric mapping
VBM
:   voxel-based morphometry
WMH
:   white matter hyperintensities" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node9948--5" data-node-nid="9948" id="top-node-9948--61476401996" data-pisa="ajnr;31/7/1247" data-pisa-master="ajnr;ajnr.A2070" data-apath="/ajnr/31/7/1247.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
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      <h1 class="highwire-cite-title" id="page-title">Effects of Age on the Glucose Metabolic Changes in Mild Cognitive Impairment</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">K. Kantarci</span>, <span class="highwire-citation-author" data-delta="1">M.L. Senjem</span>, <span class="highwire-citation-author" data-delta="2">V.J. Lowe</span>, <span class="highwire-citation-author" data-delta="3">H.J. Wiste</span>, <span class="highwire-citation-author" data-delta="4">S.D. Weigand</span>, <span class="highwire-citation-author" data-delta="5">B.J. Kemp</span>, <span class="highwire-citation-author" data-delta="6">A.R. Frank</span>, <span class="highwire-citation-author" data-delta="7">M.M. Shiung</span>, <span class="highwire-citation-author" data-delta="8">B.F. Boeve</span>, <span class="highwire-citation-author" data-delta="9">D.S. Knopman</span>, <span class="highwire-citation-author" data-delta="10">R.C. Petersen</span> and <span class="highwire-citation-author" data-delta="11">C.R. Jack</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">August 2010,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1247-1253; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2070 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-9948--61476401996" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">K. Kantarci </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.%2BKantarci%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kantarci%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AK.%2BKantarci%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">M.L. 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<p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> Decreased glucose metabolism in the temporal and parietal lobes on FDG-PET is recognized as an early imaging marker for the AD pathology. Our objective was to investigate the effects of age on FDG-PET findings in aMCI.</p>
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<p id="p-3"><strong>MATERIALS AND METHODS:</strong> Twenty-five patients with aMCI at 55–86 years of age (median = 73 years) and 25 age- and sex-matched CN subjects underwent FDG-PET. SPM5 was used to compare the FDG uptake in patients in aMCI-old (&gt;73 years) and aMCI-young (≤73 years) groups with CN subjects. The findings in the aMCI-old patients were independently validated in a separate cohort of 10 aMCI and 13 CN subjects older than 73 years of age.</p>
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<p id="p-4"><strong>RESULTS:</strong> The pattern of decreased glucose metabolism and gray matter atrophy in the medial temporal, posterior cingulate, precuneus, lateral parietal, and temporal lobes in aMCI-young subjects was consistent with the typical pattern observed in AD. The pattern of glucose metabolic changes in aMCI-old subjects was different, predominantly involving the frontal lobes and the left parietal lobe. Gray matter atrophy in aMCI-old subjects was less pronounced than that in the aMCI-young subjects, involving the hippocampus and the basal forebrain in both hemispheres</p>
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<p id="p-5"><strong>CONCLUSIONS:</strong> Pathologic heterogeneity may be underlying the absence of AD-like glucose metabolic changes in older compared with younger patients with aMCI. This may be an important consideration for the clinical use of temporoparietal hypometabolism on FDG-PET as a marker for early diagnosis of AD in aMCI.</p>
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</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">AAL<span class="def-item-dt-sep"></span></dt><dd>automated anatomic labeling<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">AD<span class="def-item-dt-sep"></span></dt><dd>Alzheimer disease<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">ADRC/ADPR<span class="def-item-dt-sep"></span></dt><dd>Alzheimer's Disease Research Center/Alzheimer's Disease Patient Registry<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">aMCI<span class="def-item-dt-sep"></span></dt><dd>amnestic mild cognitive impairment<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">CDR<span class="def-item-dt-sep"></span></dt><dd>Clinical Dementia Rating<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">CN<span class="def-item-dt-sep"></span></dt><dd>cognitively normal<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">DCT<span class="def-item-dt-sep"></span></dt><dd>discrete cosine transformation<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">FDG-PET<span class="def-item-dt-sep"></span></dt><dd>fluorodeoxyglucose–positron-emission tomography<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">FLAIR<span class="def-item-dt-sep"></span></dt><dd>fluid-attenuated inversion recovery<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">IQR<span class="def-item-dt-sep"></span></dt><dd>interquartile range<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">MCI<span class="def-item-dt-sep"></span></dt><dd>mild cognitive impairment<span class="def-item-dd-sep"></span></dd><dt id="def-item-12">MMSE<span class="def-item-dt-sep"></span></dt><dd>Mini-Mental State Examination<span class="def-item-dd-sep"></span></dd><dt id="def-item-13">SPM<span class="def-item-dt-sep"></span></dt><dd>statistical parametric mapping<span class="def-item-dd-sep"></span></dd><dt id="def-item-14">VBM<span class="def-item-dt-sep"></span></dt><dd>voxel-based morphometry<span class="def-item-dd-sep"></span></dd><dt id="def-item-15">WMH<span class="def-item-dt-sep"></span></dt><dd>white matter hyperintensities</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at 
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 31</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 7 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Aug 2010 </div></div>
      
      
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1247-1253; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2070 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Kantarci</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.L.</span> <span class="nlm-surname">Senjem</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">V.J.</span> <span class="nlm-surname">Lowe</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">H.J.</span> <span class="nlm-surname">Wiste</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">S.D.</span> <span class="nlm-surname">Weigand</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">B.J.</span> <span class="nlm-surname">Kemp</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">A.R.</span> <span class="nlm-surname">Frank</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">M.M.</span> <span class="nlm-surname">Shiung</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">B.F.</span> <span class="nlm-surname">Boeve</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">D.S.</span> <span class="nlm-surname">Knopman</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">R.C.</span> <span class="nlm-surname">Petersen</span></span>, <span class="highwire-citation-author" data-delta="11"><span class="nlm-given-names">C.R.</span> <span class="nlm-surname">Jack</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1247-1253; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2070 </span></div>
  
  
  
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