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<meta name="DC.Title" content="Delay Correction for the Assessment of Blood-Brain Barrier Permeability Using First-Pass Dynamic Perfusion CT" />
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<meta name="DC.Date" content="2011-08-01" />
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<meta name="DC.Description" content="SUMMARY: Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.

ACA
:   anterior cerebral artery
AIF
:   arterial input function
BBB
:   blood-brain barrier
BBBP
:   blood-brain barrier permeability
CBF
:   cerebral blood flow
CBV
:   cerebral blood volume
CI
:   confidence interval
CTA
:   CT angiography
FLAIR
:   fluid-attenuated inversion recovery
GEE
:   generalized estimating equations
MCA
:   middle cerebral artery
√MSE
:   root mean squared errors
MSE
:   mean squared error
MTT
:   mean transit time
NCCT
:   noncontrast CT
PCA
:   posterior cerebral artery
PCT
:   perfusion CT
PET
:   positron-emission tomography
RIF
:   region input function
rtPA
:   recombinant tissue plasminogen activator
TTP
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&lt;p&gt;Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.&lt;/p&gt;" />
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<meta name="twitter:title" content="Delay Correction for the Assessment of Blood-Brain Barrier Permeability Using First-Pass Dynamic Perfusion CT" />
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<meta name="twitter:description" content="SUMMARY: Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.

ACA
:   anterior cerebral artery
AIF
:   arterial input function
BBB
:   blood-brain barrier
BBBP
:   blood-brain barrier permeability
CBF
:   cerebral blood flow
CBV
:   cerebral blood volume
CI
:   confidence interval
CTA
:   CT angiography
FLAIR
:   fluid-attenuated inversion recovery
GEE
:   generalized estimating equations
MCA
:   middle cerebral artery
√MSE
:   root mean squared errors
MSE
:   mean squared error
MTT
:   mean transit time
NCCT
:   noncontrast CT
PCA
:   posterior cerebral artery
PCT
:   perfusion CT
PET
:   positron-emission tomography
RIF
:   region input function
rtPA
:   recombinant tissue plasminogen activator
TTP
:   time to peak" />
<meta name="og-title" property="og:title" content="Delay Correction for the Assessment of Blood-Brain Barrier Permeability Using First-Pass Dynamic Perfusion CT" />
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<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="SUMMARY: Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.

ACA
:   anterior cerebral artery
AIF
:   arterial input function
BBB
:   blood-brain barrier
BBBP
:   blood-brain barrier permeability
CBF
:   cerebral blood flow
CBV
:   cerebral blood volume
CI
:   confidence interval
CTA
:   CT angiography
FLAIR
:   fluid-attenuated inversion recovery
GEE
:   generalized estimating equations
MCA
:   middle cerebral artery
√MSE
:   root mean squared errors
MSE
:   mean squared error
MTT
:   mean transit time
NCCT
:   noncontrast CT
PCA
:   posterior cerebral artery
PCT
:   perfusion CT
PET
:   positron-emission tomography
RIF
:   region input function
rtPA
:   recombinant tissue plasminogen activator
TTP
:   time to peak" />
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">T. Schneider</span>, <span class="highwire-citation-author" data-delta="1">J. Hom</span>, <span class="highwire-citation-author" data-delta="2">J. Bredno</span>, <span class="highwire-citation-author" data-delta="3">J.W. Dankbaar</span>, <span class="highwire-citation-author" data-delta="4">S.-C. Cheng</span> and <span class="highwire-citation-author" data-delta="5">M. Wintermark</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">August 2011,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">E134-E138; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2152 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-11437--61440722875" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">T. Schneider </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=T.%2BSchneider%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Schneider%20T&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AT.%2BSchneider%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J. 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Dankbaar </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.W.%2BDankbaar%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Dankbaar%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.W.%2BDankbaar%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">S.-C. Cheng </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.-C.%2BCheng%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Cheng%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.-C.%2BCheng%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">M. 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<p id="p-2"><strong>SUMMARY:</strong> Hemorrhagic transformation is a serious potential complication of ischemic stroke with damage to the BBB as one of the contributing mechanisms. BBB permeability measurements extracted from PCT by using the Patlak model can provide a valuable assessment of the extent of BBB damage. Unfortunately, Patlak assumptions require extended PCT acquisition, increasing the risk of motion artifacts. A necessary correction is presented for obtaining accurate BBB permeability measurements from first-pass PCT.</p>
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</div><div class="section glossary" id="glossary-1"><h2>Abbreviations</h2><dl id="def-list-1"><dt id="def-item-1">ACA<span class="def-item-dt-sep"></span></dt><dd>anterior cerebral artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">AIF<span class="def-item-dt-sep"></span></dt><dd>arterial input function<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">BBB<span class="def-item-dt-sep"></span></dt><dd>blood-brain barrier<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">BBBP<span class="def-item-dt-sep"></span></dt><dd>blood-brain barrier permeability<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">CBF<span class="def-item-dt-sep"></span></dt><dd>cerebral blood flow<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">CBV<span class="def-item-dt-sep"></span></dt><dd>cerebral blood volume<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">CI<span class="def-item-dt-sep"></span></dt><dd>confidence interval<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">CTA<span class="def-item-dt-sep"></span></dt><dd>CT angiography<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">FLAIR<span class="def-item-dt-sep"></span></dt><dd>fluid-attenuated inversion recovery<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">GEE<span class="def-item-dt-sep"></span></dt><dd>generalized estimating equations<span class="def-item-dd-sep"></span></dd><dt id="def-item-11">MCA<span class="def-item-dt-sep"></span></dt><dd>middle cerebral artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-12">√MSE<span class="def-item-dt-sep"></span></dt><dd>root mean squared errors<span class="def-item-dd-sep"></span></dd><dt id="def-item-13">MSE<span class="def-item-dt-sep"></span></dt><dd>mean squared error<span class="def-item-dd-sep"></span></dd><dt id="def-item-14">MTT<span class="def-item-dt-sep"></span></dt><dd>mean transit time<span class="def-item-dd-sep"></span></dd><dt id="def-item-15">NCCT<span class="def-item-dt-sep"></span></dt><dd>noncontrast CT<span class="def-item-dd-sep"></span></dd><dt id="def-item-16">PCA<span class="def-item-dt-sep"></span></dt><dd>posterior cerebral artery<span class="def-item-dd-sep"></span></dd><dt id="def-item-17">PCT<span class="def-item-dt-sep"></span></dt><dd>perfusion CT<span class="def-item-dd-sep"></span></dd><dt id="def-item-18">PET<span class="def-item-dt-sep"></span></dt><dd>positron-emission tomography<span class="def-item-dd-sep"></span></dd><dt id="def-item-19">RIF<span class="def-item-dt-sep"></span></dt><dd>region input function<span class="def-item-dd-sep"></span></dd><dt id="def-item-20">rtPA<span class="def-item-dt-sep"></span></dt><dd>recombinant tissue plasminogen activator<span class="def-item-dd-sep"></span></dd><dt id="def-item-21">TTP<span class="def-item-dt-sep"></span></dt><dd>time to peak</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">Copyright © American Society of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at <a href="http://www.ajnr.org">www.ajnr.org</a></p></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/32/7/E134.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 32</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 7 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Aug 2011 </div></div>
      
      
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      <div class="highwire-cite-title">Delay Correction for the Assessment of Blood-Brain Barrier Permeability Using First-Pass Dynamic Perfusion CT</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Schneider</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Hom</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Bredno</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.W.</span> <span class="nlm-surname">Dankbaar</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">S.-C.</span> <span class="nlm-surname">Cheng</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Wintermark</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2011, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">E134-E138; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2152 </span></div>
  
  
  
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      <div class="highwire-cite-title">Delay Correction for the Assessment of Blood-Brain Barrier Permeability Using First-Pass Dynamic Perfusion CT</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Schneider</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Hom</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Bredno</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.W.</span> <span class="nlm-surname">Dankbaar</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">S.-C.</span> <span class="nlm-surname">Cheng</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Wintermark</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Aug 2011, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">32 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(7) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">E134-E138; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2152 </span></div>
  
  
  
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