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High-Pass-Filtered Phase Image: Left- versus Right-Handed MR Imaging Systems
============================================================================

* T.M. Mehemed
* A. Yamamoto

We read with interest the article entitled “Detection of Intratumoral Calcification in Oligodendrogliomas by Susceptibility-Weighted MR Imaging”1 and would like to comment on the appearance of calcification on the high-pass-filtered phase images.

The authors reported that the paramagnetic (authors wrote “diamagnetic”) hemorrhagic component of the tumor would cause a negative phase shift and appear as dark signal on the high-pass-filtered phase images, while the diamagnetic (authors wrote “paramagnetic”) intratumoral calcifications would cause an opposite positive phase shift and appear as bright signal on the high-pass-filtered phase images. This description is true, but only in the case of right-handed MR imaging systems, while in left-handed MR imaging systems, the complete opposite signal would be seen: Paramagnetic substances would appear bright, while diamagnetic substances would appear dark.2,3

In Figs 2*D* and 3*D* of the above-mentioned article, the high-pass-filtered phase images are those of a left-handed MR imaging system, evident by the bright signal of the veins (paramagnetic deoxyhemoglobin).3

The article showed that high-pass-filtered phase images can depict intratumoral calcification in oligodendrogliomas better than conventional MR images; this finding has been reported before.4 Understanding the contrast appearance of high-pass-filtered phase images on left-handed versus right-handed MR imaging systems would make distinguishing diamagnetic calcification from paramagnetic hemorrhage a much easier task and prevent any possible confusion.

## REFERENCES

1.  1. Zulfiqar M, Dumrongpisutikul N, Intrapiromkul J, et al. Detection of intratumoral calcification in oligodendrogliomas by susceptibility-weighted MR imaging. AJNR Am J Neuroradiol 2012;33:858–64
    
    [Abstract/FREE Full Text](http://www.ajnr.org/lookup/ijlink/YTozOntzOjQ6InBhdGgiO3M6MTQ6Ii9sb29rdXAvaWpsaW5rIjtzOjU6InF1ZXJ5IjthOjQ6e3M6ODoibGlua1R5cGUiO3M6NDoiQUJTVCI7czoxMToiam91cm5hbENvZGUiO3M6NDoiYWpuciI7czo1OiJyZXNpZCI7czo4OiIzMy81Lzg1OCI7czo0OiJhdG9tIjtzOjE5OiIvYWpuci8zNC82L0U3Mi5hdG9tIjt9czo4OiJmcmFnbWVudCI7czowOiIiO30=) 

2.  2. 1.  Haacke EM, 
    2.  Reichenbach JR
    
    Duyn J, Speck O. Brain Anatomy with Phase. In: Haacke EM, Reichenbach JR. Susceptibility Weighted Imaging in MRI: Basic Concepts and Clinical Applications. Hoboken, New Jersey: John Wiley & Sons; 2011:121–36
    
    

3.  3. 1.  Haacke EM, 
    2.  Reichenbach JR
    
    Mittal S, Thomas B, Wu Z, et al. Novel approaches to imaging brain tumors. In: Haacke EM, Reichenbach JR. Susceptibility Weighted Imaging in MRI: Basic Concepts and Clinical Applications. Hoboken, New Jersey: John Wiley & Sons; 2011:151–70
    
    

4.  4. Wu Z, Mittal S, Kish K, et al. Identification of calcification with MRI using susceptibility-weighted imaging: a case study. J Magn Reson Imaging 2009;29:177–82
    
    [CrossRef](http://www.ajnr.org/lookup/external-ref?access_num=10.1002/jmri.21617&link_type=DOI) 
    
    [PubMed](http://www.ajnr.org/lookup/external-ref?access_num=19097156&link_type=MED&atom=%2Fajnr%2F34%2F6%2FE72.atom) 

*   © 2013 by American Journal of Neuroradiology