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<meta name="DC.Title" content="Advanced Fiber Tracking in Early Acquired Brain Injury Causing Cerebral Palsy" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4072" />
<meta name="DC.Date" content="2015-01-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2015 by American Journal of Neuroradiology. 
Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Diffusion-weighted MR imaging and fiber tractography can be used to investigate alterations in white matter tracts in patients with early acquired brain lesions and cerebral palsy. Most existing studies have used diffusion tensor tractography, which is limited in areas of complex fiber structures or pathologic processes. We explored a combined normalization and probabilistic fiber-tracking method for more realistic fiber tractography in this patient group.

MATERIALS AND METHODS: This cross-sectional study included 17 children with unilateral cerebral palsy and 24 typically developing controls. DWI data were collected at 1.5T (45 directions, b =1000 s/mm2). Regions of interest were defined on a study-specific fractional anisotropy template and mapped onto subjects for fiber tracking. Probabilistic fiber tracking of the corticospinal tract and thalamic projections to the somatosensory cortex was performed by using constrained spherical deconvolution. Tracts were qualitatively assessed, and DTI parameters were extracted close to and distant from lesions and compared between groups.

RESULTS: The corticospinal tract and thalamic projections to the somatosensory cortex were realistically reconstructed in both groups. Structural changes to tracts were seen in the cerebral palsy group and included splits, dislocations, compaction of the tracts, or failure to delineate the tract and were associated with underlying pathology seen on conventional MR imaging. Comparisons of DTI parameters indicated primary and secondary neurodegeneration along the corticospinal tract. Corticospinal tract and thalamic projections to the somatosensory cortex showed dissimilarities in both structural changes and DTI parameters.

CONCLUSIONS: Our proposed method offers a sensitive means to explore alterations in WM tracts to further understand pathophysiologic changes following early acquired brain injury.

CerPed
:   cerebral peduncle
CP
:   cerebral palsy
CSD
:   constrained spherical deconvolution
CST
:   corticospinal tract
FA
:   fractional anisotropy
FTA
:   fiber-tract assessment
M1
:   primary motor cortex
MD
:   mean diffusivity
PLIC
:   posterior limb of the internal capsule
TRS1
:   thalamic projections to the somatosensory cortex" />
<meta name="DC.Contributor" content="F. Lennartsson" />
<meta name="DC.Contributor" content="L. Holmström" />
<meta name="DC.Contributor" content="A.-C. Eliasson" />
<meta name="DC.Contributor" content="O. Flodmark" />
<meta name="DC.Contributor" content="H. Forssberg" />
<meta name="DC.Contributor" content="J.-D. Tournier" />
<meta name="DC.Contributor" content="B. Vollmer" />
<meta name="article:published_time" content="2015-01-01" />
<meta name="article:section" content="Pediatrics" />
<meta name="citation_title" content="Advanced Fiber Tracking in Early Acquired Brain Injury Causing Cerebral Palsy" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Diffusion-weighted MR imaging and fiber tractography can be used to investigate alterations in white matter tracts in patients with early acquired brain lesions and cerebral palsy. Most existing studies have used diffusion tensor tractography, which is limited in areas of complex fiber structures or pathologic processes. We explored a combined normalization and probabilistic fiber-tracking method for more realistic fiber tractography in this patient group.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;This cross-sectional study included 17 children with unilateral cerebral palsy and 24 typically developing controls. DWI data were collected at 1.5T (45 directions, &lt;i&gt;b&lt;/i&gt;=1000 s/mm&lt;sup&gt;2&lt;/sup&gt;). Regions of interest were defined on a study-specific fractional anisotropy template and mapped onto subjects for fiber tracking. Probabilistic fiber tracking of the corticospinal tract and thalamic projections to the somatosensory cortex was performed by using constrained spherical deconvolution. Tracts were qualitatively assessed, and DTI parameters were extracted close to and distant from lesions and compared between groups.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The corticospinal tract and thalamic projections to the somatosensory cortex were realistically reconstructed in both groups. Structural changes to tracts were seen in the cerebral palsy group and included splits, dislocations, compaction of the tracts, or failure to delineate the tract and were associated with underlying pathology seen on conventional MR imaging. Comparisons of DTI parameters indicated primary and secondary neurodegeneration along the corticospinal tract. Corticospinal tract and thalamic projections to the somatosensory cortex showed dissimilarities in both structural changes and DTI parameters.&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Our proposed method offers a sensitive means to explore alterations in WM tracts to further understand pathophysiologic changes following early acquired brain injury.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
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<meta name="citation_mjid" content="ajnr;36/1/181" />
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<meta name="citation_issn" content="0195-6108" />
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<meta name="citation_author" content="F. Lennartsson" />
<meta name="citation_author_institution" content="aFrom the Department of Neuroradiology (F.L., O.F.), Karolinska University Hospital, Stockholm, Sweden" />
<meta name="citation_author_institution" content="bDepartments of Clinical Neurosciences (F.L., O.F.)" />
<meta name="citation_author" content="L. Holmström" />
<meta name="citation_author_institution" content="cWomen's and Children's Health (L.H., A.-C.E., H.F., B.V.), Karolinska Institute, Stockholm, Sweden" />
<meta name="citation_author" content="A.-C. Eliasson" />
<meta name="citation_author_institution" content="cWomen's and Children's Health (L.H., A.-C.E., H.F., B.V.), Karolinska Institute, Stockholm, Sweden" />
<meta name="citation_author" content="O. Flodmark" />
<meta name="citation_author_institution" content="aFrom the Department of Neuroradiology (F.L., O.F.), Karolinska University Hospital, Stockholm, Sweden" />
<meta name="citation_author_institution" content="bDepartments of Clinical Neurosciences (F.L., O.F.)" />
<meta name="citation_author" content="H. Forssberg" />
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<meta name="twitter:title" content="Advanced Fiber Tracking in Early Acquired Brain Injury Causing Cerebral Palsy" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Diffusion-weighted MR imaging and fiber tractography can be used to investigate alterations in white matter tracts in patients with early acquired brain lesions and cerebral palsy. Most existing studies have used diffusion tensor tractography, which is limited in areas of complex fiber structures or pathologic processes. We explored a combined normalization and probabilistic fiber-tracking method for more realistic fiber tractography in this patient group.

MATERIALS AND METHODS: This cross-sectional study included 17 children with unilateral cerebral palsy and 24 typically developing controls. DWI data were collected at 1.5T (45 directions, b =1000 s/mm2). Regions of interest were defined on a study-specific fractional anisotropy template and mapped onto subjects for fiber tracking. Probabilistic fiber tracking of the corticospinal tract and thalamic projections to the somatosensory cortex was performed by using constrained spherical deconvolution. Tracts were qualitatively assessed, and DTI parameters were extracted close to and distant from lesions and compared between groups.

RESULTS: The corticospinal tract and thalamic projections to the somatosensory cortex were realistically reconstructed in both groups. Structural changes to tracts were seen in the cerebral palsy group and included splits, dislocations, compaction of the tracts, or failure to delineate the tract and were associated with underlying pathology seen on conventional MR imaging. Comparisons of DTI parameters indicated primary and secondary neurodegeneration along the corticospinal tract. Corticospinal tract and thalamic projections to the somatosensory cortex showed dissimilarities in both structural changes and DTI parameters.

CONCLUSIONS: Our proposed method offers a sensitive means to explore alterations in WM tracts to further understand pathophysiologic changes following early acquired brain injury.

CerPed
:   cerebral peduncle
CP
:   cerebral palsy
CSD
:   constrained spherical deconvolution
CST
:   corticospinal tract
FA
:   fractional anisotropy
FTA
:   fiber-tract assessment
M1
:   primary motor cortex
MD
:   mean diffusivity
PLIC
:   posterior limb of the internal capsule
TRS1
:   thalamic projections to the somatosensory cortex" />
<meta name="og-title" property="og:title" content="Advanced Fiber Tracking in Early Acquired Brain Injury Causing Cerebral Palsy" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/36/1/181" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Diffusion-weighted MR imaging and fiber tractography can be used to investigate alterations in white matter tracts in patients with early acquired brain lesions and cerebral palsy. Most existing studies have used diffusion tensor tractography, which is limited in areas of complex fiber structures or pathologic processes. We explored a combined normalization and probabilistic fiber-tracking method for more realistic fiber tractography in this patient group.

MATERIALS AND METHODS: This cross-sectional study included 17 children with unilateral cerebral palsy and 24 typically developing controls. DWI data were collected at 1.5T (45 directions, b =1000 s/mm2). Regions of interest were defined on a study-specific fractional anisotropy template and mapped onto subjects for fiber tracking. Probabilistic fiber tracking of the corticospinal tract and thalamic projections to the somatosensory cortex was performed by using constrained spherical deconvolution. Tracts were qualitatively assessed, and DTI parameters were extracted close to and distant from lesions and compared between groups.

RESULTS: The corticospinal tract and thalamic projections to the somatosensory cortex were realistically reconstructed in both groups. Structural changes to tracts were seen in the cerebral palsy group and included splits, dislocations, compaction of the tracts, or failure to delineate the tract and were associated with underlying pathology seen on conventional MR imaging. Comparisons of DTI parameters indicated primary and secondary neurodegeneration along the corticospinal tract. Corticospinal tract and thalamic projections to the somatosensory cortex showed dissimilarities in both structural changes and DTI parameters.

CONCLUSIONS: Our proposed method offers a sensitive means to explore alterations in WM tracts to further understand pathophysiologic changes following early acquired brain injury.

CerPed
:   cerebral peduncle
CP
:   cerebral palsy
CSD
:   constrained spherical deconvolution
CST
:   corticospinal tract
FA
:   fractional anisotropy
FTA
:   fiber-tract assessment
M1
:   primary motor cortex
MD
:   mean diffusivity
PLIC
:   posterior limb of the internal capsule
TRS1
:   thalamic projections to the somatosensory cortex" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node13950--5" data-node-nid="13950" id="top-node-13950--61954590749" data-pisa="ajnr;36/1/181" data-pisa-master="ajnr;ajnr.A4072" data-apath="/ajnr/36/1/181.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Pediatrics</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Advanced Fiber Tracking in Early Acquired Brain Injury Causing Cerebral Palsy</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">F. Lennartsson</span>, <span class="highwire-citation-author" data-delta="1">L. Holmström</span>, <span class="highwire-citation-author" data-delta="2">A.-C. Eliasson</span>, <span class="highwire-citation-author" data-delta="3">O. Flodmark</span>, <span class="highwire-citation-author" data-delta="4">H. Forssberg</span>, <span class="highwire-citation-author" data-delta="5">J.-D. Tournier</span> and <span class="highwire-citation-author" data-delta="6">B. Vollmer</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">January 2015,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">36 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">181-187; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4072 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-13950--61954590749" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">F. Lennartsson </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neuroradiology (F.L., O.F.), Karolinska University Hospital, Stockholm, Sweden</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Departments of Clinical Neurosciences (F.L., O.F.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.%2BLennartsson%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lennartsson%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.%2BLennartsson%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">L. Holmström </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Women's and Children's Health (L.H., A.-C.E., H.F., B.V.), Karolinska Institute, Stockholm, Sweden</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=L.%2BHolmstr%C3%B6m%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Holmstr%C3%B6m%20L&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AL.%2BHolmstr%25C3%25B6m%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">A.-C. Eliasson </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Women's and Children's Health (L.H., A.-C.E., H.F., B.V.), Karolinska Institute, Stockholm, Sweden</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=A.-C.%2BEliasson%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Eliasson%20A&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AA.-C.%2BEliasson%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">O. Flodmark </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Neuroradiology (F.L., O.F.), Karolinska University Hospital, Stockholm, Sweden</div><div class='author-affiliation'><span class='nlm-sup'>b</span>Departments of Clinical Neurosciences (F.L., O.F.)</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=O.%2BFlodmark%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Flodmark%20O&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AO.%2BFlodmark%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">H. Forssberg </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>c</span>Women's and Children's Health (L.H., A.-C.E., H.F., B.V.), Karolinska Institute, Stockholm, Sweden</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.%2BForssberg%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Forssberg%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.%2BForssberg%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">J.-D. Tournier </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>d</span>The Florey Institute of Neuroscience and Mental Health (J.-D.T.), Melbourne, Victoria, Australia</div><div class='author-affiliation'><span class='nlm-sup'>e</span>Department of Medicine (J.-D.T.), University of Melbourne, Victoria, Australia</div><div class='author-affiliation'><span class='nlm-sup'>f</span>Centre for the Developing Brain (J.-D.T.)</div><div class='author-affiliation'><span class='nlm-sup'>g</span>Department of Biomedical Engineering (J.-D.T.), Division of Imaging Sciences and Biomedical Engineering, King's College London, London, United Kingdom</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.-D.%2BTournier%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Tournier%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.-D.%2BTournier%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">B. 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<p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> Diffusion-weighted MR imaging and fiber tractography can be used to investigate alterations in white matter tracts in patients with early acquired brain lesions and cerebral palsy. Most existing studies have used diffusion tensor tractography, which is limited in areas of complex fiber structures or pathologic processes. We explored a combined normalization and probabilistic fiber-tracking method for more realistic fiber tractography in this patient group.</p>
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<p id="p-3"><strong>MATERIALS AND METHODS:</strong> This cross-sectional study included 17 children with unilateral cerebral palsy and 24 typically developing controls. DWI data were collected at 1.5T (45 directions, <em>b</em>=1000 s/mm<sup>2</sup>). Regions of interest were defined on a study-specific fractional anisotropy template and mapped onto subjects for fiber tracking. Probabilistic fiber tracking of the corticospinal tract and thalamic projections to the somatosensory cortex was performed by using constrained spherical deconvolution. Tracts were qualitatively assessed, and DTI parameters were extracted close to and distant from lesions and compared between groups.</p>
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<p id="p-4"><strong>RESULTS:</strong> The corticospinal tract and thalamic projections to the somatosensory cortex were realistically reconstructed in both groups. Structural changes to tracts were seen in the cerebral palsy group and included splits, dislocations, compaction of the tracts, or failure to delineate the tract and were associated with underlying pathology seen on conventional MR imaging. Comparisons of DTI parameters indicated primary and secondary neurodegeneration along the corticospinal tract. Corticospinal tract and thalamic projections to the somatosensory cortex showed dissimilarities in both structural changes and DTI parameters.</p>
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<p id="p-5"><strong>CONCLUSIONS:</strong> Our proposed method offers a sensitive means to explore alterations in WM tracts to further understand pathophysiologic changes following early acquired brain injury.</p>
</div></div><div class="section glossary" id="glossary-1">
<h2 class="">ABBREVIATIONS:</h2>
<dl id="def-list-1"><dt id="def-item-1">CerPed<span class="def-item-dt-sep"></span></dt><dd>cerebral peduncle<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">CP<span class="def-item-dt-sep"></span></dt><dd>cerebral palsy<span class="def-item-dd-sep"></span></dd><dt id="def-item-3">CSD<span class="def-item-dt-sep"></span></dt><dd>constrained spherical deconvolution<span class="def-item-dd-sep"></span></dd><dt id="def-item-4">CST<span class="def-item-dt-sep"></span></dt><dd>corticospinal tract<span class="def-item-dd-sep"></span></dd><dt id="def-item-5">FA<span class="def-item-dt-sep"></span></dt><dd>fractional anisotropy<span class="def-item-dd-sep"></span></dd><dt id="def-item-6">FTA<span class="def-item-dt-sep"></span></dt><dd>fiber-tract assessment<span class="def-item-dd-sep"></span></dd><dt id="def-item-7">M1<span class="def-item-dt-sep"></span></dt><dd>primary motor cortex<span class="def-item-dd-sep"></span></dd><dt id="def-item-8">MD<span class="def-item-dt-sep"></span></dt><dd>mean diffusivity<span class="def-item-dd-sep"></span></dd><dt id="def-item-9">PLIC<span class="def-item-dt-sep"></span></dt><dd>posterior limb of the internal capsule<span class="def-item-dd-sep"></span></dd><dt id="def-item-10">TRS1<span class="def-item-dt-sep"></span></dt><dd>thalamic projections to the somatosensory cortex</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2015 by American Journal of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at <a href="http://www.ajnr.org">www.ajnr.org</a></p></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/36/1/181.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 36</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 1 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Jan 2015 </div></div>
      
      
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Lennartsson</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Holmström</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.-C.</span> <span class="nlm-surname">Eliasson</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">O.</span> <span class="nlm-surname">Flodmark</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Forssberg</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">J.-D.</span> <span class="nlm-surname">Tournier</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Vollmer</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2015, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">36 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">181-187; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4072 </span></div>
  
  
  
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    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0"><span class="nlm-given-names">F.</span> <span class="nlm-surname">Lennartsson</span></span>, <span class="highwire-citation-author" data-delta="1"><span class="nlm-given-names">L.</span> <span class="nlm-surname">Holmström</span></span>, <span class="highwire-citation-author" data-delta="2"><span class="nlm-given-names">A.-C.</span> <span class="nlm-surname">Eliasson</span></span>, <span class="highwire-citation-author" data-delta="3"><span class="nlm-given-names">O.</span> <span class="nlm-surname">Flodmark</span></span>, <span class="highwire-citation-author" data-delta="4"><span class="nlm-given-names">H.</span> <span class="nlm-surname">Forssberg</span></span>, <span class="highwire-citation-author" data-delta="5"><span class="nlm-given-names">J.-D.</span> <span class="nlm-surname">Tournier</span></span>, <span class="highwire-citation-author" data-delta="6"><span class="nlm-given-names">B.</span> <span class="nlm-surname">Vollmer</span></span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Jan 2015, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">36 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(1) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">181-187; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4072 </span></div>
  
  
  
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