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<p id="p-1"><strong>SUMMARY:</strong> Natalizumab is a humanized IgG4κ monoclonal antibody that is a selective adhesion molecule inhibitor, which prevents adhesion of leukocytes to endothelial cells. It is the first monoclonal antibody approved by the FDA for the treatment of relapsing-remitting MS. This article will review the mechanism of action and clinical role of this agent.</p>
</div></div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">FDA<span class="def-item-dt-sep"></span></dt><dd>US Food and Drug Administration<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">FLAIR<span class="def-item-dt-sep"></span></dt><dd>fluid-attenuated inversion recovery<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">FSE<span class="def-item-dt-sep"></span></dt><dd>fast spin-echo<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">IgG<span class="def-item-dt-sep"></span></dt><dd>immunoglobulin G<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">MAdCAM-1<span class="def-item-dt-sep"></span></dt><dd>mucosal adressin cell adhesion molecule<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">MS<span class="def-item-dt-sep"></span></dt><dd>multiple sclerosis<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">PML<span class="def-item-dt-sep"></span></dt><dd>progressive multifocal leukoencephalopathy<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">TOUCH<span class="def-item-dt-sep"></span></dt><dd>Tysabri Outreach Unified Commitment to Health<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">VCAM -1<span class="def-item-dt-sep"></span></dt><dd>vascular cell adhesion molecule-1</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/31/9/1588.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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