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<meta name="DC.Title" content="Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes" />
<meta name="DC.Identifier" content="10.3174/ajnr.A3720" />
<meta name="DC.Date" content="2014-03-01" />
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<meta name="DC.Description" content="BACKGROUND AND PURPOSE: An increased prevalence of disabilities is being observed as more preterm infants survive. This study was conducted to evaluate correlations between brain MR imaging measurements taken at a term-equivalent age and neurodevelopmental outcome at 2 years' corrected age among very low–birth-weight infants.

MATERIALS AND METHODS: Of the various brain MR imaging measurements obtained at term-equivalent ages, reproducible measurements of the transcerebellar diameter and anteroposterior length of the corpus callosum on sagittal images were compared with neurodevelopmental outcomes evaluated by the Bayley Scales of Infant Development (II) at 2 years' corrected age (mean ± standard deviation, 16.1 ± 6.4 months of age).

RESULTS: Ninety infants were enrolled. The mean gestational age at birth was 27 weeks and the mean birth weight was 805.5 g. A short corpus callosal length was associated with a Mental Developmental Index &lt;70 ( P = .047) and high-risk or diagnosed cerebral palsy ( P = .049). A small transcerebellar diameter was associated with a Psychomotor Developmental Index &lt;70 ( P = .003), Mental Developmental Index &lt;70 ( P = .004), and major neurologic disability ( P = .006).

CONCLUSIONS: A small transcerebellar diameter and short corpus callosal length on brain MR imaging at a term-equivalent age are related to adverse neurodevelopmental outcomes at a corrected age of 2 years and could be a useful adjunctive tool for counseling parents about future developmental outcomes.

AED
:   antiepileptic drug
NICU
:   neonatal intensive care unit
MDI
:   Mental Developmental Index
PDI
:   Psychomotor Developmental Index
TCD
:   transcerebellar diameter" />
<meta name="DC.Contributor" content="H.W. Park" />
<meta name="DC.Contributor" content="H.-K. Yoon" />
<meta name="DC.Contributor" content="S.B. Han" />
<meta name="DC.Contributor" content="B.S. Lee" />
<meta name="DC.Contributor" content="I.Y. Sung" />
<meta name="DC.Contributor" content="K.S. Kim" />
<meta name="DC.Contributor" content="E.A. Kim" />
<meta name="article:published_time" content="2014-03-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;An increased prevalence of disabilities is being observed as more preterm infants survive. This study was conducted to evaluate correlations between brain MR imaging measurements taken at a term-equivalent age and neurodevelopmental outcome at 2 years9 corrected age among very low–birth-weight infants.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;Of the various brain MR imaging measurements obtained at term-equivalent ages, reproducible measurements of the transcerebellar diameter and anteroposterior length of the corpus callosum on sagittal images were compared with neurodevelopmental outcomes evaluated by the Bayley Scales of Infant Development (II) at 2 years9 corrected age (mean ± standard deviation, 16.1 ± 6.4 months of age).&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;Ninety infants were enrolled. The mean gestational age at birth was 27 weeks and the mean birth weight was 805.5 g. A short corpus callosal length was associated with a Mental Developmental Index &amp;lt;70 (&lt;i&gt;P&lt;/i&gt; = .047) and high-risk or diagnosed cerebral palsy (&lt;i&gt;P&lt;/i&gt; = .049). A small transcerebellar diameter was associated with a Psychomotor Developmental Index &amp;lt;70 (&lt;i&gt;P&lt;/i&gt; = .003), Mental Developmental Index &amp;lt;70 (&lt;i&gt;P&lt;/i&gt; = .004), and major neurologic disability (&lt;i&gt;P&lt;/i&gt; = .006).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;A small transcerebellar diameter and short corpus callosal length on brain MR imaging at a term-equivalent age are related to adverse neurodevelopmental outcomes at a corrected age of 2 years and could be a useful adjunctive tool for counseling parents about future developmental outcomes.&lt;/p&gt;" />
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<meta name="twitter:title" content="Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: An increased prevalence of disabilities is being observed as more preterm infants survive. This study was conducted to evaluate correlations between brain MR imaging measurements taken at a term-equivalent age and neurodevelopmental outcome at 2 years' corrected age among very low–birth-weight infants.

MATERIALS AND METHODS: Of the various brain MR imaging measurements obtained at term-equivalent ages, reproducible measurements of the transcerebellar diameter and anteroposterior length of the corpus callosum on sagittal images were compared with neurodevelopmental outcomes evaluated by the Bayley Scales of Infant Development (II) at 2 years' corrected age (mean ± standard deviation, 16.1 ± 6.4 months of age).

RESULTS: Ninety infants were enrolled. The mean gestational age at birth was 27 weeks and the mean birth weight was 805.5 g. A short corpus callosal length was associated with a Mental Developmental Index &lt;70 ( P = .047) and high-risk or diagnosed cerebral palsy ( P = .049). A small transcerebellar diameter was associated with a Psychomotor Developmental Index &lt;70 ( P = .003), Mental Developmental Index &lt;70 ( P = .004), and major neurologic disability ( P = .006).

CONCLUSIONS: A small transcerebellar diameter and short corpus callosal length on brain MR imaging at a term-equivalent age are related to adverse neurodevelopmental outcomes at a corrected age of 2 years and could be a useful adjunctive tool for counseling parents about future developmental outcomes.

AED
:   antiepileptic drug
NICU
:   neonatal intensive care unit
MDI
:   Mental Developmental Index
PDI
:   Psychomotor Developmental Index
TCD
:   transcerebellar diameter" />
<meta name="og-title" property="og:title" content="Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/35/3/599" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: An increased prevalence of disabilities is being observed as more preterm infants survive. This study was conducted to evaluate correlations between brain MR imaging measurements taken at a term-equivalent age and neurodevelopmental outcome at 2 years' corrected age among very low–birth-weight infants.

MATERIALS AND METHODS: Of the various brain MR imaging measurements obtained at term-equivalent ages, reproducible measurements of the transcerebellar diameter and anteroposterior length of the corpus callosum on sagittal images were compared with neurodevelopmental outcomes evaluated by the Bayley Scales of Infant Development (II) at 2 years' corrected age (mean ± standard deviation, 16.1 ± 6.4 months of age).

RESULTS: Ninety infants were enrolled. The mean gestational age at birth was 27 weeks and the mean birth weight was 805.5 g. A short corpus callosal length was associated with a Mental Developmental Index &lt;70 ( P = .047) and high-risk or diagnosed cerebral palsy ( P = .049). A small transcerebellar diameter was associated with a Psychomotor Developmental Index &lt;70 ( P = .003), Mental Developmental Index &lt;70 ( P = .004), and major neurologic disability ( P = .006).

CONCLUSIONS: A small transcerebellar diameter and short corpus callosal length on brain MR imaging at a term-equivalent age are related to adverse neurodevelopmental outcomes at a corrected age of 2 years and could be a useful adjunctive tool for counseling parents about future developmental outcomes.

AED
:   antiepileptic drug
NICU
:   neonatal intensive care unit
MDI
:   Mental Developmental Index
PDI
:   Psychomotor Developmental Index
TCD
:   transcerebellar diameter" />
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      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">H.W. Park</span>, <span class="highwire-citation-author" data-delta="1">H.-K. Yoon</span>, <span class="highwire-citation-author" data-delta="2">S.B. Han</span>, <span class="highwire-citation-author" data-delta="3">B.S. Lee</span>, <span class="highwire-citation-author" data-delta="4">I.Y. Sung</span>, <span class="highwire-citation-author" data-delta="5">K.S. Kim</span> and <span class="highwire-citation-author" data-delta="6">E.A. Kim</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 2014,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">599-603; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A3720 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-12911--6881047975" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">H.W. Park </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Pediatrics (H.W.P.), Division of Neonatology, Konkuk University Hospital, Konkuk University School of Medicine, Seoul, Korea</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.W.%2BPark%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Park%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.W.%2BPark%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">H.-K. Yoon </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>b</span>Departments of Radiology (H.-K.Y.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.-K.%2BYoon%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Yoon%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.-K.%2BYoon%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">S.B. Han </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Clinical Epidemiology and Biostatistics (S.B.H.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.B.%2BHan%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Han%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.B.%2BHan%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">B.S. Lee </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Pediatrics, Division of Neonatology (B.S.L., K.S.K., E.A.K.), Asan Medical Center Children's Hospital, University of Ulsan, College of Medicine, Seoul, Korea.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=B.S.%2BLee%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lee%20B&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AB.S.%2BLee%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">I.Y. Sung </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>Rehabilitation (I.Y.S.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=I.Y.%2BSung%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Sung%20I&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AI.Y.%2BSung%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">K.S. Kim </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Pediatrics, Division of Neonatology (B.S.L., K.S.K., E.A.K.), Asan Medical Center Children's Hospital, University of Ulsan, College of Medicine, Seoul, Korea.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=K.S.%2BKim%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Kim%20K&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AK.S.%2BKim%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">E.A. 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    <div class="messages highwire-corrections highwire-correction-type-correction highwire-correction-type-correction"><h3 class="highwire-corrections-title">This article has a correction. Please see:</h3><ul class="highwire-corrections-list"><li class="relation-849 first last"><a href="/content/35/7/E4" class="" data-icon-position="" data-hide-link-title="0">ERRATUM - July 01, 2014</a></li></ul></div>  </div>

  
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<p id="p-1"><strong>BACKGROUND AND PURPOSE:</strong> An increased prevalence of disabilities is being observed as more preterm infants survive. This study was conducted to evaluate correlations between brain MR imaging measurements taken at a term-equivalent age and neurodevelopmental outcome at 2 years' corrected age among very low–birth-weight infants.</p>
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<p id="p-2"><strong>MATERIALS AND METHODS:</strong> Of the various brain MR imaging measurements obtained at term-equivalent ages, reproducible measurements of the transcerebellar diameter and anteroposterior length of the corpus callosum on sagittal images were compared with neurodevelopmental outcomes evaluated by the Bayley Scales of Infant Development (II) at 2 years' corrected age (mean ± standard deviation, 16.1 ± 6.4 months of age).</p>
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<p id="p-3"><strong>RESULTS:</strong> Ninety infants were enrolled. The mean gestational age at birth was 27 weeks and the mean birth weight was 805.5 g. A short corpus callosal length was associated with a Mental Developmental Index &lt;70 (<em>P</em> = .047) and high-risk or diagnosed cerebral palsy (<em>P</em> = .049). A small transcerebellar diameter was associated with a Psychomotor Developmental Index &lt;70 (<em>P</em> = .003), Mental Developmental Index &lt;70 (<em>P</em> = .004), and major neurologic disability (<em>P</em> = .006).</p>
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<p id="p-4"><strong>CONCLUSIONS:</strong> A small transcerebellar diameter and short corpus callosal length on brain MR imaging at a term-equivalent age are related to adverse neurodevelopmental outcomes at a corrected age of 2 years and could be a useful adjunctive tool for counseling parents about future developmental outcomes.</p>
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</div><div class="section glossary" id="glossary-1"><h2>ABBREVIATIONS:</h2>
<dl id="def-list-1"><dt id="def-item-1">AED<span class="def-item-dt-sep"></span></dt><dd>antiepileptic drug<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">NICU<span class="def-item-dt-sep"></span></dt><dd>neonatal intensive care unit<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">MDI<span class="def-item-dt-sep"></span></dt><dd>Mental Developmental Index<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">PDI<span class="def-item-dt-sep"></span></dt><dd>Psychomotor Developmental Index<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">TCD<span class="def-item-dt-sep"></span></dt><dd>transcerebellar diameter</dd></dl>
</div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2014 by American Journal of Neuroradiology</li></ul><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/35/3/599.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 35</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 3 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Mar 2014 </div></div>
      
      
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      <div class="highwire-cite-title">Brain MRI Measurements at a Term-Equivalent Age and Their Relationship to Neurodevelopmental Outcomes</div>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">H.W.</span> <span class="nlm-surname">Park</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">H.-K.</span> <span class="nlm-surname">Yoon</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">S.B.</span> <span class="nlm-surname">Han</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">B.S.</span> <span class="nlm-surname">Lee</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">I.Y.</span> <span class="nlm-surname">Sung</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">K.S.</span> <span class="nlm-surname">Kim</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">E.A.</span> <span class="nlm-surname">Kim</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2014, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">599-603; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3720 </span></div>
  
  
  
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2014, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">35 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">599-603; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A3720 </span></div>
  
  
  
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