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    Index by author — May 01, 2016, 37 (5) | American Journal of Neuroradiology  
    
















    





















    
  
  




    
    

  

      


    

      

  
  
  

    

  

    

  

                
    

      

  

    

  
      
  
  

    


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Index by author
  	
      
May 01, 2016; Volume 37,Issue 5 

  
  
   

  
  



  


  
  



			

		

	
	
 	
	  
  

		
		

			

			  

  
      
  
  

    
  1. Buchert, M.
    1. 
  
  
      
      INTERVENTIONAL 
      
  
      
      Open Access
      
  
      Endovascular Cooling Catheter for Selective Brain Hypothermia: An Animal Feasibility Study of Cooling Performance  
    	
      G. Cattaneo, M. Schumacher, C. Maurer, J. Wolfertz, T. Jost, M. Büchert, A. Keuler, L. Boos, M.J. Shah, K. Foerster, W.-D. Niesen, G. Ihorst, H. Urbach and S. Meckel
      
  
    	
      American Journal of Neuroradiology May 2016, 37 (5) 885-891; DOI: https://doi.org/10.3174/ajnr.A4625 
      
  
  
  

      

  2. Buonacorrsi, G.
    1. 
  
  
      
      EDITOR'S CHOICEADULT BRAIN 
      
  
      
      Open Access
      
  
      Mitotic Activity in Glioblastoma Correlates with Estimated Extravascular Extracellular Space Derived from Dynamic Contrast-Enhanced MR Imaging  
    	
      S.J. Mills, D. du Plessis, P. Pal, G. Thompson, G. Buonacorrsi, C. Soh, G.J.M. Parker and A. Jackson
      
  
    	
      American Journal of Neuroradiology May 2016, 37 (5) 811-817; DOI: https://doi.org/10.3174/ajnr.A4623 
      
  
    	
      Twenty-eight patients with newly presenting glioblastoma multiforme underwent preoperative conventional imaging and T1 dynamic contrast-enhanced MRI. Parametric maps of the initial area under the contrast agent concentration curve, contrast transfer coefficient, estimate of volume of the extravascular extracellular space, and estimate of blood plasma volume were generated, and the enhancing fraction was calculated. High values of the estimate of volume of the extravascular extracellular space were associated with a fibrillary histologic pattern and increased mitotic activity. This finding is counterintuitive to the standard concept that more proliferative tumors would be more densely packed with cells and have less extracellular space. As the authors point out, this surprising finding requires more investigation to understand whether this relationship will hold, and what the underlying mechanism might be.
      
  
  

      

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