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<meta name="DC.Title" content="MR Spectroscopy Detects Lipid Peaks in Cerebrotendinous Xanthomatosis" />
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<meta name="DC.Description" content="SUMMARY: CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation.

a.u.
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Cho
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CNS
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Cr
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CTX
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Lip
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Lip09
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Lip13
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mIns
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MRS
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PRESS
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&lt;p&gt;CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation.&lt;/p&gt;" />
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<meta name="twitter:title" content="MR Spectroscopy Detects Lipid Peaks in Cerebrotendinous Xanthomatosis" />
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<meta name="twitter:description" content="SUMMARY: CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation.

a.u.
:   arbitrary unit
Cho
:   choline-containing compounds
CNS
:   central nervous system
Cr
:   creatine/phosphocreatine
CTX
:   cerebrotendinous xanthomatosis
Lip
:   lipid
Lip09
:   lipid signals at 0.9 ppm
Lip13
:   lipid signals at 1.3 ppm
mIns
:   myo-inositol
MRS
:   MR spectroscopy
NAA
:   N -acetylaspartate
PRESS
:   point-resolved spectroscopy sequence
STEAM
:   short echo time stimulated echo acquisition mode
VOI
:   volume of interest" />
<meta name="og-title" property="og:title" content="MR Spectroscopy Detects Lipid Peaks in Cerebrotendinous Xanthomatosis" />
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<meta name="og-description" property="og:description" content="SUMMARY: CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation.

a.u.
:   arbitrary unit
Cho
:   choline-containing compounds
CNS
:   central nervous system
Cr
:   creatine/phosphocreatine
CTX
:   cerebrotendinous xanthomatosis
Lip
:   lipid
Lip09
:   lipid signals at 0.9 ppm
Lip13
:   lipid signals at 1.3 ppm
mIns
:   myo-inositol
MRS
:   MR spectroscopy
NAA
:   N -acetylaspartate
PRESS
:   point-resolved spectroscopy sequence
STEAM
:   short echo time stimulated echo acquisition mode
VOI
:   volume of interest" />
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">E.K. Embiruçu</span>, <span class="highwire-citation-author" data-delta="1">M.C.G. Otaduy</span>, <span class="highwire-citation-author" data-delta="2">A.K. Taneja</span>, <span class="highwire-citation-author" data-delta="3">C.C. Leite</span>, <span class="highwire-citation-author" data-delta="4">F. Kok</span> and <span class="highwire-citation-author" data-delta="5">L.T. Lucato</span></span></div>
  
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<div id="hw-article-author-popups-top-node-9760--6384296031" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">E.K. 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Leite </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.C.%2BLeite%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Leite%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.C.%2BLeite%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">F. 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<p id="p-1"><strong>SUMMARY:</strong> CTX is a rare lipid-storage disease. Novel MRS findings from 3 patients, using a short TE, were the presence of lipid peaks at 0.9 and 1.3 ppm in the depth of the cerebellar hemisphere; this might represent an additional marker of disease that is CNS-specific and noninvasive. A decrease in NAA concentration was also detected and attributed to neuroaxonal damage. One patient presented an increase in mIns concentration, pointing to gliosis and astrocytic proliferation.</p>
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</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">a.u.<span class="def-item-dt-sep"></span></dt><dd>arbitrary unit<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">Cho<span class="def-item-dt-sep"></span></dt><dd>choline-containing compounds<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">CNS<span class="def-item-dt-sep"></span></dt><dd>central nervous system<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">Cr<span class="def-item-dt-sep"></span></dt><dd>creatine/phosphocreatine<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">CTX<span class="def-item-dt-sep"></span></dt><dd>cerebrotendinous xanthomatosis<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">Lip<span class="def-item-dt-sep"></span></dt><dd>lipid<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">Lip09<span class="def-item-dt-sep"></span></dt><dd>lipid signals at 0.9 ppm<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">Lip13<span class="def-item-dt-sep"></span></dt><dd>lipid signals at 1.3 ppm<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">mIns<span class="def-item-dt-sep"></span></dt><dd>myo-inositol<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">MRS<span class="def-item-dt-sep"></span></dt><dd>MR spectroscopy<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">NAA<span class="def-item-dt-sep"></span></dt><dd><em>N</em>-acetylaspartate<span class="def-item-dd-sep"></span></dd><dt id="def-item-12">PRESS<span class="def-item-dt-sep"></span></dt><dd>point-resolved spectroscopy sequence<span class="def-item-dd-sep"></span></dd><dt id="def-item-13">STEAM<span class="def-item-dt-sep"></span></dt><dd>short echo time stimulated echo acquisition mode<span class="def-item-dd-sep"></span></dd><dt id="def-item-14">VOI<span class="def-item-dt-sep"></span></dt><dd>volume of interest</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/31/7/1347.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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      <div class="highwire-cite-title">MR Spectroscopy Detects Lipid Peaks in Cerebrotendinous Xanthomatosis</div>  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">E.K.</span> <span class="nlm-surname">Embiruçu</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">M.C.G.</span> <span class="nlm-surname">Otaduy</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.K.</span> <span class="nlm-surname">Taneja</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">C.C.</span> <span class="nlm-surname">Leite</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Kok</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">L.T.</span> <span class="nlm-surname">Lucato</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2010, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">31 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1347-1349; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A1885 </span></div>
  
  
  
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