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<meta name="DC.Title" content="Pretreatment Diagnosis of Suprasellar Papillary Craniopharyngioma and Germ Cell Tumors of Adult Patients" />
<meta name="DC.Identifier" content="10.3174/ajnr.A4142" />
<meta name="DC.Date" content="2015-03-01" />
<meta name="DC.Publisher" content="American Journal of Neuroradiology" />
<meta name="DC.Rights" content="© 2015 by American Journal of Neuroradiology. 
Indicates open access to non-subscribers at www.ajnr.org" />
<meta name="DC.AccessRights" content="open-access" />
<meta name="DC.Description" content="BACKGROUND AND PURPOSE: Suprasellar papillary craniopharyngiomas and germ cell tumors in adults share some clinical and imaging similarities but have different therapeutic strategies and outcomes. This study aimed to evaluate the pretreatment diagnosis of these 2 tumors to improve the therapeutic outcome.

MATERIALS AND METHODS: We retrospectively enrolled 18 adults with papillary craniopharyngiomas and 17 with germ cell tumors. The MR imaging findings were evaluated, including signal change and anatomic extension. The medical records were reviewed to collect clinical findings, management, and outcomes.

RESULTS: The clinical findings of papillary craniopharyngiomas versus germ cell tumors were as follows: age: 46 ± 13.9 years versus 23 ± 7.1 years ( P &lt; .0001); diabetes insipidus: 2/18 (11%) versus 11/17 (65%) ( P = .001); recurrence 13/16 (81%) versus 4/17 (24%) ( P = .0031). The MR imaging findings of papillary craniopharyngiomas versus germ cell tumors were as follows—pituitary stalk thickening: 1.6 ± 0.4 mm versus 5.4 ± 4.2 mm ( P &lt; .0001); vertical infundibular extension: 1/18 (6%) versus 16/17 (94%) ( P &lt; .0001); sagittal spheric shape: 17/18 (94%) versus 1/17 (6%) ( P &lt; .0001); diffusion restriction: 1/17 (6%) versus 8/12 (67%) ( P = .0009).

CONCLUSIONS: Younger age, diabetes insipidus, MR imaging characteristics of restricted diffusion, and vertical infundibular extension favor the diagnosis of germ cell tumors. Spheric shape without infundibular infiltration provides clues to papillary craniopharyngiomas, which originate from the pars tuberalis and are located outside the third ventricle. We suggest that suprasellar germ cell tumor is possibly an intraventricular lesion. Appropriate treatment planning can be initiated according to the diagnosis and anatomic location.

GCT
:   germ cell tumor
PCP
:   papillary craniopharyngioma" />
<meta name="DC.Contributor" content="H.-J. Lee" />
<meta name="DC.Contributor" content="C.-C. Wu" />
<meta name="DC.Contributor" content="H.-M. Wu" />
<meta name="DC.Contributor" content="S.-C. Hung" />
<meta name="DC.Contributor" content="J.-F. Lirng" />
<meta name="DC.Contributor" content="C.-B. Luo" />
<meta name="DC.Contributor" content="F.-C. Chang" />
<meta name="DC.Contributor" content="W.-Y. Guo" />
<meta name="article:published_time" content="2015-03-01" />
<meta name="article:section" content="Brain" />
<meta name="citation_title" content="Pretreatment Diagnosis of Suprasellar Papillary Craniopharyngioma and Germ Cell Tumors of Adult Patients" />
<meta name="citation_abstract" lang="en" content="&lt;h3&gt;BACKGROUND AND PURPOSE:&lt;/h3&gt;
&lt;p&gt;Suprasellar papillary craniopharyngiomas and germ cell tumors in adults share some clinical and imaging similarities but have different therapeutic strategies and outcomes. This study aimed to evaluate the pretreatment diagnosis of these 2 tumors to improve the therapeutic outcome.&lt;/p&gt;&lt;h3&gt;MATERIALS AND METHODS:&lt;/h3&gt;
&lt;p&gt;We retrospectively enrolled 18 adults with papillary craniopharyngiomas and 17 with germ cell tumors. The MR imaging findings were evaluated, including signal change and anatomic extension. The medical records were reviewed to collect clinical findings, management, and outcomes.&lt;/p&gt;&lt;h3&gt;RESULTS:&lt;/h3&gt;
&lt;p&gt;The clinical findings of papillary craniopharyngiomas versus germ cell tumors were as follows: age: 46 ± 13.9 years versus 23 ± 7.1 years (&lt;i&gt;P&lt;/i&gt; &amp;lt; .0001); diabetes insipidus: 2/18 (11%) versus 11/17 (65%) (&lt;i&gt;P&lt;/i&gt; = .001); recurrence 13/16 (81%) versus 4/17 (24%) (&lt;i&gt;P&lt;/i&gt; = .0031). The MR imaging findings of papillary craniopharyngiomas versus germ cell tumors were as follows—pituitary stalk thickening: 1.6 ± 0.4 mm versus 5.4 ± 4.2 mm (&lt;i&gt;P&lt;/i&gt; &amp;lt; .0001); vertical infundibular extension: 1/18 (6%) versus 16/17 (94%) (&lt;i&gt;P&lt;/i&gt; &amp;lt; .0001); sagittal spheric shape: 17/18 (94%) versus 1/17 (6%) (&lt;i&gt;P&lt;/i&gt; &amp;lt; .0001); diffusion restriction: 1/17 (6%) versus 8/12 (67%) (&lt;i&gt;P&lt;/i&gt; = .0009).&lt;/p&gt;&lt;h3&gt;CONCLUSIONS:&lt;/h3&gt;
&lt;p&gt;Younger age, diabetes insipidus, MR imaging characteristics of restricted diffusion, and vertical infundibular extension favor the diagnosis of germ cell tumors. Spheric shape without infundibular infiltration provides clues to papillary craniopharyngiomas, which originate from the pars tuberalis and are located outside the third ventricle. We suggest that suprasellar germ cell tumor is possibly an intraventricular lesion. Appropriate treatment planning can be initiated according to the diagnosis and anatomic location.&lt;/p&gt;" />
<meta name="citation_journal_title" content="American Journal of Neuroradiology" />
<meta name="citation_publisher" content="American Journal of Neuroradiology" />
<meta name="citation_publication_date" content="2015/03/01" />
<meta name="citation_mjid" content="ajnr;36/3/508" />
<meta name="citation_id" content="36/3/508" />
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<meta name="citation_issn" content="0195-6108" />
<meta name="citation_issn" content="1936-959X" />
<meta name="citation_doi" content="10.3174/ajnr.A4142" />
<meta name="citation_pmid" content="25339645" />
<meta name="citation_volume" content="36" />
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<meta name="citation_firstpage" content="508" />
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<meta name="citation_author" content="H.-J. Lee" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan." />
<meta name="citation_author_orcid" content="http://orcid.org/0000-0002-9303-7165" />
<meta name="citation_author" content="C.-C. Wu" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan." />
<meta name="citation_author" content="H.-M. Wu" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan." />
<meta name="citation_author" content="S.-C. Hung" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan." />
<meta name="citation_author" content="J.-F. Lirng" />
<meta name="citation_author_institution" content="aFrom the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan." />
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<meta name="twitter:title" content="Pretreatment Diagnosis of Suprasellar Papillary Craniopharyngioma and Germ Cell Tumors of Adult Patients" />
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<meta name="twitter:description" content="BACKGROUND AND PURPOSE: Suprasellar papillary craniopharyngiomas and germ cell tumors in adults share some clinical and imaging similarities but have different therapeutic strategies and outcomes. This study aimed to evaluate the pretreatment diagnosis of these 2 tumors to improve the therapeutic outcome.

MATERIALS AND METHODS: We retrospectively enrolled 18 adults with papillary craniopharyngiomas and 17 with germ cell tumors. The MR imaging findings were evaluated, including signal change and anatomic extension. The medical records were reviewed to collect clinical findings, management, and outcomes.

RESULTS: The clinical findings of papillary craniopharyngiomas versus germ cell tumors were as follows: age: 46 ± 13.9 years versus 23 ± 7.1 years ( P &lt; .0001); diabetes insipidus: 2/18 (11%) versus 11/17 (65%) ( P = .001); recurrence 13/16 (81%) versus 4/17 (24%) ( P = .0031). The MR imaging findings of papillary craniopharyngiomas versus germ cell tumors were as follows—pituitary stalk thickening: 1.6 ± 0.4 mm versus 5.4 ± 4.2 mm ( P &lt; .0001); vertical infundibular extension: 1/18 (6%) versus 16/17 (94%) ( P &lt; .0001); sagittal spheric shape: 17/18 (94%) versus 1/17 (6%) ( P &lt; .0001); diffusion restriction: 1/17 (6%) versus 8/12 (67%) ( P = .0009).

CONCLUSIONS: Younger age, diabetes insipidus, MR imaging characteristics of restricted diffusion, and vertical infundibular extension favor the diagnosis of germ cell tumors. Spheric shape without infundibular infiltration provides clues to papillary craniopharyngiomas, which originate from the pars tuberalis and are located outside the third ventricle. We suggest that suprasellar germ cell tumor is possibly an intraventricular lesion. Appropriate treatment planning can be initiated according to the diagnosis and anatomic location.

GCT
:   germ cell tumor
PCP
:   papillary craniopharyngioma" />
<meta name="og-title" property="og:title" content="Pretreatment Diagnosis of Suprasellar Papillary Craniopharyngioma and Germ Cell Tumors of Adult Patients" />
<meta name="og-url" property="og:url" content="http://ajnr-stage2.stage.highwire.org/content/36/3/508" />
<meta name="og-site-name" property="og:site_name" content="American Journal of Neuroradiology" />
<meta name="og-description" property="og:description" content="BACKGROUND AND PURPOSE: Suprasellar papillary craniopharyngiomas and germ cell tumors in adults share some clinical and imaging similarities but have different therapeutic strategies and outcomes. This study aimed to evaluate the pretreatment diagnosis of these 2 tumors to improve the therapeutic outcome.

MATERIALS AND METHODS: We retrospectively enrolled 18 adults with papillary craniopharyngiomas and 17 with germ cell tumors. The MR imaging findings were evaluated, including signal change and anatomic extension. The medical records were reviewed to collect clinical findings, management, and outcomes.

RESULTS: The clinical findings of papillary craniopharyngiomas versus germ cell tumors were as follows: age: 46 ± 13.9 years versus 23 ± 7.1 years ( P &lt; .0001); diabetes insipidus: 2/18 (11%) versus 11/17 (65%) ( P = .001); recurrence 13/16 (81%) versus 4/17 (24%) ( P = .0031). The MR imaging findings of papillary craniopharyngiomas versus germ cell tumors were as follows—pituitary stalk thickening: 1.6 ± 0.4 mm versus 5.4 ± 4.2 mm ( P &lt; .0001); vertical infundibular extension: 1/18 (6%) versus 16/17 (94%) ( P &lt; .0001); sagittal spheric shape: 17/18 (94%) versus 1/17 (6%) ( P &lt; .0001); diffusion restriction: 1/17 (6%) versus 8/12 (67%) ( P = .0009).

CONCLUSIONS: Younger age, diabetes insipidus, MR imaging characteristics of restricted diffusion, and vertical infundibular extension favor the diagnosis of germ cell tumors. Spheric shape without infundibular infiltration provides clues to papillary craniopharyngiomas, which originate from the pars tuberalis and are located outside the third ventricle. We suggest that suprasellar germ cell tumor is possibly an intraventricular lesion. Appropriate treatment planning can be initiated according to the diagnosis and anatomic location.

GCT
:   germ cell tumor
PCP
:   papillary craniopharyngioma" />
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    <div class="highwire-article-citation highwire-citation-type-highwire-article node14009--5" data-node-nid="14009" id="top-node-14009--61242473758" data-pisa="ajnr;36/3/508" data-pisa-master="ajnr;ajnr.A4142" data-apath="/ajnr/36/3/508.atom" data-hw-author-tooltip-instance="highwire_author_tooltip"><div class="highwire-cite highwire-cite-highwire-article highwire-citation-jcore-article-title-complete clearfix has-author-tooltip highwire-citation-highwire-article-top-a">
  
  
      <div class="highwire-cite-overline"><span  class="highwire-cite-metadata-article-type highwire-cite-metadata">Research Article</span><span class="separator-pipe"></span><span  class="highwire-cite-metadata-art-cat highwire-cite-metadata"><span class="wrapper">Brain</span></span></div>
  
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      <h1 class="highwire-cite-title" id="page-title">Pretreatment Diagnosis of Suprasellar Papillary Craniopharyngioma and Germ Cell Tumors of Adult Patients</h1>  
    	<div class="highwire-cite-authors"><span  class="highwire-citation-authors"><span class="highwire-citation-author first" data-delta="0">H.-J. Lee</span>, <span class="highwire-citation-author" data-delta="1">C.-C. Wu</span>, <span class="highwire-citation-author" data-delta="2">H.-M. Wu</span>, <span class="highwire-citation-author" data-delta="3">S.-C. Hung</span>, <span class="highwire-citation-author" data-delta="4">J.-F. Lirng</span>, <span class="highwire-citation-author" data-delta="5">C.-B. Luo</span>, <span class="highwire-citation-author" data-delta="6">F.-C. Chang</span> and <span class="highwire-citation-author" data-delta="7">W.-Y. Guo</span></span></div>
  
    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">March 2015,  </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">36 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">508-517; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata">DOI: https://doi.org/10.3174/ajnr.A4142 </span></div>
  
  
  
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<div id="hw-article-author-popups-top-node-14009--61242473758" style="display: none;"><div class="author-tooltip-0"><div class="author-tooltip-name">H.-J. Lee </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.-J.%2BLee%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lee%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link"><a href="/search/author1%3AH.-J.%2BLee%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li><li class="author-orcid-link last"><a href="http://orcid.org/0000-0002-9303-7165" target="_blank" class="" data-icon-position="" data-hide-link-title="0">ORCID record for H.-J. Lee</a></li></ul></div><div class="author-tooltip-1"><div class="author-tooltip-name">C.-C. Wu </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.-C.%2BWu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wu%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.-C.%2BWu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-2"><div class="author-tooltip-name">H.-M. Wu </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=H.-M.%2BWu%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Wu%20H&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AH.-M.%2BWu%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-3"><div class="author-tooltip-name">S.-C. Hung </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=S.-C.%2BHung%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Hung%20S&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AS.-C.%2BHung%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-4"><div class="author-tooltip-name">J.-F. Lirng </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=J.-F.%2BLirng%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Lirng%20J&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AJ.-F.%2BLirng%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-5"><div class="author-tooltip-name">C.-B. Luo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=C.-B.%2BLuo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Luo%20C&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AC.-B.%2BLuo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-6"><div class="author-tooltip-name">F.-C. Chang </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=F.-C.%2BChang%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Chang%20F&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AF.-C.%2BChang%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div><div class="author-tooltip-7"><div class="author-tooltip-name">W.-Y. Guo </div><div class="author-tooltip-affiliation"><span class="author-tooltip-text"><div class='author-affiliation'><span class='nlm-sup'>a</span>From the Department of Radiology, Taipei Veterans General Hospital, Taipei, Taiwan; and School of Medicine, National Yang-Ming University, Taipei, Taiwan.</div></span></div><ul class="author-tooltip-find-more"><li class="author-tooltip-gs-link first"><a href="/lookup/google-scholar?link_type=googlescholar&amp;gs_type=author&amp;author%5B0%5D=W.-Y.%2BGuo%2B" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on Google Scholar</a></li><li class="author-tooltip-pubmed-link"><a href="/lookup/external-ref?access_num=Guo%20W&amp;link_type=AUTHORSEARCH" target="_blank" class="" data-icon-position="" data-hide-link-title="0">Find this author on PubMed</a></li><li class="author-site-search-link last"><a href="/search/author1%3AW.-Y.%2BGuo%2B" rel="nofollow" class="" data-icon-position="" data-hide-link-title="0">Search for this author on this site</a></li></ul></div></div></div>  </div>

  
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<p id="p-2"><strong>BACKGROUND AND PURPOSE:</strong> Suprasellar papillary craniopharyngiomas and germ cell tumors in adults share some clinical and imaging similarities but have different therapeutic strategies and outcomes. This study aimed to evaluate the pretreatment diagnosis of these 2 tumors to improve the therapeutic outcome.</p>
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<p id="p-3"><strong>MATERIALS AND METHODS:</strong> We retrospectively enrolled 18 adults with papillary craniopharyngiomas and 17 with germ cell tumors. The MR imaging findings were evaluated, including signal change and anatomic extension. The medical records were reviewed to collect clinical findings, management, and outcomes.</p>
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<p id="p-4"><strong>RESULTS:</strong> The clinical findings of papillary craniopharyngiomas versus germ cell tumors were as follows: age: 46 ± 13.9 years versus 23 ± 7.1 years (<em>P</em> &lt; .0001); diabetes insipidus: 2/18 (11%) versus 11/17 (65%) (<em>P</em> = .001); recurrence 13/16 (81%) versus 4/17 (24%) (<em>P</em> = .0031). The MR imaging findings of papillary craniopharyngiomas versus germ cell tumors were as follows—pituitary stalk thickening: 1.6 ± 0.4 mm versus 5.4 ± 4.2 mm (<em>P</em> &lt; .0001); vertical infundibular extension: 1/18 (6%) versus 16/17 (94%) (<em>P</em> &lt; .0001); sagittal spheric shape: 17/18 (94%) versus 1/17 (6%) (<em>P</em> &lt; .0001); diffusion restriction: 1/17 (6%) versus 8/12 (67%) (<em>P</em> = .0009).</p>
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<p id="p-5"><strong>CONCLUSIONS:</strong> Younger age, diabetes insipidus, MR imaging characteristics of restricted diffusion, and vertical infundibular extension favor the diagnosis of germ cell tumors. Spheric shape without infundibular infiltration provides clues to papillary craniopharyngiomas, which originate from the pars tuberalis and are located outside the third ventricle. We suggest that suprasellar germ cell tumor is possibly an intraventricular lesion. Appropriate treatment planning can be initiated according to the diagnosis and anatomic location.</p>
</div></div><div class="section glossary" id="glossary-1">
<h2 class="">ABBREVIATIONS:</h2>
<dl id="def-list-1"><dt id="def-item-1">GCT<span class="def-item-dt-sep"></span></dt><dd>germ cell tumor<span class="def-item-dd-sep"></span></dd><dt id="def-item-2">PCP<span class="def-item-dt-sep"></span></dt><dd>papillary craniopharyngioma</dd></dl></div><ul class="copyright-statement"><li class="fn" id="copyright-statement-1">© 2015 by American Journal of Neuroradiology</li></ul><div class="license" id="license-1"><p id="p-1">Indicates open access to non-subscribers at <a href="http://www.ajnr.org" rel="license">www.ajnr.org</a></p></div><span class="highwire-journal-article-marker-end"></span></div><span class="related-urls"></span></div><a href="http://ajnr-stage2.stage.highwire.org/content/36/3/508.full" class="hw-link hw-link-article-full-text" data-icon-position="" data-hide-link-title="0">View Full Text</a></div>  </div>

  
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        	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-volume highwire-cite-metadata">Vol. 36</span>, <span  class="highwire-cite-metadata-issue highwire-cite-metadata">Issue 3 </span><div  class="highwire-cite-metadata-pubdate highwire-cite-metadata">1 Mar 2015 </div></div>
      
      
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    	<div class="highwire-cite-metadata"><span  class="highwire-cite-metadata-oa-ind highwire-cite-metadata"><i class="highwire-oa-indicator"></i> </span><span  class="highwire-cite-metadata-journal highwire-cite-metadata">American Journal of Neuroradiology </span><span  class="highwire-cite-metadata-date highwire-cite-metadata">Mar 2015, </span><span  class="highwire-cite-metadata-volume highwire-cite-metadata">36 </span><span  class="highwire-cite-metadata-issue highwire-cite-metadata">(3) </span><span  class="highwire-cite-metadata-pages highwire-cite-metadata">508-517; </span><span  class="highwire-cite-metadata-doi highwire-cite-metadata"><span class="label">DOI:</span> 10.3174/ajnr.A4142 </span></div>
  
  
  
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