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<!DOCTYPE html>
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<meta name="category" content="research-article" />
<meta name="HW.identifier" content="/ajnr/35/2/278.atom" />
<meta name="HW.pisa" content="ajnr;35/2/278" />
<meta name="DC.Format" content="text/html" />
<meta name="DC.Language" content="en" />
<meta name="DC.Title" content="62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [18F]Fluorodeoxyglucose and L-Methyl-[11C]Methionine PET" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3679" />
<meta name="DC.Date" content="2014-02-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2014 by American Journal of Neuroradiology. Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) was developed as a hypoxic radiotracer in PET. We compared imaging features among MR imaging and 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)-PET, FDG-PET, and L-methyl-[11C]methionine)-PET in gliomas.

MATERIALS AND METHODS: We enrolled 23 patients who underwent 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)-PET and FDG-PET and 19 (82.6%) who underwent L-methyl-[11C]methionine)–PET, with all 23 patients undergoing surgery and their diagnosis being then confirmed by histologic examination as a glioma. Semiquantitative and volumetric analysis were used for the comparison.

RESULTS: There were 10 newly diagnosed glioblastoma multiforme and 13 nonglioblastoma multiforme (grades II and III), including 4 recurrences without any adjuvant treatment. The maximum standardized uptake value and tumor/background ratios of 62Cu-diacetyl-bis(N4-methylthiosemicarbazone), as well as L-methyl-[11C]methionine, were significantly higher in glioblastoma multiforme than in nonglioblastoma multiforme ( P = .03 and P = .03, respectively); no significant differences were observed on FDG. At a tumor/background ratio cutoff threshold of 1.9, 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) was most predictive of glioblastoma multiforme, with 90.0% sensitivity and 76.9% specificity. The positive and negative predictive values, respectively, for glioblastoma multiforme were 75.0% and 85.7% on 62Cu-diacetyl-bis(N4-methylthiosemicarbazone), 83.3% and 60.0% on L-methyl-[11C]methionine, and 72.7% and 75.0% on MR imaging. In glioblastoma multiforme, volumetric analysis demonstrated that 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) uptake had significant correlations with FDG ( r = 0.68, P = .03) and L-methyl-[11C]methionine ( r = 0.87, P = .03). However, the 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)–active region was heterogeneously distributed in 50.0% (5/10) of FDG-active and 0% (0/6) of L-methyl-[11C]methionine)–active regions.

CONCLUSIONS: 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) may be a practical radiotracer in the prediction of glioblastoma multiforme. In addition to FDG-PET, L-methyl-[11C]methionine)–PET, and MR imaging, 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)-PET may provide intratumoral hypoxic information useful in establishing targeted therapeutic strategies for patients with glioblastoma multiforme.

62Cu-ATSM
:   62Cu-diacetyl-bis(N4-methylthiosemicarbazone)
GBM
:   glioblastoma multiforme
MET
:   L-methyl-[11C]methionine
non-GBM gliomas
:   World Health Organization grade II and III gliomas
SUVmax
:   maximum standardized uptake value
T/B ratio
:   tumor/background ratio" />
<meta name="DC.Contributor" content="K. Tateishi" />
<meta name="DC.Contributor" content="U. Tateishi" />
<meta name="DC.Contributor" content="S. Nakanowatari" />
<meta name="DC.Contributor" content="M. Ohtake" />
<meta name="DC.Contributor" content="R. Minamimoto" />
<meta name="DC.Contributor" content="J. Suenaga" />
<meta name="DC.Contributor" content="H. Murata" />
<meta name="DC.Contributor" content="K. Kubota" />
<meta name="DC.Contributor" content="T. Inoue" />
<meta name="DC.Contributor" content="N. Kawahara" />
<meta name="article:published_time" content="2014-02-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [18F]Fluorodeoxyglucose and L-Methyl-[11C]Methionine PET" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;&lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone) was developed as a hypoxic radiotracer in PET. We compared imaging features among MR imaging and &lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone)-PET, FDG-PET, and L-methyl-[&lt;sup&gt;11&lt;/sup&gt;C]methionine)-PET in gliomas.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;We enrolled 23 patients who underwent &lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone)-PET and FDG-PET and 19 (82.6%) who underwent L-methyl-[&lt;sup&gt;11&lt;/sup&gt;C]methionine)–PET, with all 23 patients undergoing surgery and their diagnosis being then confirmed by histologic examination as a glioma. Semiquantitative and volumetric analysis were used for the comparison.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;There were 10 newly diagnosed glioblastoma multiforme and 13 nonglioblastoma multiforme (grades II and III), including 4 recurrences without any adjuvant treatment. The maximum standardized uptake value and tumor/background ratios of &lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone), as well as L-methyl-[&lt;sup&gt;11&lt;/sup&gt;C]methionine, were significantly higher in glioblastoma multiforme than in nonglioblastoma multiforme (&lt;i&gt;P&lt;/i&gt; = .03 and &lt;i&gt;P&lt;/i&gt; = .03, respectively); no significant differences were observed on FDG. At a tumor/background ratio cutoff threshold of 1.9, &lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone) was most predictive of glioblastoma multiforme, with 90.0% sensitivity and 76.9% specificity. The positive and negative predictive values, respectively, for glioblastoma multiforme were 75.0% and 85.7% on &lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone), 83.3% and 60.0% on L-methyl-[&lt;sup&gt;11&lt;/sup&gt;C]methionine, and 72.7% and 75.0% on MR imaging. In glioblastoma multiforme, volumetric analysis demonstrated that &lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone) uptake had significant correlations with FDG (&lt;i&gt;r&lt;/i&gt; = 0.68, &lt;i&gt;P&lt;/i&gt; = .03) and L-methyl-[&lt;sup&gt;11&lt;/sup&gt;C]methionine (&lt;i&gt;r&lt;/i&gt; = 0.87, &lt;i&gt;P&lt;/i&gt; = .03). However, the &lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone)–active region was heterogeneously distributed in 50.0% (5/10) of FDG-active and 0% (0/6) of L-methyl-[&lt;sup&gt;11&lt;/sup&gt;C]methionine)–active regions.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;&lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone) may be a practical radiotracer in the prediction of glioblastoma multiforme. In addition to FDG-PET, L-methyl-[&lt;sup&gt;11&lt;/sup&gt;C]methionine)–PET, and MR imaging, &lt;sup&gt;62&lt;/sup&gt;Cu-diacetyl-bis(N&lt;sup&gt;4&lt;/sup&gt;-methylthiosemicarbazone)-PET may provide intratumoral hypoxic information useful in establishing targeted therapeutic strategies for patients with glioblastoma multiforme.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2014/02/01" />
<meta name="citation_mjid" content="ajnr;35/2/278" />
<meta name="citation_id" content="35/2/278" />
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<meta name="citation_abstract_html_url" content="http://ajnr-stage2.stage.highwire.org/content/35/2/278.abstract" />
<meta name="citation_full_html_url" content="http://ajnr-stage2.stage.highwire.org/content/35/2/278.full" />
<meta name="citation_pdf_url" content="http://ajnr-stage2.stage.highwire.org/content/ajnr/35/2/278.full.pdf" />
<meta name="citation_issn" content="0195-6108" />
<meta name="citation_issn" content="1936-959X" />
<meta name="citation_doi" content="10.3174/ajnr.A3679" />
<meta name="citation_pmid" content="23928140" />
<meta name="citation_volume" content="35" />
<meta name="citation_issue" content="2" />
<meta name="citation_article_type" content="Research Article" />
<meta name="citation_section" content="Brain" />
<meta name="citation_firstpage" content="278" />
<meta name="citation_lastpage" content="284" />
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<meta name="citation_author" content="K. Tateishi" />
<meta name="citation_author_institution" content="aFrom the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)" />
<meta name="citation_author" content="U. Tateishi" />
<meta name="citation_author_institution" content="bRadiology (U.T., T.I.), Graduate School of Medicine, Yokohama City University, Yokohama, Japan" />
<meta name="citation_author" content="S. Nakanowatari" />
<meta name="citation_author_institution" content="aFrom the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)" />
<meta name="citation_author" content="M. Ohtake" />
<meta name="citation_author_institution" content="aFrom the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)" />
<meta name="citation_author" content="R. Minamimoto" />
<meta name="citation_author_institution" content="cDivision of Nuclear Medicine (R.M., K.K.), Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan." />
<meta name="citation_author" content="J. Suenaga" />
<meta name="citation_author_institution" content="aFrom the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)" />
<meta name="citation_author" content="H. Murata" />
<meta name="citation_author_institution" content="aFrom the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)" />
<meta name="citation_author" content="K. Kubota" />
<meta name="citation_author_institution" content="cDivision of Nuclear Medicine (R.M., K.K.), Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan." />
<meta name="citation_author" content="T. Inoue" />
<meta name="citation_author_institution" content="bRadiology (U.T., T.I.), Graduate School of Medicine, Yokohama City University, Yokohama, Japan" />
<meta name="citation_author" content="N. Kawahara" />
<meta name="citation_author_institution" content="aFrom the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)" />
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<meta name="twitter:title" content="62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [18F]Fluorodeoxyglucose and L-Methyl-[11C]Methionine PET" />
<meta name="twitter:card" content="summary_large_image" />
<meta name="twitter:image" content="http://ajnr-stage2.stage.highwire.org/sites/default/files/highwire/ajnr/35/2.cover-source.jpg" />
<meta name="twitter:description" content="BACKGROUND AND PURPOSE: 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) was developed as a hypoxic radiotracer in PET. We compared imaging features among MR imaging and 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)-PET, FDG-PET, and L-methyl-[11C]methionine)-PET in gliomas.

MATERIALS AND METHODS: We enrolled 23 patients who underwent 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)-PET and FDG-PET and 19 (82.6%) who underwent L-methyl-[11C]methionine)–PET, with all 23 patients undergoing surgery and their diagnosis being then confirmed by histologic examination as a glioma. Semiquantitative and volumetric analysis were used for the comparison.

RESULTS: There were 10 newly diagnosed glioblastoma multiforme and 13 nonglioblastoma multiforme (grades II and III), including 4 recurrences without any adjuvant treatment. The maximum standardized uptake value and tumor/background ratios of 62Cu-diacetyl-bis(N4-methylthiosemicarbazone), as well as L-methyl-[11C]methionine, were significantly higher in glioblastoma multiforme than in nonglioblastoma multiforme ( P = .03 and P = .03, respectively); no significant differences were observed on FDG. At a tumor/background ratio cutoff threshold of 1.9, 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) was most predictive of glioblastoma multiforme, with 90.0% sensitivity and 76.9% specificity. The positive and negative predictive values, respectively, for glioblastoma multiforme were 75.0% and 85.7% on 62Cu-diacetyl-bis(N4-methylthiosemicarbazone), 83.3% and 60.0% on L-methyl-[11C]methionine, and 72.7% and 75.0% on MR imaging. In glioblastoma multiforme, volumetric analysis demonstrated that 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) uptake had significant correlations with FDG ( r = 0.68, P = .03) and L-methyl-[11C]methionine ( r = 0.87, P = .03). However, the 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)–active region was heterogeneously distributed in 50.0% (5/10) of FDG-active and 0% (0/6) of L-methyl-[11C]methionine)–active regions.

CONCLUSIONS: 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) may be a practical radiotracer in the prediction of glioblastoma multiforme. In addition to FDG-PET, L-methyl-[11C]methionine)–PET, and MR imaging, 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)-PET may provide intratumoral hypoxic information useful in establishing targeted therapeutic strategies for patients with glioblastoma multiforme.

62Cu-ATSM
:   62Cu-diacetyl-bis(N4-methylthiosemicarbazone)
GBM
:   glioblastoma multiforme
MET
:   L-methyl-[11C]methionine
non-GBM gliomas
:   World Health Organization grade II and III gliomas
SUVmax
:   maximum standardized uptake value
T/B ratio
:   tumor/background ratio" />
<meta name="og-title" property="og:title" content="62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [18F]Fluorodeoxyglucose and L-Methyl-[11C]Methionine PET" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/35/2/278" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) was developed as a hypoxic radiotracer in PET. We compared imaging features among MR imaging and 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)-PET, FDG-PET, and L-methyl-[11C]methionine)-PET in gliomas.

MATERIALS AND METHODS: We enrolled 23 patients who underwent 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)-PET and FDG-PET and 19 (82.6%) who underwent L-methyl-[11C]methionine)–PET, with all 23 patients undergoing surgery and their diagnosis being then confirmed by histologic examination as a glioma. Semiquantitative and volumetric analysis were used for the comparison.

RESULTS: There were 10 newly diagnosed glioblastoma multiforme and 13 nonglioblastoma multiforme (grades II and III), including 4 recurrences without any adjuvant treatment. The maximum standardized uptake value and tumor/background ratios of 62Cu-diacetyl-bis(N4-methylthiosemicarbazone), as well as L-methyl-[11C]methionine, were significantly higher in glioblastoma multiforme than in nonglioblastoma multiforme ( P = .03 and P = .03, respectively); no significant differences were observed on FDG. At a tumor/background ratio cutoff threshold of 1.9, 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) was most predictive of glioblastoma multiforme, with 90.0% sensitivity and 76.9% specificity. The positive and negative predictive values, respectively, for glioblastoma multiforme were 75.0% and 85.7% on 62Cu-diacetyl-bis(N4-methylthiosemicarbazone), 83.3% and 60.0% on L-methyl-[11C]methionine, and 72.7% and 75.0% on MR imaging. In glioblastoma multiforme, volumetric analysis demonstrated that 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) uptake had significant correlations with FDG ( r = 0.68, P = .03) and L-methyl-[11C]methionine ( r = 0.87, P = .03). However, the 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)–active region was heterogeneously distributed in 50.0% (5/10) of FDG-active and 0% (0/6) of L-methyl-[11C]methionine)–active regions.

CONCLUSIONS: 62Cu-diacetyl-bis(N4-methylthiosemicarbazone) may be a practical radiotracer in the prediction of glioblastoma multiforme. In addition to FDG-PET, L-methyl-[11C]methionine)–PET, and MR imaging, 62Cu-diacetyl-bis(N4-methylthiosemicarbazone)-PET may provide intratumoral hypoxic information useful in establishing targeted therapeutic strategies for patients with glioblastoma multiforme.

62Cu-ATSM
:   62Cu-diacetyl-bis(N4-methylthiosemicarbazone)
GBM
:   glioblastoma multiforme
MET
:   L-methyl-[11C]methionine
non-GBM gliomas
:   World Health Organization grade II and III gliomas
SUVmax
:   maximum standardized uptake value
T/B ratio
:   tumor/background ratio" />
<meta name="og-type" property="og:type" content="article" />
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    <title>62Cu-Diacetyl-Bis (N4-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [18F]Fluorodeoxyglucose and L-Methyl-[11C]Methionine PET | American Journal of Neuroradiology</title>  
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node12814--5" data-node-nid="12814" id="top-node-12814--61129014286" data-pisa="ajnr;35/2/278" data-pisa-master="ajnr;ajnr.A3679" data-apath="/ajnr/35/2/278.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Brain</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title"><sup>62</sup>Cu-Diacetyl-Bis (N<sup>4</sup>-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [<sup>18</sup>F]Fluorodeoxyglucose and L-Methyl-[<sup>11</sup>C]Methionine PET</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">K. Tateishi</span>, <span class="highwire-citation-author" data-delta="1">U. Tateishi</span>, <span class="highwire-citation-author" data-delta="2">S. Nakanowatari</span>, <span class="highwire-citation-author" data-delta="3">M. Ohtake</span>, <span class="highwire-citation-author" data-delta="4">R. Minamimoto</span>, <span class="highwire-citation-author" data-delta="5">J. Suenaga</span>, <span class="highwire-citation-author" data-delta="6">H. Murata</span>, <span class="highwire-citation-author" data-delta="7">K. Kubota</span>, <span class="highwire-citation-author" data-delta="8">T. Inoue</span> and <span class="highwire-citation-author" data-delta="9">N. Kawahara</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">February 2014,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">278-284; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3679 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12814--61129014286" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">K. Tateishi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.%2BTateishi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tateishi%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AK.%2BTateishi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">U. Tateishi </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Radiology (U.T., T.I.), Graduate School of Medicine, Yokohama City University, Yokohama, Japan</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=U.%2BTateishi%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tateishi%20U&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AU.%2BTateishi%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">S. Nakanowatari </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.%2BNakanowatari%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Nakanowatari%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.%2BNakanowatari%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">M. Ohtake </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=M.%2BOhtake%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Ohtake%20M&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AM.%2BOhtake%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">R. Minamimoto </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Division of Nuclear Medicine (R.M., K.K.), Department of Radiology, National Center for Global Health and Medicine, Tokyo, Japan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=R.%2BMinamimoto%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Minamimoto%20R&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AR.%2BMinamimoto%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">J. 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Murata </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Departments of Neurosurgery (K.T., S.N., M.O., J.S., H.M., N.K.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BMurata%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Murata%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.%2BMurata%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">K. 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<p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone) was developed as a hypoxic radiotracer in PET. We compared imaging features among MR imaging and <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone)-PET, FDG-PET, and L-methyl-[<sup>11</sup>C]methionine)-PET in gliomas.</p>
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<p id="p-3"><strong>MATERIALS AND METHODS:</strong> We enrolled 23 patients who underwent <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone)-PET and FDG-PET and 19 (82.6%) who underwent L-methyl-[<sup>11</sup>C]methionine)–PET, with all 23 patients undergoing surgery and their diagnosis being then confirmed by histologic examination as a glioma. Semiquantitative and volumetric analysis were used for the comparison.</p>
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<div id="sec-3" class="subsection">

<p id="p-4"><strong>RESULTS:</strong> There were 10 newly diagnosed glioblastoma multiforme and 13 nonglioblastoma multiforme (grades II and III), including 4 recurrences without any adjuvant treatment. The maximum standardized uptake value and tumor/background ratios of <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone), as well as L-methyl-[<sup>11</sup>C]methionine, were significantly higher in glioblastoma multiforme than in nonglioblastoma multiforme (<em>P</em> = .03 and <em>P</em> = .03, respectively); no significant differences were observed on FDG. At a tumor/background ratio cutoff threshold of 1.9, <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone) was most predictive of glioblastoma multiforme, with 90.0% sensitivity and 76.9% specificity. The positive and negative predictive values, respectively, for glioblastoma multiforme were 75.0% and 85.7% on <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone), 83.3% and 60.0% on L-methyl-[<sup>11</sup>C]methionine, and 72.7% and 75.0% on MR imaging. In glioblastoma multiforme, volumetric analysis demonstrated that <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone) uptake had significant correlations with FDG (<em>r</em> = 0.68, <em>P</em> = .03) and L-methyl-[<sup>11</sup>C]methionine (<em>r</em> = 0.87, <em>P</em> = .03). However, the <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone)–active region was heterogeneously distributed in 50.0% (5/10) of FDG-active and 0% (0/6) of L-methyl-[<sup>11</sup>C]methionine)–active regions.</p>
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<p id="p-5"><strong>CONCLUSIONS:</strong> <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone) may be a practical radiotracer in the prediction of glioblastoma multiforme. In addition to FDG-PET, L-methyl-[<sup>11</sup>C]methionine)–PET, and MR imaging, <sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone)-PET may provide intratumoral hypoxic information useful in establishing targeted therapeutic strategies for patients with glioblastoma multiforme.</p>
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</div><div class="section glossary" id="glossary-1">
<h2>ABBREVIATIONS:</h2>
<dl id="def-list-1"><dt id="def-item-1"><sup>62</sup>Cu-ATSM<span class="def-item-dt-sep"></span></dt><dd><sup>62</sup>Cu-diacetyl-bis(N<sup>4</sup>-methylthiosemicarbazone)<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">GBM<span class="def-item-dt-sep"></span></dt><dd>glioblastoma multiforme<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">MET<span class="def-item-dt-sep"></span></dt><dd>L-methyl-[<sup>11</sup>C]methionine<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">non-GBM gliomas<span class="def-item-dt-sep"></span></dt><dd>World Health Organization grade II and III gliomas<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">SUV<sub>max</sub><span class="def-item-dt-sep"></span></dt><dd>maximum standardized uptake value<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">T/B ratio<span class="def-item-dt-sep"></span></dt><dd>tumor/background ratio</dd></dl>
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      <div class="highwire-cite-title"><sup>62</sup>Cu-Diacetyl-Bis (N<sup>4</sup>-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [<sup>18</sup>F]Fluorodeoxyglucose and L-Methyl-[<sup>11</sup>C]Methionine PET</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Tateishi</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">U.</span> <span class="nlm-surname">Tateishi</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Nakanowatari</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Ohtake</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Minamimoto</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Suenaga</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Murata</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Kubota</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Inoue</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Kawahara</span></span></span></div>
  
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      <div class="highwire-cite-title"><sup>62</sup>Cu-Diacetyl-Bis (N<sup>4</sup>-Methylthiosemicarbazone) PET in Human Gliomas: Comparative Study with [<sup>18</sup>F]Fluorodeoxyglucose and L-Methyl-[<sup>11</sup>C]Methionine PET</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Tateishi</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">U.</span> <span class="nlm-surname">Tateishi</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">S.</span> <span class="nlm-surname">Nakanowatari</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">M.</span> <span class="nlm-surname">Ohtake</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">R.</span> <span class="nlm-surname">Minamimoto</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">J.</span> <span class="nlm-surname">Suenaga</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Murata</span></span>, <span class="highwire-citation-author" data-delta="7"><span class="nlm-given-names">K.</span> <span class="nlm-surname">Kubota</span></span>, <span class="highwire-citation-author" data-delta="8"><span class="nlm-given-names">T.</span> <span class="nlm-surname">Inoue</span></span>, <span class="highwire-citation-author" data-delta="9"><span class="nlm-given-names">N.</span> <span class="nlm-surname">Kawahara</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Feb 2014, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(2) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">278-284; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3679 </span></div>
  
  
  
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