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<meta name="DC.Title" content="A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values" />
<meta name="DC.Identifier" content="10.3174/ajnr.A2844" />
<meta name="DC.Date" content="2012-04-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2012 by American Journal of Neuroradiology. 
Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: DTI is increasingly being used as a measure to study tissue damage in several neurologic diseases. Our aim was to investigate the comparability of DTI measures between different MR imaging magnets and platforms.

MATERIALS AND METHODS: Two healthy volunteers underwent DTI on five 3T MR imaging scanners (3 Trios and 2 Signas) by using a matched 33 noncollinear diffusion-direction pulse sequence. Within each subject, a total of 16 white matter (corpus callosum, periventricular, and deep white matter) and gray matter (cortical and deep gray) ROIs were drawn on a single image set and then were coregistered to the other images. Mean FA, ADC, and longitudinal and transverse diffusivities were calculated within each ROI. Concordance correlations were derived by comparing ROI DTI values among each of the 5 magnets.

RESULTS: Mean concordance for FA was 0.96; for both longitudinal and transverse diffusivities, it was 0.93; and for ADC, it was 0.88. Mean scan-rescan concordance was 0.96–0.97 for all DTI measures. Concordance correlations within platforms were, in general, better than those between platforms for all DTI measures (mean concordance of 0.96).

CONCLUSIONS: We found that a 3T magnet and high-angular-resolution pulse sequence yielded comparable DTI measurements across different MR imaging magnets and platforms. Our results indicate that FA is the most comparable measure across magnets, followed by individual diffusivities. The comparability of DTI measures between different magnets supports the feasibility of multicentered clinical trials by using DTI as an outcome measure.

CV
:   coefficient of variation
FA
:   fractional anisotropy
λ⊥
:   transverse diffusivity
λ‖
:   longitudinal diffusivity
MPRAGE
:   magnetization-prepared rapid acquisition of gradient echo
TIM
:   Total Imaging Matrix" />
<meta name="DC.Contributor" content="R.J. Fox" />
<meta name="DC.Contributor" content="K. Sakaie" />
<meta name="DC.Contributor" content="J.-C. Lee" />
<meta name="DC.Contributor" content="J.P. Debbins" />
<meta name="DC.Contributor" content="Y. Liu" />
<meta name="DC.Contributor" content="D.L. Arnold" />
<meta name="DC.Contributor" content="E.R. Melhem" />
<meta name="DC.Contributor" content="C.H. Smith" />
<meta name="DC.Contributor" content="M.D. Philips" />
<meta name="DC.Contributor" content="M. Lowe" />
<meta name="DC.Contributor" content="E. Fisher" />
<meta name="article:published_time" content="2012-04-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;DTI is increasingly being used as a measure to study tissue damage in several neurologic diseases. Our aim was to investigate the comparability of DTI measures between different MR imaging magnets and platforms.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Two healthy volunteers underwent DTI on five 3T MR imaging scanners (3 Trios and 2 Signas) by using a matched 33 noncollinear diffusion-direction pulse sequence. Within each subject, a total of 16 white matter (corpus callosum, periventricular, and deep white matter) and gray matter (cortical and deep gray) ROIs were drawn on a single image set and then were coregistered to the other images. Mean FA, ADC, and longitudinal and transverse diffusivities were calculated within each ROI. Concordance correlations were derived by comparing ROI DTI values among each of the 5 magnets.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Mean concordance for FA was 0.96; for both longitudinal and transverse diffusivities, it was 0.93; and for ADC, it was 0.88. Mean scan-rescan concordance was 0.96–0.97 for all DTI measures. Concordance correlations within platforms were, in general, better than those between platforms for all DTI measures (mean concordance of 0.96).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;We found that a 3T magnet and high-angular-resolution pulse sequence yielded comparable DTI measurements across different MR imaging magnets and platforms. Our results indicate that FA is the most comparable measure across magnets, followed by individual diffusivities. The comparability of DTI measures between different magnets supports the feasibility of multicentered clinical trials by using DTI as an outcome measure.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2012/04/01" />
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<meta name="citation_reference" content="citation_journal_title=Annals of the New York Academy of Sciences;citation_journal_abbrev=Ann. N. Y. Acad. Sci.;citation_author=Y. Ge;citation_author=M. Law;citation_author=RI. Grossman;citation_title=Applications of Diffusion Tensor MR Imaging in Multiple Sclerosis;citation_pages=202-219;citation_volume=1064;citation_year=2005;citation_issue=1;citation_issn=0077-8923;citation_pmid=16394158;citation_doi=10.1196/annals.1340.039" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=C. Pierpaoli;citation_author=PJ. Basser;citation_title=Toward a quantitative assessment of diffusion anisotropy.;citation_pages=893-906;citation_volume=36;citation_year=1996;citation_issue=6;citation_pmid=8946355;citation_doi=10.1002/mrm.1910360612" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=R. Bammer;citation_author=M. Augustin;citation_author=S. Strasser-Fuchs;citation_title=Magnetic resonance diffusion tensor imaging for characterizing diffuse and focal white matter abnormalities in multiple sclerosis.;citation_pages=583-591;citation_volume=44;citation_year=2000;citation_issue=4;citation_pmid=11025514;citation_doi=10.1002/1522-2594(200010)44:4&lt;583::AID-MRM12&gt;3.0.CO;2-O" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=DJ. Werring;citation_author=CA. Clark;citation_author=GJ. Barker;citation_title=Diffusion tensor imaging of lesions and normal-appearing white matter in multiple sclerosis;citation_pages=1626-1626;citation_volume=52;citation_year=1999;citation_issue=8;citation_issn=0028-3878;citation_pmid=10331689;citation_doi=10.1212/WNL.52.8.1626" />
<meta name="citation_reference" content="citation_journal_title=Archives of Neurology;citation_journal_abbrev=Arch Neurol;citation_author=M. Filippi;citation_author=G. Iannucci;citation_author=M. Cercignani;citation_title=A Quantitative Study of Water Diffusion in Multiple Sclerosis Lesions and Normal-Appearing White Matter Using Echo-Planar Imaging;citation_pages=1017-1021;citation_volume=57;citation_year=2000;citation_issue=7;citation_issn=0003-9942;citation_pmid=10891984;citation_doi=10.1001/archneur.57.7.1017" />
<meta name="citation_reference" content="citation_journal_title=Neurology;citation_journal_abbrev=Neurology;citation_author=O. Ciccarelli;citation_author=DJ. Werring;citation_author=CA. Wheeler-Kingshott;citation_title=Investigation of MS normal-appearing brain using diffusion tensor MRI with clinical correlations;citation_pages=926-933;citation_volume=56;citation_year=2001;citation_issue=7;citation_issn=0028-3878;citation_pmid=11294931;citation_doi=10.1212/WNL.56.7.926" />
<meta name="citation_reference" content="citation_journal_title=J Neurol. Sci;citation_author=JA. Maldjian;citation_author=RI. Grossman;citation_title=Future applications of DWI in MS;citation_pages=S55-57;citation_volume=186;citation_year=2001;citation_pmid=11334991;citation_doi=10.1016/S0022-510X(01)00494-4" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance imaging :  JMRI;citation_journal_abbrev=J Magn Reson Imaging;citation_author=E. Pagani;citation_author=JG. Hirsch;citation_author=PJ. Pouwels;citation_title=Intercenter differences in diffusion tensor MRI acquisition.;citation_pages=1458-1468;citation_volume=31;citation_year=2010;citation_issue=6;citation_pmid=20512899;citation_doi=10.1002/jmri.22186" />
<meta name="citation_reference" content="citation_journal_abbrev=NeuroImage;citation_author=C. Vollmar;citation_author=J. O'Muircheartaigh;citation_author=GJ. Barker;citation_title=Identical, but not the same: intra-site and inter-site reproducibility of fractional anisotropy measures on two 3.0T scanners.;citation_pages=1384-1394;citation_volume=51;citation_year=2010;citation_issue=4;citation_pmid=20338248;citation_doi=10.1016/j.neuroimage.2010.03.046" />
<meta name="citation_reference" content="citation_journal_title=IEEE Trans Pattern Analysis;citation_author=PJ. Besl;citation_author=ND. McKay;citation_title=A method for registration of 3-D shapes;citation_pages=239-56;citation_volume=14;citation_year=1992;citation_doi=10.1109/34.121791" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance. Series B;citation_journal_abbrev=J Magn Reson B;citation_author=PJ. Basser;citation_author=J. Mattiello;citation_author=D. LeBihan;citation_title=Estimation of the effective self-diffusion tensor from the NMR spin echo.;citation_pages=247-254;citation_volume=103;citation_year=1994;citation_issue=3;citation_pmid=8019776;citation_doi=10.1006/jmrb.1994.1037" />
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<meta name="citation_reference" content="citation_journal_title=Biometrics;citation_author=LI-K. Lin;citation_title=A note on the concordance correlation coefficient;citation_pages=324-25;citation_volume=56;citation_year=2000;citation_doi=10.1111/j.0006-341X.2000.00324.x" />
<meta name="citation_reference" content="citation_journal_title=Magnetic resonance in medicine :  official journal of the Society of Magnetic Resonance in Medicine / Society of Magnetic Resonance in Medicine;citation_journal_abbrev=Magn Reson Med;citation_author=DK. Jones;citation_title=The effect of gradient sampling schemes on measures derived from diffusion tensor MRI: a Monte Carlo study.;citation_pages=807-815;citation_volume=51;citation_year=2004;citation_issue=4;citation_pmid=15065255;citation_doi=10.1002/mrm.20033" />
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<meta name="citation_reference" content="citation_journal_title=American Journal of Neuroradiology;citation_journal_abbrev=Am. J. Neuroradiol.;citation_author=H. Oouchi;citation_author=K. Yamada;citation_author=K. Sakai;citation_title=Diffusion Anisotropy Measurement of Brain White Matter Is Affected by Voxel Size: Underestimation Occurs in Areas with Crossing Fibers;citation_pages=1102-1106;citation_volume=28;citation_year=2007;citation_issue=6;citation_issn=0195-6108;citation_pmid=17569968;citation_doi=10.3174/ajnr.A0488" />
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<meta name="citation_reference" content="citation_journal_title=Neuroimage;citation_author=E. Heiervang;citation_author=TE. Behrens;citation_author=CE. Mackay;citation_title=Between session reproducibility and between subject variability of diffusion MR and tractography measures;citation_pages=867-77;citation_volume=33;citation_year=2006;citation_pmid=17000119;citation_doi=10.1016/j.neuroimage.2006.07.037" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance imaging :  JMRI;citation_journal_abbrev=J Magn Reson Imaging;citation_author=A. Pfefferbaum;citation_author=E. Adalsteinsson;citation_author=EV. Sullivan;citation_title=Replicability of diffusion tensor imaging measurements of fractional anisotropy and trace in brain.;citation_pages=427-433;citation_volume=18;citation_year=2003;citation_issue=4;citation_pmid=14508779;citation_doi=10.1002/jmri.10377" />
<meta name="citation_reference" content="citation_journal_title=Journal of magnetic resonance imaging :  JMRI;citation_journal_abbrev=J Magn Reson Imaging;citation_author=B. Jasperse;citation_author=P. Valsasina;citation_author=V. Neacsu;citation_title=Intercenter agreement of brain atrophy measurement in multiple sclerosis patients using manually-edited SIENA and SIENAX.;citation_pages=881-885;citation_volume=26;citation_year=2007;citation_issue=4;citation_pmid=17896359;citation_doi=10.1002/jmri.21101" />
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<meta name="twitter:title" content="A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: DTI is increasingly being used as a measure to study tissue damage in several neurologic diseases. Our aim was to investigate the comparability of DTI measures between different MR imaging magnets and platforms.

MATERIALS AND METHODS: Two healthy volunteers underwent DTI on five 3T MR imaging scanners (3 Trios and 2 Signas) by using a matched 33 noncollinear diffusion-direction pulse sequence. Within each subject, a total of 16 white matter (corpus callosum, periventricular, and deep white matter) and gray matter (cortical and deep gray) ROIs were drawn on a single image set and then were coregistered to the other images. Mean FA, ADC, and longitudinal and transverse diffusivities were calculated within each ROI. Concordance correlations were derived by comparing ROI DTI values among each of the 5 magnets.

RESULTS: Mean concordance for FA was 0.96; for both longitudinal and transverse diffusivities, it was 0.93; and for ADC, it was 0.88. Mean scan-rescan concordance was 0.96–0.97 for all DTI measures. Concordance correlations within platforms were, in general, better than those between platforms for all DTI measures (mean concordance of 0.96).

CONCLUSIONS: We found that a 3T magnet and high-angular-resolution pulse sequence yielded comparable DTI measurements across different MR imaging magnets and platforms. Our results indicate that FA is the most comparable measure across magnets, followed by individual diffusivities. The comparability of DTI measures between different magnets supports the feasibility of multicentered clinical trials by using DTI as an outcome measure.

CV
:   coefficient of variation
FA
:   fractional anisotropy
λ⊥
:   transverse diffusivity
λ‖
:   longitudinal diffusivity
MPRAGE
:   magnetization-prepared rapid acquisition of gradient echo
TIM
:   Total Imaging Matrix" />
<meta name="og-title" property="og:title" content="A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/33/4/695" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: DTI is increasingly being used as a measure to study tissue damage in several neurologic diseases. Our aim was to investigate the comparability of DTI measures between different MR imaging magnets and platforms.

MATERIALS AND METHODS: Two healthy volunteers underwent DTI on five 3T MR imaging scanners (3 Trios and 2 Signas) by using a matched 33 noncollinear diffusion-direction pulse sequence. Within each subject, a total of 16 white matter (corpus callosum, periventricular, and deep white matter) and gray matter (cortical and deep gray) ROIs were drawn on a single image set and then were coregistered to the other images. Mean FA, ADC, and longitudinal and transverse diffusivities were calculated within each ROI. Concordance correlations were derived by comparing ROI DTI values among each of the 5 magnets.

RESULTS: Mean concordance for FA was 0.96; for both longitudinal and transverse diffusivities, it was 0.93; and for ADC, it was 0.88. Mean scan-rescan concordance was 0.96–0.97 for all DTI measures. Concordance correlations within platforms were, in general, better than those between platforms for all DTI measures (mean concordance of 0.96).

CONCLUSIONS: We found that a 3T magnet and high-angular-resolution pulse sequence yielded comparable DTI measurements across different MR imaging magnets and platforms. Our results indicate that FA is the most comparable measure across magnets, followed by individual diffusivities. The comparability of DTI measures between different magnets supports the feasibility of multicentered clinical trials by using DTI as an outcome measure.

CV
:   coefficient of variation
FA
:   fractional anisotropy
λ⊥
:   transverse diffusivity
λ‖
:   longitudinal diffusivity
MPRAGE
:   magnetization-prepared rapid acquisition of gradient echo
TIM
:   Total Imaging Matrix" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node11873--5" data-node-nid="11873" id="top-node-11873--6762263723" data-pisa="ajnr;33/4/695" data-pisa-master="ajnr;ajnr.A2844" data-apath="/ajnr/33/4/695.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Brain</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">R.J. Fox</span>, <span class="highwire-citation-author" data-delta="1">K. Sakaie</span>, <span class="highwire-citation-author" data-delta="2">J.-C. Lee</span>, <span class="highwire-citation-author" data-delta="3">J.P. Debbins</span>, <span class="highwire-citation-author" data-delta="4">Y. Liu</span>, <span class="highwire-citation-author" data-delta="5">D.L. Arnold</span>, <span class="highwire-citation-author" data-delta="6">E.R. Melhem</span>, <span class="highwire-citation-author" data-delta="7">C.H. Smith</span>, <span class="highwire-citation-author" data-delta="8">M.D. Philips</span>, <span class="highwire-citation-author" data-delta="9">M. Lowe</span> and <span class="highwire-citation-author" data-delta="10">E. Fisher</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">April 2012,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">33 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">695-700; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2844 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-11873--6762263723" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">R.J. Fox </div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.J.%2BFox%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Fox%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.J.%2BFox%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">K. 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<p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> DTI is increasingly being used as a measure to study tissue damage in several neurologic diseases. Our aim was to investigate the comparability of DTI measures between different MR imaging magnets and platforms.</p>
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<p id="p-3"><strong>MATERIALS AND METHODS:</strong> Two healthy volunteers underwent DTI on five 3T MR imaging scanners (3 Trios and 2 Signas) by using a matched 33 noncollinear diffusion-direction pulse sequence. Within each subject, a total of 16 white matter (corpus callosum, periventricular, and deep white matter) and gray matter (cortical and deep gray) ROIs were drawn on a single image set and then were coregistered to the other images. Mean FA, ADC, and longitudinal and transverse diffusivities were calculated within each ROI. Concordance correlations were derived by comparing ROI DTI values among each of the 5 magnets.</p> 
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<p id="p-4"><strong>RESULTS:</strong> Mean concordance for FA was 0.96; for both longitudinal and transverse diffusivities, it was 0.93; and for ADC, it was 0.88. Mean scan-rescan concordance was 0.96–0.97 for all DTI measures. Concordance correlations within platforms were, in general, better than those between platforms for all DTI measures (mean concordance of 0.96).</p>
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<p id="p-5"><strong>CONCLUSIONS:</strong> We found that a 3T magnet and high-angular-resolution pulse sequence yielded comparable DTI measurements across different MR imaging magnets and platforms. Our results indicate that FA is the most comparable measure across magnets, followed by individual diffusivities. The comparability of DTI measures between different magnets supports the feasibility of multicentered clinical trials by using DTI as an outcome measure.</p>
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</div><div class="section glossary" id="glossary-1">
<h2>ABBREVIATIONS:</h2>
<dl id="def-list-1"><dt id="def-item-1">CV<span class="def-item-dt-sep"></span></dt><dd>coefficient of variation<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">FA<span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">λ<sub>⊥</sub><span class="def-item-dt-sep"></span></dt><dd>transverse diffusivity<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">λ<sub>‖</sub><span class="def-item-dt-sep"></span></dt><dd>longitudinal diffusivity<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">MPRAGE<span class="def-item-dt-sep"></span></dt><dd>magnetization-prepared rapid acquisition of gradient echo<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">TIM<span class="def-item-dt-sep"></span></dt><dd>Total Imaging Matrix</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2012 by American Journal of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at <a href="http://www.ajnr.org">www.ajnr.org</a>
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 33</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 4 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Apr 2012 </div></div>
      
      
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      <div class="highwire-cite-title">A Validation Study of Multicenter Diffusion Tensor Imaging: Reliability of Fractional Anisotropy and Diffusivity Values</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">R.J.</span> <span class="nlm-surname">Fox</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Sakaie</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">J.-C.</span> <span class="nlm-surname">Lee</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">J.P.</span> <span class="nlm-surname">Debbins</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">Y.</span> <span class="nlm-surname">Liu</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">D.L.</span> <span class="nlm-surname">Arnold</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">E.R.</span> <span class="nlm-surname">Melhem</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">C.H.</span> <span class="nlm-surname">Smith</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">M.D.</span> <span class="nlm-surname">Philips</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Lowe</span></span>, <span class="highwire-citation-author" data-delta="10"><span class="nlm-given-names">E.</span> <span class="nlm-surname">Fisher</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Apr 2012, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">33 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(4) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">695-700; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2844 </span></div>
  
  
  
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