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<meta name="DC.Description" content="SUMMARY: Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.

EMA
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&lt;p&gt;Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.&lt;/p&gt;" />
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<meta name="twitter:title" content="MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings" />
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<meta name="twitter:description" content="SUMMARY: Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.

EMA
:   epithelial membrane antigen
HMB-45
:   human melanoma black-45
IHC
:   immunohistochemistry
MM
:   meningeal melanocytoma" />
<meta name="og-title" property="og:title" content="MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings" />
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<meta name="og-description" property="og:description" content="SUMMARY: Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.

EMA
:   epithelial membrane antigen
HMB-45
:   human melanoma black-45
IHC
:   immunohistochemistry
MM
:   meningeal melanocytoma" />
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      <h1 class="highwire-cite-title" id="page-title">MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">G.Q. Hou</span>, <span class="highwire-citation-author" data-delta="1">J.C. Sun</span>, <span class="highwire-citation-author" data-delta="2">X.J. Zhang</span>, <span class="highwire-citation-author" data-delta="3">B.X. Shen</span>, <span class="highwire-citation-author" data-delta="4">X.J. Zhu</span>, <span class="highwire-citation-author" data-delta="5">L. Liang</span> and <span class="highwire-citation-author" data-delta="6">X.L. Zhang</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">September 2012,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">33 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1525-1529; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A2987 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12048--6898413745" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">G.Q. Hou </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>aFrom the Department of Medical Image Center (G.Q.H., B.X.S.), Nanshan Hospital, Guangdong Medical College, Guangdong Province, People's Republic of China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=G.Q.%2BHou%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hou%20G&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AG.Q.%2BHou%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">J.C. Sun </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>bDepartment of Pathology (J.C.S., X.J. Zhang, L.L.), School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China</div><div class='author-affiliation'>cGuangdong Province Key Laboratory of Molecular Tumor Pathology (J.C.S., X.J. Zhang, L.L.), Guangzhou, Guangdong Province, People's Republic of China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.C.%2BSun%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sun%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.C.%2BSun%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">X.J. Zhang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>bDepartment of Pathology (J.C.S., X.J. Zhang, L.L.), School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China</div><div class='author-affiliation'>cGuangdong Province Key Laboratory of Molecular Tumor Pathology (J.C.S., X.J. Zhang, L.L.), Guangzhou, Guangdong Province, People's Republic of China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=X.J.%2BZhang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zhang%20X&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AX.J.%2BZhang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">B.X. Shen </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>aFrom the Department of Medical Image Center (G.Q.H., B.X.S.), Nanshan Hospital, Guangdong Medical College, Guangdong Province, People's Republic of China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B.X.%2BShen%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Shen%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AB.X.%2BShen%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">X.J. Zhu </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>dDepartment of Medical Image Center (X.L.Z., X.J. Zhu), Nanfang Hospital, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=X.J.%2BZhu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Zhu%20X&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AX.J.%2BZhu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">L. Liang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'>bDepartment of Pathology (J.C.S., X.J. Zhang, L.L.), School of Basic Medical Sciences, Southern Medical University, Guangzhou, Guangdong Province, People's Republic of China</div><div class='author-affiliation'>cGuangdong Province Key Laboratory of Molecular Tumor Pathology (J.C.S., X.J. Zhang, L.L.), Guangzhou, Guangdong Province, People's Republic of China</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.%2BLiang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Liang%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AL.%2BLiang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">X.L. 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<p id="p-2"><strong>SUMMARY:</strong> Our aim was to better understand and improve the accuracy of the preoperative diagnosis of intraspinal MM by a combined analysis of MR imaging and pathologic findings. All 5 patients had undergone unenhanced and contrast-enhanced MR imaging examinations. All tumor samples had immunohistochemical reactions to HMB-45, vimentin, S-100, EMA, and Leu-7 antibodies. All 5 cases were located in the intradural extramedullary compartment. Two cases had multifocal lesions, and 3 cases were solitary. Two cases showed homogeneously strong enhancement, and 3 cases showed moderate enhancement on contrast-enhanced T1WI. The tumor cells had positive reactions to HMB-45, vimentin, and S-100 antibodies. MR imaging plays an important role in the detection and diagnosis of intraspinal MM. Final diagnosis should be based on histopathology and IHC examinations.</p>
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</div><div class="section glossary" id="glossary-1"><h2>ABBREVIATIONS:</h2>
<dl id="def-list-1"><dt id="def-item-1">EMA<span class="def-item-dt-sep"></span></dt><dd>epithelial membrane antigen<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">HMB-45<span class="def-item-dt-sep"></span></dt><dd>human melanoma black-45<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">IHC<span class="def-item-dt-sep"></span></dt><dd>immunohistochemistry<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">MM<span class="def-item-dt-sep"></span></dt><dd>meningeal melanocytoma</dd></dl>
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      <div class="highwire-cite-title">MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings</div>  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2012, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">33 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1525-1529; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2987 </span></div>
  
  
  
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      <div class="highwire-cite-title">MR Imaging Findings of the Intraspinal Meningeal Melanocytoma: Correlation with Histopathologic Findings</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">G.Q.</span> <span class="nlm-surname">Hou</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">J.C.</span> <span class="nlm-surname">Sun</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">X.J.</span> <span class="nlm-surname">Zhang</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">B.X.</span> <span class="nlm-surname">Shen</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">X.J.</span> <span class="nlm-surname">Zhu</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Liang</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">X.L.</span> <span class="nlm-surname">Zhang</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Sep 2012, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">33 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(8) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">1525-1529; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A2987 </span></div>
  
  
  
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