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<meta name="DC.Title" content="Impact of Retrievable Stents on Acute Ischemic Stroke Treatment" />
<meta name="DC.Identifier" content="10.3174/ajnr.A2494" />
<meta name="DC.Date" content="2011-08-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology. 
Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable stents shorten time to recanalization in the multimodal approach for endovascular stroke treatment.

MATERIALS AND METHODS: Forty consecutive patients with acute ischemic stroke and undergoing endovascular therapy were included. Treatment included thromboaspiration, thrombus disruption, thrombolysis, PTA, and stent placement. In 17 patients, a retrievable stent was used (group A) in addition to multimodal therapy. The remaining 23 patients constituted group B. Baseline characteristics, occlusion sites, urokinase dose, recanalization rate, and time to recanalization were compared between the groups.

RESULTS: Median NIHSS scores were higher in group A compared with group B on admission (19 versus 12.5; P = .018) but were not significantly different at day 1 (14 versus 10; P = .6). Intra-arterial thrombolysis was used in significantly fewer patients of group A than group B (53% versus 87%, respectively; P = .017), and median urokinase dose was lower in group A than in group B (250,000 IU versus 700,000 IU; P = .006). Time to recanalization was significantly shorter in group A compared with group B (median time to recanalization 52.5 minutes versus 90 minutes, respectively; P = .001). Recanalization rate was higher in group A than group B (94% versus 78%; P = .17).

CONCLUSIONS: Addition of retrievable stents to the multimodal endovascular approach for acute ischemic stroke treatment significantly reduces time to recanalization and further increases the recanalization rate.

IQR
:   interquartile range
IU
:   internationals unit(s)
mRS
:   modified Rankin Scale
NIHSS
:   National Institutes of Health Stroke Scale
PTA
:   percutaneous transluminal balloon angioplasty
TIMI
:   Thrombolysis in Myocardial Infarction" />
<meta name="DC.Contributor" content="C. Brekenfeld" />
<meta name="DC.Contributor" content="G. Schroth" />
<meta name="DC.Contributor" content="P. Mordasini" />
<meta name="DC.Contributor" content="U. Fischer" />
<meta name="DC.Contributor" content="M.-L. Mono" />
<meta name="DC.Contributor" content="A. Weck" />
<meta name="DC.Contributor" content="M. Arnold" />
<meta name="DC.Contributor" content="M. El-Koussy" />
<meta name="DC.Contributor" content="J. Gralla" />
<meta name="article:published_time" content="2011-08-01" />
<meta name="article:section" content="Interventional" />
<meta name="citation_title" content="Impact of Retrievable Stents on Acute Ischemic Stroke Treatment" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable stents shorten time to recanalization in the multimodal approach for endovascular stroke treatment.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Forty consecutive patients with acute ischemic stroke and undergoing endovascular therapy were included. Treatment included thromboaspiration, thrombus disruption, thrombolysis, PTA, and stent placement. In 17 patients, a retrievable stent was used (group A) in addition to multimodal therapy. The remaining 23 patients constituted group B. Baseline characteristics, occlusion sites, urokinase dose, recanalization rate, and time to recanalization were compared between the groups.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Median NIHSS scores were higher in group A compared with group B on admission (19 versus 12.5; &lt;i&gt;P&lt;/i&gt; = .018) but were not significantly different at day 1 (14 versus 10; &lt;i&gt;P&lt;/i&gt; = .6). Intra-arterial thrombolysis was used in significantly fewer patients of group A than group B (53% versus 87%, respectively; &lt;i&gt;P&lt;/i&gt; = .017), and median urokinase dose was lower in group A than in group B (250,000 IU versus 700,000 IU; &lt;i&gt;P&lt;/i&gt; = .006). Time to recanalization was significantly shorter in group A compared with group B (median time to recanalization 52.5 minutes versus 90 minutes, respectively; &lt;i&gt;P&lt;/i&gt; = .001). Recanalization rate was higher in group A than group B (94% versus 78%; &lt;i&gt;P&lt;/i&gt; = .17).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Addition of retrievable stents to the multimodal endovascular approach for acute ischemic stroke treatment significantly reduces time to recanalization and further increases the recanalization rate.&lt;/p&gt;" />
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<meta name="twitter:title" content="Impact of Retrievable Stents on Acute Ischemic Stroke Treatment" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable stents shorten time to recanalization in the multimodal approach for endovascular stroke treatment.

MATERIALS AND METHODS: Forty consecutive patients with acute ischemic stroke and undergoing endovascular therapy were included. Treatment included thromboaspiration, thrombus disruption, thrombolysis, PTA, and stent placement. In 17 patients, a retrievable stent was used (group A) in addition to multimodal therapy. The remaining 23 patients constituted group B. Baseline characteristics, occlusion sites, urokinase dose, recanalization rate, and time to recanalization were compared between the groups.

RESULTS: Median NIHSS scores were higher in group A compared with group B on admission (19 versus 12.5; P = .018) but were not significantly different at day 1 (14 versus 10; P = .6). Intra-arterial thrombolysis was used in significantly fewer patients of group A than group B (53% versus 87%, respectively; P = .017), and median urokinase dose was lower in group A than in group B (250,000 IU versus 700,000 IU; P = .006). Time to recanalization was significantly shorter in group A compared with group B (median time to recanalization 52.5 minutes versus 90 minutes, respectively; P = .001). Recanalization rate was higher in group A than group B (94% versus 78%; P = .17).

CONCLUSIONS: Addition of retrievable stents to the multimodal endovascular approach for acute ischemic stroke treatment significantly reduces time to recanalization and further increases the recanalization rate.

IQR
:   interquartile range
IU
:   internationals unit(s)
mRS
:   modified Rankin Scale
NIHSS
:   National Institutes of Health Stroke Scale
PTA
:   percutaneous transluminal balloon angioplasty
TIMI
:   Thrombolysis in Myocardial Infarction" />
<meta name="og-title" property="og:title" content="Impact of Retrievable Stents on Acute Ischemic Stroke Treatment" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/32/7/1269" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable stents shorten time to recanalization in the multimodal approach for endovascular stroke treatment.

MATERIALS AND METHODS: Forty consecutive patients with acute ischemic stroke and undergoing endovascular therapy were included. Treatment included thromboaspiration, thrombus disruption, thrombolysis, PTA, and stent placement. In 17 patients, a retrievable stent was used (group A) in addition to multimodal therapy. The remaining 23 patients constituted group B. Baseline characteristics, occlusion sites, urokinase dose, recanalization rate, and time to recanalization were compared between the groups.

RESULTS: Median NIHSS scores were higher in group A compared with group B on admission (19 versus 12.5; P = .018) but were not significantly different at day 1 (14 versus 10; P = .6). Intra-arterial thrombolysis was used in significantly fewer patients of group A than group B (53% versus 87%, respectively; P = .017), and median urokinase dose was lower in group A than in group B (250,000 IU versus 700,000 IU; P = .006). Time to recanalization was significantly shorter in group A compared with group B (median time to recanalization 52.5 minutes versus 90 minutes, respectively; P = .001). Recanalization rate was higher in group A than group B (94% versus 78%; P = .17).

CONCLUSIONS: Addition of retrievable stents to the multimodal endovascular approach for acute ischemic stroke treatment significantly reduces time to recanalization and further increases the recanalization rate.

IQR
:   interquartile range
IU
:   internationals unit(s)
mRS
:   modified Rankin Scale
NIHSS
:   National Institutes of Health Stroke Scale
PTA
:   percutaneous transluminal balloon angioplasty
TIMI
:   Thrombolysis in Myocardial Infarction" />
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      <h1 class="highwire-cite-title" id="page-title">Impact of Retrievable Stents on Acute Ischemic Stroke Treatment</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">C. Brekenfeld</span>, <span class="highwire-citation-author" data-delta="1">G. Schroth</span>, <span class="highwire-citation-author" data-delta="2">P. Mordasini</span>, <span class="highwire-citation-author" data-delta="3">U. Fischer</span>, <span class="highwire-citation-author" data-delta="4">M.-L. Mono</span>, <span class="highwire-citation-author" data-delta="5">A. Weck</span>, <span class="highwire-citation-author" data-delta="6">M. Arnold</span>, <span class="highwire-citation-author" data-delta="7">M. El-Koussy</span> and <span class="highwire-citation-author" data-delta="8">J. Gralla</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">August 2011,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1269-1273; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2494 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-11443--657368134" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">C. Brekenfeld </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.%2BBrekenfeld%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Brekenfeld%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.%2BBrekenfeld%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">G. 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<p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> Retrievable stents combine the high recanalization rate of stents and the capability of removing the thrombus offered by mechanical thrombectomy devices. We hypothesized that retrievable stents shorten time to recanalization in the multimodal approach for endovascular stroke treatment.</p>
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<p id="p-3"><strong>MATERIALS AND METHODS:</strong> Forty consecutive patients with acute ischemic stroke and undergoing endovascular therapy were included. Treatment included thromboaspiration, thrombus disruption, thrombolysis, PTA, and stent placement. In 17 patients, a retrievable stent was used (group A) in addition to multimodal therapy. The remaining 23 patients constituted group B. Baseline characteristics, occlusion sites, urokinase dose, recanalization rate, and time to recanalization were compared between the groups.</p>
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<p id="p-4"><strong>RESULTS:</strong> Median NIHSS scores were higher in group A compared with group B on admission (19 versus 12.5; <em>P</em> = .018) but were not significantly different at day 1 (14 versus 10; <em>P</em> = .6). Intra-arterial thrombolysis was used in significantly fewer patients of group A than group B (53% versus 87%, respectively; <em>P</em> = .017), and median urokinase dose was lower in group A than in group B (250,000 IU versus 700,000 IU; <em>P</em> = .006). Time to recanalization was significantly shorter in group A compared with group B (median time to recanalization 52.5 minutes versus 90 minutes, respectively; <em>P</em> = .001). Recanalization rate was higher in group A than group B (94% versus 78%; <em>P</em> = .17).</p>
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<p id="p-5"><strong>CONCLUSIONS:</strong> Addition of retrievable stents to the multimodal endovascular approach for acute ischemic stroke treatment significantly reduces time to recanalization and further increases the recanalization rate.</p>
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</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">IQR<span class="def-item-dt-sep"></span></dt><dd>interquartile range<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">IU<span class="def-item-dt-sep"></span></dt><dd>internationals unit(s)<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">mRS<span class="def-item-dt-sep"></span></dt><dd>modified Rankin Scale<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">NIHSS<span class="def-item-dt-sep"></span></dt><dd>National Institutes of Health Stroke Scale<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">PTA<span class="def-item-dt-sep"></span></dt><dd>percutaneous transluminal balloon angioplasty<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">TIMI<span class="def-item-dt-sep"></span></dt><dd>Thrombolysis in Myocardial Infarction</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at <a href="http://www.ajnr.org">www.ajnr.org</a></p></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/32/7/1269.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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      <div class="highwire-cite-title">Impact of Retrievable Stents on Acute Ischemic Stroke Treatment</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">C.</span> <span class="nlm-surname">Brekenfeld</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">G.</span> <span class="nlm-surname">Schroth</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">P.</span> <span class="nlm-surname">Mordasini</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">U.</span> <span class="nlm-surname">Fischer</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">M.-L.</span> <span class="nlm-surname">Mono</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">A.</span> <span class="nlm-surname">Weck</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Arnold</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">M.</span> <span class="nlm-surname">El-Koussy</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Gralla</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2011, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1269-1273; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2494 </span></div>
  
  
  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2011, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1269-1273; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2494 </span></div>
  
  
  
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