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<meta name="DC.Title" content="Assessment of Lateral Geniculate Nucleus Atrophy with 3T MR Imaging and Correlation with Clinical Stage of Glaucoma" />
<meta name="DC.Identifier" content="10.3174/ajnr.A2486" />
<meta name="DC.Date" content="2011-08-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="Copyright © American Society of Neuroradiology" />
<meta name="DC.AccessRights" content="restricted" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Although previous animal studies have shown structural changes in ocular hypertension such as atrophy of the LGN, such changes have not been thoroughly studied in human glaucoma patients nor correlation made with clinical stage. Our aim was to investigate prospectively LGN atrophy in patients with POAG using 3T MR imaging and correlation with the clinical stage of disease.

MATERIALS AND METHODS: Twenty-six patients with known POAG and 26 age-matched healthy volunteers were included in this institutional review board−approved study. All subjects underwent imaging on a 3T MR imaging system with a PD and GM sequence. LGN height and volume were measured by 2 blinded neuroradiologists. Measurements were compared and correlated with clinical glaucoma severity as assessed by static threshold visual field parameters.

RESULTS: Average maximum LGN height in patients with glaucoma on PD images was 4.36 ± 0.61 mm (right) and 4.31 ± 0.61 mm (left), significantly less ( P &lt; 10−3) than respective measurements of 5.05 ± 0.41 and 4.99 ± 0.41 mm in volunteers. With the GM sequences, such respective measurements were also less ( P &lt; 10−3) in patients with glaucoma (4.20 ± 0.71 mm right, 4.00 ± 0.85 mm left) versus respective measurements in volunteers (4.88 ± 0.51 mm right, 4.77 ± 0.47 mm left). Average LGN volumes in the patient group were 98.0 ± 27.2 mm3 (right) and 93.7 ± 25.8 mm3 (left) with the PD sequence versus respective measurements of 85.2 ± 27.1 and 80.5 ± 23.6 mm3 with the GM sequence. All height and volume measurements were greater in volunteers ( P &lt; 10−3). In the patient group, both maximum height and volume of the LGN with both sequences were significantly correlated with cumulative clinical glaucoma stage ( P &lt; .05).

CONCLUSIONS: MR imaging measurements of LGN height and volume are diminished in patients with glaucoma, with the extent of atrophy correlating to clinical stage, suggesting a novel imaging marker of disease severity.

BRAVO
:   brain volume imaging
FA
:   fractional anisotropy
fMRI
:   functional MR imaging
GM
:   gray matter
GMhL
:   maximum height of the left LGN with the GM sequence
GMhR
:   maximum height of the right LGN with the GM sequence
GMvL
:   maximum volume of the left LGN with the GM sequence
GMvR
:   maximum volume of the right LGN with the GM sequence
LGN
:   lateral geniculate nucleus
MD
:   mean diffusivity
MDS
:   mean deviation score
PD
:   proton density
PDhL
:   maximum height of the left LGN with the PD sequence
PDhR
:   maximum height of the right LGN with the PD sequence
PDvL
:   volume of the left LGN with the PD sequence
PDvR
:   volume of the right LGN with the PD sequence
POAG
:   primary open-angle glaucoma
stage A
:   the sum of the clinical stages of both eyes
stage L
:   the clinical stage of the left eye of a patient with POAG
stage R
:   the clinical stage of the right eye of a patient with POAG
Sum
:   the summation of height and volume bilaterally" />
<meta name="DC.Contributor" content="H. Dai" />
<meta name="DC.Contributor" content="K.T. Mu" />
<meta name="DC.Contributor" content="J.P. Qi" />
<meta name="DC.Contributor" content="C.Y. Wang" />
<meta name="DC.Contributor" content="W.Z. Zhu" />
<meta name="DC.Contributor" content="L.M. Xia" />
<meta name="DC.Contributor" content="Z.Q. Chen" />
<meta name="DC.Contributor" content="H. Zhang" />
<meta name="DC.Contributor" content="F. Ai" />
<meta name="DC.Contributor" content="J.N. Morelli" />
<meta name="article:published_time" content="2011-08-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="Assessment of Lateral Geniculate Nucleus Atrophy with 3T MR Imaging and Correlation with Clinical Stage of Glaucoma" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Although previous animal studies have shown structural changes in ocular hypertension such as atrophy of the LGN, such changes have not been thoroughly studied in human glaucoma patients nor correlation made with clinical stage. Our aim was to investigate prospectively LGN atrophy in patients with POAG using 3T MR imaging and correlation with the clinical stage of disease.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Twenty-six patients with known POAG and 26 age-matched healthy volunteers were included in this institutional review board−approved study. All subjects underwent imaging on a 3T MR imaging system with a PD and GM sequence. LGN height and volume were measured by 2 blinded neuroradiologists. Measurements were compared and correlated with clinical glaucoma severity as assessed by static threshold visual field parameters.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Average maximum LGN height in patients with glaucoma on PD images was 4.36 ± 0.61 mm (right) and 4.31 ± 0.61 mm (left), significantly less (&lt;i&gt;P&lt;/i&gt; &amp;lt; 10&lt;sup&gt;−3&lt;/sup&gt;) than respective measurements of 5.05 ± 0.41 and 4.99 ± 0.41 mm in volunteers. With the GM sequences, such respective measurements were also less (&lt;i&gt;P&lt;/i&gt; &amp;lt; 10&lt;sup&gt;−3&lt;/sup&gt;) in patients with glaucoma (4.20 ± 0.71 mm right, 4.00 ± 0.85 mm left) versus respective measurements in volunteers (4.88 ± 0.51 mm right, 4.77 ± 0.47 mm left). Average LGN volumes in the patient group were 98.0 ± 27.2 mm&lt;sup&gt;3&lt;/sup&gt; (right) and 93.7 ± 25.8 mm&lt;sup&gt;3&lt;/sup&gt; (left) with the PD sequence versus respective measurements of 85.2 ± 27.1 and 80.5 ± 23.6 mm&lt;sup&gt;3&lt;/sup&gt; with the GM sequence. All height and volume measurements were greater in volunteers (&lt;i&gt;P&lt;/i&gt; &amp;lt; 10&lt;sup&gt;−3&lt;/sup&gt;). In the patient group, both maximum height and volume of the LGN with both sequences were significantly correlated with cumulative clinical glaucoma stage (&lt;i&gt;P&lt;/i&gt; &amp;lt; .05).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;MR imaging measurements of LGN height and volume are diminished in patients with glaucoma, with the extent of atrophy correlating to clinical stage, suggesting a novel imaging marker of disease severity.&lt;/p&gt;" />
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<meta name="twitter:title" content="Assessment of Lateral Geniculate Nucleus Atrophy with 3T MR Imaging and Correlation with Clinical Stage of Glaucoma" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/32/7.cover.gif" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Although previous animal studies have shown structural changes in ocular hypertension such as atrophy of the LGN, such changes have not been thoroughly studied in human glaucoma patients nor correlation made with clinical stage. Our aim was to investigate prospectively LGN atrophy in patients with POAG using 3T MR imaging and correlation with the clinical stage of disease.

MATERIALS AND METHODS: Twenty-six patients with known POAG and 26 age-matched healthy volunteers were included in this institutional review board−approved study. All subjects underwent imaging on a 3T MR imaging system with a PD and GM sequence. LGN height and volume were measured by 2 blinded neuroradiologists. Measurements were compared and correlated with clinical glaucoma severity as assessed by static threshold visual field parameters.

RESULTS: Average maximum LGN height in patients with glaucoma on PD images was 4.36 ± 0.61 mm (right) and 4.31 ± 0.61 mm (left), significantly less ( P &lt; 10−3) than respective measurements of 5.05 ± 0.41 and 4.99 ± 0.41 mm in volunteers. With the GM sequences, such respective measurements were also less ( P &lt; 10−3) in patients with glaucoma (4.20 ± 0.71 mm right, 4.00 ± 0.85 mm left) versus respective measurements in volunteers (4.88 ± 0.51 mm right, 4.77 ± 0.47 mm left). Average LGN volumes in the patient group were 98.0 ± 27.2 mm3 (right) and 93.7 ± 25.8 mm3 (left) with the PD sequence versus respective measurements of 85.2 ± 27.1 and 80.5 ± 23.6 mm3 with the GM sequence. All height and volume measurements were greater in volunteers ( P &lt; 10−3). In the patient group, both maximum height and volume of the LGN with both sequences were significantly correlated with cumulative clinical glaucoma stage ( P &lt; .05).

CONCLUSIONS: MR imaging measurements of LGN height and volume are diminished in patients with glaucoma, with the extent of atrophy correlating to clinical stage, suggesting a novel imaging marker of disease severity.

BRAVO
:   brain volume imaging
FA
:   fractional anisotropy
fMRI
:   functional MR imaging
GM
:   gray matter
GMhL
:   maximum height of the left LGN with the GM sequence
GMhR
:   maximum height of the right LGN with the GM sequence
GMvL
:   maximum volume of the left LGN with the GM sequence
GMvR
:   maximum volume of the right LGN with the GM sequence
LGN
:   lateral geniculate nucleus
MD
:   mean diffusivity
MDS
:   mean deviation score
PD
:   proton density
PDhL
:   maximum height of the left LGN with the PD sequence
PDhR
:   maximum height of the right LGN with the PD sequence
PDvL
:   volume of the left LGN with the PD sequence
PDvR
:   volume of the right LGN with the PD sequence
POAG
:   primary open-angle glaucoma
stage A
:   the sum of the clinical stages of both eyes
stage L
:   the clinical stage of the left eye of a patient with POAG
stage R
:   the clinical stage of the right eye of a patient with POAG
Sum
:   the summation of height and volume bilaterally" />
<meta name="og-title" property="og:title" content="Assessment of Lateral Geniculate Nucleus Atrophy with 3T MR Imaging and Correlation with Clinical Stage of Glaucoma" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/32/7/1347" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Although previous animal studies have shown structural changes in ocular hypertension such as atrophy of the LGN, such changes have not been thoroughly studied in human glaucoma patients nor correlation made with clinical stage. Our aim was to investigate prospectively LGN atrophy in patients with POAG using 3T MR imaging and correlation with the clinical stage of disease.

MATERIALS AND METHODS: Twenty-six patients with known POAG and 26 age-matched healthy volunteers were included in this institutional review board−approved study. All subjects underwent imaging on a 3T MR imaging system with a PD and GM sequence. LGN height and volume were measured by 2 blinded neuroradiologists. Measurements were compared and correlated with clinical glaucoma severity as assessed by static threshold visual field parameters.

RESULTS: Average maximum LGN height in patients with glaucoma on PD images was 4.36 ± 0.61 mm (right) and 4.31 ± 0.61 mm (left), significantly less ( P &lt; 10−3) than respective measurements of 5.05 ± 0.41 and 4.99 ± 0.41 mm in volunteers. With the GM sequences, such respective measurements were also less ( P &lt; 10−3) in patients with glaucoma (4.20 ± 0.71 mm right, 4.00 ± 0.85 mm left) versus respective measurements in volunteers (4.88 ± 0.51 mm right, 4.77 ± 0.47 mm left). Average LGN volumes in the patient group were 98.0 ± 27.2 mm3 (right) and 93.7 ± 25.8 mm3 (left) with the PD sequence versus respective measurements of 85.2 ± 27.1 and 80.5 ± 23.6 mm3 with the GM sequence. All height and volume measurements were greater in volunteers ( P &lt; 10−3). In the patient group, both maximum height and volume of the LGN with both sequences were significantly correlated with cumulative clinical glaucoma stage ( P &lt; .05).

CONCLUSIONS: MR imaging measurements of LGN height and volume are diminished in patients with glaucoma, with the extent of atrophy correlating to clinical stage, suggesting a novel imaging marker of disease severity.

BRAVO
:   brain volume imaging
FA
:   fractional anisotropy
fMRI
:   functional MR imaging
GM
:   gray matter
GMhL
:   maximum height of the left LGN with the GM sequence
GMhR
:   maximum height of the right LGN with the GM sequence
GMvL
:   maximum volume of the left LGN with the GM sequence
GMvR
:   maximum volume of the right LGN with the GM sequence
LGN
:   lateral geniculate nucleus
MD
:   mean diffusivity
MDS
:   mean deviation score
PD
:   proton density
PDhL
:   maximum height of the left LGN with the PD sequence
PDhR
:   maximum height of the right LGN with the PD sequence
PDvL
:   volume of the left LGN with the PD sequence
PDvR
:   volume of the right LGN with the PD sequence
POAG
:   primary open-angle glaucoma
stage A
:   the sum of the clinical stages of both eyes
stage L
:   the clinical stage of the left eye of a patient with POAG
stage R
:   the clinical stage of the right eye of a patient with POAG
Sum
:   the summation of height and volume bilaterally" />
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      <h1 class="highwire-cite-title" id="page-title">Assessment of Lateral Geniculate Nucleus Atrophy with 3T MR Imaging and Correlation with Clinical Stage of Glaucoma</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">H. Dai</span>, <span class="highwire-citation-author" data-delta="1">K.T. Mu</span>, <span class="highwire-citation-author" data-delta="2">J.P. Qi</span>, <span class="highwire-citation-author" data-delta="3">C.Y. Wang</span>, <span class="highwire-citation-author" data-delta="4">W.Z. Zhu</span>, <span class="highwire-citation-author" data-delta="5">L.M. Xia</span>, <span class="highwire-citation-author" data-delta="6">Z.Q. Chen</span>, <span class="highwire-citation-author" data-delta="7">H. Zhang</span>, <span class="highwire-citation-author" data-delta="8">F. Ai</span> and <span class="highwire-citation-author" data-delta="9">J.N. Morelli</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">August 2011,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1347-1353; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2486 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-11413--61391653968" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">H. Dai </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BDai%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dai%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.%2BDai%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">K.T. 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<p id="p-1"><strong>BACKGROUND AND PURPOSE:</strong> Although previous animal studies have shown structural changes in ocular hypertension such as atrophy of the LGN, such changes have not been thoroughly studied in human glaucoma patients nor correlation made with clinical stage. Our aim was to investigate prospectively LGN atrophy in patients with POAG using 3T MR imaging and correlation with the clinical stage of disease.</p>
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<p id="p-2"><strong>MATERIALS AND METHODS:</strong> Twenty-six patients with known POAG and 26 age-matched healthy volunteers were included in this institutional review board−approved study. All subjects underwent imaging on a 3T MR imaging system with a PD and GM sequence. LGN height and volume were measured by 2 blinded neuroradiologists. Measurements were compared and correlated with clinical glaucoma severity as assessed by static threshold visual field parameters.</p>
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<p id="p-3"><strong>RESULTS:</strong> Average maximum LGN height in patients with glaucoma on PD images was 4.36 ± 0.61 mm (right) and 4.31 ± 0.61 mm (left), significantly less (<em>P</em> &lt; 10<sup>−3</sup>) than respective measurements of 5.05 ± 0.41 and 4.99 ± 0.41 mm in volunteers. With the GM sequences, such respective measurements were also less (<em>P</em> &lt; 10<sup>−3</sup>) in patients with glaucoma (4.20 ± 0.71 mm right, 4.00 ± 0.85 mm left) versus respective measurements in volunteers (4.88 ± 0.51 mm right, 4.77 ± 0.47 mm left). Average LGN volumes in the patient group were 98.0 ± 27.2 mm<sup>3</sup> (right) and 93.7 ± 25.8 mm<sup>3</sup> (left) with the PD sequence versus respective measurements of 85.2 ± 27.1 and 80.5 ± 23.6 mm<sup>3</sup> with the GM sequence. All height and volume measurements were greater in volunteers (<em>P</em> &lt; 10<sup>−3</sup>). In the patient group, both maximum height and volume of the LGN with both sequences were significantly correlated with cumulative clinical glaucoma stage (<em>P</em> &lt; .05).</p>
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<p id="p-4"><strong>CONCLUSIONS:</strong> MR imaging measurements of LGN height and volume are diminished in patients with glaucoma, with the extent of atrophy correlating to clinical stage, suggesting a novel imaging marker of disease severity.</p>
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</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">BRAVO<span class="def-item-dt-sep"></span></dt><dd>brain volume imaging<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">FA<span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">fMRI<span class="def-item-dt-sep"></span></dt><dd>functional MR imaging<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">GM<span class="def-item-dt-sep"></span></dt><dd>gray matter<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">GMhL<span class="def-item-dt-sep"></span></dt><dd>maximum height of the left LGN with the GM sequence<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">GMhR<span class="def-item-dt-sep"></span></dt><dd>maximum height of the right LGN with the GM sequence<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">GMvL<span class="def-item-dt-sep"></span></dt><dd>maximum volume of the left LGN with the GM sequence<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">GMvR<span class="def-item-dt-sep"></span></dt><dd>maximum volume of the right LGN with the GM sequence<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">LGN<span class="def-item-dt-sep"></span></dt><dd>lateral geniculate nucleus<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">MD<span class="def-item-dt-sep"></span></dt><dd>mean diffusivity<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">MDS<span class="def-item-dt-sep"></span></dt><dd>mean deviation score<span class="def-item-dd-sep"></span></dd><dt id="def-item-12">PD<span class="def-item-dt-sep"></span></dt><dd>proton density<span class="def-item-dd-sep"></span></dd><dt id="def-item-13">PDhL<span class="def-item-dt-sep"></span></dt><dd>maximum height of the left LGN with the PD sequence<span class="def-item-dd-sep"></span></dd><dt id="def-item-14">PDhR<span class="def-item-dt-sep"></span></dt><dd>maximum height of the right LGN with the PD sequence<span class="def-item-dd-sep"></span></dd><dt id="def-item-15">PDvL<span class="def-item-dt-sep"></span></dt><dd>volume of the left LGN with the PD sequence<span class="def-item-dd-sep"></span></dd><dt id="def-item-16">PDvR<span class="def-item-dt-sep"></span></dt><dd>volume of the right LGN with the PD sequence<span class="def-item-dd-sep"></span></dd><dt id="def-item-17">POAG<span class="def-item-dt-sep"></span></dt><dd>primary open-angle glaucoma<span class="def-item-dd-sep"></span></dd><dt id="def-item-18">stage A<span class="def-item-dt-sep"></span></dt><dd>the sum of the clinical stages of both eyes<span class="def-item-dd-sep"></span></dd><dt id="def-item-19">stage L<span class="def-item-dt-sep"></span></dt><dd>the clinical stage of the left eye of a patient with POAG<span class="def-item-dd-sep"></span></dd><dt id="def-item-20">stage R<span class="def-item-dt-sep"></span></dt><dd>the clinical stage of the right eye of a patient with POAG<span class="def-item-dd-sep"></span></dd><dt id="def-item-21">Sum<span class="def-item-dt-sep"></span></dt><dd>the summation of height and volume bilaterally</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/32/7/1347.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 32</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 7 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Aug 2011 </div></div>
      
      
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      <div class="highwire-cite-title">Assessment of Lateral Geniculate Nucleus Atrophy with 3T MR Imaging and Correlation with Clinical Stage of Glaucoma</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Dai</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">K.T.</span> <span class="nlm-surname">Mu</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.P.</span> <span class="nlm-surname">Qi</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">C.Y.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">W.Z.</span> <span class="nlm-surname">Zhu</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">L.M.</span> <span class="nlm-surname">Xia</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Z.Q.</span> <span class="nlm-surname">Chen</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Ai</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">J.N.</span> <span class="nlm-surname">Morelli</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2011, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1347-1353; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2486 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Dai</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">K.T.</span> <span class="nlm-surname">Mu</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.P.</span> <span class="nlm-surname">Qi</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">C.Y.</span> <span class="nlm-surname">Wang</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">W.Z.</span> <span class="nlm-surname">Zhu</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">L.M.</span> <span class="nlm-surname">Xia</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">Z.Q.</span> <span class="nlm-surname">Chen</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Ai</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">J.N.</span> <span class="nlm-surname">Morelli</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2011, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1347-1353; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2486 </span></div>
  
  
  
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